-
2
-
-
0034320568
-
Mechanisms of apoptosis
-
Reed JC. Mechanisms of apoptosis. Am J Pathol 2000; 157: 1415-30.
-
(2000)
Am J Pathol
, vol.157
, pp. 1415-1430
-
-
Reed, J.C.1
-
3
-
-
0026670335
-
Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: An overview
-
Wyllie AH. Apoptosis and the regulation of cell numbers in normal and neoplastic tissues: an overview. Cancer Metastasis Rev 1992; 11: 95-103.
-
(1992)
Cancer Metastasis Rev
, vol.11
, pp. 95-103
-
-
Wyllie, A.H.1
-
4
-
-
0035409448
-
Programmed cell death and apoptosis: Origins of the theory
-
Lockshin RA, Zakeri Z. Programmed cell death and apoptosis: origins of the theory. Nat Rev Mol Cell Biol 2001; 2: 545-50.
-
(2001)
Nat Rev Mol Cell Biol
, vol.2
, pp. 545-550
-
-
Lockshin, R.A.1
Zakeri, Z.2
-
5
-
-
33847146814
-
Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus
-
Maiese K, Morhan SD, Chong ZZ. Oxidative stress biology and cell injury during type 1 and type 2 diabetes mellitus. Curr Neurovasc Res 2007; 4: 63-71.
-
(2007)
Curr Neurovasc Res
, vol.4
, pp. 63-71
-
-
Maiese, K.1
Morhan, S.D.2
Chong, Z.Z.3
-
6
-
-
0038324375
-
Caspase-mediated cell death in hematological malignancies: Theoretical considerations, methods of assessment, and clinical implications
-
Smolewski P, Darzynkiewicz Z, Robak T. Caspase-mediated cell death in hematological malignancies: theoretical considerations, methods of assessment, and clinical implications. Leuk Lymphoma 2003; 44: 1089-104.
-
(2003)
Leuk Lymphoma
, vol.44
, pp. 1089-1104
-
-
Smolewski, P.1
Darzynkiewicz, Z.2
Robak, T.3
-
7
-
-
33646140580
-
The role of p73 in hematological malignancies
-
Pluta A, Nyman U, Joseph B, et al. The role of p73 in hematological malignancies. Leukemia 2006; 20: 757-66.
-
(2006)
Leukemia
, vol.20
, pp. 757-766
-
-
Pluta, A.1
Nyman, U.2
Joseph, B.3
-
9
-
-
2942536156
-
Functional evaluation of the role of inhibitor of apoptosis proteins in chronic lymphocytic leukemia
-
Schliep S, Decker T, Schneller F, Wagner H, Hacker G. Functional evaluation of the role of inhibitor of apoptosis proteins in chronic lymphocytic leukemia. Exp Hematol 2004; 32: 556-62
-
(2004)
Exp Hematol
, vol.32
, pp. 556-562
-
-
Schliep, S.1
Decker, T.2
Schneller, F.3
Wagner, H.4
Hacker, G.5
-
10
-
-
40449090791
-
Livin' on the edge: Imaging dendritic spine turnover in the peri-infarct zone during ischemic stroke and recovery
-
Brown CE, Murphy TH. Livin' on the edge: imaging dendritic spine turnover in the peri-infarct zone during ischemic stroke and recovery. Neuroscientist 2008; 14(2):139-46.
-
(2008)
Neuroscientist
, vol.14
, Issue.2
, pp. 139-146
-
-
Brown, C.E.1
Murphy, T.H.2
-
11
-
-
21644463065
-
The inhibitor of apoptosis protein family and its antagonists in acute leukemias
-
Wrzesień-Kuś A, Smolewski P, Sobczak-Pluta A, et al. The inhibitor of apoptosis protein family and its antagonists in acute leukemias. Apoptosis 2004; 9: 705-15.
-
(2004)
Apoptosis
, vol.9
, pp. 705-715
-
-
Wrzesień-Kuś, A.1
Smolewski, P.2
Sobczak-Pluta, A.3
-
12
-
-
1842455117
-
Differential expression of surviving in bone marrow cells from patients with acute lymphocytic leukemia and chronic lymphocytic leukemia
-
Nakagawa Y, Yamaguchi S, Hasegawa M, et al. Differential expression of surviving in bone marrow cells from patients with acute lymphocytic leukemia and chronic lymphocytic leukemia. Leuk Res 2004; 28: 487-4.
-
(2004)
Leuk Res
, vol.28
, pp. 487-494
-
-
Nakagawa, Y.1
Yamaguchi, S.2
Hasegawa, M.3
-
13
-
-
0035353212
-
Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia
-
Granziero L, Ghia P, Circosta P, et al. Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia. Blood 2001; 97: 2777-83.
-
(2001)
Blood
, vol.97
, pp. 2777-2783
-
-
Granziero, L.1
Ghia, P.2
Circosta, P.3
-
14
-
-
27244436272
-
Expression of C-IAP1, C-IAP2 and SURVIVIN discriminates different types of lymphoid malignancies
-
de Graaf AO, van Krieken JH, Tonnissen E, et al. Expression of C-IAP1, C-IAP2 and SURVIVIN discriminates different types of lymphoid malignancies. Br J Haematol 2005; 130: 852-9.
-
(2005)
Br J Haematol
, vol.130
, pp. 852-859
-
-
de Graaf, A.O.1
van Krieken, J.H.2
Tonnissen, E.3
-
15
-
-
33750037957
-
Expression of inhibitor of apoptosis proteins in B-cell non-Hodgkin and Hodgkin lymphomas
-
Akyurek N, Ren Y, Rassidakis GZ, et al. Expression of inhibitor of apoptosis proteins in B-cell non-Hodgkin and Hodgkin lymphomas. Cancer 2006; 107: 1844-51.
-
(2006)
Cancer
, vol.107
, pp. 1844-1851
-
-
Akyurek, N.1
Ren, Y.2
Rassidakis, G.Z.3
-
16
-
-
0037427441
-
Mammalian mitochondrial IAP binding proteins
-
Vaux DL, Silke J. Mammalian mitochondrial IAP binding proteins. Biochem Biophys Res Commun 2003; 304: 499-504.
-
(2003)
Biochem Biophys Res Commun
, vol.304
, pp. 499-504
-
-
Vaux, D.L.1
Silke, J.2
-
17
-
-
0030698127
-
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specifi c caspases
-
Roy N, Deveraux QL, Takahashi R, et al. The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specifi c caspases. EMBO J 1997; 16: 6914-25.
-
(1997)
EMBO J
, vol.16
, pp. 6914-6925
-
-
Roy, N.1
Deveraux, Q.L.2
Takahashi, R.3
-
18
-
-
11844293427
-
P53 and prognosis: New insights and further complexity
-
Vousden KH, Prives C: P53 and prognosis: new insights and further complexity. Cell 2005; 120: 7-10.
-
(2005)
Cell
, vol.120
, pp. 7-10
-
-
Vousden, K.H.1
Prives, C.2
-
19
-
-
0034607655
-
Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
-
Yang Y, Fang S, Jensen JP, et al. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 2000; 288: 874-7.
-
(2000)
Science
, vol.288
, pp. 874-877
-
-
Yang, Y.1
Fang, S.2
Jensen, J.P.3
-
20
-
-
34547126428
-
The inhibitors of apoptosis (IAPs) as cancer targets
-
Hunter AM, LaCasse EC, Korneluk RG. The inhibitors of apoptosis (IAPs) as cancer targets. Apoptosis 2007; 12: 1543-68.
-
(2007)
Apoptosis
, vol.12
, pp. 1543-1568
-
-
Hunter, A.M.1
Lacasse, E.C.2
Korneluk, R.G.3
-
21
-
-
0034616945
-
Smac, a mitochondrial protein that promotes cytochrom c-dependent caspase activation by eliminating IAP inhibition
-
Du C, Fang M, Li Y, et al. Smac, a mitochondrial protein that promotes cytochrom c-dependent caspase activation by eliminating IAP inhibition. Cell 2000; 102: 33-42.
-
(2000)
Cell
, vol.102
, pp. 33-42
-
-
Du, C.1
Fang, M.2
Li, Y.3
-
22
-
-
0034921727
-
Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs
-
Verhagen AM, Coulson EJ, Vaux DL. Inhibitor of apoptosis proteins and their relatives: IAPs and other BIRPs. Genome Biol 2001; 2: 30091-10.
-
(2001)
Genome Biol
, vol.2
, pp. 30091-30110
-
-
Verhagen, A.M.1
Coulson, E.J.2
Vaux, D.L.3
-
23
-
-
0034721940
-
NMR structure and mutagenesis of the third BIR domain of the inhibitor of apoptosis protein
-
Sun C, Cai M, Meadows RP, et al. NMR structure and mutagenesis of the third BIR domain of the inhibitor of apoptosis protein. XIAP J Biol Chem 2000; 275: 33777-81.
-
(2000)
XIAP J Biol Chem
, vol.275
, pp. 33777-33781
-
-
Sun, C.1
Cai, M.2
Meadows, R.P.3
-
24
-
-
0036088471
-
IAP proteins: Blocking the road to death's door
-
Salvesen GS, Duckett CS. IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol 2002; 3: 401-10.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 401-410
-
-
Salvesen, G.S.1
Duckett, C.S.2
-
25
-
-
17144377113
-
IAPs,RINGs and ubiquitylation
-
Vaux DL, Silke J. IAPs, RINGs and ubiquitylation. Nat Rev Mol Cell Biol 2005; 6(4): 287-97.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, Issue.4
, pp. 287-297
-
-
Vaux, D.L.1
Silke, J.2
-
26
-
-
34249799878
-
XIAP induced NF-kappaB activation via BIR1/TAB1 interaction and BIR1 dimerization
-
Lu M, Lin SC, Huang Y, et al. XIAP induced NF-kappaB activation via BIR1/TAB1 interaction and BIR1 dimerization. Mol Cell 2007; 26: 689-702.
