Effect of dimerization on the stability and catalytic activity of dihydrofolate reductase from the hyperthermophile Thermotoga maritima

Biochemistry

Volumn 48, Issue 25, 2009, Pages 5922-5933

  Loveridge, E Joel ^a   Rodriguez, Robert J ^a   Swanwick, Richard S ^a,b   Allemann, Rudolf K ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACILLUS STEAROTHERMOPHILUS; CATALYTIC ACTIVITY; CATALYTIC CYCLES; CORRELATED MOTIONS; DIHYDROFOLATE REDUCTASE; DIMER INTERFACE; EXPERIMENTAL CONDITIONS; HYDRIDE TRANSFERS; HYPERTHERMOPHILE; HYPERTHERMOPHILES; MELTING TEMPERATURES; MONOMERIC FORMS; THERMAL STABILITY; THERMOTOGA MARITIMA; TURNOVER NUMBER; TURNOVER RATE; WILD TYPES; ZWITTERIONIC DETERGENTS;

AMINES; AMINO ACIDS; BACTERIOLOGY; CATALYSIS; CATALYST ACTIVITY; DIMERIZATION; ELECTROCHEMICAL SENSORS; ENZYME ACTIVITY; ENZYMES; ESCHERICHIA COLI; MELTING POINT; OLIGOMERIZATION; ORGANIC ACIDS;

RATE CONSTANTS;

DIHYDROFOLATE REDUCTASE;

ARTICLE; CATALYSIS; DIMERIZATION; ENZYME METABOLISM; ENZYME STABILITY; GEOBACILLUS STEAROTHERMOPHILUS; NONHUMAN; PRIORITY JOURNAL; THERMOSTABILITY; THERMOTOGA MARITIMA;

AMINO ACID SUBSTITUTION; ANIONS; CATALYSIS; ENZYME STABILITY; GENETIC VARIATION; HYDROPHOBICITY; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN CONFORMATION; PROTEIN MULTIMERIZATION; TETRAHYDROFOLATE DEHYDROGENASE; THERMOTOGA MARITIMA;

ESCHERICHIA COLI; GEOBACILLUS STEAROTHERMOPHILUS; THERMOTOGA MARITIMA;

EID: 67649610422     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi900411a     Document Type: Article

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