Different reaction mechanisms for mesophilic and thermophilic dihydrofolate reductases

Journal of the American Chemical Society

Volumn 131, Issue 20, 2009, Pages 6926-6927

  Loverldge, E Joel ^a   Behiry, Enas M ^a   Swanwick, Richard S ^a,b   Allemann, Rudolf K ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; CONCERTED REACTIONS; DIHYDROFOLATE REDUCTASE; E. COLI; HYDRIDE TRANSFERS; MECHANISTIC DIFFERENCES; MESOPHILIC; MULTIPLE ISOTOPE EFFECT; QUATERNARY STRUCTURE; REACTION MECHANISM; SOLVENT KINETIC ISOTOPE EFFECTS; THERMOPHILIC ENZYMES; THERMOTOGA MARITIMA;

CARRIER MOBILITY; ENZYMES; ESCHERICHIA COLI; ISOTOPES; PROTON TRANSFER; REACTION RATES;

PH;

DIHYDROFOLATE REDUCTASE; BACTERIAL PROTEIN;

ARTICLE; MESOPHILE; REDUCTION; TEMPERATURE; THERMOPHILE; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; ENZYMOLOGY; ESCHERICHIA COLI; KINETICS; METABOLISM; PH; THERMOTOGA MARITIMA;

BACTERIAL PROTEINS; CATALYSIS; ESCHERICHIA COLI; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; TETRAHYDROFOLATE DEHYDROGENASE; THERMOTOGA MARITIMA;

EID: 70349085827     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja901441k     Document Type: Article

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