Design, synthesis, and evaluation of a potent, cell-permeable, conformationally constrained second mitochondria derived activator of caspase (Smac) mimetic

Journal of Medicinal Chemistry

Volumn 49, Issue 26, 2006, Pages 7916-7920

  Sun, Haiying ^a   Nikolovska Coleska, Zaneta ^a   Lu, Jianfeng ^a   Qiu, Su ^a   Yang, Chao Yie ^a   Gao, Wei ^a   Meagher, Jennifer ^b   Stuckey, Jeanne ^b   Wang, Shaomeng ^a  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 9; CASPASE 9 INHIBITOR; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE; SM 131; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING COMPETITION; CANCER CELL CULTURE; CELL DEATH; CELL GROWTH; CELL MEMBRANE PERMEABILITY; DRUG BINDING; DRUG CONFORMATION; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50;

AZEPINES; BINDING, COMPETITIVE; BREAST NEOPLASMS; CASPASE 3; CASPASE 9; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; ENZYME ACTIVATION; HETEROCYCLIC COMPOUNDS; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MITOCHONDRIA; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR MIMICRY; PROTEIN BINDING; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 33845919012     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061108d     Document Type: Article

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