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Volumn 29, Issue 19, 2010, Pages 3370-3380

Saccharomyces cerevisiae Mre11/Rad50/Xrs2 and Ku proteins regulate association of Exo1 and Dna2 with DNA breaks

Author keywords

double strand break; Ku; Mre11; resection; Saccharomyces cerevisiae

Indexed keywords

KU ANTIGEN; MRE11 PROTEIN; NUCLEASE; NUCLEASE DNA2; NUCLEASE EXO1; NUCLEASE SAE2; NUCLEASE XRS2; RAD50 PROTEIN; UNCLASSIFIED DRUG; DEOXYRIBONUCLEASE; DNA BINDING PROTEIN; DNA HELICASE; DNA2 PROTEIN, S CEREVISIAE; ENDONUCLEASE; EXODEOXYRIBONUCLEASE; EXODEOXYRIBONUCLEASE I; HIGH AFFINITY DNA-BINDING FACTOR, S CEREVISIAE; MRE11 PROTEIN, S CEREVISIAE; MULTIPROTEIN COMPLEX; RAD50 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; SAE2 PROTEIN, S CEREVISIAE; XRS2 PROTEIN, S CEREVISIAE;

EID: 77957786786     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2010.219     Document Type: Article
Times cited : (185)

References (52)
  • 1
    • 11244269445 scopus 로고    scopus 로고
    • The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle
    • Aylon Y, Liefshitz B, Kupiec M (2004) The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle. EMBO J 23: 4868-4875
    • (2004) EMBO J , vol.23 , pp. 4868-4875
    • Aylon, Y.1    Liefshitz, B.2    Kupiec, M.3
  • 2
    • 0037449738 scopus 로고    scopus 로고
    • Okazaki fragment maturation in yeast. I. Distribution of functions between FEN1 and DNA2
    • Ayyagari R, Gomes XV, Gordenin DA, Burgers PM (2003) Okazaki fragment maturation in yeast. I. Distribution of functions between FEN1 and DNA2. J Biol Chem 278: 1618-1625
    • (2003) J Biol Chem , vol.278 , pp. 1618-1625
    • Ayyagari, R.1    Gomes, X.V.2    Gordenin, D.A.3    Burgers, P.M.4
  • 3
    • 0035954737 scopus 로고    scopus 로고
    • RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes
    • Bae SH, Bae KH, Kim JA, Seo YS (2001) RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes. Nature 412: 456-461
    • (2001) Nature , vol.412 , pp. 456-461
    • Bae, S.H.1    Bae, K.H.2    Kim, J.A.3    Seo, Y.S.4
  • 4
    • 65849336044 scopus 로고    scopus 로고
    • At loose ends: Resecting a double-strand break
    • Bernstein KA, Rothstein R (2009) At loose ends: resecting a double-strand break. Cell 137: 807-810
    • (2009) Cell , vol.137 , pp. 807-810
    • Bernstein, K.A.1    Rothstein, R.2
  • 5
    • 2442520305 scopus 로고    scopus 로고
    • EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-defi-cient Saccharomyces cerevisiae
    • Bertuch AA, Lundblad V (2004) EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-defi-cient Saccharomyces cerevisiae. Genetics 166: 1651-1659
    • (2004) Genetics , vol.166 , pp. 1651-1659
    • Bertuch, A.A.1    Lundblad, V.2
  • 7
    • 0032721091 scopus 로고    scopus 로고
    • The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae
    • Bressan DA, Baxter BK, Petrini JH (1999) The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae. Mol Cell Biol 19: 7681-7687
    • (1999) Mol Cell Biol , vol.19 , pp. 7681-7687
    • Bressan, D.A.1    Baxter, B.K.2    Petrini, J.H.3
  • 8
    • 0031664401 scopus 로고    scopus 로고
    • Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11
    • Bressan DA, Olivares HA, Nelms BE, Petrini JH (1998) Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11. Genetics 150: 591-600
    • (1998) Genetics , vol.150 , pp. 591-600
    • Bressan, D.A.1    Olivares, H.A.2    Nelms, B.E.3    Petrini, J.H.4
  • 9
    • 59249107930 scopus 로고    scopus 로고