-
(2007)
Mol Cell
, vol.26
, pp. 689-702
-
-
Lu, M.1
Lin, S.C.2
Huang, Y.3
-
27
-
-
0035902601
-
Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
-
Suzuki Y, Nakabayashi Y, Takahashi R. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc Natl Acad Sci USA 2001; 98: 8662-7.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 8662-8667
-
-
Suzuki, Y.1
Nakabayashi, Y.2
Takahashi, R.3
-
28
-
-
0032508414
-
NF-kB antiapoptosis: Induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
-
Wang CY, Mayo MW, Korneluk RG, et al. NF-kB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 1998; 281: 1680-3.
-
(1998)
Science
, vol.281
, pp. 1680-1683
-
-
Wang, C.Y.1
Mayo, M.W.2
Korneluk, R.G.3
-
29
-
-
0030885421
-
Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control
-
Chu ZL, McKinsey TA, Liu L, et al. Suppression of tumor necrosis factor-induced cell death by inhibitor of apoptosis c-IAP2 is under NF-kappaB control. Proc Natl Acad Sci USA 1997; 94: 10057-62.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 10057-10062
-
-
Chu, Z.L.1
McKinsey, T.A.2
Liu, L.3
-
30
-
-
0035793557
-
Livin, a novel inhibitor of apoptosis protein family member
-
Kasof GM, Gomes BC. Livin, a novel inhibitor of apoptosis protein family member. J Biol Chem 2001; 276: 3238-46.
-
(2001)
J Biol Chem
, vol.276
, pp. 3238-3246
-
-
Kasof, G.M.1
Gomes, B.C.2
-
31
-
-
0034700491
-
Structural basis of IAP recognition by Smac/DIABLO
-
Wu G, Chai J, Suber TL, et al. Structural basis of IAP recognition by Smac/DIABLO. Nature 2000; 408: 1008-12.
-
(2000)
Nature
, vol.408
, pp. 1008-1012
-
-
Wu, G.1
Chai, J.2
Suber, T.L.3
-
32
-
-
2342471409
-
Toxic proteins released from mitochondria in cell death
-
Saelens X, Festjens N, Vande Walle L, et al. Toxic proteins released from mitochondria in cell death. Oncogene 2004; 23: 2861-74.
-
(2004)
Oncogene
, vol.23
, pp. 2861-2874
-
-
Saelens, X.1
Festjens, N.2
Vande, W.L.3
-
33
-
-
39449115415
-
The mitochondrial serine protease HtrA2/Omi: An overview
-
Vande Walle L, Lamkanfi M, Vandenabeele P. The mitochondrial serine protease HtrA2/Omi: an overview. Cell Death Differ 2008; 15: 453-60.
-
(2008)
Cell Death Differ
, vol.15
, pp. 453-460
-
-
Vande, W.L.1
Lamkanfi, M.2
Vandenabeele, P.3
-
34
-
-
2342445559
-
Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells
-
Yang QH, Du C. Smac/DIABLO selectively reduces the levels of c-IAP1 and c-IAP2 but not that of XIAP and livin in HeLa cells. J Biol Chem 2004; 279: 16963-70.
-
(2004)
J Biol Chem
, vol.279
, pp. 16963-16970
-
-
Yang, Q.H.1
Du, C.2
-
36
-
-
18244386261
-
The serine protease Omi/HtrA2 is released from mitochondria during apoptosis Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity
-
van Loo G, van Gurp M, Depuydt B, et al. The serine protease Omi/HtrA2 is released from mitochondria during apoptosis Omi interacts with caspase-inhibitor XIAP and induces enhanced caspase activity. Cell Death Differ 2002; 9: 20-6.
-
(2002)
Cell Death Differ
, vol.9
, pp. 20-26
-
-
van Loo, G.1
van Gurp, M.2
Depuydt, B.3
-
37
-
-
0034616942
-
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins
-
Verhagen AM, Ekert PG, Pakusch M, et al. Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins. Cell 2000; 102: 43-53.
-
(2000)
Cell
, vol.102
, pp. 43-53
-
-
Verhagen, A.M.1
Ekert, P.G.2
Pakusch, M.3
-
38
-
-
34548817572
-
Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex
-
Arora V, Cheung HH, Plenchette S, et al. Degradation of survivin by the X-linked inhibitor of apoptosis (XIAP)-XAF1 complex. Biol Chem 2007; 282: 26202-9.
-
(2007)
Biol Chem
, vol.282
, pp. 26202-26209
-
-
Arora, V.1
Cheung, H.H.2
Plenchette, S.3
-
39
-
-
33344464822
-
Apoptotic effect of fl udarabine is independent of expression of IAPs in B-cell chronic lymphocytic leukemia
-
Silva KL, Vasconcellos DV, Castro ED, et al. Apoptotic effect of fl udarabine is independent of expression of IAPs in B-cell chronic lymphocytic leukemia. Apoptosis 2006; 11: 277-85.
-
(2006)
Apoptosis
, vol.11
, pp. 277-285
-
-
Silva, K.L.1
Vasconcellos, D.V.2
Castro, E.D.3
-
40
-
-
0038481230
-
The resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA microarrays
-
Vallat L, Magdelenat H, Merle-Beral H, et al. The resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA microarrays. Blood 2003; 101: 4598-606.
-
(2003)
Blood
, vol.101
, pp. 4598-4606
-
-
Vallat, L.1
Magdelenat, H.2
Merle-Beral, H.3
-
41
-
-
0037111664
-
Tumor necrosis factor receptor-associated factor 1 gene overexpression in Bcell chronic lymphocytic leukemia: Analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis
-
Munzert G, Kirchner D, Stobbe H, et al. Tumor necrosis factor receptor-associated factor 1 gene overexpression in Bcell chronic lymphocytic leukemia: analysis of NF-kappa B/Rel-regulated inhibitors of apoptosis. Blood 2002; 100: 3749-56.
-
(2002)
Blood
, vol.100
, pp. 3749-3756
-
-
Munzert, G.1
Kirchner, D.2
Stobbe, H.3
-
42
-
-
0038203261
-
The distinct gene expression profiles of chronic lymphocytic leukemia and multiple myeloma suggest different anti-apoptotic mechanisms but predict only some differences in phenotype
-
Zent CS, Zhan F, Schichman SA, et al. The distinct gene expression profiles of chronic lymphocytic leukemia and multiple myeloma suggest different anti-apoptotic mechanisms but predict only some differences in phenotype. Leuk Res. 2003; 27: 765-74.
-
(2003)
Leuk Res
, vol.27
, pp. 765-774
-
-
Zent, C.S.1
Zhan, F.2
Schichman, S.A.3
-
43
-
-
76049117295
-
Expression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemia
-
Grzybowska-Izydorczyk O, Cebula B, Robak T, Smolewski P. Expression and prognostic significance of the inhibitor of apoptosis protein (IAP) family and its antagonists in chronic lymphocytic leukaemia. Eur J Cancer 2010; 46: 800-10.
-
(2010)
Eur J Cancer
, vol.46
, pp. 800-810
-
-
Grzybowska-Izydorczyk, O.1
Cebula, B.2
Robak, T.3
Smolewski, P.4
-
44
-
-
0037211252
-
Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro
-
Bilim V, Kasahara T, Hara N, et al. Role of XIAP in the malignant phenotype of transitional cell cancer (TCC) and therapeutic activity of XIAP antisense oligonucleotides against multidrug-resistant TCC in vitro. Int J Cancer 2003; 103: 29-37.
-
(2003)
Int J Cancer
, vol.103
, pp. 29-37
-
-
Bilim, V.1
Kasahara, T.2
Hara, N.3
-
45
-
-
0037478904
-
Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo
-
Hu Y, Cherton-Horvat G, Dragowska V. Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo. Clin Cancer Res 2003; 9: 2826-36.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2826-2836
-
-
Hu, Y.1
Cherton-Horvat, G.2
Dragowska, V.3
-
46
-
-
3042660431
-
The inhibitor of apoptosis protein family (IAPs): An emerging therapeutic target in cancer
-
Nachmias B, Ashhab Y, Ben-Yehuda D. The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer. Semin Cancer Biol 2004; 14: 231-3.
-
(2004)
Semin Cancer Biol
, vol.14
, pp. 231-233
-
-
Nachmias, B.1
Ashhab, Y.2
Ben-Yehuda, D.3
-
47
-
-
0033572308
-
Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18
-
Morgan JA, Yin Y, Borowsky AD, et al. Breakpoints of the t(11;18)(q21;q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. Cancer Res 1999; 59: 6205-13.
-
(1999)
Cancer Res
, vol.59
, pp. 6205-6213
-
-
Morgan, J.A.1
Yin, Y.2
Borowsky, A.D.3
-
48
-
-
33749389926
-
The inhibitor of apoptosis protein fusion c-IAP2MALT1 stimulates NFkappaB activation independently of TRAF1 AND TRAF2
-
Varfolomeev E, Wayson SM, Dixit VM, et al. The inhibitor of apoptosis protein fusion c-IAP2MALT1 stimulates NFkappaB activation independently of TRAF1 AND TRAF2. J Biol Chem 2006; 281: 29022-9.
-
(2006)
J Biol Chem
, vol.281
, pp. 29022-29029
-
-
Varfolomeev, E.1
Wayson, S.M.2
Dixit, V.M.3
-
49
-
-
0033151510
-
The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas
-
Dierlamm J, Baens M, Wlodarska I, et al. The apoptosis inhibitor gene API2 and a novel 18q gene, MLT, are recurrently rearranged in the t(11;18)(q21;q21) associated with mucosa-associated lymphoid tissue lymphomas. Blood 1999; 93: 3601-9.
