Moritella cold-active dihydrofolate reductase: Are there natural limits to optimization of catalytic efficiency at low temperature?

Journal of Bacteriology

Volumn 185, Issue 18, 2003, Pages 5519-5526

  Xu, Ying ^a   Feller, Georges ^b   Gerday, Charles ^b   Glansdorff, Nicolas ^a  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROFOLATE REDUCTASE; METHOTREXATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; TRIMETHOPRIM;

ARTICLE; BACTERIAL GROWTH; BACTERIUM; BINDING AFFINITY; CATALYSIS; ENTHALPY; ENZYME ACTIVITY; ENZYME DENATURATION; ENZYME KINETICS; ENZYME STABILITY; ESCHERICHIA COLI; LACTOBACILLUS CASEI; LOW TEMPERATURE; MORITELLA PROFUNDA; NONHUMAN; PRIORITY JOURNAL; TEMPERATURE DEPENDENCE; THERMOTOGA MARITIMA;

AMINO ACID SEQUENCE; CATALYSIS; CLONING, MOLECULAR; COLD; ENZYME ACTIVATION; ENZYME STABILITY; FOLIC ACID ANTAGONISTS; GENE EXPRESSION REGULATION, BACTERIAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; KINETICS; METHOTREXATE; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MORITELLA; NADP; PROTEIN CONFORMATION; PROTEIN DENATURATION; SEQUENCE HOMOLOGY, AMINO ACID; TEMPERATURE; TETRAHYDROFOLATE DEHYDROGENASE; TRIMETHOPRIM;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; LACTOBACILLUS; LACTOBACILLUS CASEI; MORITELLA; MORITELLA PROFUNDA; THERMOTOGA; THERMOTOGA MARITIMA;

EID: 0042337202     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.185.18.5519-5526.2003     Document Type: Article

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