-
1
-
-
0019960812
-
A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene
-
DOI 10.1038/300149a0
-
Reddy, E.P., Reynold, R.K., Santos, E. & Barbacid, M. A point mutation is responsible for the acquisition of transforming properties of the T24 human bladder carcinoma oncogene. Nature 300, 149-152 (1982). (Pubitemid 12006347)
-
(1982)
Nature
, vol.300
, Issue.5888
, pp. 149-152
-
-
Reddy, E.P.1
Reynolds, R.K.2
Santos, E.3
Barbacid, M.4
-
2
-
-
0019947771
-
Mechanism of activation of a human oncogene
-
DOI 10.1038/300143a0
-
Tabin, C.J. Mechanism of activation of a human oncogene. Nature 300, 143-149 (1982). (Pubitemid 12006346)
-
(1982)
Nature
, vol.300
, Issue.5888
, pp. 143-149
-
-
Tabin, C.J.1
Bradley, S.M.2
Bargmann, C.I.3
-
3
-
-
0020624456
-
Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations
-
Capon, D.J. et al. Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations. Nature 304, 507-513 (1983). (Pubitemid 13026946)
-
(1983)
Nature
, vol.304
, Issue.5926
, pp. 507-513
-
-
Capon, D.J.1
Seeburg, P.H.2
McGrath, J.P.3
-
4
-
-
0020578806
-
Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene
-
McGrath, J.P. et al. Structure and organization of the human Ki-ras proto-oncogene and a related processed pseudogene. Nature 304, 501-506 (1983). (Pubitemid 13026945)
-
(1983)
Nature
, vol.304
, Issue.5926
, pp. 501-506
-
-
McGrath, J.P.1
Capon, D.J.2
Smith, D.H.3
-
5
-
-
0020624455
-
Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1
-
Shimizu, K. et al. Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. Nature 304, 497-500 (1983). (Pubitemid 13026944)
-
(1983)
Nature
, vol.304
, Issue.5926
, pp. 497-500
-
-
Shimizu, K.1
Birnbaum, D.2
Ruley, M.A.3
-
6
-
-
0021871489
-
Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia
-
DOI 10.1038/315726a0
-
Bos, J.L. et al. Amino-acid substitutions at codon 13 of the N-ras oncogene in human acute myeloid leukaemia. Nature 315, 726-730 (1985). (Pubitemid 15022925)
-
(1985)
Nature
, vol.315
, Issue.6022
, pp. 726-730
-
-
Bos, J.L.1
Toksoz, D.2
Marshall, C.J.3
-
7
-
-
0037264633
-
Targeting RAS signalling pathways in cancer therapy
-
DOI 10.1038/nrc969
-
Downward, J. Targeting RAS signalling pathways in cancer therapy. Nat. Rev. Cancer 3, 11-22 (2003). (Pubitemid 37328883)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.1
, pp. 11-22
-
-
Downward, J.1
-
8
-
-
47349089381
-
Farnesyltransferase inhibitors: A detailed chemical view on an elusive biological problem
-
DOI 10.2174/092986708784638825
-
Sousa, S.F., Fernandes, P.A. & Ramos, M.J. Farnesyltransferase inhibitors: a detailed chemical view on an elusive biological problem. Curr. Med. Chem. 15, 1478-1492 (2008). (Pubitemid 351997780)
-
(2008)
Current Medicinal Chemistry
, vol.15
, Issue.15
, pp. 1478-1492
-
-
Sousa, S.F.1
Fernandes, P.A.2
Ramos, M.J.3
-
9
-
-
77951016969
-
A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non-small cell lung cancer
-
Haura, E.B. et al. A phase II study of PD-0325901, an oral MEK inhibitor, in previously treated patients with advanced non-small cell lung cancer. Clin. Cancer Res. 16, 2450-2457 (2010)
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 2450-2457
-
-
Haura, E.B.1
-
10
-
-
65349189958
-
American Society of Clinical Oncology provisional clinical opinion: Testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy
-
Allegra, C.J. et al. American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy. J. Clin. Oncol. 27, 2091-2096 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 2091-2096
-
-
Allegra, C.J.1
-
11
-
-
38649099966
-
KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab
-
DOI 10.1200/JCO.2007.12.5906
-
Lièvre, A. et al. KRAS mutations as an independent prognostic factor in patients with advanced colorectal cancer treated with cetuximab. J. Clin. Oncol. 26, 374-379 (2008). (Pubitemid 351171687)
-
(2008)
Journal of Clinical Oncology
, vol.26
, Issue.3
, pp. 374-379
-
-
Lievre, A.1
Bachet, J.-B.2
Boige, V.3
Cayre, A.4
Le Corre, D.5
Buc, E.6
Ychou, M.7
Bouche, O.8
Landi, B.9
Louvet, C.10
Andre, T.11
Bibeau, F.12
Diebold, M.-D.13
Rougier, P.14
Ducreux, M.15
Tomasic, G.16
Emile, J.-F.17
Penault-Llorca, F.18
Laurent-Puig, P.19
-
12
-
-
42649145667
-
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
-
Amado, R.G. et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J. Clin. Oncol. 26, 1626-1634 (2008).
