Coupling of protein motions and hydrogen transfer during catalysis by Escherichia coli dihydrofolate reductase

Biochemical Journal

Volumn 394, Issue 1, 2006, Pages 259-265

  Swanwick, Richard S ^a   Maglia, Giovanni ^b   Tey, Lai Hock ^a   Allemann, Rudolf K ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Dihydrofolate reductase; Dynamics; Hydrogen transfer; Kinetics; Protein motions; Tunnelling

Indexed keywords

ACTIVATION ENERGY; CATALYSIS; ESCHERICHIA COLI; ISOTOPES; RATE CONSTANTS;

DIHYDROFOLATE REDUCTASE; HYDROGEN TRANSFER; KINETICS; PROTEIN MOTIONS; TUNNELLING;

ENZYMES;

DEUTERIUM; DIHYDROFOLATE REDUCTASE; HYDROGEN; ISOTOPE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ARTICLE; CATALYSIS; ENZYME MECHANISM; ENZYME STRUCTURE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTON TRANSPORT; QUANTUM MECHANICS; STEADY STATE; TEMPERATURE DEPENDENCE; THERMODYNAMICS;

CATALYSIS; ESCHERICHIA COLI; HYDROGEN; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; MOVEMENT; PROTEIN CONFORMATION; TEMPERATURE; TETRAHYDROFOLATE DEHYDROGENASE;

ESCHERICHIA COLI;

EID: 32944457660     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051464     Document Type: Article

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