-
1
-
-
33947547892
-
Molecular architecture and biological reactions
-
Pauling, L. Molecular architecture and biological reactions. Chem. Eng. News 24, 1375 (1946).
-
(1946)
Chem. Eng. News
, vol.24
, pp. 1375
-
-
Pauling, L.1
-
2
-
-
0013852463
-
Structure of hen egg-white lysozyme - A 3-dimensional Fourier synthesis at 2Å resolution
-
Blake, C.C.F. et al. Structure of hen egg-white lysozyme - a 3-dimensional Fourier synthesis at 2Å resolution. Nature 206, 757-761 (1965).
-
(1965)
Nature
, vol.206
, pp. 757-761
-
-
Blake, C.C.F.1
-
3
-
-
78651189765
-
On the nature of allosteric transitions - A plausible model
-
Monod, J., Wyman, J. & Changeux, J.P. On the nature of allosteric transitions - a plausible model. J. Mol. Biol. 12, 88-118 (1965).
-
(1965)
J. Mol. Biol.
, vol.12
, pp. 88-118
-
-
Monod, J.1
Wyman, J.2
Changeux, J.P.3
-
4
-
-
0022419169
-
A protein structure from nuclear magnetic-resonance data - Lac repressor headpiece
-
Kaptein, R., Zuiderweg, E.R.P., Scheek, R.M., Boelens, R. & Vangunsteren, W.F. A protein structure from nuclear magnetic-resonance data - Lac repressor headpiece. J. Mol. Biol. 182, 179-182 (1985).
-
(1985)
J. Mol. Biol.
, vol.182
, pp. 179-182
-
-
Kaptein, R.1
Zuiderweg, E.R.P.2
Scheek, R.M.3
Boelens, R.4
Vangunsteren, W.F.5
-
5
-
-
0024573393
-
Hydrogen tunneling in enzyme-reactions
-
This was the first clear demonstration of significant room temperature tunneling in an enzyme-catalyzed reaction
-
Cha, Y., Murray, C.J. & Klinman, J.P. Hydrogen tunneling in enzyme-reactions. Science 243, 1325-1330 (1989). This was the first clear demonstration of significant room temperature tunneling in an enzyme-catalyzed reaction.
-
(1989)
Science
, vol.243
, pp. 1325-1330
-
-
Cha, Y.1
Murray, C.J.2
Klinman, J.P.3
-
6
-
-
62249181529
-
An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling
-
Klinman, J.P. An integrated model for enzyme catalysis emerges from studies of hydrogen tunneling. Chem. Phys. Lett. 471, 179-193 (2009).
-
(2009)
Chem. Phys. Lett.
, vol.471
, pp. 179-193
-
-
Klinman, J.P.1
-
8
-
-
0022991435
-
Selective chemical catalysis by an antibody
-
Pollack, S.J., Jacobs, J.W. & Schultz, P.B. Selective chemical catalysis by an antibody. Science 234, 1570-1573 (1986).
-
(1986)
Science
, vol.234
, pp. 1570-1573
-
-
Pollack, S.J.1
Jacobs, J.W.2
Schultz, P.B.3
-
9
-
-
0033791659
-
Critical analysis of antibody catalysis
-
Hilvert, D. Critical analysis of antibody catalysis. Annu. Rev. Biochem. 69, 751-793 (2000).
-
(2000)
Annu. Rev. Biochem.
, vol.69
, pp. 751-793
-
-
Hilvert, D.1
-
10
-
-
48249098990
-
Protein design by directed evolution
-
Jäckel, C., Kast, P. & Hilvert, D. Protein design by directed evolution. Annu. Rev. Biophys. 37, 153-173 (2008).
-
(2008)
Annu. Rev. Biophys.
, vol.37
, pp. 153-173
-
-
Jäckel, C.1
Kast, P.2
Hilvert, D.3
-
11
-
-
9344270529
-
Directed evolution of a glycosynthase via chemical complementation
-
Lin, H.N., Tao, H.Y. & Cornish, V.W. Directed evolution of a glycosynthase via chemical complementation. J. Am. Chem. Soc. 126, 15051-15059 (2004).