    • Interplay of Mre11 nuclease with Dna2 plus Sgs1 in Rad51-dependent recombinational repair
    • Budd ME, Campbell JL (2009) Interplay of Mre11 nuclease with Dna2 plus Sgs1 in Rad51-dependent recombinational repair. PLoS One 4: e4267
    • (2009) PLoS One , vol.4
    • Budd, M.E.1    Campbell, J.L.2
  • 11
    • 0035930342 scopus 로고    scopus 로고
    • Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes
    • Chen L, Trujillo K, Ramos W, Sung P, Tomkinson AE (2001) Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes. Mol Cell 8: 1105-1115
    • (2001) Mol Cell , vol.8 , pp. 1105-1115
    • Chen, L.1    Trujillo, K.2    Ramos, W.3    Sung, P.4    Tomkinson, A.E.5
  • 12
    • 48649086824 scopus 로고    scopus 로고
    • The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle
    • Clerici M, Mantiero D, Guerini I, Lucchini G, Longhese MP (2008) The Yku70-Yku80 complex contributes to regulate double-strand break processing and checkpoint activation during the cell cycle. EMBO Rep 9: 810-818
    • (2008) EMBO Rep , vol.9 , pp. 810-818
    • Clerici, M.1    Mantiero, D.2    Guerini, I.3    Lucchini, G.4    Longhese, M.P.5
  • 13
    • 0024356877 scopus 로고
    • HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex
    • de Vries E, van Driel W, Bergsma WG, Arnberg AC, van der Vliet PC (1989) HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex. J Mol Biol 208: 65-78
    • (1989) J Mol Biol , vol.208 , pp. 65-78
    • De Vries, E.1    Van Driel, W.2    Bergsma, W.G.3    Arnberg, A.C.4    Van Der Vliet, P.C.5
  • 14
    • 0032476658 scopus 로고    scopus 로고
    • Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination
    • Furuse M, Nagase Y, Tsubouchi H, Murakami-Murofushi K, Shibata T, Ohta K (1998) Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. EMBO J 17: 6412-6425
    • (1998) EMBO J , vol.17 , pp. 6412-6425
    • Furuse, M.1    Nagase, Y.2    Tsubouchi, H.3    Murakami-Murofushi, K.4    Shibata, T.5    Ohta, K.6
  • 15
    • 53649090109 scopus 로고    scopus 로고
    • DNA helicases Sgs1 and BLM promote DNA double-strand break resection
    • Gravel S, Chapman JR, Magill C, Jackson SP (2008) DNA helicases Sgs1 and BLM promote DNA double-strand break resection. Genes Dev 22: 2767-2772
    • (2008) Genes Dev , vol.22 , pp. 2767-2772
    • Gravel, S.1    Chapman, J.R.2    Magill, C.3    Jackson, S.P.4
  • 16
    • 0242721689 scopus 로고    scopus 로고
    • End resection initiates genomic instability in the absence of telomerase
    • Hackett JA, Greider CW (2003) End resection initiates genomic instability in the absence of telomerase. Mol Cell Biol 23: 8450-8461
    • (2003) Mol Cell Biol , vol.23 , pp. 8450-8461
    • Hackett, J.A.1    Greider, C.W.2
  • 17
    • 0035906860 scopus 로고    scopus 로고
    • Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase
    • Hopfner KP, Karcher A, Craig L, Woo TT, Carney JP, Tainer JA (2001) Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Cell 105: 473-485
    • (2001) Cell , vol.105 , pp. 473-485
    • Hopfner, K.P.1    Karcher, A.2    Craig, L.3    Woo, T.T.4    Carney, J.P.5    Tainer, J.A.6
  • 18
    • 53549093050 scopus 로고    scopus 로고
    • The P. furiosus mre11/rad50 complex promotes 5 strand resection at a DNA double-strand break
    • Hopkins BB, Paull TT (2008) The P. furiosus mre11/rad50 complex promotes 5 strand resection at a DNA double-strand break. Cell 135: 250-260
    • (2008) Cell , vol.135 , pp. 250-260
    • Hopkins, B.B.1    Paull, T.T.2
