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Volumn 55, Issue 2, 2010, Pages 260-266

XIAP expression is post-transcriptionally upregulated in childhood ALL and is associated with glucocorticoid response in T-cell ALL

Author keywords

ALL; Molecular biology; Molecular diagnosis therapy; Pediatric hematology oncology

Indexed keywords

MESSENGER RNA; PREDNISONE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; X LINKED INHIBITOR OF APOPTOSIS;

EID: 77955123282     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.22541     Document Type: Article
Times cited : (44)

References (50)
  • 2
    • 47149100125 scopus 로고    scopus 로고
    • Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: Treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95
    • Moricke A, Reiter A, Zimmermann M, et al. Risk-adjusted therapy of acute lymphoblastic leukemia can decrease treatment burden and improve survival: Treatment results of 2169 unselected pediatric and adolescent patients enrolled in the trial ALL-BFM 95. Blood 2008;111:4477-4489.
    • (2008) Blood , vol.111 , pp. 4477-4489
    • Moricke, A.1    Reiter, A.2    Zimmermann, M.3
  • 3
    • 0344246893 scopus 로고    scopus 로고
    • Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia
    • Dordelmann M, Reiter A, Borkhardt A, et al. Prednisone response is the strongest predictor of treatment outcome in infant acute lymphoblastic leukemia. Blood 1999;94:1209-1217.
    • (1999) Blood , vol.94 , pp. 1209-1217
    • Dordelmann, M.1    Reiter, A.2    Borkhardt, A.3
  • 4
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 6
    • 0035902601 scopus 로고    scopus 로고
    • Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death
    • Suzuki Y, Nakabayashi Y, Takahashi R. Ubiquitin-protein ligase activity of X-linked inhibitor of apoptosis protein promotes proteasomal degradation of caspase-3 and enhances its anti-apoptotic effect in Fas-induced cell death. Proc Natl Acad Sci USA 2001;98:8662-8667.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8662-8667
    • Suzuki, Y.1    Nakabayashi, Y.2    Takahashi, R.3
  • 7
    • 20744449274 scopus 로고    scopus 로고
    • Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation
    • Dai Y, Rahmani M, Dent P, et al. Blockade of histone deacetylase inhibitor-induced RelA/p65 acetylation and NF-kappaB activation potentiates apoptosis in leukemia cells through a process mediated by oxidative damage, XIAP downregulation, and c-Jun N-terminal kinase 1 activation. Mol Cell Biol 2005;25:5429-5444.
    • (2005) Mol Cell Biol , vol.25 , pp. 5429-5444
    • Dai, Y.1    Rahmani, M.2    Dent, P.3
  • 8
    • 0034616945 scopus 로고    scopus 로고
    • Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition
    • Du C, Fang M, Li Y, et al. Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell 2000;102:33-42.
    • (2000) Cell , vol.102 , pp. 33-42
    • Du, C.1    Fang, M.2    Li, Y.3
  • 9
    • 0034785591 scopus 로고    scopus 로고
    • A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death
    • DOI 10.1016/S1097-2765(01)00341-0
    • Suzuki Y, Imai Y, Nakayama H, et al. A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell 2001;8:613-621. (Pubitemid 32946938)
    • (2001) Molecular Cell , vol.8 , Issue.3 , pp. 613-621
    • Suzuki, Y.1    Imai, Y.2    Nakayama, H.3    Takahashi, K.4    Takio, K.5    Takahashi, R.6
  • 10
    • 0035156848 scopus 로고    scopus 로고
    • Identification of XAF1 as an antagonist of XIAP anti-Caspase activity
    • Liston P, Fong WG, Kelly NL, et al. Identification of XAF1 as an antagonist of XIAP anti-Caspase activity. Nat Cell Biol 2001;3:128-133.
    • (2001) Nat Cell Biol , vol.3 , pp. 128-133
    • Liston, P.1    Fong, W.G.2    Kelly, N.L.3
  • 11
    • 0033160190 scopus 로고    scopus 로고
    • A new internal-ribosome-entry-site motif potentiates XIAP-mediated cytoprotection
    • Holcik M, Lefebvre C,Yeh C, et al.Anewinternal-ribosome-entry-site motif potentiates XIAP-mediated cytoprotection. Nat Cell Biol 1999;1:190-192. (Pubitemid 129656025)
    • (1999) Nature Cell Biology , vol.1 , Issue.3 , pp. 190-192
    • Holcik, M.1    Lefebvre, C.2    Yeh, C.3    Chow, T.4    Korneluk, R.G.5
  • 12
    • 55549083197 scopus 로고    scopus 로고
    • Overexpression of cFLIPs inhibits oxaliplatin-mediated apoptosis through enhanced XIAP stability and Akt activation in human renal cancer cells
    • Kim S, Lee TJ, Park JW, et al. Overexpression of cFLIPs inhibits oxaliplatin-mediated apoptosis through enhanced XIAP stability and Akt activation in human renal cancer cells. J Cell Biochem 2008;105:971-979.
