Conformational changes in the active site loops of dihydrofolate reductase during the catalytic cycle

Biochemistry

Volumn 43, Issue 51, 2004, Pages 16046-16055

  Venkitakrishnan, Rani P ^a   Zaborowski, Eduardo ^a   McElheny, Dan ^a   Benkovic, Stephen J ^b   Dyson, H Jane ^a   Wright, Peter E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CONFORMATIONS; ESCHERICHIA COLI; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

BINARY COMPLEX; COUPLED LOOPED MOVEMENTS; DIHYDROFOLATE (DHF);

ENZYMES;

5,6 DIHYDRO REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; APOENZYME; DIHYDROFOLATE REDUCTASE; DIHYDROFOLIC ACID; FOLIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TETRAHYDROFOLIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL; BINDING SITE; CONFORMATIONAL TRANSITION; ENERGY TRANSFER; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; MICHAELIS CONSTANT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OXIDATION; PRIORITY JOURNAL; PROTEIN STRUCTURE; STRUCTURE ANALYSIS; WILD TYPE; X RAY CRYSTALLOGRAPHY;

CATALYTIC DOMAIN; ESCHERICHIA COLI; FOLIC ACID; NADP; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE ANALYSIS, PROTEIN; SPECTRUM ANALYSIS; TETRAHYDROFOLATE DEHYDROGENASE; TETRAHYDROFOLATES;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 11144328151     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi048119y     Document Type: Article

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