-
(2008)
J. Clin. Oncol.
, vol.26
, pp. 1626-1634
-
-
Amado, R.G.1
-
13
-
-
24944497744
-
Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib
-
Eberhard, D.A. et al. Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non-small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J. Clin. Oncol. 23, 5900-5909 (2005).
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 5900-5909
-
-
Eberhard, D.A.1
-
14
-
-
1542515338
-
A census of human cancer genes
-
Futreal, P.A. et al. A census of human cancer genes. Nat. Rev. Cancer 4, 177-183 (2004). (Pubitemid 38337497)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.3
, pp. 177-183
-
-
Futreal, P.A.1
Coin, L.2
Marshall, M.3
Down, T.4
Hubbard, T.5
Wooster, R.6
Rahman, N.7
Stratton, M.R.8
-
15
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
DOI 10.1038/nature00766
-
Davies, H. et al. Mutations of the BRAF gene in human cancer. Nature 417, 949-954 (2002). (Pubitemid 34716871)
-
(2002)
Nature
, vol.417
, Issue.6892
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
Stephens, P.4
Edkins, S.5
Clegg, S.6
Teague, J.7
Woffendin, H.8
Garnett, M.J.9
Bottomley, W.10
Davis, N.11
Dicks, E.12
Ewing, R.13
Floyd, Y.14
Gray, K.15
Hall, S.16
Hawes, R.17
Hughes, J.18
Kosmidou, V.19
Menzies, A.20
Mould, C.21
Parker, A.22
Stevens, C.23
Watt, S.24
Hooper, S.25
Wilson, R.26
Jayatilake, H.27
Gusterson, B.A.28
Cooper, C.29
Shipley, J.30
Hargrave, D.31
Pritchard-Jones, K.32
Maitland, N.33
Chenevix-Trench, G.34
Riggins, G.J.35
Bigner, D.D.36
Palmleri, G.37
Cossu, A.38
Flanagan, A.39
Nicholson, A.40
Ho, J.W.C.41
Leung, S.Y.42
Yuen, S.T.43
Weber, B.L.44
Seigler, H.F.45
Darrow, T.L.46
Paterson, H.47
Marais, R.48
Marshall, C.J.49
Wooster, R.50
Stratton, M.R.51
Futreal, P.A.52
more..
-
16
-
-
77956030786
-
Inhibition of mutated, activated BRAF in metastatic melanoma
-
Flaherty, K.T. et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N. Engl. J. Med. 363, 809-819 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 809-819
-
-
Flaherty, K.T.1
-
17
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels, Y. et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 304, 504-508, (2004).