  • 19
    • 0345447604 scopus 로고    scopus 로고
    • Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast
    • Ira G, Malkova A, Liberi G, Foiani M, Haber JE (2003) Srs2 and Sgs1-Top3 suppress crossovers during double-strand break repair in yeast. Cell 115: 401-411
    • (2003) Cell , vol.115 , pp. 401-411
    • Ira, G.1    Malkova, A.2    Liberi, G.3    Foiani, M.4    Haber, J.E.5
  • 21
    • 0028212415 scopus 로고
    • Mutations in XRS2 and RAD50 delay but do not prevent mat-ing-type switching in Saccharomyces cerevisiae
    • Ivanov EL, Sugawara N, White CI, Fabre F, Haber JE (1994) Mutations in XRS2 and RAD50 delay but do not prevent mat-ing-type switching in Saccharomyces cerevisiae. Mol Cell Biol 14: 3414-3425
    • (1994) Mol Cell Biol , vol.14 , pp. 3414-3425
    • Ivanov, E.L.1    Sugawara, N.2    White, C.I.3    Fabre, F.4    Haber, J.E.5
  • 23
    • 2442601582 scopus 로고    scopus 로고
    • On the roles of Saccharomyces cerevisiae Dna2p and Flap endonuclease 1 in Okazaki fragment processing
    • Kao HI, Veeraraghavan J, Polaczek P, Campbell JL, Bambara RA (2004) On the roles of Saccharomyces cerevisiae Dna2p and Flap endonuclease 1 in Okazaki fragment processing. J Biol Chem 279: 15014-15024
    • (2004) J Biol Chem , vol.279 , pp. 15014-15024
    • Kao, H.I.1    Veeraraghavan, J.2    Polaczek, P.3    Campbell, J.L.4    Bambara, R.A.5
  • 24
    • 10344263324 scopus 로고    scopus 로고
    • Recombination proteins in yeast
    • Krogh BO, Symington LS (2004) Recombination proteins in yeast. Annu Rev Genet 38: 233-271
    • (2004) Annu Rev Genet , vol.38 , pp. 233-271
    • Krogh, B.O.1    Symington, L.S.2
  • 25
    • 47949092912 scopus 로고    scopus 로고
    • Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome transloca-tions
    • Lee K, Zhang Y, Lee SE (2008) Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome transloca-tions. Nature 454: 543-546
    • (2008) Nature , vol.454 , pp. 543-546
    • Lee, K.1    Zhang, Y.2    Lee, S.E.3
  • 26
    • 0036245193 scopus 로고    scopus 로고
    • Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance
    • Lee SE, Bressan DA, Petrini JH, Haber JE (2002) Complementation between N-terminal Saccharomyces cerevisiae mre11 alleles in DNA repair and telomere length maintenance. DNA Repair (Amst) 1: 27-40
    • (2002) DNA Repair (Amst) , vol.1 , pp. 27-40
    • Lee, S.E.1    Bressan, D.A.2    Petrini, J.H.3    Haber, J.E.4
  • 27
    • 0032493889 scopus 로고    scopus 로고
    • Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage
    • Lee SE, Moore JK, Holmes A, Umezu K, Kolodner RD, Haber JE (1998) Saccharomyces Ku70, mre11/rad50 and RPA proteins regulate adaptation to G2/M arrest after DNA damage. Cell 94: 399-409
    • (1998) Cell , vol.94 , pp. 399-409
    • Lee, S.E.1    Moore, J.K.2    Holmes, A.3    Umezu, K.4    Kolodner, R.D.5    Haber, J.E.6
  • 28
    • 70349319253 scopus 로고    scopus 로고
    • Faithful after break-up: Suppression of chromosomal translocations
    • Lee SE, Myung K (2009) Faithful after break-up: suppression of chromosomal translocations. Cell Mol Life Sci 66: 3149-3160
    • (2009) Cell Mol Life Sci , vol.66 , pp. 3149-3160
    • Lee, S.E.1    Myung, K.2
  • 29
    • 36248942617 scopus 로고    scopus 로고
    • Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex
    • Lengsfeld BM, Rattray AJ, Bhaskara V, Ghirlando R, Paull TT (2007) Sae2 is an endonuclease that processes hairpin DNA cooperatively with the Mre11/Rad50/Xrs2 complex. Mol Cell 28: 638-651