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 15051-15059
-
-
Lin, H.N.1
Tao, H.Y.2
Cornish, V.W.3
-
12
-
-
0033908031
-
Man-made enzymes - From design to in vitro compartmentalisation
-
Griffiths, A.D. & Tawfik, D.S. Man-made enzymes - from design to in vitro compartmentalisation. Curr. Opin. Biotechnol. 11, 338-353 (2000).
-
(2000)
Curr. Opin. Biotechnol.
, vol.11
, pp. 338-353
-
-
Griffiths, A.D.1
Tawfik, D.S.2
-
13
-
-
0035903602
-
Investigating and engineering enzymes by genetic selection
-
Taylor, S.V., Kast, P. & Hilvert, D. Investigating and engineering enzymes by genetic selection. Angew. Chem. Int. Ed. 40, 3310-3335 (2001).
-
(2001)
Angew. Chem. Int. Ed.
, vol.40
, pp. 3310-3335
-
-
Taylor, S.V.1
Kast, P.2
Hilvert, D.3
-
14
-
-
43449098518
-
Kemp elimination catalysts by computational enzyme design
-
DOI 10.1038/nature06879, PII NATURE06879
-
Röthlisberger, D. et al. Kemp elimination catalysts by computational enzyme design. Nature 453, 190-195 (2008). (Pubitemid 351667979)
-
(2008)
Nature
, vol.453
, Issue.7192
, pp. 190-195
-
-
Rothlisberger, D.1
Khersonsky, O.2
Wollacott, A.M.3
Jiang, L.4
Dechancie, J.5
Betker, J.6
Gallaher, J.L.7
Althoff, E.A.8
Zanghellini, A.9
Dym, O.10
Albeck, S.11
Houk, K.N.12
Tawfik, D.S.13
Baker, D.14
-
15
-
-
0034625322
-
Trading accuracy for speed: A quantitative comparison of search algorithms in protein sequence design
-
Voigt, C.A., Gordon, D.B. & Mayo, S.L. Trading accuracy for speed: A quantitative comparison of search algorithms in protein sequence design. J. Mol. Biol. 299, 789-803 (2000).
-
(2000)
J. Mol. Biol.
, vol.299
, pp. 789-803
-
-
Voigt, C.A.1
Gordon, D.B.2
Mayo, S.L.3
-
17
-
-
33644910749
-
Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited
-
Single-molecule Michaelis Menten kinetics demonstrated a large number of rate constants contributing to observed rate constant in bulk measurements
-
English, B.P. et al. Ever-fluctuating single enzyme molecules: Michaelis-Menten equation revisited. Nat. Chem. Biol. 2, 87-94 (2006). Single-molecule Michaelis Menten kinetics demonstrated a large number of rate constants contributing to observed rate constant in bulk measurements.
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 87-94
-
-
English, B.P.1
-
18
-
-
0032484096
-
Single-molecule enzymatic dynamics
-
Lu, H.P., Xun, L.Y. & Xie, X.S. Single-molecule enzymatic dynamics. Science 282, 1877-1882 (1998).
-
(1998)
Science
, vol.282
, pp. 1877-1882
-
-
Lu, H.P.1
Xun, L.Y.2
Xie, X.S.3
-
19
-
-
36148973895
-
Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms
-
Pudney, C.R. et al. Mutagenesis of morphinone reductase induces multiple reactive configurations and identifies potential ambiguity in kinetic analysis of enzyme tunneling mechanisms. J. Am. Chem. Soc. 129, 13949-13956 (2007).
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 13949-13956
-
-
Pudney, C.R.1
-
20
-
-
3042709505
-
Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase
-
DOI 10.1073/pnas.0403337101
-
Liang, Z.X., Lee, T., Resing, K.A., Ahn, N.G. & Klinman, J.P. Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase. Proc. Natl. Acad. Sci. USA 101, 9556-9561 (2004). (Pubitemid 38869274)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.26
, pp. 9556-9561
-
-
Liang, Z.-X.1
Lee, T.2
Resing, K.A.3
Ahn, N.G.4
Klinman, J.P.5
-
21
-
-
0033519723
-
Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase
-
A thermophilic enzyme showed most efficient tunneling at elevated temperature. This stood in stark contrast to predictions that tunneling should become less important as temperature increases
-
Kohen, A., Cannio, R., Bartolucci, S. & Klinman, J.P. Enzyme dynamics and hydrogen tunnelling in a thermophilic alcohol dehydrogenase. Nature 399, 496-499 (1999). A thermophilic enzyme showed most efficient tunneling at elevated temperature. This stood in stark contrast to predictions that tunneling should become less important as temperature increases.