-
(2004)
Science
, vol.304
, pp. 504-508
-
-
Samuels, Y.1
-
18
-
-
16644393213
-
The PIK3CA gene is mutated with high frequency in human breast cancers
-
Bachman, K.E. A.P., Samuels, Y., Silliman, N., Ptak, J., Szabo, S., Konishi, H., Karakas, B., Blair, B.G., Lin, C., Peters, A.B., Velculescu, V.E. & Park, B.H. The PIK3CA gene is mutated with high frequency in human breast cancers. Cancer Biol. Ther. 3, 772-775 (2004). (Pubitemid 41351083)
-
(2004)
Cancer Biology and Therapy
, vol.3
, Issue.8
, pp. 772-775
-
-
Bachman, K.E.1
Argani, P.2
Samuels, Y.3
Silliman, N.4
Ptak, J.5
Szabo, S.6
Konishi, H.7
Karakas, B.8
Blair, B.G.9
Lin, C.10
Peters, B.A.11
Velculescu, V.E.12
Park, B.H.13
-
19
-
-
7444250290
-
Mutation of the PIK3CA gene in ovarian and breast cancer
-
DOI 10.1158/0008-5472.CAN-04-2933
-
Campbell, I.G. et al. Mutation of the PIK3CA gene in ovarian and breast cancer. Cancer Res. 64, 7678-7681 (2004). (Pubitemid 39446895)
-
(2004)
Cancer Research
, vol.64
, Issue.21
, pp. 7678-7681
-
-
Campbell, I.G.1
Russell, S.E.2
Choong, D.Y.H.3
Montgomery, K.G.4
Ciavarella, M.L.5
Hooi, C.S.F.6
Cristiano, B.E.7
Pearson, R.B.8
Phillips, W.A.9
-
20
-
-
63749129788
-
PI3K and mTOR inhibitors- a new generation of targeted anticancer agents
-
Brachmann, S., Fritsch, C., Maira, S.-M. & García- Echeverría, C. PI3K and mTOR inhibitors- a new generation of targeted anticancer agents. Curr. Opin. Cell Biol. 21, 194-198 (2009).
-
(2009)
Curr. Opin. Cell Biol.
, vol.21
, pp. 194-198
-
-
Brachmann, S.1
Fritsch, C.2
Maira, S.-M.3
García-Echeverría, C.4
-
21
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
The Cancer Genome Atlas Research Network.
-
The Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455, 1061-1068 (2008).
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
-
22
-
-
70749140937
-
Somatic mutations in p85α promote tumorigenesis through class IA PI3K activation
-
Jaiswal, B.S. et al. Somatic mutations in p85α promote tumorigenesis through class IA PI3K activation. Cancer Cell 16, 463-474 (2009).
-
(2009)
Cancer Cell
, vol.16
, pp. 463-474
-
-
Jaiswal, B.S.1
-
23
-
-
40649096375
-
Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
-
DOI 10.1073/pnas.0712169105
-
Zhao, L. & Vogt, P.K. Helical domain and kinase domain mutations in p110α of phosphatidylinositol 3-kinase induce gain of function by different mechanisms. Proc. Natl. Acad. Sci. USA 105, 2652-2657 (2008). (Pubitemid 351520568)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.7
, pp. 2652-2657
-
-
Zhao, L.1
Vogt, P.K.2
-
25
-
-
77949881462
-
The PI3K pathway as drug target in human cancer
-
Courtney, K.D., Corcoran, R.B. & Engelman, J.A. The PI3K pathway as drug target in human cancer. J. Clin. Oncol. 28, 1075-1083 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 1075-1083
-
-
Courtney, K.D.1
Corcoran, R.B.2
Engelman, J.A.3
-
26
-
-
17644424955
-
A gain-of-function mutation of JAK2 in myeloproliferative disorders
-
DOI 10.1056/NEJMoa051113
-
Kralovics, R. et al. A gain-of-function mutation of JAK2 in myeloproliferative disorders. N. Engl. J. Med. 352, 1779-1790 (2005). (Pubitemid 40570926)
-
(2005)
New England Journal of Medicine
, vol.352
, Issue.17
, pp. 1779-1790
-
-
Kralovics, R.1
Passamonti, F.2
Buser, A.S.3
Teo, S.-S.4
Tiedt, R.5
Passweg, J.R.6
Tichelli, A.7
Cazzola, M.8
Skoda, R.C.9
-
27
-
-
20244369569
-
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis
-
DOI 10.1016/j.ccr.2005.03.023
-
Levine, R.L. et al. Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis. Cancer Cell 7, 387-397 (2005). (Pubitemid 40544655)
-
(2005)
Cancer Cell
, vol.7
, Issue.4
, pp. 387-397
-
-
Levine, R.L.1
Wadleigh, M.2
Cools, J.3
Ebert, B.L.4
Wernig, G.5
Huntly, B.J.P.6
Boggon, T.J.7
Wlodarska, I.8
Clark, J.J.9
Moore, S.10
Adelsperger, J.11
Koo, S.12
Lee, J.C.13
Gabriel, S.14
Mercher, T.15
D'Andrea, A.16
Frohling, S.17
Dohner, K.18
Marynen, P.19
Vandenberghe, P.20
Mesa, R.A.21
Tefferi, A.22
Griffin, J.D.23
Eck, M.J.24
Sellers, W.R.25
Meyerson, M.26
Golub, T.R.27
Lee, S.J.28
Gilliland, D.G.29
more..