    • (2007) Mol Cell , vol.28 , pp. 638-651
    • Lengsfeld, B.M.1    Rattray, A.J.2    Bhaskara, V.3    Ghirlando, R.4    Paull, T.T.5
  • 30
    • 56049111594 scopus 로고    scopus 로고
    • Identification of the Xenopus DNA2 protein as a major nuclease for the 5-3 strand-specific processing of DNA ends
    • Liao S, Toczylowski T, Yan H (2008) Identification of the Xenopus DNA2 protein as a major nuclease for the 5-3 strand-specific processing of DNA ends. Nucleic Acids Res 36: 6091-6100
    • (2008) Nucleic Acids Res , vol.36 , pp. 6091-6100
    • Liao, S.1    Toczylowski, T.2    Yan, H.3
  • 31
    • 34948872046 scopus 로고    scopus 로고
    • Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination
    • Limbo O, Chahwan C, Yamada Y, de Bruin RA, Wittenberg C, Russell P (2007) Ctp1 is a cell-cycle-regulated protein that functions with Mre11 complex to control double-strand break repair by homologous recombination. Mol Cell 28: 134-146
    • (2007) Mol Cell , vol.28 , pp. 134-146
    • Limbo, O.1    Chahwan, C.2    Yamada, Y.3    De Bruin, R.A.4    Wittenberg, C.5    Russell, P.6
  • 32
    • 0036682516 scopus 로고    scopus 로고
    • EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants
    • Maringele L, Lydall D (2002) EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants. Genes Dev 16: 1919-1933
    • (2002) Genes Dev , vol.16 , pp. 1919-1933
    • Maringele, L.1    Lydall, D.2
  • 33
    • 53649104599 scopus 로고    scopus 로고
    • Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing
    • Mimitou EP, Symington LS (2008) Sae2, Exo1 and Sgs1 collaborate in DNA double-strand break processing. Nature 455: 770-774
    • (2008) Nature , vol.455 , pp. 770-774
    • Mimitou, E.P.1    Symington, L.S.2
  • 34
    • 68249116573 scopus 로고    scopus 로고
    • DNA end resection: Many nucleases make light work
    • Mimitou EP, Symington LS (2009) DNA end resection: many nucleases make light work. DNA Repair (Amst) 8: 983-995
    • (2009) DNA Repair (Amst) , vol.8 , pp. 983-995
    • Mimitou, E.P.1    Symington, L.S.2
  • 35
    • 0032931844 scopus 로고    scopus 로고
    • The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance
    • Moreau S, Ferguson JR, Symington LS (1999) The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol Cell Biol 19: 556-566
    • (1999) Mol Cell Biol , vol.19 , pp. 556-566
    • Moreau, S.1    Ferguson, J.R.2    Symington, L.S.3
  • 36
    • 23944459784 scopus 로고    scopus 로고
    • Endonucleolytic processing of covalent protein-linked DNA double-strand breaks
    • Neale MJ, Pan J, Keeney S (2005) Endonucleolytic processing of covalent protein-linked DNA double-strand breaks. Nature 436: 1053-1057
    • (2005) Nature , vol.436 , pp. 1053-1057
    • Neale, M.J.1    Pan, J.2    Keeney, S.3
  • 37
    • 62349103878 scopus 로고    scopus 로고
    • DNA repair in mammalian cells: DNA double-strand break repair: How to fix a broken relationship
    • Pardo B, Gomez-Gonzalez B, Aguilera A (2009) DNA repair in mammalian cells: DNA double-strand break repair: how to fix a broken relationship. Cell Mol Life Sci 66: 1039-1056
    • (2009) Cell Mol Life Sci , vol.66 , pp. 1039-1056
    • Pardo, B.1    Gomez-Gonzalez, B.2    Aguilera, A.3
  • 38
    • 0032085295 scopus 로고    scopus 로고
    • The 3 to 5 exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
    • Paull TT, Gellert M (1998) The 3 to 5 exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol Cell 1: 969-979
    • (1998) Mol Cell , vol.1 , pp. 969-979