-
(1999)
Nature
, vol.399
, pp. 496-499
-
-
Kohen, A.1
Cannio, R.2
Bartolucci, S.3
Klinman, J.P.4
-
22
-
-
0242267579
-
Evidence for Environmentally Coupled Hydrogen Tunneling during Dihydrofolate Reductase Catalysis
-
DOI 10.1021/ja035692g
-
Maglia, G. & Allemann, R.K. Evidence for environmentally coupled hydrogen tunneling during dihydrofolate reductase catalysis. J. Am. Chem. Soc. 125, 13372-13373 (2003). (Pubitemid 37352119)
-
(2003)
Journal of the American Chemical Society
, vol.125
, Issue.44
, pp. 13372-13373
-
-
Maglia, G.1
Allemann, R.K.2
-
23
-
-
63649139679
-
Nuclear quantum tunneling in the light-activated enzyme protochlorophyllide oxidoreductase
-
Heyes, D.J., Sakuma, M., de Visser, S.P. & Scrutton, N.S. Nuclear quantum tunneling in the light-activated enzyme protochlorophyllide oxidoreductase. J. Biol. Chem. 284, 3762-3767 (2009).
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 3762-3767
-
-
Heyes, D.J.1
Sakuma, M.2
De Visser, S.P.3
Scrutton, N.S.4
-
24
-
-
2142746284
-
The activated complex in chemical reactions
-
Eyring, H. The activated complex in chemical reactions. J. Chem. Phys. 3, 107-115 (1935).
-
(1935)
J. Chem. Phys.
, vol.3
, pp. 107-115
-
-
Eyring, H.1
-
26
-
-
0001674168
-
Criterion of minimum state density in the transition-state theory of bimolecular reactions
-
Garrett, B.C. & Truhlar, D.G. Criterion of minimum state density in the transition-state theory of bimolecular reactions. J. Chem. Phys. 70, 1593-1598 (1979).
-
(1979)
J. Chem. Phys.
, vol.70
, pp. 1593-1598
-
-
Garrett, B.C.1
Truhlar, D.G.2
-
27
-
-
17644400195
-
Ensemble-averaged variational transition state theory with optimized multidimensional tunneling for enzyme kinetics and other condensed-phase reactions
-
Truhlar, D.G. et al. Ensemble-averaged variational transition state theory with optimized multidimensional tunneling for enzyme kinetics and other condensed-phase reactions. Int. J. Quantum Chem. 100, 1136-1152 (2004).
-
(2004)
Int. J. Quantum Chem.
, vol.100
, pp. 1136-1152
-
-
Truhlar, D.G.1
-
28
-
-
0028864344
-
Nature of rate-limiting steps in the soybean lipoxygenase- 1 reaction
-
Glickman, M.H. & Klinman, J.P. Nature of rate-limiting steps in the soybean lipoxygenase- 1 reaction. Biochemistry 34, 14077-14092 (1995).
-
(1995)
Biochemistry
, vol.34
, pp. 14077-14092
-
-
Glickman, M.H.1
Klinman, J.P.2
-
29
-
-
0029776459
-
Large kinetic isotope effects in methane oxidation catalyzed by methane monooxygenase: Evidence for C-H bond cleavage in a reaction cycle intermediate
-
Nesheim, J.C. & Lipscomb, J.D. Large kinetic isotope effects in methane oxidation catalyzed by methane monooxygenase: evidence for C-H bond cleavage in a reaction cycle intermediate. Biochemistry 35, 10240-10247 (1996).