-
28
-
-
77956696835
-
Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis
-
Verstovsek, S. et al. Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis. N. Engl. J. Med. 363, 1117-1127 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 1117-1127
-
-
Verstovsek, S.1
-
29
-
-
33749021085
-
Somatic activation of KIT in distinct subtypes of melanoma
-
DOI 10.1200/JCO.2006.06.2984
-
Curtin, J.A., Busam, K., Pinkel, D. & Bastian, B.C. Somatic activation of KIT in distinct subtypes of melanoma. J. Clin. Oncol. 24, 4340-4346 (2006). (Pubitemid 46630793)
-
(2006)
Journal of Clinical Oncology
, vol.24
, Issue.26
, pp. 4340-4346
-
-
Curtin, J.A.1
Busam, K.2
Pinkel, D.3
Bastian, B.C.4
-
30
-
-
47249122523
-
Drug-sensitive FGFR2 mutations in endometrial carcinoma
-
DOI 10.1073/pnas.0803379105
-
Dutt, A. et al. Drug-sensitive FGFR2 mutations in endometrial carcinoma. Proc. Natl. Acad. Sci. USA 105, 8713-8717 (2008). (Pubitemid 351987745)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.25
, pp. 8713-8717
-
-
Dutt, A.1
Salvesen, H.B.2
Chen, T.H.3
Ramos, A.H.4
Onofrio, R.C.5
Hatton, C.6
Nicoletti, R.7
Winckler, W.8
Grewal, R.9
Hanna, M.10
Wyhs, N.11
Ziaugra, L.12
Richter, D.J.13
Trovik, J.14
Engelsen, I.B.15
Stefansson, I.M.16
Fennell, T.17
Cibulskis, K.18
Zody, M.C.19
Akslen, L.A.20
Gabriel, S.21
Wong, K.-K.22
Sellers, W.R.23
Meyerson, M.24
Greulich, H.25
more..
-
31
-
-
34250829395
-
Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes
-
DOI 10.1038/sj.onc.1210529, PII 1210529
-
Pollock, P.M. et al. Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes. Oncogene 26, 7158-7162 (2007). (Pubitemid 350059681)
-
(2007)
Oncogene
, vol.26
, Issue.50
, pp. 7158-7162
-
-
Pollock, P.M.1
Gartside, M.G.2
Dejeza, L.C.3
Powell, M.A.4
Mallon, M.A.5
Davies, H.6
Mohammadi, M.7
Futreal, P.A.8
Stratton, M.R.9
Trent, J.M.10
Goodfellow, P.J.11
-
32
-
-
77950866918
-
Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT
-
Handolias, D. et al. Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT. Br. J. Cancer 102, 1219-1223 (2010).
-
(2010)
Br. J. Cancer
, vol.102
, pp. 1219-1223
-
-
Handolias, D.1
-
33
-
-
59049107421
-
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
-
Van Raamsdonk, C.D. et al. Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature 457, 599-602 (2009).
-
(2009)
Nature
, vol.457
, pp. 599-602
-
-
Van Raamsdonk, C.D.1
-
34
-
-
4944232647
-
Lung cancer: Intragenic ERBB2 kinase mutations in tumours
-
Stephens, P. et al. Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature 431, 525-526 (2004).
