Solvent effects on environmentally coupled hydrogen tunnelling during catalysis by dihydrofolate reductase from Thermotoga maritima

Chemistry - A European Journal

Volumn 14, Issue 34, 2008, Pages 10782-10788

  Loveridge, E Joel ^a   Evans, Rhiannon M ^a   Allemann, Rudolf K ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Dielectric constants; Dihydrofolate reductase; Enzyme catalysis; Enzymes; Iscosity

Indexed keywords

CARRIER MOBILITY; CATALYSIS; CERAMIC CAPACITORS; DIELECTRIC WAVEGUIDES; ENZYMES; GLYCEROL; HYDRODYNAMICS; HYDROGEN; ISOTOPES; LEAD; PERMITTIVITY; SUGAR (SUCROSE); TUNNELING (EXCAVATION); VISCOSITY;

DIELECTRIC CONSTANTS; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASES; DYNAMICAL PROCESSES; ENZYME CATALYSIS; HYDRIDE TRANSFERS; ISCOSITY; KINETIC ISOTOPE EFFECTS; PROTEIN DYNAMICS; PROTEIN MOTIONS; REACTION MEDIUMS; SOLVENT EFFECTS; TEMPERATURE RANGES; TRANSFER REACTIONS;

RATE CONSTANTS;

DIHYDROFOLATE REDUCTASE; GLYCEROL; HYDROGEN; SOLVENT; SUCROSE;

ARTICLE; BIOCATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; CIRCULAR DICHROISM; ELECTRIC CONDUCTIVITY; ENZYMOLOGY; KINETICS; METABOLISM; PROTEIN CONFORMATION; PROTEIN TERTIARY STRUCTURE; SENSITIVITY AND SPECIFICITY; TEMPERATURE; THERMOTOGA MARITIMA;

BIOCATALYSIS; CIRCULAR DICHROISM; ELECTRIC CONDUCTIVITY; GLYCEROL; HYDROGEN; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SENSITIVITY AND SPECIFICITY; SOLVENTS; SUCROSE; TEMPERATURE; TETRAHYDROFOLATE DEHYDROGENASE; THERMOTOGA MARITIMA;

EID: 56749083652     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200801804     Document Type: Article

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