-
(1999)
Blood
, vol.93
, pp. 3601-3609
-
-
Dierlamm, J.1
Baens, M.2
Wlodarska, I.3
-
50
-
-
0033554647
-
A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade Bcell lymphoma of mucosaassociated lymphoid tissue
-
Akagi T, Motegi M, Tamura A, et al. A novel gene, MALT1 at 18q21, is involved in t(11;18) (q21;q21) found in low-grade Bcell lymphoma of mucosaassociated lymphoid tissue. Oncogene 1999; 18: 5785-94.
-
(1999)
Oncogene
, vol.18
, pp. 5785-5794
-
-
Akagi, T.1
Motegi, M.2
Tamura, A.3
-
51
-
-
78149468447
-
Overexpression of survivin initiates hematologic malignancies in vivo
-
Small S, Keerthivasan G, Huang Z, et al. Overexpression of survivin initiates hematologic malignancies in vivo. Leukemia 2010; 24: 1920-6.
-
(2010)
Leukemia
, vol.24
, pp. 1920-1926
-
-
Small, S.1
Keerthivasan, G.2
Huang, Z.3
-
52
-
-
84873092680
-
Prognostic significance of surviving expression in diffuse large B-cell lymphoma
-
Adida C, Haiooun C, Gaulard O, et al. Prognostic significance of surviving expression in diffuse large B-cell lymphoma. Blood 2000; 96: 1021-25
-
(2000)
Blood
, vol.96
, pp. 1021-1025
-
-
Adida, C.1
Haiooun, C.2
Gaulard, O.3
-
53
-
-
70249113006
-
Prognostic [corrected] significance of angiogenic/lymphangiogenic, antiapoptotic, inflammatory and viral factors in 88 cases with diffuse large B cell lymphoma and review of the literature
-
Paydas S, Ergin M, Seydaoglu G, et al. Prognostic [corrected] significance of angiogenic/lymphangiogenic, antiapoptotic, inflammatory and viral factors in 88 cases with diffuse large B cell lymphoma and review of the literature. Leuk Res 2009; 33: 1627-35.
-
(2009)
Leuk Res
, vol.33
, pp. 1627-1635
-
-
Paydas, S.1
Ergin, M.2
Seydaoglu, G.3
-
54
-
-
2442675594
-
Survivin expression predicts poorer prognosis in anaplastic large-cell lymphoma
-
Schlette EJ, Medeiros LJ, Goy A, et al. Survivin expression predicts poorer prognosis in anaplastic large-cell lymphoma. J Clin Oncol 2004; 22: 1682-8.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1682-1688
-
-
Schlette, E.J.1
Medeiros, L.J.2
Goy, A.3
-
55
-
-
80051669358
-
Prognostic Significance of Survivin and Caspase-3 Immunohistochemical Expression in Patients with Diffuse Large B-cell Lymphoma Treated with Rituximab and CHOP
-
Sep 18 [Epub ahead of print]
-
Mitrović Z, Ilić I, Aurer I, et al. Prognostic Significance of Survivin and Caspase-3 Immunohistochemical Expression in Patients with Diffuse Large B-cell Lymphoma Treated with Rituximab and CHOP. Pathol Oncol Res 2010 Sep 18 [Epub ahead of print].
-
(2010)
Pathol Oncol Res
-
-
Mitrović, Z.1
Ilić, I.2
Aurer, I.3
-
56
-
-
77957961226
-
Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling
-
Hussain AR, Uddin S, Ahmed M, et al. Prognostic significance of XIAP expression in DLBCL and effect of its inhibition on AKT signalling. J Pathol 2010; 222: 180-90.
-
(2010)
J Pathol
, vol.222
, pp. 180-190
-
-
Hussain, A.R.1
Uddin, S.2
Ahmed, M.3
-
57
-
-
36049033181
-
Expression of PLK1 and survivin in diffuse large B-cell lymphoma
-
Liu L, Zhang M, Zou P. Expression of PLK1 and survivin in diffuse large B-cell lymphoma. Leuk Lymphoma 2007; 48: 2179-83.
-
(2007)
Leuk Lymphoma
, vol.48
, pp. 2179-2183
-
-
Liu, L.1
Zhang, M.2
Zou, P.3
-
58
-
-
84873092633
-
Clinical and prognostic significance of apoptotic profile in patients with newly diagnosed nodal diffuse large b cell lymphoma (DLBCL)
-
Dec 30 [Epub ahead of print]
-
Markovic O, Marisavljevic D, Cemerikic V, et al. Clinical and prognostic significance of apoptotic profile in patients with newly diagnosed nodal diffuse large b cell lymphoma (DLBCL). Eur J Haematol 2010 Dec 30 [Epub ahead of print].
-
(2010)
Eur J Haematol
-
-
Markovic, O.1
Marisavljevic, D.2
Cemerikic, V.3
-
59
-
-
1542349932
-
Nuclear surviving expression in mantle cell lymphoma is associated with cell proliferation and survival
-
Martinez A, Bellosillo B, Bosch F, et al. Nuclear surviving expression in mantle cell lymphoma is associated with cell proliferation and survival. Am J Pathol 2004; 164: 501-10.
-
(2004)
Am J Pathol
, vol.164
, pp. 501-510
-
-
Martinez, A.1
Bellosillo, B.2
Bosch, F.3
-
60
-
-
78650000871
-
X-linked lymphoproliferative syndrome: A genetic condition typified by the triad of infection, immunodeficiency and lymphoma
-
Rezaei N, Mahmoudi E, Aghamohammadi A, et al. X-linked lymphoproliferative syndrome: a genetic condition typified by the triad of infection, immunodeficiency and lymphoma. Br J Haematol 2011; 152: 13-30.
-
(2011)
Br J Haematol
, vol.152
, pp. 13-30
-
-
Rezaei, N.1
Mahmoudi, E.2
Aghamohammadi, A.3
-
61
-
-
77958509989
-
Using flow cytometry to screen patients for X-linked lymphoproliferative disease due to SAP deficiency and XIAP deficiency
-
Marsh RA, Bleesing JJ, Filipovich AH. Using flow cytometry to screen patients for X-linked lymphoproliferative disease due to SAP deficiency and XIAP deficiency. J Immunol Methods 2010; 362: 1-9.
-
(2010)
J Immunol Methods
, vol.362
, pp. 1-9
-
-
Marsh, R.A.1
Bleesing, J.J.2
Filipovich, A.H.3
-
62
-
-
78650746034
-
Epstein-Barr Virus nuclear antigen 1 (EBNA1) confers resistance to apoptosis in EBV-positive B-lymphoma cells through up-regulation of survivin
-
Lu J, Murakami M, Verma SC, et al. Epstein-Barr Virus nuclear antigen 1 (EBNA1) confers resistance to apoptosis in EBV-positive B-lymphoma cells through up-regulation of survivin. Virology 2011; 410: 64-75.
-
(2011)
Virology
, vol.410
, pp. 64-75
-
-
Lu, J.1
Murakami, M.2
Verma, S.C.3
-
63
-
-
33750037357
-
Expression of Smac/DIABLO in B-cell non-Hodgkin and Hodgkin lymphomas
-
Ren Y, Akyurek N, Schlette E, et al. Expression of Smac/DIABLO in B-cell non-Hodgkin and Hodgkin lymphomas. Hum Pathol 2006; 37: 1407-13.
-
(2006)
Hum Pathol
, vol.37
, pp. 1407-1413
-
-
Ren, Y.1
Akyurek, N.2
Schlette, E.3
-
64
-
-
84655160756
-
Relationship of survivin to clinical drug resistance in Burkitt's lymphoma of the head and neck region
-
Jun 4 [Epub ahead of print]
-
Zyada MM. Relationship of survivin to clinical drug resistance in Burkitt's lymphoma of the head and neck region. Med Oncol 2010 Jun 4 [Epub ahead of print]
-
(2010)
Med Oncol
-
-
Zyada, M.M.1
-
65
-
-
0037438584
-
Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: Analyses using tissue microarrays
-
Garcia JF, Camacho FI, Morente M, et al. Hodgkin and Reed-Sternberg cells harbor alterations in the major tumor suppressor pathways and cell-cycle checkpoints: analyses using tissue microarrays. Blood 2003; 101: 681-9.
-
(2003)
Blood
, vol.101
, pp. 681-689
-
-
Garcia, J.F.1
Camacho, F.I.2
Morente, M.3
-
66
-
-
0032055536
-
Gene expression by single Reed-Sternberg cells: Pathways of apoptosis and activation
-
Messineo C, Jamerson MH, Hunter E, et al. Gene expression by single Reed-Sternberg cells: pathways of apoptosis and activation. Blood 1998; 91: 2443-51.
-
(1998)
Blood
, vol.91
, pp. 2443-2451
-
-
Messineo, C.1
Jamerson, M.H.2
Hunter, E.3
-
68
-
-
17144438370
-
Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias
-
Tamm I, Kornblau SM, Segall H, et al. Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res, 2000; 6:1796-803.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1796-1803
-
-
Tamm, I.1
Kornblau, S.M.2
Segall, H.3
-
69
-
-
2542549018
-
High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia
-
Tamm I, Richter S, Oltersdorf D, et al. High expression levels of x-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia. Clin Cancer Res 2004; 10: 3737-44.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3737-3744
-
-
Tamm, I.1
Richter, S.2
Oltersdorf, D.3
-
70
-
-
0344394469
-
Caspase-independent cell death in AML: Caspase inhibition in vitro with pancaspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis
-
Carter BZ, Kornblau SM, Tsao T, et al. Caspase-independent cell death in AML: caspase inhibition in vitro with pancaspase inhibitors or in vivo by XIAP or Survivin does not affect cell survival or prognosis. Blood 2003; 102: 4179-86.