-
(2004)
Nature
, vol.431
, pp. 525-526
-
-
Stephens, P.1
-
35
-
-
0035869407
-
Use of chemotherapy plus a monoclonal antibody against her2 for metastatic breast cancer that overexpresses HER2
-
DOI 10.1056/NEJM200103153441101
-
Slamon, D.J. et al. Use of chemotherapy plus a monoclonal antibody against HER2 for metastatic breast cancer that overexpresses HER2. N. Engl. J. Med. 344, 783-792 (2001). (Pubitemid 32222155)
-
(2001)
New England Journal of Medicine
, vol.344
, Issue.11
, pp. 783-792
-
-
Slamon, D.J.1
Leyland-Jones, B.2
Shak, S.3
Fuchs, H.4
Paton, V.5
Bajamonde, A.6
Fleming, T.7
Eiermann, W.8
Wolter, J.9
Pegram, M.10
Baselga, J.11
Norton, L.12
-
36
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
DOI 10.1056/NEJMoa040938
-
Lynch, T.J. et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 350, 2129-2139 (2004). (Pubitemid 38637993)
-
(2004)
New England Journal of Medicine
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
Louis, D.N.11
Christiani, D.C.12
Settleman, J.13
Haber, D.A.14
-
37
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons, D.W. et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321, 1807-1812 (2008).
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
-
38
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan, H. et al. IDH1 and IDH2 mutations in gliomas. N. Engl. J. Med. 360, 765-773 (2009).
-
(2009)
N. Engl. J. Med.
, vol.360
, pp. 765-773
-
-
Yan, H.1
-
39
-
-
77954697566
-
Isocitrate dehydrogenase 1 and 2 mutations in cancer: Alterations at a crossroads of cellular metabolism
-
Reitman, Z.J. & Yan, H. Isocitrate dehydrogenase 1 and 2 mutations in cancer: alterations at a crossroads of cellular metabolism. J. Natl. Cancer Inst. 102, 932-941 (2010).
-
(2010)
J. Natl. Cancer Inst.
, vol.102
, pp. 932-941
-
-
Reitman, Z.J.1
Yan, H.2
-
40
-
-
75149188170
-
Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes
-
Dalgliesh, G.L. et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes. Nature 463, 360-363 (2010).
-
(2010)
Nature
, vol.463
, pp. 360-363
-
-
Dalgliesh, G.L.1
-
41
-
-
67349203626
-
Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
-
van Haaften, G. et al. Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer. Nat. Genet. 41, 521-523 (2009).
-
(2009)
Nat. Genet.
, vol.41
, pp. 521-523
-
-
Van Haaften, G.1
-
42
-
-
77957731999
-
Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma
-
Jones, S., et al. Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinoma. Science 330, 228-231 (2010).
-
(2010)
Science
, vol.330
, pp. 228-231
-
-
Jones, S.1
-
43
-
-
77957946398
-
ARID1A mutations in endometriosis-associated ovarian carcinomas
-
Wiegand, K.C., et al. ARID1A mutations in endometriosis-associated ovarian carcinomas. N. Engl. J. Med. 363, 1532-1543 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 1532-1543
-
-
Wiegand, K.C.1
-
44
-
-
79251635938
-
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma
-
Varela, I. et al. Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma. Nature 469, 539-542 (2011).
-
(2011)
Nature
, vol.469
, pp. 539-542
-
-
Varela, I.1
-
45
-
-
77954032829
-
Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers
-
Fong, P.C. et al. Inhibition of poly(ADP-ribose) polymerase in tumors from BRCA mutation carriers. J. Clin. Oncol. 28, 2512-2519 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 2512-2519
-
-
Fong, P.C.1
-
46
-
-
77954032829
-
Poly(ADP)-ribose polymerase inhibition: Frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval
-
Fong, P.C. et al. Poly(ADP)-ribose polymerase inhibition: frequent durable responses in BRCA carrier ovarian cancer correlating with platinum-free interval. J. Clin. Oncol. 28, 2512-2519 (2010).
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 2512-2519
-
-
Fong, P.C.1
-
47
-
-
77149157867
-
Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors
-
Mendes-Pereira, A.M. et al. Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors. EMBO Mol. Med. 1, 315-322 (2009).
-
(2009)
EMBO Mol. Med.