-
(1996)
Biochemistry
, vol.35
, pp. 10240-10247
-
-
Nesheim, J.C.1
Lipscomb, J.D.2
-
30
-
-
0004152918
-
-
Robert E. Krieger Publishing Company, Malabar, India
-
Melander, L. & Saunders, W.H. Reaction Rates of Isotopic Molecules, 331 (Robert E. Krieger Publishing Company, Malabar, India, 1987).
-
(1987)
Reaction Rates of Isotopic Molecules
, pp. 331
-
-
Melander, L.1
Saunders, W.H.2
-
31
-
-
0037123216
-
Temperature-dependent isotope effects in soybean lipoxygenase-1: Correlating hydrogen tunneling with protein dynamics
-
A full tunneling model was derived from earlier work by Kuznetsov and Ulstrup (ref. 32) and used to reproduce temperature-dependent KIEs in soybean lipoxygenase
-
Knapp, M.J., Rickert, K. & Klinman, J.P. Temperature-dependent isotope effects in soybean lipoxygenase-1: correlating hydrogen tunneling with protein dynamics. J. Am. Chem. Soc. 124, 3865-3874 (2002). A full tunneling model was derived from earlier work by Kuznetsov and Ulstrup (ref. 32) and used to reproduce temperature-dependent KIEs in soybean lipoxygenase.
-
(2002)
J. Am. Chem. Soc.
, vol.124
, pp. 3865-3874
-
-
Knapp, M.J.1
Rickert, K.2
Klinman, J.P.3
-
32
-
-
0033305793
-
Proton and hydrogen atom tunnelling in hydrolytic and redox enzyme catalysis
-
Kuznetsov, A.M. & Ulstrup, J. Proton and hydrogen atom tunnelling in hydrolytic and redox enzyme catalysis. Can. J. Chem. 77, 1085-1096 (1999).
-
(1999)
Can. J. Chem.
, vol.77
, pp. 1085-1096
-
-
Kuznetsov, A.M.1
Ulstrup, J.2
-
33
-
-
28644449439
-
Modeling temperature dependent kinetic isotope effects for hydrogen transfer in a series of soybean lipoxygenase mutants: The effect of anharmonicity upon transfer distance
-
Meyer, M.P. & Klinman, J.P. Modeling temperature dependent kinetic isotope effects for hydrogen transfer in a series of soybean lipoxygenase mutants: the effect of anharmonicity upon transfer distance. Chem. Phys. 319, 283-296 (2005).
-
(2005)
Chem. Phys.
, vol.319
, pp. 283-296
-
-
Meyer, M.P.1
Klinman, J.P.2
-
34
-
-
58149383873
-
Driving force analysis of proton tunnelling across a reactivity series for an enzyme-substrate complex
-
Hothi, P. et al. Driving force analysis of proton tunnelling across a reactivity series for an enzyme-substrate complex. ChemBioChem 9, 2839-2845 (2008).
-
(2008)
ChemBioChem
, vol.9
, pp. 2839-2845
-
-
Hothi, P.1
-
35
-
-
9744244983
-
Enzymatic transition states: Thermodynamics, dynamics and analogue design
-
Schramm, V.L. Enzymatic transition states: thermodynamics, dynamics and analogue design. Arch. Biochem. Biophys. 433, 13-26 (2005).
-
(2005)
Arch. Biochem. Biophys.
, vol.433
, pp. 13-26
-
-
Schramm, V.L.1
-
36
-
-
55949096608
-
Atomic detail of chemical transformation at the transition state of an enzymatic reaction
-
Saen-Oon, S., Quaytman-Machleder, S., Schramm, V.L. & Schwartz, S.D. Atomic detail of chemical transformation at the transition state of an enzymatic reaction. Proc. Natl. Acad. Sci. USA 105, 16543-16548 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 16543-16548
-
-
Saen-Oon, S.1
Quaytman-Machleder, S.2
Schramm, V.L.3
Schwartz, S.D.4
-
37
-
-
50849111095
-
Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis
-
Boehr, D.D., Dyson, H.J. & Wright, P.E. Conformational relaxation following hydride transfer plays a limiting role in dihydrofolate reductase catalysis. Biochemistry 47, 9227-9233 (2008).