-
(2003)
Blood
, vol.102
, pp. 4179-4186
-
-
Carter, B.Z.1
Kornblau, S.M.2
Tsao, T.3
-
71
-
-
0035353163
-
Cytokineregulated expression of survivin in myeloid leukemia
-
Carter BZ, Milella M, Altieri DC, Andreeff M: Cytokineregulated expression of survivin in myeloid leukemia. Blood 2001; 97: 2784-90.
-
(2001)
Blood
, vol.97
, pp. 2784-2790
-
-
Carter, B.Z.1
Milella, M.2
Altieri, D.C.3
Andreeff, M.4
-
72
-
-
19944419093
-
XIAP expression correlates with monocytic differentiation in adult de novo AML: Impact on prognosis
-
Tamm I, Richter S, Scholz F, et al. XIAP expression correlates with monocytic differentiation in adult de novo AML: impact on prognosis. Hematol J 2004; 5: 489-95
-
(2004)
Hematol J
, vol.5
, pp. 489-495
-
-
Tamm, I.1
Richter, S.2
Scholz, F.3
-
73
-
-
77953574612
-
An antiapoptotic pattern correlates with multidrug resistance in acute myeloid leukemia patients: A comparative study of active caspase-3, cleaved PARPs, Bcl-2
-
Guenova ML, Balatzenko GN, Nikolova VR, et al. An antiapoptotic pattern correlates with multidrug resistance in acute myeloid leukemia patients: a comparative study of active caspase-3, cleaved PARPs, Bcl-2, Survivin and MDR1 gene Hematology 2010; 15: 135-43.
-
(2010)
Survivin and MDR1 Gene Hematology
, vol.15
, pp. 135-143
-
-
Guenova, M.L.1
Balatzenko, G.N.2
Nikolova, V.R.3
-
74
-
-
77955983871
-
Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients
-
Pluta A, Wrzesien-Kus A, Cebula-Obrzut B, et al. Influence of high expression of Smac/DIABLO protein on the clinical outcome in acute myeloid leukemia patients. Leuk Res 2010; 34: 1308-13.
-
(2010)
Leuk Res
, vol.34
, pp. 1308-1313
-
-
Pluta, A.1
Wrzesien-Kus, A.2
Cebula-Obrzut, B.3
-
75
-
-
53749095428
-
AML1/ETO-induced survivin expression inhibits transcriptional regulation of myeloid differentiation
-
Balkhi MY, Christopeit M, Chen Y, Geletu M, Behre G. AML1/ETO-induced survivin expression inhibits transcriptional regulation of myeloid differentiation. Exp Hematol 2008; 36: 1455-66.
-
(2008)
Exp Hematol
, vol.36
, pp. 1455-1466
-
-
Balkhi, M.Y.1
Christopeit, M.2
Chen, Y.3
Geletu, M.4
Behre, G.5
-
76
-
-
79952241213
-
Survivin selectively modulates genes deregulated in human leukemia stem cells
-
doi:10.1155/2011/946936. Epub 2010 Dec 23
-
Fukuda S, Abe M, Onishi C, et al. Survivin selectively modulates genes deregulated in human leukemia stem cells. J Oncol 2011; 2011: doi:10.1155/2011/946936. Epub 2010 Dec 23.
-
(2011)
J Oncol
, pp. 2011
-
-
Fukuda, S.1
Abe, M.2
Onishi, C.3
-
77
-
-
4544337632
-
Expression of IAP family proteins in myelodysplastic syndromes transforming to overt leukemia
-
Yamamoto K, Abe S, Nakagawa Y, et al. Expression of IAP family proteins in myelodysplastic syndromes transforming to overt leukemia. Leuk Res 2004; 28: 1203-11.
-
(2004)
Leuk Res
, vol.28
, pp. 1203-1211
-
-
Yamamoto, K.1
Abe, S.2
Nakagawa, Y.3
-
78
-
-
0346247204
-
Expression of the antiapoptotic gene survivin in myelodysplastic syndrome
-
Badran A, Yoshida A, Wano Y, et al. Expression of the antiapoptotic gene survivin in myelodysplastic syndrome. Int J Oncol 2003; 22: 59-64.
-
(2003)
Int J Oncol
, vol.22
, pp. 59-64
-
-
Badran, A.1
Yoshida, A.2
Wano, Y.3
-
79
-
-
22144460559
-
Bone marrow cells of myelodysplastic syndromes exhibit significant expression of apollon, livin and ILP-2 with reduction after transformation to overt leukemia
-
Abe S, Yamamoto K, Hasegawa M, et al. Bone marrow cells of myelodysplastic syndromes exhibit significant expression of apollon, livin and ILP-2 with reduction after transformation to overt leukemia. Leuk Res 2005; 29: 1095-6.
-
(2005)
Leuk Res
, vol.29
, pp. 1095-1096
-
-
Abe, S.1
Yamamoto, K.2
Hasegawa, M.3
-
80
-
-
34548820190
-
Overexpression of Apollon, an antiapoptotic protein, is associated with poor prognosis in childhood de novo acute myeloid leukemia
-
Sung KW, Choi J, Hwang YK, et al. Overexpression of Apollon, an antiapoptotic protein, is associated with poor prognosis in childhood de novo acute myeloid leukemia. Clin Cancer Res 2007; 13: 5109-14.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 5109-5114
-
-
Sung, K.W.1
Choi, J.2
Hwang, Y.K.3
-
81
-
-
35748933239
-
Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia
-
Troeger A, Siepermann M, Escherich G, et al. Survivin and its prognostic significance in pediatric acute B-cell precursor lymphoblastic leukemia. Haematologica 2007; 92: 1043-50.
-
(2007)
Haematologica
, vol.92
, pp. 1043-1050
-
-
Troeger, A.1
Siepermann, M.2
Escherich, G.3
-
82
-
-
33745085557
-
Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines
-
Che XF, Zheng CL, Owatari S, et al. Overexpression of survivin in primary ATL cells and sodium arsenite induces apoptosis by down-regulating survivin expression in ATL cell lines. Blood 2006; 107: 4880-7.
-
(2006)
Blood
, vol.107
, pp. 4880-4887
-
-
Che, X.F.1
Zheng, C.L.2
Owatari, S.3
-
83
-
-
77955123282
-
XIAP expression is post-transcriptionally upregulated in childhood ALL and is associated with glucocorticoid response in T-cell ALL
-
Hundsdoerfer P, Dietrich I, Schmelz K, et al. XIAP expression is post-transcriptionally upregulated in childhood ALL and is associated with glucocorticoid response in T-cell ALL. Pediatr Blood Cancer 2010; 55: 260-6.
-
(2010)
Pediatr Blood Cancer
, vol.55
, pp. 260-266
-
-
Hundsdoerfer, P.1
Dietrich, I.2
Schmelz, K.3
-
84
-
-
33846209478
-
Expression of livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia
-
Choi J, Hwang YK, Sung KW, et al. Expression of livin, an antiapoptotic protein, is an independent favorable prognostic factor in childhood acute lymphoblastic leukemia. Blood 2007; 109: 471-7.
-
(2007)
Blood
, vol.109
, pp. 471-477
-
-
Choi, J.1
Hwang, Y.K.2
Sung, K.W.3
-
85
-
-
73249114293
-
Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia
-
Yang YL, Lin SR, Chen JS, et al. Expression and prognostic significance of the apoptotic genes BCL2L13, Livin, and CASP8AP2 in childhood acute lymphoblastic leukemia. Leuk Res 2010; 34: 18-23.
-
(2010)
Leuk Res
, vol.34
, pp. 18-23
-
-
Yang, Y.L.1
Lin, S.R.2
Chen, J.S.3
-
86
-
-
0034611661
-
Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia
-
Arico M, Valsecchi MG, Camitta B, et al. Outcome of treatment in children with Philadelphia chromosome-positive acute lymphoblastic leukemia. N Engl J Med 2000; 342: 998-1006.
-
(2000)
N Engl J Med
, vol.342
, pp. 998-1006
-
-
Arico, M.1
Valsecchi, M.G.2
Camitta, B.3
-
87
-
-
0028349911
-
11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia
-
Pui CH, Behm FG, Downing JR, et al. 11q23/MLL rearrangement confers a poor prognosis in infants with acute lymphoblastic leukemia. J Clin Oncol 1994; 12: 909-15.
-
(1994)
J Clin Oncol
, vol.12
, pp. 909-915
-
-
Pui, C.H.1
Behm, F.G.2
Downing, J.R.3
-
88
-
-
0027172909
-
Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome
-
Chen CS, Sorensen PH, Domer PH, et al. Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome. Blood 1993; 81: 2386-93.
-
(1993)
Blood
, vol.81
, pp. 2386-2393
-
-
Chen, C.S.1
Sorensen, P.H.2
Domer, P.H.3
-
89
-
-
38049016503
-
Expression and significance of X-linked inhibitor of apoptosis protein and its antagonized proteins in acute leukemia
-
Chen G-H, Lin F-R, Ren J-H, et al. Expression and significance of X-linked inhibitor of apoptosis protein and its antagonized proteins in acute leukemia. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2006; 14: 639-43.
-
(2006)
Zhongguo Shi Yan Xue Ye Xue Za Zhi
, vol.14
, pp. 639-643
-
-
Chen, G.-H.1
Lin, F.-R.2
Ren, J.-H.3
-
90
-
-
36749047445
-
c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1
-
Xu L, Zhu J, Hu X, et al. c-IAP1 cooperates with Myc by acting as a ubiquitin ligase for Mad1. Mol Cell 2007; 28: 914-22.
-
(2007)
Mol Cell
, vol.28
, pp. 914-922
-
-
Xu, L.1
Zhu, J.2
Hu, X.3
-
91
-
-
33750589355
-
IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes
-
Nakagawa Y, Abe S, Kurata M, et al. IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes. Am J Hematol 2006; 81: 824-31.