, vol.1
, pp. 315-322
-
-
Mendes-Pereira, A.M.1
-
48
-
-
77954358148
-
PTEN loss compromises homologous recombination repair in astrocytes: Implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors
-
McEllin, B. et al. PTEN loss compromises homologous recombination repair in astrocytes: implications for glioblastoma therapy with temozolomide or poly(ADP-ribose) polymerase inhibitors. Cancer Res. 70, 5457-5464 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 5457-5464
-
-
McEllin, B.1
-
49
-
-
33845999615
-
Essential role for nuclear PTEN in maintaining chromosomal integrity
-
DOI 10.1016/j.cell.2006.11.042, PII S0092867406015534
-
Shen, W.H. et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 128, 157-170 (2007). (Pubitemid 46048887)
-
(2007)
Cell
, vol.128
, Issue.1
, pp. 157-170
-
-
Shen, W.H.1
Balajee, A.S.2
Wang, J.3
Wu, H.4
Eng, C.5
Pandolfi, P.P.6
Yin, Y.7
-
50
-
-
77951115122
-
International network of cancer genome projects
-
The International Cancer Genome Consortium
-
The International Cancer Genome Consortium. International network of cancer genome projects. Nature 464, 993-998 (2010).
-
(2010)
Nature
, vol.464
, pp. 993-998
-
-
-
51
-
-
54049118823
-
Oncogenic mutations of ALK kinase in neuroblastoma
-
Chen, Y. et al. Oncogenic mutations of ALK kinase in neuroblastoma. Nature 455, 971-974 (2008).
-
(2008)
Nature
, vol.455
, pp. 971-974
-
-
Chen, Y.1
-
52
-
-
54049149961
-
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
-
Janoueix-Lerosey, I. et al. Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma. Nature 455, 967-970 (2008).
-
(2008)
Nature
, vol.455
, pp. 967-970
-
-
Janoueix-Lerosey, I.1
-
53
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
DOI 10.1038/nature05945, PII NATURE05945
-
Soda, M. et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 448, 561-566 (2007). (Pubitemid 47206930)
-
(2007)
Nature
, vol.448
, Issue.7153
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
Takada, S.4
Yamashita, Y.5
Ishikawa, S.6
Fujiwara, S.-I.7
Watanabe, H.8
Kurashina, K.9
Hatanaka, H.10
Bando, M.11
Ohno, S.12
Ishikawa, Y.13
Aburatani, H.14
Niki, T.15
Sohara, Y.16
Sugiyama, Y.17
Mano, H.18
-
54
-
-
27344451557
-
Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer
-
DOI 10.1126/science.1117679
-
Tomlins, S.A. et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 310, 644-648 (2005). (Pubitemid 41528150)
-
(2005)
Science
, vol.310
, Issue.5748
, pp. 644-648
-
-
Tomlins, S.A.1
Rhodes, D.R.2
Perner, S.3
Dhanasekaran, S.M.4
Mehra, R.5
Sun, X.-W.6
Varambally, S.7
Cao, X.8
Tchinda, J.9
Kuefer, R.10
Lee, C.11
Montie, J.E.12
Shah, R.B.13
Pienta, K.J.14
Rubin, M.A.15
Chinnaiyan, A.M.16
-
55
-
-
41649109807
-
Translating insights from the cancer genome into clinical practice
-
DOI 10.1038/nature06914, PII NATURE06914
-
Chin, L. & Gray, J.W. Translating insights from the cancer genome into clinical practice. Nature 452, 553-563 (2008). (Pubitemid 351483369)
-
(2008)
Nature
, vol.452
, Issue.7187
, pp. 553-563
-
-
Chin, L.1
Gray, J.W.2
-
56
-
-
73649123907
-
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
-
Verhaak, R.G.W. et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17, 98-110 (2010).
-
(2010)
Cancer Cell
, vol.17
, pp. 98-110
-
-
Verhaak, R.G.W.1
-
57
-
-
0033614962
-
Essential role for oncogenic ras in tumour maintenance
-
DOI 10.1038/22788
-
Chin, L. et al. Essential role for oncogenic Ras in tumour maintenance. Nature 400, 468-472 (1999). (Pubitemid 29361802)
-
(1999)
Nature
, vol.400
, Issue.6743
, pp. 468-472
-
-
Chin, L.1
Tam, A.2
Pomerantz, J.3
Wong, M.4
Holash, J.5
Bardeesy, N.6
Shen, Q.7
O'Hagan, R.8
Pantginis, J.9
Zhou, H.10
Horner II, J.W.11
Cordon-Cardo, C.12
Yancopoulos, G.D.13
DePinho, R.A.14
-
58
-
-
74549180398
-
The brothers RAF
-
Kwong, L.N. & Chin, L. The brothers RAF. Cell 140, 180-182 (2010).
