Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.

ACS chemical biology

Volumn 1, Issue 8, 2006, Pages 525-533

  Zobel, Kerry ^a   Wang, Lan ^a   Varfolomeev, Eugene ^a   Franklin, Matthew C ^a   Elliott, Linda O ^a   Wallweber, Heidi J A ^a   Okawa, David C ^a   Flygare, John A ^a   Vucic, Domagoj ^a   Fairbrother, Wayne J ^a   Deshayes, Kurt ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMIMETIC MATERIAL; CASPASE; INHIBITOR OF APOPTOSIS PROTEIN; SIGNAL PEPTIDE;

APOPTOSIS; ARTICLE; BINDING SITE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; DRUG DESIGN; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; HUMAN; METABOLISM; NEOPLASM; PATHOLOGY; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

APOPTOSIS; BINDING SITES; BIOMIMETIC MATERIALS; CASPASES; CELL LINE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME ACTIVATION; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, MOLECULAR; NEOPLASMS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 37749037799     PISSN: None     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb600276q     Document Type: Article

References (0)