Loss of heterozygosity or: How I learned to stop worrying and love mitotic recombination

American Journal of Human Genetics

Volumn 61, Issue 5, 1997, Pages 995-999

  Tischfield, Jay A ^a  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER SUSCEPTIBILITY; GENE MUTATION; GENETIC ANALYSIS; GENETIC SUSCEPTIBILITY; HETEROZYGOSITY LOSS; HUMAN; PRIORITY JOURNAL; REVIEW; SOMATIC CELL GENETICS;

EID: 0030776156     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/301617     Document Type: Article

References (30)

1. -/- mutant of the chicken DT40 cell line. Cell 89:185-193
2. Cappione AJ, French BL, Skuse GR (1997) A potential role for NF1 mRNA editing in the pathogenesis of NF1 tumors. Am J Hum Genet 60:305-312
3. Ceci JD (1996) Encyclopedia of the mouse genome. V. Mouse chromosome 8. Mamm Genome 6 (special issue): S151-S169
4. de Nooij-van Dalen AG, van Buuren-van Seggelen VHA, Mulder A, Gelsthorpe K, Cole J, Lohman PHM, Giphart-Gassler M (1997) Isolation and molecular characterization of spontaneous mutants of lymphoblastoid cells with extended loss of heterozygosity. Mutat Res 374:51-62
5. De Sepulveda P, Guenet J-L, Panthier J-J (1995) Phenotypic reversions at the W/Kit locus mediated by mitotic recombination in mice. Mol Cell Biol 15:5898-5905
6. Engle SJ, Stockelman MG, Chen J, Boivin G, Yum M-N, Davies PM, Ying MY, et al (1996) Adenine phosphoribosyltransferase-deficient mice develop 2,8-dihydroxadenine nephrolithiasis. Proc Natl Acad Sci USA 93:5307-5312
7. Essers J, Hendriks RW, Swagemakers SMA, Troelstra C, de Wit J, Bootsma D, Hoeijmakers JHJ, et al (1997) Disruption of mouse RAD54 reduces ionizing radiation resistance and homologous recombination. Cell 89:195-204
8. Fujimori A, Tachibana A, Tatsumi K (1992) Allelic losses in mutations at the aprt locus of human lymphoblastoid cells. Mutat Res 269:55-62
9. Gupta PK, Sahota A, Boyadjiev SA, Bye S, Shao C, O'Neill JP, Hunter TC, et al (1997a) High frequency in vivo loss of heterozygosity is primarily a consequence of mitotic recombination. Cancer Res 57:1188-1193
10. Gupta PK, Shao C, Zhu Y, Sahota A, Tischfield JA (1997b) Loss of heterozygosity analysis in a human fibrosarcoma cell line. Cytogenet Cell Genet 76:214-218
11. Jackson SP, Jeggo PA (1995) DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK. Trends Biochem Sci 20:412-415
12. Jonkman MF, Scheffer H, Stulp R, Pas HH, Nijenhuis M, Heeres K, Owaribe K, et al (1997) Revertant mosaicism in epidermolysis bullosa caused by mitotic gene conversion. Cell 88:543-551
13. Kinzler K, Vogelstein B (1996) Lessons from hereditary colorectal cancer. Cell 87:159-170
14. Kinzler KW, Vogelstein B (1997) Introduction to cancer genetics. In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease CD-ROM, 7th ed. McGraw-Hill, New York
15. Knudson AG (1993) Antioncogenes and human cancer. Proc Natl Acad Sci USA 90:10914-10921
16. Kushiro J-I, Hirai Y, Kusunoki Y, Kyoizumi S, Kodama Y, Wakisaka A, Jeffreys A, et al (1992) Development of a flow-cytometric HLA-A locus mutation assay for human peripheral blood lymphocytes. Mutat Res 272:17-29
17. Levine AJ (1997) p53, the cellular gatekeeper for growth and division. Cell 88:323-331
18. Lloyd DC, Edwards AA (1983) Chromosome aberrations in human lymphocytes: effect of radiation quality, dose, and dose rate. In: Ishihara T, Sasaki MS (eds) Radiation-induced chromosome damage in man. Allan R Liss, New York, pp 23-49
19. Loeb LA (1991) Mutator phenotype may be required for multistage carcinogenesis. Cancer Res 51:3075-3080
20. Morley AA (1991) Mitotic recombination in mammalian cells in vivo. Mutat Res 250:345-349
21. Moynahan ME, Jasin M (1997) Loss of heterozygosity induced by a chromosomal double-strand break. Proc Natl Acad Sci USA 94:8988-8993
22. Phear G, Bhattacharyya NP, Meuth M (1996) Loss of heterozygosity and base substitution at the APRT locus in mismatch-repair-proficient and -deficient colorectal carcinoma cell lines. Mol Cell Biol 16:6516-6523
23. Qian F, Germino GG (1997) "Mistakes happen": somatic mutation and disease. Am J Hum Genet 61:1000-1005 (in this issue)
24. 1-induced liver cancer: is mitotic recombination involved? Mol Carcinog 19:147-152
25. Shao C, Gupta PK, Sun Y, Sahota A, Tischfield JA (1996) Complex chromosomal mechanisms lead to APRT loss of heterozygosity in heteroploid cells. Cytogenet Cell Genet 75: 216-221
26. Shinohara A, Ogawa T (1995) Homologous recombination and the roles of double-strand breaks. Trends Biochem Sci 20:387-391
27. Simmonds HA, Sahota AS, Van Acker KJ (1997) Adenine phophoribosyltransferase deficiency and 2,8-dihydroxyadenine lithiasis In: Scriver CR, Beaudet AL, Sly WS, Valle D (eds) The metabolic and molecular bases of inherited disease CD-ROM, 7th ed. McGraw-Hill, New York
28. Smith LE, Grosovsky AJ (1993) Genetic instability on chromosome 16 in a human B lymphoblastoid cell line. Somat Cell Mol Genet 19:515-527
29. Stambrook PJ, Shao C, Stockelman M, Boivin G, Engle SJ, Tischfield JA (1996) APRT: a versatile in vivo resident reporter of local mutation and loss of heterozygosity. Environ Mol Mutagen 28:471-482
30. Tischfield JA, Ruddle FH (1974) Assignment of the gene for adenine phosphoribosyltransferase to human chromosome 16 by mouse-human somatic cell hybridization. Proc Natl Acad Sci USA 71:45-49