-
(2006)
Am J Hematol
, vol.81
, pp. 824-831
-
-
Nakagawa, Y.1
Abe, S.2
Kurata, M.3
-
92
-
-
0141954004
-
Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: Implications for drugresistant melanoma
-
Nachmias B, Ashhab Y, Bucholtz V, et al. Caspase-mediated cleavage converts Livin from an antiapoptotic to a proapoptotic factor: implications for drugresistant melanoma. Cancer Res 2003; 63: 6340-9.
-
(2003)
Cancer Res
, vol.63
, pp. 6340-6349
-
-
Nachmias, B.1
Ashhab, Y.2
Bucholtz, V.3
-
94
-
-
77955980391
-
Survivin is upregulated in myeloma cell lines cocultured with mesenchymal stem cells
-
Wang X, Zhang Z, Yao C. Survivin is upregulated in myeloma cell lines cocultured with mesenchymal stem cells. Leuk Res 2010; 34: 1325-9.
-
(2010)
Leuk Res
, vol.34
, pp. 1325-1329
-
-
Wang, X.1
Zhang, Z.2
Yao, C.3
-
95
-
-
58149252352
-
Impact of XIAP protein levels on the survival of myeloma cells
-
Desplanques G, Giuliani N, Delsignore R, Rizzoli V, Bataille R, Barillé-Nion S Impact of XIAP protein levels on the survival of myeloma cells. Haematologica 2009; 94(1): 87-93
-
(2009)
Haematologica
, vol.94
, Issue.1
, pp. 87-93
-
-
Desplanques, G.1
Giuliani, N.2
Delsignore, R.3
Rizzoli, V.4
Bataille, R.5
Barillé-Nion, S.6
-
96
-
-
0037231171
-
Expression of the antiapoptotic gene surviving in chronic myeloid leukemia
-
Badran A, Yoshida A, Wano Y, et al. Expression of the antiapoptotic gene surviving in chronic myeloid leukemia. Anticancer Res 2003; 23: 589-92.
-
(2003)
Anticancer Res
, vol.23
, pp. 589-592
-
-
Badran, A.1
Yoshida, A.2
Wano, Y.3
-
97
-
-
0037307753
-
Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: Up-regulation of cIAP2 by granulocyte colonystimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia
-
Hasegawa T, Suzuki K, Sakamoto C, et al. Expression of the inhibitor of apoptosis (IAP) family members in human neutrophils: up-regulation of cIAP2 by granulocyte colonystimulating factor and overexpression of cIAP2 in chronic neutrophilic leukemia. Blood 2003; 101: 1164-71.
-
(2003)
Blood
, vol.101
, pp. 1164-1171
-
-
Hasegawa, T.1
Suzuki, K.2
Sakamoto, C.3
-
99
-
-
24944545947
-
Disruption of the inhibitor of apoptosis protein survivin sensitizes Bcr-ablpositive cells to STI571-induced apoptosis
-
Wang Z, Sampath J, Fukuda S, Pelus LM. Disruption of the inhibitor of apoptosis protein survivin sensitizes Bcr-ablpositive cells to STI571-induced apoptosis. Cancer Res 2005; 65: 8224-32.
-
(2005)
Cancer Res
, vol.65
, pp. 8224-8232
-
-
Wang, Z.1
Sampath, J.2
Fukuda, S.3
Pelus, L.M.4
-
100
-
-
33745183273
-
Application of XIAP antisense to cancer and other proliferative disorders: Development of AEG35156/GEM640
-
LaCasse EC, Kandimalla ER, Winocour P, et al. Application of XIAP antisense to cancer and other proliferative disorders: development of AEG35156/GEM640. Ann N Y Acad Sci 2005; 1058: 215-34.
-
(2005)
Ann N Y Acad Sci
, vol.1058
, pp. 215-234
-
-
Lacasse, E.C.1
Kandimalla, E.R.2
Winocour, P.3
-
101
-
-
10744228158
-
Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia
-
Carter BZ, Milella M, Tsao T, et al. Regulation and targeting of antiapoptotic XIAP in acute myeloid leukemia. Leukemia 2003; 17: 2081-9.
-
(2003)
Leukemia
, vol.17
, pp. 2081-2089
-
-
Carter, B.Z.1
Milella, M.2
Tsao, T.3
-
102
-
-
33645103808
-
Chemosensitization effects of XIAP downregulation in K562 leukemia cells
-
Lima RT, Martins LM, Guimaraes JE, et al. Chemosensitization effects of XIAP downregulation in K562 leukemia cells. J Chemother 2006; 18: 98-102.
-
(2006)
J Chemother
, vol.18
, pp. 98-102
-
-
Lima, R.T.1
Martins, L.M.2
Guimaraes, J.E.3
-
103
-
-
33748990325
-
Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting Xlinked inhibitor of apoptosis
-
LaCasse EC, Cherton-Horvat GG, Hewitt KE, et al. Preclinical characterization of AEG35156/GEM 640, a second-generation antisense oligonucleotide targeting Xlinked inhibitor of apoptosis. Clin Cancer Res 2006; 12: 5231-41.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 5231-5241
-
-
Lacasse, E.C.1
Cherton-Horvat, G.G.2
Hewitt, K.E.3
-
104
-
-
62449333195
-
AEG 35156, a XIAP antisense oligonucleotide, suppresses XIAP levels in targeted tissues isolatedd from pre-clinical models and from patients
-
DC
-
LaCasse E, Morris S, Ward T, et al. AEG 35156, a XIAP antisense oligonucleotide, suppresses XIAP levels in targeted tissues isolatedd from pre-clinical models and from patients. 97th American Association Cancer Research Annual Meeting Washington, DC 2006.
-
(2006)
97th American Association Cancer Research Annual Meeting Washington
-
-
Lacasse, E.1
Morris, S.2
Ward, T.3
-
105
-
-
55949092012
-
Cell-penetrating peptide-conjugated XIAP-inhibitory cyclic hexapeptides enter into Jurkat cells and inhibit cell proliferation
-
Sasaki Y, Minamizawa M, Ambo A, et al. Cell-penetrating peptide-conjugated XIAP-inhibitory cyclic hexapeptides enter into Jurkat cells and inhibit cell proliferation. FEBS J 2008; 275: 6011-21.
-
(2008)
FEBS J
, vol.275
, pp. 6011-6021
-
-
Sasaki, Y.1
Minamizawa, M.2
Ambo, A.3
-
107
-
-
84873079863
-
XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34(+)38 (-) cells in a phase 1/2 study of patients with relapsed/refractory AML
-
Oct 12 [Epub ahead of print]
-
Carter BZ, Mak DH, Morris SJ, et al. XIAP antisense oligonucleotide (AEG35156) achieves target knockdown and induces apoptosis preferentially in CD34(+)38 (-) cells in a phase 1/2 study of patients with relapsed/refractory AML. Apoptosis 2010 Oct 12 [Epub ahead of print].
-
(2010)
Apoptosis
-
-
Carter, B.Z.1
Mak, D.H.2
Morris, S.J.3
-
108
-
-
55949097249
-
A phase I trial of AEG35156 (XIAP antisense) administered as 2-hour intravenous infusions in patients with advanced tumours
-
Jolivet J, Dean E, Ward T, et al. A phase I trial of AEG35156 (XIAP antisense) administered as 2-hour intravenous infusions in patients with advanced tumours. J Clin Oncol (Meeting Abstr) 2008; 26: 3541.
-
(2008)
J Clin Oncol (Meeting Abstr)
, vol.26
, pp. 3541
-
-
Jolivet, J.1
Dean, E.2
Ward, T.3
-
110
-
-
1542608418
-
Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lymphoma
-
Ansell SM, Arendt BK, Grote DM, et al. Inhibition of survivin expression suppresses the growth of aggressive non-Hodgkin's lymphoma. Leukemia 2004; 18: 616-23.
-
(2004)
Leukemia
, vol.18
, pp. 616-623
-
-
Ansell, S.M.1
Arendt, B.K.2
Grote, D.M.3
-
111
-
-
40049106474
-
Terameprocol, a novel site-specific transcription inhibitor with anticancer activity
-
Smolewski P. Terameprocol, a novel site-specific transcription inhibitor with anticancer activity. I Drugs 2008; 11: 204-14.
-
(2008)
I Drugs
, vol.11
, pp. 204-214
-
-
Smolewski, P.1
-
112
-
-
33748314821
-
A phase I study of YM155, a novel survivin uppressant, administered by 168 h continuous infusion to patients with advanced solid tumors
-
Tolcher AW, Antonia S, Lewis LD, et al. A phase I study of YM155, a novel survivin uppressant, administered by 168 h continuous infusion to patients with advanced solid tumors. J Clin Oncol (Meeting Abstr) 2006; 24: 3014.
-
(2006)
J Clin Oncol (Meeting Abstr)
, vol.24
, pp. 3014
-
-
Tolcher, A.W.1
Antonia, S.2
Lewis, L.D.3
-
113
-
-
84873077674
-
-
http://clinicaltrialsgov/ct2/show/NCT00664677.
-
-
-
-
114
-
-
34548574823
-
YM155, a novel small-molecule surviving suppressant, induces regression of established human hormonerefractory prostate tumor xenografts
-
Nakahara T, Takeuchi M, Kinoyama I, et al. YM155, a novel small-molecule surviving suppressant, induces regression of established human hormonerefractory prostate tumor xenografts. Cancer Res 2007; 67: 8014-21.