    • (2008) J Cell Biochem , vol.105 , pp. 971-979
    • Kim, S.1    Lee, T.J.2    Park, J.W.3
  • 13
    • 73949114594 scopus 로고    scopus 로고
    • Increased expression of inhibitor of apoptosis proteins, survivin and XIAP, in non-small cell lung carcinoma
    • Krepela E, Dankova P, Moravcikova E, et al. Increased expression of inhibitor of apoptosis proteins, survivin and XIAP, in non-small cell lung carcinoma. Int J Oncol 2009;35:1449-1462.
    • (2009) Int J Oncol , vol.35 , pp. 1449-1462
    • Krepela, E.1    Dankova, P.2    Moravcikova, E.3
  • 14
    • 17144438370 scopus 로고    scopus 로고
    • Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias
    • Tamm I, Kornblau SM, Segall H, et al. Expression and prognostic significance of IAP-family genes in human cancers and myeloid leukemias. Clin Cancer Res 2000;6:1796-1803.
    • (2000) Clin Cancer Res , vol.6 , pp. 1796-1803
    • Tamm, I.1    Kornblau, S.M.2    Segall, H.3
  • 15
    • 58149252352 scopus 로고    scopus 로고
    • Impact of XIAP protein levels on the survival of myeloma cells
    • Desplanques G, Giuliani N, Delsignore R, et al. Impact of XIAP protein levels on the survival of myeloma cells. Haematologica 2009;94:87-93.
    • (2009) Haematologica , vol.94 , pp. 87-93
    • Desplanques, G.1    Giuliani, N.2    Delsignore, R.3
  • 16
    • 9144271651 scopus 로고    scopus 로고
    • Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - A Europe against cancer program
    • Beillard E, Pallisgaard N, van der Velden VH, et al. Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time' quantitative reverse-transcriptase polymerase chain reaction (RQ-PCR) - A Europe against cancer program. Leukemia 2003;17:2474-2486.
    • (2003) Leukemia , vol.17 , pp. 2474-2486
    • Beillard, E.1    Pallisgaard, N.2    Van Der Velden, V.H.3
  • 17
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 18
    • 34247399924 scopus 로고    scopus 로고
    • Superiority of allogeneic hematopoietic stem-cell transplantation compared with chemotherapy alone in high-risk childhood T-cell acute lymphoblastic leukemia: Results from ALL-BFM 90 and 95
    • Schrauder A, Reiter A, Gadner H, et al. Superiority of allogeneic hematopoietic stem-cell transplantation compared with chemotherapy alone in high-risk childhood T-cell acute lymphoblastic leukemia: Results from ALL-BFM 90 and 95. J Clin Oncol 2006;24:5742-5749.
    • (2006) J Clin Oncol , vol.24 , pp. 5742-5749
    • Schrauder, A.1    Reiter, A.2    Gadner, H.3
  • 19
    • 16844378813 scopus 로고    scopus 로고
    • Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells
    • Berezovskaya O, Schimmer AD, Glinskii AB, et al. Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells. Cancer Res 2005;65:2378-2386.
    • (2005) Cancer Res , vol.65 , pp. 2378-2386
    • Berezovskaya, O.1    Schimmer, A.D.2    Glinskii, A.B.3
  • 20
    • 3843091721 scopus 로고    scopus 로고
    • XIAP expression is an independent prognostic marker in clear-cell renal carcinomas
    • Ramp U, Krieg T, Caliskan E, et al. XIAP expression is an independent prognostic marker in clear-cell renal carcinomas. Hum Pathol 2004;35:1022-1028.
    • (2004) Hum Pathol , vol.35 , pp. 1022-1028
    • Ramp, U.1    Krieg, T.2    Caliskan, E.3
  • 21
    • 27544469150 scopus 로고    scopus 로고
    • Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia
    • Maia S, Haining WN, Ansen S, et al. Gene expression profiling identifies BAX-delta as a novel tumor antigen in acute lymphoblastic leukemia. Cancer Res 2005;65:10050-10058.
