The temperature dependence of the kinetic isotope effects of dihydrofolate reductase from thermotoga maritima is influenced by intersubunit interactions

Biochemistry

Volumn 49, Issue 25, 2010, Pages 5390-5396

  Loveridge, E Joel ^a   Allemann, Rudolf K ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHARGED RESIDUES; CONFORMATIONAL ENSEMBLE; DIHYDROFOLATE; DIHYDROFOLATE REDUCTASE; DIMER INTERFACE; HIGH THERMAL STABILITY; HOMODIMERS; HYDRIDE TRANSFERS; HYDROPHOBIC CORE; HYPERTHERMOPHILES; INTERSUBUNIT INTERACTION; KINETIC ISOTOPE EFFECTS; MELTING TEMPERATURES; OPPOSITE CHARGE; PROTEIN MOTION; REACTION COORDINATES; SALT BRIDGES; SIDE CHAINS; TEMPERATURE DEPENDENCE; THERMAL STABILITY; THERMOTOGA MARITIMA;

CARRIER MOBILITY; DIMERIZATION; ISOTOPES; TEMPERATURE DISTRIBUTION;

THERMODYNAMIC STABILITY;

DIHYDROFOLATE REDUCTASE; DIHYDROFOLIC ACID; ISOTOPE;

ARTICLE; CATALYSIS; CHEMICAL INTERACTION; CIRCULAR DICHROISM; CONFORMATION; CONTROLLED STUDY; DENATURATION; DIMERIZATION; GEL PERMEATION CHROMATOGRAPHY; HYPERTHERMOPHILE; KINETICS; MELTING POINT; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; TEMPERATURE DEPENDENCE; THERMOSTABILITY; THERMOTOGA MARITIMA;

BASE SEQUENCE; DIMERIZATION; DNA PRIMERS; ENZYME STABILITY; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; TEMPERATURE; TETRAHYDROFOLATE DEHYDROGENASE; THERMOTOGA MARITIMA;

THERMOTOGA MARITIMA;

EID: 77953879146     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100761x     Document Type: Article

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