The catalytic effect of dihydrofolate reductase and its mutants is determined by reorganization energies

Biochemistry

Volumn 46, Issue 20, 2007, Pages 6011-6025

  Liu, Hanbin ^a   Warshel, Arieh ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; CATALYST ACTIVITY; CHEMICAL BONDS; FREE ENERGY; MUTAGENESIS;

DIHYDROFOLATE REDUCTASE; MUTANTS; REORGANIZATION ENERGIES; VALENCE BONDS;

ENZYMES;

DIHYDROFOLATE REDUCTASE; SOLVENT; WATER;

AQUEOUS SOLUTION; ARTICLE; CATALYSIS; CATALYST; CORRELATION ANALYSIS; ELECTRICITY; ENERGY; ENZYME ACTIVATION; ENZYME ACTIVITY; MOTION; PARAMETER; POLYMERIZATION; PRIORITY JOURNAL; REACTION ANALYSIS; SIMULATION; SOLUTE;

ALLOSTERIC REGULATION; AMINO ACID SUBSTITUTION; CATALYSIS; COMPUTER SIMULATION; ELECTROSTATICS; ENZYME ACTIVATION; MODELS, CHEMICAL; MUTATION; TETRAHYDROFOLATE DEHYDROGENASE; THERMODYNAMICS;

EID: 34249104188     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi700201w     Document Type: Article

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