-
(2007)
Cancer Res
, vol.67
, pp. 8014-8021
-
-
Nakahara, T.1
Takeuchi, M.2
Kinoyama, I.3
-
115
-
-
77954176768
-
Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs
-
Iwasa T, Okamoto I, Takezawa K, et al. Marked anti-tumour activity of the combination of YM155, a novel survivin suppressant, and platinum-based drugs. Br J Cancer 2010; 103: 36-42.
-
(2010)
Br J Cancer
, vol.103
, pp. 36-42
-
-
Iwasa, T.1
Okamoto, I.2
Takezawa, K.3
-
116
-
-
79951717493
-
Broad spectrum and potent antitumor activities of YM155, a novel small-molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models
-
Dec 14 doi: 101111/j1349-7006201001834x [Epub ahead of print]
-
Nakahara T, Kita A, Yamanaka K, et al. Broad spectrum and potent antitumor activities of YM155, a novel small-molecule survivin suppressant, in a wide variety of human cancer cell lines and xenograft models. Cancer Sci 2010 Dec 14 doi: 101111/j1349-7006201001834x [Epub ahead of print].
-
(2010)
Cancer Sci
-
-
Nakahara, T.1
Kita, A.2
Yamanaka, K.3
-
117
-
-
66649126940
-
Phase I study of YM155, a novel survivin suppressant, in patients with advanced solid tumors
-
Satoh T, Okamoto I, Miyazaki M, et al. Phase I study of YM155, a novel survivin suppressant, in patients with advanced solid tumors. Clin Cancer Res 2009; 15: 3872-80.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 3872-3880
-
-
Satoh, T.1
Okamoto, I.2
Miyazaki, M.3
-
118
-
-
34447137342
-
Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC
-
Goga A, Yang D, Tward AD, et al. Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC. Nat Med 2007; 13: 820-7.
-
(2007)
Nat Med
, vol.13
, pp. 820-827
-
-
Goga, A.1
Yang, D.2
Tward, A.D.3
-
119
-
-
70350228525
-
RGDownregulation of c-FLIP Enhances death of cancer cells by smac mimetic compound
-
Cheung HH, Mahoney DJ, Lacasse EC, Korneluk. RGDownregulation of c-FLIP Enhances death of cancer cells by smac mimetic compound. Cancer Res 2009; 69: 7729-38.
-
(2009)
Cancer Res
, vol.69
, pp. 7729-7738
-
-
Cheung, H.H.1
Mahoney, D.J.2
Lacasse, E.C.3
Korneluk4
-
120
-
-
78549233741
-
-
Liu X, Ryland L, Yang J, Liao A, et al. Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia Blood 2010; 116: 4192-201.
-
(2010)
Targeting of Survivin By Nanoliposomal Ceramide Induces Complete Remission In a Rat Model of NK-LGL Leukemia Blood
, vol.116
, pp. 4192-4201
-
-
Liu, X.1
Ryland, L.2
Yang, J.3
Liao, A.4
-
121
-
-
9144265592
-
Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors
-
Wang Z, Cuddy M, Samuel T, et al. Cellular, biochemical, and genetic analysis of mechanism of small molecule IAP inhibitors. J Biol Chem 2004; 279: 48168-76.
-
(2004)
J Biol Chem
, vol.279
, pp. 48168-48176
-
-
Wang, Z.1
Cuddy, M.2
Samuel, T.3
-
122
-
-
9144234685
-
Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity
-
Schimmer AD, Welsh K, Pinilla C, et al. Small-molecule antagonists of apoptosis suppressor XIAP exhibit broad antitumor activity. Cancer Cell 2004; 5: 25-35.
-
(2004)
Cancer Cell
, vol.5
, pp. 25-35
-
-
Schimmer, A.D.1
Welsh, K.2
Pinilla, C.3
-
123
-
-
16844378813
-
Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer
-
Berezovskaya O, Schimmer AD, Glinskii AB, et al. Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer. Cancer Res 2005; 65: 2378-86.
-
(2005)
Cancer Res
, vol.65
, pp. 2378-2386
-
-
Berezovskaya, O.1
Schimmer, A.D.2
Glinskii, A.B.3
-
124
-
-
20844437755
-
Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells
-
Carter BZ, Gronda M, Wang Z, et al. Small-molecule XIAP inhibitors derepress downstream effector caspases and induce apoptosis of acute myeloid leukemia cells. Blood 2005; 105: 4043-50.
-
(2005)
Blood
, vol.105
, pp. 4043-4050
-
-
Carter, B.Z.1
Gronda, M.2
Wang, Z.3
-
125
-
-
38049160750
-
Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells
-
Cillessen SAc, Reed JC, Welsh K, et al. Small-molecule XIAP antagonist restores caspase-9 mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells. Blood 2008; 111: 369-75.
-
(2008)
Blood
, vol.111
, pp. 369-375
-
-
Sac, C.1
Reed, J.C.2
Welsh, K.3
-
126
-
-
23944469907
-
Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis
-
Kater AP, Dicker F, Mangiola M, et al. Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis. Blood 2005; 106: 1742-8.
-
(2005)
Blood
, vol.106
, pp. 1742-1748
-
-
Kater, A.P.1
Dicker, F.2
Mangiola, M.3
-
127
-
-
0041913978
-
Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/Caspase-3 interaction
-
Wu TY, Wagner KW, Bursulaya B,et al. Development and characterization of nonpeptidic small molecule inhibitors of the XIAP/Caspase-3 interaction. Chem Biol 2003; 10: 759-67
-
(2003)
Chem Biol
, vol.10
, pp. 759-767
-
-
Wu, T.Y.1
Wagner, K.W.2
Bursulaya, B.3
-
128
-
-
4143099131
-
Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer
-
Oost TK, Sun C, Armstrong RC, et al. Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. J Med Chem 2004; 47: 4417-26.
-
(2004)
J Med Chem
, vol.47
, pp. 4417-4426
-
-
Oost, T.K.1
Sun, C.2
Armstrong, R.C.3
-
129
-
-
27744526342
-
A small molecule Smacmimic compound induces apoptosis and sensitizes TRAILand etoposide-induced apoptosis in breast cancer cells
-
Bockbrader KM, Tan M, Sun Y. A small molecule Smacmimic compound induces apoptosis and sensitizes TRAILand etoposide-induced apoptosis in breast cancer cells. Oncogene 2005; 24: 7381-8.
-
(2005)
Oncogene
, vol.24
, pp. 7381-7388
-
-
Bockbrader, K.M.1
Tan, M.2
Sun, Y.3
-
130
-
-
37749037799
-
Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs
-
Zobel K, Wang L, Varfolomeev E, et al. Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol 2006; 1: 525-33.
-
(2006)
ACS Chem Biol
, vol.1
, pp. 525-533
-
-
Zobel, K.1
Wang, L.2
Varfolomeev, E.3
-
131
-
-
33845919012
-
Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic
-
Sun H, Nikolovska-Coleska Z, Lu J, et al. Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic. J Med Chem 2006; 49: 7916-20.
-
(2006)
J Med Chem
, vol.49
, pp. 7916-7920
-
-
Sun, H.1
Nikolovska-Coleska, Z.2
Lu, J.3
-
132
-
-
19944434282
-
Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics
-
Sun H, Nikolovska-Coleska Z, Chen J, et al. Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics. Bioorg Med Chem Lett 2005; 15: 793-7.
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 793-797
-
-
Sun, H.1
Nikolovska-Coleska, Z.2
Chen, J.3
-
133
-
-
4444243683
-
A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death
-
Li L, Thomas RM, Suzuki H, et al. A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death. Science 2004; 305: 14714.
-
(2004)
Science
, vol.305
, pp. 14714
-
-
Li, L.1
Thomas, R.M.2
Suzuki, H.3
-
134
-
-
0042161811
-
XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells
-
Kashkar H, Haefs C, Shin H, et al. XIAP-mediated caspase inhibition in Hodgkin's lymphoma-derived B cells. J Exp Med 2003; 198: 341-7.
-
(2003)
J Exp Med
, vol.198
, pp. 341-347
-
-
Kashkar, H.1
Haefs, C.2
Shin, H.3
-
135
-
-
33846878524
-
Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM)
-
Chauhan D, Neri P, Velankar M, et al. Targeting mitochondrial factor Smac/DIABLO as therapy for multiple myeloma (MM). Blood 2007; 109: 1220-7.
-
(2007)
Blood
, vol.109
, pp. 1220-1227
-
-
Chauhan, D.1
Neri, P.2
Velankar, M.3
-
136
-
-
0036565885
-
Ectopic overexpression of second mitochondriaderived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative- (BMS 247550) and Apo-2L/TRAIL-induced apoptosis
-
Guo F, Nimmanapalli R, Paranawithana S, et al. Ectopic overexpression of second mitochondriaderived activator of caspases (Smac/DIABLO) or cotreatment with N-terminus of Smac/DIABLO peptide potentiates epothilone B derivative- (BMS 247550) and Apo-2L/TRAIL-induced apoptosis. Blood 2002; 99: 3419-26.
-
(2002)
Blood
, vol.99
, pp. 3419-3426
-
-
Guo, F.1
Nimmanapalli, R.2
Paranawithana, S.3
-
137
-
-
33751195938
-
XIAP targeting sensitizes Hodgkin's lymphoma cells for cytolytic T-cell attack
-
Kashkar H, Seeger JM, Hombach A, et al. XIAP targeting sensitizes Hodgkin's lymphoma cells for cytolytic T-cell attack. Blood 2006; 108: 3434-40.
-
(2006)
Blood
, vol.108
, pp. 3434-3440
-
-
Kashkar, H.1
Seeger, J.M.2
Hombach, A.3
-
138
-
-
0037456993
-
Role of Smac in human leukaemic cell apoptosis and proliferation
-
Jia L, Patwari Y, Kelsey SM, et al. Role of Smac in human leukaemic cell apoptosis and proliferation. Oncogene 2003; 22: 1589-99.
