Diagnostic chemical shift markers for loop conformation and substrate and cofactor binding in dihydrofolate reductase complexes

Protein Science

Volumn 12, Issue 10, 2003, Pages 2230-2238

  Osborne, Michael J ^a   Venkitakrishnan, Rani P ^a   Dyson, H Jane ^a   Wright, Peter E ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Conformational change; Dihydrofolate reductase; Enzyme mechanism; Met 20 loop

Indexed keywords

ADENOSINE; CARBON 13; DIHYDROFOLATE REDUCTASE; FOLIC ACID; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NITROGEN 15; PROTON; PTERIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIBOSE;

ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONFORMATION; CONFORMATIONAL TRANSITION; ENZYME ACTIVE SITE; NONHUMAN; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CARBON ISOTOPES; ESCHERICHIA COLI PROTEINS; FOLIC ACID; HYDROGEN; MODELS, MOLECULAR; NADP; NITROGEN ISOTOPES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY; TETRAHYDROFOLATE DEHYDROGENASE;

ESCHERICHIA COLI;

EID: 0141746385     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.03219603     Document Type: Article

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