    • (2005) Cancer Res , vol.65 , pp. 10050-10058
    • Maia, S.1    Haining, W.N.2    Ansen, S.3
  • 22
    • 1242271228 scopus 로고    scopus 로고
    • Translational regulation of X-linked inhibitor of apoptosis protein by interleukin-6: A novel mechanism of tumor cell survival
    • Yamagiwa Y, Marienfeld C, Meng F, et al. Translational regulation of X-linked inhibitor of apoptosis protein by interleukin-6: A novel mechanism of tumor cell survival. Cancer Res 2004;64:1293-1298.
    • (2004) Cancer Res , vol.64 , pp. 1293-1298
    • Yamagiwa, Y.1    Marienfeld, C.2    Meng, F.3
  • 23
    • 0034121076 scopus 로고    scopus 로고
    • Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: Role of la autoantigen in XIAP translation
    • Holcik M, Korneluk RG. Functional characterization of the X-linked inhibitor of apoptosis (XIAP) internal ribosome entry site element: Role of La autoantigen in XIAP translation. Mol Cell Biol 2000;20:4648-4657.
    • (2000) Mol Cell Biol , vol.20 , pp. 4648-4657
    • Holcik, M.1    Korneluk, R.G.2
  • 24
    • 0037215485 scopus 로고    scopus 로고
    • The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2
    • DOI 10.1128/MCB.23.1.280-288.2003
    • Holcik M, Gordon BW, Korneluk RG. The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2. Mol Cell Biol 2003;23:280-288. (Pubitemid 36008520)
    • (2003) Molecular and Cellular Biology , vol.23 , Issue.1 , pp. 280-288
    • Holcik, M.1    Gordon, B.W.2    Korneluk, R.G.3
  • 25
    • 0033980394 scopus 로고    scopus 로고
    • Anovel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation
    • Henis-Korenblit S, Strumpf NL, Goldstaub D, et al.Anovel form of DAP5 protein accumulates in apoptotic cells as a result of caspase cleavage and internal ribosome entry site-mediated translation. Mol Cell Biol 2000;20:496-506.
    • (2000) Mol Cell Biol , vol.20 , pp. 496-506
    • Henis-Korenblit, S.1    Strumpf, N.L.2    Goldstaub, D.3
  • 26
    • 26444583962 scopus 로고    scopus 로고
    • Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation
    • Hundsdoerfer P, Thoma C, HentzeMW. Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation. Proc Natl Acad Sci 2005;102:13421-13426.
    • (2005) Proc Natl Acad Sci , vol.102 , pp. 13421-13426
    • Hundsdoerfer, P.1    Thoma, C.2    Hentze, M.W.3
  • 27
    • 65349089029 scopus 로고    scopus 로고
    • Regulation of XIAP translation and induction by MDM2 following irradiation
    • Gu L, Zhu N, Zhang H, et al. Regulation of XIAP translation and induction by MDM2 following irradiation. Cancer Cell 2009;15:363-375.
    • (2009) Cancer Cell , vol.15 , pp. 363-375
    • Gu, L.1    Zhu, N.2    Zhang, H.3
  • 28
    • 1242317030 scopus 로고    scopus 로고
    • Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP)
    • Dan HC, Sun M, Kaneko S, et al. Akt phosphorylation and stabilization of X-linked inhibitor of apoptosis protein (XIAP). J Biol Chem 2004;279:5405-5412.
    • (2004) J Biol Chem , vol.279 , pp. 5405-5412
    • Dan, H.C.1    Sun, M.2    Kaneko, S.3
  • 29
    • 34250892539 scopus 로고    scopus 로고
    • Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection
    • Dohi T, Xia F, Altieri DC. Compartmentalized phosphorylation of IAP by protein kinase A regulates cytoprotection. Mol Cell 2007;27:17-28.