-
(2003)
Oncogene
, vol.22
, pp. 1589-1599
-
-
Jia, L.1
Patwari, Y.2
Kelsey, S.M.3
-
139
-
-
36048999753
-
IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis
-
Varfolomeev E, Blankenship JW, Wayson SM, et al. IAP antagonists induce autoubiquitination of c-IAPs, NF-kappaB activation, and TNFalpha-dependent apoptosis. Cell 2007; 131: 669-81.
-
(2007)
Cell
, vol.131
, pp. 669-681
-
-
Varfolomeev, E.1
Blankenship, J.W.2
Wayson, S.M.3
-
140
-
-
37549000486
-
A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling
-
Gaither A, Porter D, Yao Y, et al. A Smac mimetic rescue screen reveals roles for inhibitor of apoptosis proteins in tumor necrosis factor-alpha signaling. Cancer Res 2007; 67: 11493-8.
-
(2007)
Cancer Res
, vol.67
, pp. 11493-11498
-
-
Gaither, A.1
Porter, D.2
Yao, Y.3
-
141
-
-
35948994157
-
Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis
-
Petersen SL, Wang L, Yalcin-Chin A, et al. Autocrine TNFalpha signaling renders human cancer cells susceptible to Smac-mimetic-induced apoptosis. Cancer Cell 2007; 12: 445-56.
-
(2007)
Cancer Cell
, vol.12
, pp. 445-456
-
-
Petersen, S.L.1
Wang, L.2
Yalcin-Chin, A.3
-
142
-
-
36148954336
-
IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis
-
Vince JE, Wong WW, Khan N, et al. IAP antagonists target cIAP1 to induce TNFalpha-dependent apoptosis. Cell 2007; 131: 682-93.
-
(2007)
Cell
, vol.131
, pp. 682-693
-
-
Vince, J.E.1
Wong, W.W.2
Khan, N.3
-
143
-
-
70449686047
-
Inhibiting the inhibitors: Retro-inverso Smac peptides
-
Hossbach J, Michalsky E, Henklein P, et al. Inhibiting the inhibitors: retro-inverso Smac peptides. Peptides 2009; 30: 2374-9.
-
(2009)
Peptides
, vol.30
, pp. 2374-2379
-
-
Hossbach, J.1
Michalsky, E.2
Henklein, P.3
-
144
-
-
0034700495
-
Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain
-
Liu Z, Sun C, Olejniczak ET, et al. Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain. Nature 2000; 408: 1004-8.
-
(2000)
Nature
, vol.408
, pp. 1004-1008
-
-
Liu, Z.1
Sun, C.2
Olejniczak, E.T.3
-
145
-
-
19944426570
-
Structurebased design of potent, conformationally constrained Smac mimetics
-
Sun H, Nikolovska-Coleska Z, Yang CY et al. Structurebased design of potent, conformationally constrained Smac mimetics. J Am Chem Soc 2004; 126: 16686-7.
-
(2004)
J Am Chem Soc
, vol.126
, pp. 16686-16687
-
-
Sun, H.1
Nikolovska-Coleska, Z.2
Yang, C.Y.3
-
146
-
-
3843086358
-
Structurebased design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site
-
Sun H, Nikolovska-Coleska Z, Yang CY, et al. Structurebased design, synthesis, and evaluation of conformationally constrained mimetics of the second mitochondria-derived activator of caspase that target the X-linked inhibitor of apoptosis protein/caspase-9 interaction site. J Med Chem 2004; 47: 4147-50.
-
(2004)
J Med Chem
, vol.47
, pp. 4147-4150
-
-
Sun, H.1
Nikolovska-Coleska, Z.2
Yang, C.Y.3
-
147
-
-
56749160346
-
Structurebased design, synthesis, evaluation and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP)
-
Sun H, Stuckey JA, Nikolovska-Coleska Z, et al. Structurebased design, synthesis, evaluation and crystallographic studies of conformationally constrained Smac mimetics as inhibitors of the X-linked inhibitor of apoptosis protein (XIAP). J Med Chem 2008; 51: 7169-80.
-
(2008)
J Med Chem
, vol.51
, pp. 7169-7180
-
-
Sun, H.1
Stuckey, J.A.2
Nikolovska-Coleska, Z.3
-
148
-
-
33845919012
-
Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic
-
Sun H, Nikolovska-Coleska Z, Lu J, et al. Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic. J Med Chem 2006; 49: 7916-20.
-
(2006)
J Med Chem
, vol.49
, pp. 7916-7920
-
-
Sun, H.1
Nikolovska-Coleska, Z.2
Lu, J.3
-
149
-
-
56449103218
-
SM-164: A novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP
-
Lu J, Bai L, Sun H, Nikolovska-Coleska Z, et al. SM-164: A novel, bivalent Smac mimetic that induces apoptosis and tumor regression by concurrent removal of the blockade of cIAP-1/2 and XIAP. Cancer Res 2008; 68: 9384-93.
-
(2008)
Cancer Res
, vol.68
, pp. 9384-9393
-
-
Lu, J.1
Bai, L.2
Sun, H.3
Nikolovska-Coleska, Z.4
-
150
-
-
43049152912
-
TNF-alpha induces two distinct caspase-8 activation pathways
-
Wang L, Du F, Wang X. TNF-alpha induces two distinct caspase-8 activation pathways. Cell 2008; 133: 693-703.
-
(2008)
Cell
, vol.133
, pp. 693-703
-
-
Wang, L.1
Du, F.2
Wang, X.3
-
151
-
-
44949240664
-
cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination
-
Bertrand MJ, Milutinovic S, Dickson KM, et al. cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination. Mol Cell 2008; 30: 689-700.
-
(2008)
Mol Cell
, vol.30
, pp. 689-700
-
-
Bertrand, M.J.1
Milutinovic, S.2
Dickson, K.M.3
-
152
-
-
77955376177
-
Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression
-
Petersen SL, Peyton M, Minna JD, Wang X. Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression. Proc Natl Acad Sci U S A 2010; 107: 11936-41.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 11936-11941
-
-
Petersen, S.L.1
Peyton, M.2
Minna, J.D.3
Wang, X.4
-
153
-
-
37749037799
-
Design, Synthesis, and Biological Activity of a Potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs
-
Zobel K, Wang L, Varfolomeev E, et al. Design, Synthesis, and Biological Activity of a Potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs. ACS Chem Biol 2006; 1: 525-34.
-
(2006)
ACS Chem Biol
, vol.1
, pp. 525-534
-
-
Zobel, K.1
Wang, L.2
Varfolomeev, E.3
-
154
-
-
27744526342
-
A small molecule Smacmimic compound induces apoptosis and sensitizes TRAILand etoposide-induced apoptosis in breast cancer cells
-
Bockbrader KM, Tan M, Sun Y. A small molecule Smacmimic compound induces apoptosis and sensitizes TRAILand etoposide-induced apoptosis in breast cancer cells. Oncogene 2005; 24: 7381-8.
-
(2005)
Oncogene
, vol.24
, pp. 7381-7388
-
-
Bockbrader, K.M.1
Tan, M.2
Sun, Y.3
-
157
-
-
34447308516
-
Potentiation of antileukemic therapies by Smac mimetic, LBW242: Effects on mutant FLT3-expressing cells
-
Weisberg E, Kung AL, Wright RD, et al. Potentiation of antileukemic therapies by Smac mimetic, LBW242: effects on mutant FLT3-expressing cells. Mol Cancer Ther 2007; 6: 1951-61.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 1951-1961
-
-
Weisberg, E.1
Kung, A.L.2
Wright, R.D.3
-
158
-
-
64349110093
-
Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold
-
Cohen F, Alicke B, Elliott LO, et al. Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold. J Med Chem 2009; 52: 1723-30.
-
(2009)
J Med Chem
, vol.52
, pp. 1723-1730
-
-
Cohen, F.1
Alicke, B.2
Elliott, L.O.3
-
159
-
-
33749259614
-
Design, synthesis and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein
-
Chen J, Nikolovska-Coleska Z, Wang G, et al. Design, synthesis and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis protein. Bioorg Med Chem Lett 2006; 16: 5805-8.
-
(2006)
Bioorg Med Chem Lett
, vol.16
, pp. 5805-5808
-
-
Chen, J.1
Nikolovska-Coleska, Z.2
Wang, G.3
-
160
-
-
2342448582
-
Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database
-
Nikolovska-Coleska Z, Xu L, Hu Z, et al. Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem 2004; 47: 2430-40.
-
(2004)
J Med Chem
, vol.47
, pp. 2430-2440
-
-
Nikolovska-Coleska, Z.1
Xu, L.2
Hu, Z.3
-
161
-
-
84873090383
-
Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells
-
Jul 13 [Epub ahead of print]
-
Hu R, Zhu K, Li Y, et al. Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells. Med Oncol 2010 Jul 13 [Epub ahead of print].
-
(2010)
Med Oncol
-
-
Hu, R.1
Zhu, K.2
Li, Y.3
-
163
-
-
35448936116
-
Biochemical basis for enhanced binding of peptide dimers to X-Linked inhibitor of apoptosis protein
-
Splan KE, Allen JE, McLendon GL. Biochemical basis for enhanced binding of peptide dimers to X-Linked inhibitor of apoptosis protein. Biochemistry 2007; 46: 11938-44.
-
(2007)
Biochemistry
, vol.46
, pp. 11938-11944
-
-
Splan, K.E.1
Allen, J.E.2
McLendon, G.L.3
-
164
-
-
33947160238
-
Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP
-
Wist AD, Gu L, Riedl SJ, et al. Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP. Bioorg Med Chem 2007; 15: 2935-43.
-
(2007)
Bioorg Med Chem
, vol.15
, pp. 2935-2943
-
-
Wist, A.D.1
Gu, L.2
Riedl, S.J.3
-
165
-
-
33745253109
-
Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach
-
Zender L, Spector MS, Xue W, et al. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell 2006; 125: 1253-67.