-
(2008)
Biochemistry
, vol.47
, pp. 9227-9233
-
-
Boehr, D.D.1
Dyson, H.J.2
Wright, P.E.3
-
38
-
-
17044401342
-
Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis
-
DOI 10.1073/pnas.0500699102
-
McElheny, D., Schnell, J.R., Lansing, J.C., Dyson, H.J. & Wright, P.E. Defining the role of active-site loop fluctuations in dihydrofolate reductase catalysis. Proc. Natl. Acad. Sci. USA 102, 5032-5037 (2005). (Pubitemid 40503734)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.14
, pp. 5032-5037
-
-
McElheny, D.1
Schnell, J.R.2
Lansing, J.C.3
Dyson, H.J.4
Wright, P.E.5
-
39
-
-
37249032102
-
Dynamic personalities of proteins
-
Henzler-Wildman, K. & Kern, D. Dynamic personalities of proteins. Nature 450, 964-972 (2007).
-
(2007)
Nature
, vol.450
, pp. 964-972
-
-
Henzler-Wildman, K.1
Kern, D.2
-
40
-
-
36849039429
-
A hierarchy of timescales in protein dynamics is linked to enzyme catalysis
-
Henzler-Wildman, K.A. et al. A hierarchy of timescales in protein dynamics is linked to enzyme catalysis. Nature 450, 913-916 (2007).
-
(2007)
Nature
, vol.450
, pp. 913-916
-
-
Henzler-Wildman, K.A.1
-
41
-
-
38749105098
-
Two-dimensional reaction free energy surfaces of catalytic reaction: Effects of protein conformational dynamics on enzyme catalysis
-
DOI 10.1021/jp076533c
-
Min, W., Xie, X.S. & Bagchi, B. Two-dimensional reaction free energy surfaces of catalytic reaction: effects of protein conformational dynamics on enzyme catalysis. J. Phys. Chem. B 112, 454-466 (2008). (Pubitemid 351184620)
-
(2008)
Journal of Physical Chemistry B
, vol.112
, Issue.2
, pp. 454-466
-
-
Min, W.1
Xie, X.S.2
Bagchi, B.3
-
42
-
-
43849102169
-
Remote mutations and active site dynamics correlate with catalytic properties of purine nucleoside phosphorylase
-
Saen-Oon, S., Ghanem, M., Schramm, V.L. & Schwartz, S.D. Remote mutations and active site dynamics correlate with catalytic properties of purine nucleoside phosphorylase. Biophys. J. 94, 4078-4088 (2008).
-
(2008)
Biophys. J.
, vol.94
, pp. 4078-4088
-
-
Saen-Oon, S.1
Ghanem, M.2
Schramm, V.L.3
Schwartz, S.D.4
-
43
-
-
0031025267
-
Effects of protein glycosylation on catalysis: Changes in hydrogen tunneling and enthalpy of activation in the glucose oxidase reaction
-
DOI 10.1021/bi962492r
-
Kohen, A., Jonsson, T. & Klinman, J.P. Effects of protein glycosylation on catalysis: changes in hydrogen tunneling and enthalpy of activation in the glucose oxidase reaction. Biochemistry 36, 2603-2611 (1997). (Pubitemid 27106654)
-
(1997)
Biochemistry
, vol.36
, Issue.9
, pp. 2603-2611
-
-
Kohen, A.1
Jonsson, T.2
Klinman, J.P.3
-
44
-
-
0037046991
-
Comparison of rates and kinetic isotope effects using PEG-modified variants and glycoforms of glucose oxidase: The relationship of modification of the protein envelope to C-H activation and tunneling
-
Seymour, S.L. & Klinman, J.P. Comparison of rates and kinetic isotope effects using PEG-modified variants and glycoforms of glucose oxidase: the relationship of modification of the protein envelope to C-H activation and tunneling. Biochemistry 41, 8747-8758 (2002).
-
(2002)
Biochemistry
, vol.41
, pp. 8747-8758
-
-
Seymour, S.L.1
Klinman, J.P.2
-
45
-
-
0035916307
-
Probes of hydrogen tunneling with horse liver alcohol dehydrogenase at subzero temperatures
-
Tsai, S.C. & Klinman, J.P. Probes of hydrogen tunneling with horse liver alcohol dehydrogenase at subzero temperatures. Biochemistry 40, 2303-2311 (2001).