    • (2007) Mol Cell , vol.27 , pp. 17-28
    • Dohi, T.1    Xia, F.2    Altieri, D.C.3
  • 30
    • 0345686726 scopus 로고    scopus 로고
    • Protein expression of the glucocorticoid receptor in childhood acute lymphoblastic leukemia
    • Lauten M, Cario G, Asgedom G, et al. Protein expression of the glucocorticoid receptor in childhood acute lymphoblastic leukemia. Haematologica 2003;88:1253-1258. (Pubitemid 37456380)
    • (2003) Haematologica , vol.88 , Issue.11 , pp. 1253-1258
    • Lauten, M.1    Cario, G.2    Asgedom, G.3    Welte, K.4    Schrappe, M.5
  • 31
    • 4344700576 scopus 로고    scopus 로고
    • Glucocorticoid-induced apoptosis and glucocorticoid resistance: Molecular mechanisms and clinical relevance
    • Schmidt S, Rainer J, Ploner C, et al. Glucocorticoid-induced apoptosis and glucocorticoid resistance: Molecular mechanisms and clinical relevance. Cell Death Differ 2004;11:S45-S55.
    • (2004) Cell Death Differ , vol.11
    • Schmidt, S.1    Rainer, J.2    Ploner, C.3
  • 32
    • 33749443714 scopus 로고    scopus 로고
    • Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
    • Wei G, Twomey D, Lamb J, et al. Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer Cell 2006;10:331-342.
    • (2006) Cancer Cell , vol.10 , pp. 331-342
    • Wei, G.1    Twomey, D.2    Lamb, J.3
  • 33
    • 20144387309 scopus 로고    scopus 로고
    • Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas
    • Muris JJ, Cillessen SA, Vos W, et al. Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas. Blood 2005;105:2916-2923.
    • (2005) Blood , vol.105 , pp. 2916-2923
    • Muris, J.J.1    Cillessen, S.A.2    Vos, W.3
  • 34
    • 2542549018 scopus 로고    scopus 로고
    • High expression levels of X-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia
    • Tamm I, Richter S, Oltersdorf D, et al. High expression levels of X-linked inhibitor of apoptosis protein and survivin correlate with poor overall survival in childhood de novo acute myeloid leukemia. Clin Cancer Res 2004;10:3737-3744.
    • (2004) Clin Cancer Res , vol.10 , pp. 3737-3744
    • Tamm, I.1    Richter, S.2    Oltersdorf, D.3
  • 35
    • 34247862306 scopus 로고    scopus 로고
    • Overexpression of XIAP expression in renal cell carcinoma predicts a worse prognosis
    • Mizutani Y, Nakanishi H, Li YN, et al. Overexpression of XIAP expression in renal cell carcinoma predicts a worse prognosis. Int J Oncol 2007;30:919-925.
    • (2007) Int J Oncol , vol.30 , pp. 919-925
    • Mizutani, Y.1    Nakanishi, H.2    Li, Y.N.3
  • 36
    • 33750589355 scopus 로고    scopus 로고
    • IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes
    • Nakagawa Y, Abe S, Kurata M, et al. IAP family protein expression correlates with poor outcome of multiple myeloma patients in association with chemotherapy-induced overexpression of multidrug resistance genes. Am J Hematol 2006;81:824-831.
    • (2006) Am J Hematol , vol.81 , pp. 824-831
    • Nakagawa, Y.1    Abe, S.2    Kurata, M.3
  • 37
    • 35948933880 scopus 로고    scopus 로고
    • Expression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrence
    • Seligson DB, Hongo F, Huerta-Yepez S, et al. Expression of X-linked inhibitor of apoptosis protein is a strong predictor of human prostate cancer recurrence. Clin Cancer Res 2007;13:6056-6063.
    • (2007) Clin Cancer Res , vol.13 , pp. 6056-6063
    • Seligson, D.B.1    Hongo, F.2    Huerta-Yepez, S.3
  • 38
    • 5044225888 scopus 로고    scopus 로고
    • Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
    • Weng AP, Ferrando AA, Lee W, et al. Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 2004;306:269-271.
    • (2004) Science , vol.306 , pp. 269-271
    • Weng, A.P.1    Ferrando, A.A.2    Lee, W.3
  • 39
    • 33947598062 scopus 로고    scopus 로고
    • Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation
    • snmLiu WH, Hsiao HW, Tsou WI, et al. Notch inhibits apoptosis by direct interference with XIAP ubiquitination and degradation. EMBO J 2007;26:1660-1669.