    • Paull, T.T.1    Gellert, M.2
  • 39
    • 0033563229 scopus 로고    scopus 로고
    • Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
    • Paull TT, Gellert M (1999) Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev 13: 1276-1288
    • (1999) Genes Dev , vol.13 , pp. 1276-1288
    • Paull, T.T.1    Gellert, M.2
  • 41
    • 38049155945 scopus 로고    scopus 로고
    • Regulation of DNA double-strand break repair pathway choice
    • Shrivastav M, De Haro LP, Nickoloff JA (2008) Regulation of DNA double-strand break repair pathway choice. Cell Res 18: 134-147
    • (2008) Cell Res , vol.18 , pp. 134-147
    • Shrivastav, M.1    De Haro, L.P.2    Nickoloff, J.A.3
  • 44
    • 0035929667 scopus 로고    scopus 로고
    • DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex
    • Trujillo KM, Sung P (2001) DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50*Mre11 complex. J Biol Chem 276: 35458-35464
    • (2001) J Biol Chem , vol.276 , pp. 35458-35464
    • Trujillo, K.M.1    Sung, P.2
  • 45
    • 0033915812 scopus 로고    scopus 로고
    • Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cere-visiae
    • Tsubouchi H, Ogawa H (2000) Exo1 roles for repair of DNA double-strand breaks and meiotic crossing over in Saccharomyces cere-visiae. Mol Biol Cell 11: 2221-2233
    • (2000) Mol Biol Cell , vol.11 , pp. 2221-2233
    • Tsubouchi, H.1    Ogawa, H.2
  • 46
    • 0032567108 scopus 로고    scopus 로고
    • Complex formation and functional versatility of Mre11 of budding yeast in recombination
    • Usui T, Ohta T, Oshiumi H, Tomizawa J, Ogawa H, Ogawa T (1998) Complex formation and functional versatility of Mre11 of budding yeast in recombination. Cell 95: 705-716
    • (1998) Cell , vol.95 , pp. 705-716
    • Usui, T.1    Ohta, T.2    Oshiumi, H.3    Tomizawa, J.4    Ogawa, H.5    Ogawa, T.6
  • 47
    • 0035833552 scopus 로고    scopus 로고
    • Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
    • Walker JR, Corpina RA, Goldberg J (2001) Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 412: 607-614
    • (2001) Nature , vol.412 , pp. 607-614
    • Walker, J.R.1    Corpina, R.A.2    Goldberg, J.3
  • 48
    • 58149151222 scopus 로고    scopus 로고
    • Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae
    • Wasko BM, Holland CL, Resnick MA, Lewis LK (2009) Inhibition of DNA double-strand break repair by the Ku heterodimer in mrx mutants of Saccharomyces cerevisiae. DNA Repair (Amst) 8: 162-169
    • (2009) DNA Repair (Amst) , vol.8 , pp. 162-169
    • Wasko, B.M.1    Holland, C.L.2    Resnick, M.A.3    Lewis, L.K.4
  • 50
    • 45149104841 scopus 로고    scopus 로고
    • Recruitment and dissociation of nonhomologous end joining proteins at a DNA double-strand break in Saccharomyces cerevisiae
    • Wu D, Topper LM, Wilson TE (2008) Recruitment and dissociation of nonhomologous end joining proteins at a DNA double-strand break in Saccharomyces cerevisiae. Genetics 178: 1237-1249
    • (2008) Genetics , vol.178 , pp. 1237-1249
    • Wu, D.1    Topper, L.M.2    Wilson, T.E.3
  • 52
    • 51549095956 scopus 로고    scopus 로고
    • Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends
    • Zhu Z, Chung WH, Shim EY, Lee SE, Ira G (2008) Sgs1 helicase and two nucleases Dna2 and Exo1 resect DNA double-strand break ends. Cell 134: 981-994
    • (2008) Cell , vol.134 , pp. 981-994
    • Zhu, Z.1    Chung, W.H.2    Shim, E.Y.3    Lee, S.E.4    Ira, G.5


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