Solvent effects on catalysis by Escherichia coli dihydrofolate reductase

Journal of the American Chemical Society

Volumn 132, Issue 3, 2010, Pages 1137-1143

  Loveridge, E Joel ^a   Tey, Lai Hock ^a   Allemann, Rudolf K ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION BARRIERS; BULK SOLVENTS; CATALYTIC PROPERTIES; CO-SOLUTES; COFACTORS; CONFORMATIONAL SUBSTATES; COSOLVENTS; COUPLED MODELS; DIELECTRIC CONSTANTS; DIHYDROFOLATE REDUCTASE; E. COLI; HYDRIDE TRANSFERS; HYPERTHERMOPHILES; KINETIC ISOTOPE EFFECTS; PROTEIN MOTION; RATE OF REACTION; REACTION CATALYZED; REACTION MEDIUM; SOLVENT COMPOSITION; SOLVENT EFFECTS; TEMPERATURE DEPENDENCE; THERMOTOGA MARITIMA; TUNNELING ,;

CARRIER MOBILITY; CATALYSIS; CONFORMATIONS; ESCHERICHIA COLI; ISOTOPES; PROTEINS; REACTION RATES; TEMPERATURE DISTRIBUTION; TUNNELING (EXCAVATION); WIND TUNNELS;

SOLVENTS;

ANION; DIHYDROFOLATE REDUCTASE; HYDRIDE; HYDROGEN; ISOTOPE; SOLVENT; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL REACTION; CIRCULAR DICHROISM; DIELECTRIC CONSTANT; ENZYME CONFORMATION; ENZYME SUBSTRATE; ESCHERICHIA COLI; HYPERTHERMOPHILE; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN STRUCTURE; PROTEIN TRANSPORT; SOLVENT EFFECT; TEMPERATURE DEPENDENCE; THERMOTOGA MARITIMA;

CATALYSIS; ESCHERICHIA COLI; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; SOLVENTS; TEMPERATURE; TETRAHYDROFOLATE DEHYDROGENASE; THERMOTOGA MARITIMA;

EID: 76149110500     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja909353c     Document Type: Article

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