    • (2007) EMBO J , vol.26 , pp. 1660-1669
    • SnmLiu, W.H.1    Hsiao, H.W.2    Tsou, W.I.3
  • 40
    • 33747155025 scopus 로고    scopus 로고
    • Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia
    • DOI 10.1182/blood-2005-12-4956
    • Breit S, Stanulla M, Flohr T, et al. Activating NOTCH1 mutations predict favorable early treatment response and long-term outcome in childhood precursor T-cell lymphoblastic leukemia. Blood 2006;108:1151-1157. (Pubitemid 44232009)
    • (2006) Blood , vol.108 , Issue.4 , pp. 1151-1157
    • Breit, S.1    Stanulla, M.2    Flohr, T.3    Schrappe, M.4    Ludwig, W.-D.5    Tolle, G.6    Happich, M.7    Muckenthaler, M.U.8    Kulozik, A.E.9
  • 41
    • 0034607655 scopus 로고    scopus 로고
    • Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
    • Yang Y, Fang S, Jensen JP, et al. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 2000;288:874-877.
    • (2000) Science , vol.288 , pp. 874-877
    • Yang, Y.1    Fang, S.2    Jensen, J.P.3
  • 42
    • 70349235938 scopus 로고    scopus 로고
    • High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16. 1 as a genomic marker for unfavorable early treatment response
    • RemkeM, Pfister S,KoxC, et al. High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF-beta and PI3K-AKT pathways and deletions at 6q15-16. 1 as a genomic marker for unfavorable early treatment response. Blood 2009;114:1053-1062.
    • (2009) Blood , vol.114 , pp. 1053-1062
    • Remke, M.1    Pfister, S.2    Kox, C.3
  • 43
    • 43049178128 scopus 로고    scopus 로고
    • Copy number alterations in childhood acute lymphoblastic leukemia and their association with minimal residual disease
    • Steinemann D, Cario G, Stanulla M, et al. Copy number alterations in childhood acute lymphoblastic leukemia and their association with minimal residual disease. Genes Chromosomes Cancer 2008;47:471-480.
    • (2008) Genes Chromosomes Cancer , vol.47 , pp. 471-480
    • Steinemann, D.1    Cario, G.2    Stanulla, M.3
  • 44
    • 75649131205 scopus 로고    scopus 로고
    • Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML
    • Carter BZ, Mak DH, Schober WD, et al. Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML. Blood 2010;115:306-314.
    • (2010) Blood , vol.115 , pp. 306-314
    • Carter, B.Z.1    Mak, D.H.2    Schober, W.D.3
  • 45
    • 65549139431 scopus 로고    scopus 로고
    • Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma
    • Vogler M, Walczak H, Stadel D, et al. Small molecule XIAP inhibitors enhance TRAIL-induced apoptosis and antitumor activity in preclinical models of pancreatic carcinoma. Cancer Res 2009;69:2425-2434.
    • (2009) Cancer Res , vol.69 , pp. 2425-2434
    • Vogler, M.1    Walczak, H.2    Stadel, D.3
  • 46
    • 38049160750 scopus 로고    scopus 로고
    • Small-molecule XIAP antagonist restores caspase-9-mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells
    • Cillessen SA, Reed JC, Welsh K, et al. Small-molecule XIAP antagonist restores caspase-9-mediated apoptosis in XIAP-positive diffuse large B-cell lymphoma cells. Blood 2008;111:369-375.
    • (2008) Blood , vol.111 , pp. 369-375
    • Cillessen, S.A.1    Reed, J.C.2    Welsh, K.3
  • 48
    • 0035037802 scopus 로고    scopus 로고
    • Characterization of XIAP-deficient mice
    • Harlin H, Reffey SB, Duckett CS, et al. Characterization of XIAP-deficient mice. Mol Cell Biol 2001;21:3604-3608.
    • (2001) Mol Cell Biol , vol.21 , pp. 3604-3608
    • Harlin, H.1    Reffey, S.B.2    Duckett, C.S.3
  • 49
    • 77949889993 scopus 로고    scopus 로고
    • Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis
    • Loeder S, Drensek A, Jeremias I, et al. Small molecule XIAP inhibitors sensitize childhood acute leukemia cells for CD95-induced apoptosis. Int J Cancer 2010;126:2216-2228.
    • (2010) Int J Cancer , vol.126 , pp. 2216-2228
    • Loeder, S.1    Drensek, A.2    Jeremias, I.3
  • 50
    • 85042587668 scopus 로고    scopus 로고
    • Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance
    • Fakler M, Loder S,Vogler M, et al. Small molecule XIAP inhibitors cooperate with TRAIL to induce apoptosis in childhood acute leukemia cells and overcome Bcl-2-mediated resistance. Blood 2009;8:1710-1722.
    • (2009) Blood , vol.8 , pp. 1710-1722
    • Fakler, M.1    Loder, S.2    Vogler, M.3


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