-
(2001)
Biochemistry
, vol.40
, pp. 2303-2311
-
-
Tsai, S.C.1
Klinman, J.P.2
-
46
-
-
33750441144
-
Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase
-
DOI 10.1073/pnas.0606976103
-
Wang, L., Goodey, N.M., Benkovic, S.J. & Kohen, A. Coordinated effects of distal mutations on environmentally coupled tunneling in dihydrofolate reductase. Proc. Natl. Acad. Sci. USA 103, 15753-15758 (2006). (Pubitemid 44657539)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.43
, pp. 15753-15758
-
-
Wang, L.1
Goodey, N.M.2
Benkovic, S.J.3
Kohen, A.4
-
47
-
-
39549094013
-
Enzyme structure and dynamics affect hydrogen tunneling: The impact of a remote side chain (1553) in soybean lipoxygenase- 1
-
A distal mutation in SLO produced temperature-dependent KIEs. X-ray structures of the mutant enzymes showed no changes, implying that dynamical changes are required to account for the kinetic behavior
-
Meyer, M.P., Tomchick, D.R. & Klinman, J.P. Enzyme structure and dynamics affect hydrogen tunneling: the impact of a remote side chain (1553) in soybean lipoxygenase- 1. Proc. Natl. Acad. Sci. USA 105, 1146-1151 (2008). A distal mutation in SLO produced temperature-dependent KIEs. X-ray structures of the mutant enzymes showed no changes, implying that dynamical changes are required to account for the kinetic behavior.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 1146-1151
-
-
Meyer, M.P.1
Tomchick, D.R.2
Klinman, J.P.3
-
48
-
-
34547456661
-
Origin of the temperature dependence of isotope effects in enzymatic reactions: The case of dihydrofolate reductase
-
DOI 10.1021/jp070938f
-
Liu, H.B. & Warshel, A. Origin of the temperature dependence of isotope effects in enzymatic reactions: the case of dihydrofolate reductase. J. Phys. Chem. B 111, 7852-7861 (2007). (Pubitemid 47169697)
-
(2007)
Journal of Physical Chemistry B
, vol.111
, Issue.27
, pp. 7852-7861
-
-
Liu, H.1
Warshel, A.2
-
49
-
-
52949128744
-
On the relationship between folding and chemical landscapes in enzyme catalysis
-
Roca, M., Messer, B., Hilvert, D. & Warshel, A. On the relationship between folding and chemical landscapes in enzyme catalysis. Proc. Natl. Acad. Sci. USA 105, 13877-13882 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 13877-13882
-
-
Roca, M.1
Messer, B.2
Hilvert, D.3
Warshel, A.4
-
50
-
-
0033955055
-
Protein dynamics in enzymatic catalysis: Exploration of dihydrofolate reductase
-
Radkiewicz, J.L. & Brooks, C.L. Protein dynamics in enzymatic catalysis: exploration of dihydrofolate reductase. J. Am. Chem. Soc. 122, 225-231 (2000).
-
(2000)
J. Am. Chem. Soc.
, vol.122
, pp. 225-231
-
-
Radkiewicz, J.L.1
Brooks, C.L.2
-
51
-
-
17644400195
-
Ensemble-averaged variational transition state theory with optimized multidimensional tunneling for enzyme kinetics and other condensed-phase reactions
-
Truhlar, D.G. et al. Ensemble-averaged variational transition state theory with optimized multidimensional tunneling for enzyme kinetics and other condensed-phase reactions. Int. J. Quantum Chem. 100, 1136-1152 (2004).
-
(2004)
Int. J. Quantum Chem.
, vol.100
, pp. 1136-1152
-
-
Truhlar, D.G.1
-
52
-
-
40849097646
-
Free-energy landscape of enzyme catalysis
-
Benkovic, S.J., Hammes, G.G. & Hammes-Schiffer, S. Free-energy landscape of enzyme catalysis. Biochemistry 47, 3317-3321 (2008).