-
(2006)
Cell
, vol.125
, pp. 1253-1267
-
-
Zender, L.1
Spector, M.S.2
Xue, W.3
-
166
-
-
77950820911
-
Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells
-
Cheung CH, Chen HH, Cheng LT, et al. Targeting Hsp90 with small molecule inhibitors induces the over-expression of the anti-apoptotic molecule, survivin, in human A549, HONE-1 and HT-29 cancer cells. Mol Cancer 2010; 9: 77-87.
-
(2010)
Mol Cancer
, vol.9
, pp. 77-87
-
-
Cheung, C.H.1
Chen, H.H.2
Cheng, L.T.3
-
167
-
-
77956712168
-
Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner
-
Probst B L, Liu L, Ramesh V, et al. Smac mimetics increase cancer cell response to chemotherapeutics in a TNF-α-dependent manner. Cell Death Diff 2010; 17: 1645-54.
-
(2010)
Cell Death Diff
, vol.17
, pp. 1645-1654
-
-
Probst, B.L.1
Liu, L.2
Ramesh, V.3
-
168
-
-
84873094958
-
-
http://www.news-medical.net/news/20100108/TetraLogic-Pharmaceuticals-commences-its-TL32711-SMAC-mimetic-Phase-1-clinical-trial.aspx.
-
-
-
-
169
-
-
51649114209
-
Spongistatin 1: A new chemosensitizing marine compound that degrades XIAP
-
Schyschka L, Rudy A, Jeremias I, et al. Spongistatin 1: a new chemosensitizing marine compound that degrades XIAP. Leukemia 2008; 22: 1737-45.
-
(2008)
Leukemia
, vol.22
, pp. 1737-1745
-
-
Schyschka, L.1
Rudy, A.2
Jeremias, I.3
-
170
-
-
78649305848
-
Thiocolchicoside exhibits anticancer effects through downregulation of NF- {kappa}B pathway and its regulated gene products linked to inflammation and cancer
-
Reuter S, Prasad S, Phromnoi K, et al. Thiocolchicoside exhibits anticancer effects through downregulation of NF- {kappa}B pathway and its regulated gene products linked to inflammation and cancer. Cancer Prev Res (Phila) 2010; 3: 1462-72.
-
(2010)
Cancer Prev Res (Phila)
, vol.3
, pp. 1462-1472
-
-
Reuter, S.1
Prasad, S.2
Phromnoi, K.3
-
171
-
-
77957902911
-
Pentoxifylline augments TRAIL/Apo2L mediated apoptosis in cutaneous T cell lymphoma (HuT-78 and MyLa) by modulating the expression of antiapoptotic proteins and death receptors
-
Gahlot S, Khan MA, Rishi L, Majumdar S. Pentoxifylline augments TRAIL/Apo2L mediated apoptosis in cutaneous T cell lymphoma (HuT-78 and MyLa) by modulating the expression of antiapoptotic proteins and death receptors. Biochem Pharmacol 2010; 80: 1650-61.
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 1650-1661
-
-
Gahlot, S.1
Khan, M.A.2
Rishi, L.3
Majumdar, S.4
-
172
-
-
77951215549
-
Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors
-
Sung B, Park B, Yadav VR, Aggarwal BB. Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors. J Biol Chem 2010; 285: 11498-507.
-
(2010)
J Biol Chem
, vol.285
, pp. 11498-11507
-
-
Sung, B.1
Park, B.2
Yadav, V.R.3
Aggarwal, B.B.4
-
174
-
-
71549134615
-
A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia
-
Loeder S, Zenz T, Schnaiter A, et al. A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia. Cancer Res 2009; 69: 8977-86.
-
(2009)
Cancer Res
, vol.69
, pp. 8977-8986
-
-
Loeder, S.1
Zenz, T.2
Schnaiter, A.3
-
175
-
-
69949180337
-
Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2/Stat3
-
Capitani S, Miscia S, Marchisio M. Enhancement of TRAIL cytotoxicity by AG-490 in human ALL cells is characterized by downregulation of cIAP-1 and cIAP-2 through inhibition of Jak2/Stat3. Cell Res 2009; 19: 1079-89.
-
(2009)
Cell Res
, vol.19
, pp. 1079-1089
-
-
Capitani, S.1
Miscia, S.2
Marchisio, M.3
-
176
-
-
64949101030
-
TP-110, a new proteasome inhibitor, down-regulates IAPs in human multiple myeloma cells
-
Iijima M, Momose I, Ikeda D. TP-110, a new proteasome inhibitor, down-regulates IAPs in human multiple myeloma cells. Anticancer Res 2009; 29: 977-85.
-
(2009)
Anticancer Res
, vol.29
, pp. 977-985
-
-
Iijima, M.1
Momose, I.2
Ikeda, D.3
-
177
-
-
66449104640
-
Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model
-
Sung B, Kunnumakkara AB, Sethi G, et al. Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model. Mol Cancer Ther 2009; 8: 959-70.
-
(2009)
Mol Cancer Ther
, vol.8
, pp. 959-970
-
-
Sung, B.1
Kunnumakkara, A.B.2
Sethi, G.3
-
178
-
-
65949114070
-
E1B 55-kDa deleted, Ad5/F35 fiber chimeric adenovirus, a potential oncolytic agent for Blymphocytic malignancies
-
Wang G, Li G, Liu H, et al. E1B 55-kDa deleted, Ad5/F35 fiber chimeric adenovirus, a potential oncolytic agent for Blymphocytic malignancies. J Gene Med 2009; 11: 477-85.
-
(2009)
J Gene Med
, vol.11
, pp. 477-485
-
-
Wang, G.1
Li, G.2
Liu, H.3
-
179
-
-
84655166468
-
Berberine-induced apoptosis via decreasing the survivin protein in K562 cell line
-
Jun 2 [Epub ahead of print]
-
Pazhang Y, Ahmadian S, Mahmoudian M, Shafiezadeh M. Berberine-induced apoptosis via decreasing the survivin protein in K562 cell line. Med Oncol 2010 Jun 2 [Epub ahead of print].
-
(2010)
Med Oncol
-
-
Pazhang, Y.1
Ahmadian, S.2
Mahmoudian, M.3
Shafiezadeh, M.4
-
180
-
-
80053938344
-
The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukemia and significantly increases the efficacy of nilotinib
-
Nov 21 doi: 101111/j1582-4934 [Epub ahead of print]
-
Kelly KR, Ecsedy J, Medina E, et al. The novel Aurora A kinase inhibitor MLN8237 is active in resistant chronic myeloid leukemia and significantly increases the efficacy of nilotinib. J Cell Mol Med 2010 Nov 21 doi: 101111/j1582-4934 [Epub ahead of print].
-
(2010)
J Cell Mol Med
-
-
Kelly, K.R.1
Ecsedy, J.2
Medina, E.3
-
181
-
-
75649131205
-
Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML
-
Carter BZ, Mak DH, Schober WD, et al. Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML. Blood 2010; 115: 306-14.
-
(2010)
Blood
, vol.115
, pp. 306-314
-
-
Carter, B.Z.1
Mak, D.H.2
Schober, W.D.3
-
182
-
-
84861596550
-
LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: A novel class of agent with high apoptotic effect in chronic myeloid leukemia cells
-
May 25 [Epub ahead of print]
-
Maia RC, Vasconcelos FC, de Sá Bacelar T, et al. LQB-118, a pterocarpanquinone structurally related to lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone]: a novel class of agent with high apoptotic effect in chronic myeloid leukemia cells. Invest New Drugs 2010 May 25 [Epub ahead of print].
-
(2010)
Invest New Drugs
-
-
Maia, R.C.1
Vasconcelos, F.C.2
de Sá, B.T.3
-
183
-
-
77954611291
-
-
Tong WG, Chen R, Plunkett W, et al. Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma J Clin Oncol 2010; 28: 3015-22.
-
(2010)
Phase I and Pharmacologic Study of SNS-032, a Potent and Selective Cdk2, 7, and 9 Inhibitor, In Patients With Advanced Chronic Lymphocytic Leukemia and Multiple Myeloma J Clin Oncol
, vol.28
, pp. 3015-3022
-
-
Tong, W.G.1
Chen, R.2
Plunkett, W.3
-
184
-
-
79951530814
-
Novel and emerging drugs for acute myeloid leukemia: Pharmacology and therapeutic activity
-
Robak T, Szmigielska-Kapłon A, Pluta A, et al. Novel and emerging drugs for acute myeloid leukemia: pharmacology and therapeutic activity. Curr Med Chem 2011; 18: 638-66.
-
(2011)
Curr Med Chem
, vol.18
, pp. 638-666
-
-
Robak, T.1
Szmigielska-Kapłon, A.2
Pluta, A.3
-
185
-
-
72149089893
-
Current and emerging treatments for chronic lymphocytic leukaemia
-
Robak T, Jamroziak K, Robak P. Current and emerging treatments for chronic lymphocytic leukaemia. Drugs. 2009; 69: 2415-49.
-
(2009)
Drugs
, vol.69
, pp. 2415-2449
-
-
Robak, T.1
Jamroziak, K.2
Robak, P.3
-
186
-
-
79952078495
-
Biology, risk stratification, and therapy of pediatric acute leukemias: An update
-
Pui CH, Carroll WL, Meshinchi S, Arceci RJ. Biology, risk stratification, and therapy of pediatric acute leukemias: an update. J Clin Oncol 2011; 10; 29: 551-65.
-
(2011)
J Clin Oncol
, vol.10
, Issue.29
, pp. 551-565
-
-
Pui, C.H.1
Carroll, W.L.2
Meshinchi, S.3
Arceci, R.J.4
|