-
(2010)
Cell
, vol.140
, pp. 180-182
-
-
Kwong, L.N.1
Chin, L.2
-
59
-
-
70349336416
-
Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK
-
Shaw, A.T. et al. Clinical features and outcome of patients with non-small-cell lung cancer who harbor EML4-ALK. J. Clin. Oncol. 27, 4247-4253 (2009).
-
(2009)
J. Clin. Oncol.
, vol.27
, pp. 4247-4253
-
-
Shaw, A.T.1
-
60
-
-
48249114422
-
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
-
Koivunen, J.P. et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin. Cancer Res. 14, 4275-4283 (2008).
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 4275-4283
-
-
Koivunen, J.P.1
-
61
-
-
58149382583
-
A mouse model for EML4-ALK-positive lung cancer
-
Soda, M. et al. A mouse model for EML4-ALK-positive lung cancer. Proc. Natl. Acad. Sci. USA 105, 19893-19897 (2008).
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 19893-19897
-
-
Soda, M.1
-
62
-
-
44849126091
-
Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors
-
McDermott, U. et al. Genomic alterations of anaplastic lymphoma kinase may sensitize tumors to anaplastic lymphoma kinase inhibitors. Cancer Res. 68, 3389-3395 (2008).
-
(2008)
Cancer Res.
, vol.68
, pp. 3389-3395
-
-
McDermott, U.1
-
63
-
-
78049425319
-
Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer
-
Kwak, E.L. et al. Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer. N. Engl. J. Med. 363, 1693-1703 (2010).
-
(2010)
N. Engl. J. Med.
, vol.363
, pp. 1693-1703
-
-
Kwak, E.L.1
-
64
-
-
77955368298
-
The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease
-
Dierks, C. et al. The ITK-SYK fusion oncogene induces a T-cell lymphoproliferative disease in mice mimicking human disease. Cancer Res. 70, 6193-6204 (2010).
-
(2010)
Cancer Res.
, vol.70
, pp. 6193-6204
-
-
Dierks, C.1
-
65
-
-
77952295698
-
The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma
-
Pechloff, K. et al. The fusion kinase ITK-SYK mimics a T cell receptor signal and drives oncogenesis in conditional mouse models of peripheral T cell lymphoma. J. Exp. Med. 207, 1031-1044 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1031-1044
-
-
Pechloff, K.1
-
66
-
-
77954315861
-
Spleen tyrosine kinases: Biology, therapeutic targets and drugs
-
Riccaboni, M., Bianchi, I. & Petrillo, P. Spleen tyrosine kinases: biology, therapeutic targets and drugs. Drug Discov. Today 15, 517-530 (2010).
-
(2010)
Drug Discov. Today
, vol.15
, pp. 517-530
-
-
Riccaboni, M.1
Bianchi, I.2
Petrillo, P.3
-
67
-
-
77951690557
-
Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic
-
Uckun, F.M., Ek, R.O., Jan, S.T., Chen, C.L. & Qazi, S. Targeting SYK kinase-dependent anti-apoptotic resistance pathway in B-lineage acute lymphoblastic leukaemia (ALL) cells with a potent SYK inhibitory pentapeptide mimic. Br. J. Haematol. 149, 508-517 (2010).
-
(2010)
Br. J. Haematol.
, vol.149
, pp. 508-517
-
-
Uckun, F.M.1
Ek, R.O.2
Jan, S.T.3
Chen, C.L.4
Qazi, S.5
-
68
-
-
77951729433
-
FDA approval summary: Temsirolimus as treatment for advanced renal cell carcinoma
-
Kwitkowski, V.E. et al. FDA approval summary: temsirolimus as treatment for advanced renal cell carcinoma. Oncologist 15, 428-435 (2010).
-
(2010)
Oncologist
, vol.15
, pp. 428-435
-
-
Kwitkowski, V.E.1
|