-
(2008)
Biochemistry
, vol.47
, pp. 3317-3321
-
-
Benkovic, S.J.1
Hammes, G.G.2
Hammes-Schiffer, S.3
-
53
-
-
33748367252
-
Arrhenius curves of hydrogen transfers: Tunnel effects, isotope effects and effects of pre-equilibria
-
DOI 10.1098/rstb.2006.1872
-
Limbach, H.H., Lopez, J.M. & Kohen, A. Arrhenius curves of hydrogen transfers: tunnel effects, isotope effects and effects of pre-equilibria. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 361, 1399-1415 (2006). (Pubitemid 44338500)
-
(2006)
Philosophical Transactions of the Royal Society B: Biological Sciences
, vol.361
, Issue.1472
, pp. 1399-1415
-
-
Limbach, H.-H.1
Lopez, J.M.2
Kohen, A.3
-
54
-
-
1542327706
-
Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate
-
DOI 10.1073/pnas.0400091101
-
Zhang, Z.Q., Rajagopalan, P.T.R., Selzer, T., Benkovic, S.J. & Hammes, G.G. Single-molecule and transient kinetics investigation of the interaction of dihydrofolate reductase with NADPH and dihydrofolate. Proc. Natl. Acad. Sci. USA 101, 2764-2769 (2004). (Pubitemid 38327685)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.9
, pp. 2764-2769
-
-
Zhang, Z.1
Rajagopalan, P.T.R.2
Selzer, T.3
Benkovic, S.J.4
Hammes, G.G.5
-
56
-
-
33748354485
-
The role of enzyme dynamics and tunnelling in catalysing hydride transfer: Studies of distal mutants of dihydrofolate reductase
-
A distal mutation in DHFR led to temperature-dependent KIEs. This was surprising because of the distance between a relatively conservative M-W mutation and the active site of the enzyme
-
Wang, L., Goodey, N.M., Benkovic, S.J. & Kohen, A. The role of enzyme dynamics and tunnelling in catalysing hydride transfer: studies of distal mutants of dihydrofolate reductase. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 361, 1307-1315 (2006). A distal mutation in DHFR led to temperature-dependent KIEs. This was surprising because of the distance between a relatively conservative M-W mutation and the active site of the enzyme.
-
(2006)
Philos. Trans. R. Soc. Lond., B, Biol. Sci.
, vol.361
, pp. 1307-1315
-
-
Wang, L.1
Goodey, N.M.2
Benkovic, S.J.3
Kohen, A.4
-
57
-
-
4744343045
-
Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair
-
DOI 10.1038/nsmb821
-
Wolf-Watz, M. et al. Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair. Nat. Struct. Mol. Biol. 11, 945-949 (2004). (Pubitemid 39315297)
-
(2004)
Nature Structural and Molecular Biology
, vol.11
, Issue.10
, pp. 945-949
-
-
Wolf-Watz, M.1
Thai, V.2
Henzler-Wildman, K.3
Hadjipavlou, G.4
Eisenmesser, E.Z.5
Kern, D.6
-
58
-
-
0014253008
-
Allosteric interactions in aspartate transcarbamylase 2. Evidence for different conformational states of protein in presence and absence of specific ligands
-
Gerhart, J.C. & Schachman, H.K. Allosteric interactions in aspartate transcarbamylase 2. Evidence for different conformational states of protein in presence and absence of specific ligands. Biochemistry 7, 538-552 (1968).
-
(1968)
Biochemistry
, vol.7
, pp. 538-552
-
-
Gerhart, J.C.1
Schachman, H.K.2
-
59
-
-
0345832242
-
Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase
-
Schnell, J.R., Dyson, H.J. & Wright, P.E. Effect of cofactor binding and loop conformation on side chain methyl dynamics in dihydrofolate reductase. Biochemistry 43, 374-383 (2004).
-
(2004)
Biochemistry
, vol.43
, pp. 374-383
-
-
Schnell, J.R.1
Dyson, H.J.2
Wright, P.E.3
-
60
-
-
0022004980
-
Electron transfers in chemistry and biology
-
Marcus, R.A. & Sutin, N. Electron transfers in chemistry and biology. Biochim. Biophys. Acta 811, 265-322 (1985).
