Structure-based design, synthesis and biochemical testing of novel and potent Smac peptido-mimetics

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 3, 2005, Pages 793-797

  Sun, Haiying ^a   Nikolovska Coleska, Zaneta ^a   Chen, Jianyong ^a   Yang, Chao Yie ^a   Tomita, York ^b   Pan, Hongguang ^b   Yoshioka, Yoshiko ^b   Krajewski, Krzysztof ^c   Roller, Peter P ^c   Wang, Shaomeng ^a  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Peptido mimetics; Smac; XIAP

Indexed keywords

PEPTIDE; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE;

APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER CELL; CHEMICAL ANALYSIS; CONTROLLED STUDY; DRUG POTENCY; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; X RAY ANALYSIS;

BINDING SITES; CARRIER PROTEINS; DRUG DESIGN; HUMANS; HYDROPHOBICITY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAGNETIC RESONANCE SPECTROSCOPY; MITOCHONDRIAL PROTEINS; MODELS, MOLECULAR; MOLECULAR MIMICRY; PEPTIDES; PROTEIN BINDING; PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 19944434282     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.11.008     Document Type: Article

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