-
(1985)
Biochim. Biophys. Acta
, vol.811
, pp. 265-322
-
-
Marcus, R.A.1
Sutin, N.2
-
61
-
-
44449093622
-
Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase
-
DOI 10.1021/ja800471f
-
Pang, J.Y., Hay, S., Scrutton, N.S. & Sutcliffe, M.J. Deep tunneling dominates the biologically important hydride transfer reaction from NADH to FMN in morphinone reductase. J. Am. Chem. Soc. 130, 7092-7097 (2008). (Pubitemid 351770152)
-
(2008)
Journal of the American Chemical Society
, vol.130
, Issue.22
, pp. 7092-7097
-
-
Pang, J.1
Hay, S.2
Scrutton, N.S.3
Sutcliffe, M.J.4
-
62
-
-
0033537697
-
Enzymatic H-transfer requires vibration-driven extreme tunneling
-
Basran, J., Sutcliffe, M.J. & Scrutton, N.S. Enzymatic H-transfer requires vibrationdriven extreme tunneling. Biochemistry 38, 3218-3222 (1999). (Pubitemid 129501380)
-
(1999)
Biochemistry
, vol.38
, Issue.10
, pp. 3218-3222
-
-
Basran, J.1
Sutcliffe, M.J.2
Scrutton, N.S.3
-
63
-
-
0034673186
-
Kinetic studies of the mechanism of carbon-hydrogen bond breakage by the heterotetrameric sarcosine oxidase of Arthrobacter sp. 1-IN
-
DOI 10.1021/bi991941v
-
Harris, R.J., Meskys, R., Sutcliffe, M.J. & Scrutton, N.S. Kinetic studies of the mechanism of carbon-hydrogen bond breakage by the heterotetrameric sarcosine oxidase of Arthrobacter sp 1-IN. Biochemistry 39, 1189-1198 (2000). (Pubitemid 30090683)
-
(2000)
Biochemistry
, vol.39
, Issue.6
, pp. 1189-1198
-
-
Harris, R.J.1
Meskys, R.2
Sutcliffe, M.J.3
Scrutton, N.S.4
-
64
-
-
34249676309
-
An internal equilibrium preorganizes the enzyme-substrate complex for hydride tunneling in choline oxidase
-
DOI 10.1021/bi700255v
-
Fan, F. & Gadda, G. An internal equilibrium preorganizes the enzyme-substrate complex for hydride tunneling in choline oxidase. Biochemistry 46, 6402-6408 (2007). (Pubitemid 46842883)
-
(2007)
Biochemistry
, vol.46
, Issue.21
, pp. 6402-6408
-
-
Fan, F.1
Gadda, G.2
-
65
-
-
33947465376
-
Use of hydrogen isotope effects to identify the attacking nucleophile in the enolization of ketones catalyzed by acetic acid
-
Swain, C.G., Stivers, E.C., Reuwer, J.F. & Schaad, L.J. Use of hydrogen isotope effects to identify the attacking nucleophile in the enolization of ketones catalyzed by acetic acid. J. Am. Chem. Soc. 80, 5885-5893 (1958).
-
(1958)
J. Am. Chem. Soc.
, vol.80
, pp. 5885-5893
-
-
Swain, C.G.1
Stivers, E.C.2
Reuwer, J.F.3
Schaad, L.J.4
-
66
-
-
18444390849
-
Translation of phase waves of de Broglie
-
Haslett, J.W. Translation of phase waves of de Broglie. Am. J. Phys. 41, 445 (1973).
-
(1973)
Am. J. Phys.
, vol.41
, pp. 445
-
-
Haslett, J.W.1
-
67
-
-
0010884753
-
Theory of oxidation-reduction reactions involving electron transfer. 1
-
Marcus, R.A. Theory of oxidation-reduction reactions involving electron transfer. 1. J. Chem. Phys. 24, 966-978 (1956).
-
(1956)
J. Chem. Phys.
, vol.24
, pp. 966-978
-
-
Marcus, R.A.1
|