메뉴 건너뛰기




Volumn 11, Issue 10, 2011, Pages 1422-1432

The essential roles of Toll-like receptor signaling pathways in sterile inflammatory diseases

Author keywords

Autoimmunity; Ligands; Sterile inflammation; Toll like receptors

Indexed keywords

BETA INTERFERON; CPG OLIGODEOXYNUCLEOTIDE; HIGH MOBILITY GROUP B1 PROTEIN; INTERFERON REGULATORY FACTOR 3; MYELOID DIFFERENTIATION FACTOR 88; SMALL INTERFERING RNA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 11; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR ADAPTOR MOLECULE 2; TUMOR NECROSIS FACTOR ALPHA;

EID: 80053221916     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2011.04.026     Document Type: Review
Times cited : (86)

References (171)
  • 1
    • 20644450804 scopus 로고    scopus 로고
    • Negative regulation of toll-like receptor-mediated immune responses
    • DOI 10.1038/nri1630
    • F.Y. Liew, D. Xu, E.K. Brint, and L.A. O'Neill Negative regulation of Toll-like receptor-mediated immune responses Nat Rev Immunol 5 2005 446 458 (Pubitemid 40835033)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.6 , pp. 446-458
    • Liew, F.Y.1    Xu, D.2    Brint, E.K.3    O'Neill, L.A.J.4
  • 2
    • 12444341944 scopus 로고    scopus 로고
    • Toll-like receptors in innate immunity
    • K. Takeda, and S. Akira Toll-like receptors in innate immunity Int Immunol 17 2005 1 14
    • (2005) Int Immunol , vol.17 , pp. 1-14
    • Takeda, K.1    Akira, S.2
  • 3
    • 23044494509 scopus 로고    scopus 로고
    • The role of Toll-like receptor signalling in the pathogenesis of arthritis
    • DOI 10.1016/j.cellimm.2005.04.018, PII S0008874905000559, Molecular and Cellular Interactions in Chronic Inflamatory Autoimmune Diseases
    • F. Brentano, D. Kyburz, O. Schorr, R. Gay, and S. Gay The role of Toll-like receptor signalling in the pathogenesis of arthritis Cell Immunol 233 2005 90 96 (Pubitemid 41074060)
    • (2005) Cellular Immunology , vol.233 , Issue.2 , pp. 90-96
    • Brentano, F.1    Kyburz, D.2    Schorr, O.3    Gay, R.4    Gay, S.5
  • 5
    • 78649696296 scopus 로고    scopus 로고
    • Endogenous Toll-like receptor ligands and their biological significance
    • L. Yu, L. Wang, and S. Chen Endogenous Toll-like receptor ligands and their biological significance J Cell Mol Med 14 2010 2592 2603
    • (2010) J Cell Mol Med , vol.14 , pp. 2592-2603
    • Yu, L.1    Wang, L.2    Chen, S.3
  • 6
    • 34547788305 scopus 로고    scopus 로고
    • The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling
    • DOI 10.1189/jlb.1206750
    • F.J. Sheedy, and L.A. O'Neill The Troll in Toll: Mal and Tram as bridges for TLR2 and TLR4 signaling J Leukoc Biol 82 2007 196 203 (Pubitemid 47230627)
    • (2007) Journal of Leukocyte Biology , vol.82 , Issue.2 , pp. 196-203
    • Sheedy, F.J.1    O'Neill, L.A.J.2
  • 7
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • DOI 10.1016/j.cell.2006.02.015, PII S0092867406001905
    • S. Akira, S. Uematsu, and O. Takeuchi Pathogen recognition and innate immunity Cell 124 2006 783 801 (Pubitemid 43261452)
    • (2006) Cell , vol.124 , Issue.4 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 9
    • 33750542135 scopus 로고    scopus 로고
    • 'Toll' gates for future immunotherapy
    • K.J. Ishii, S. Uematsu, and S. Akira 'Toll' gates for future immunotherapy Curr Pharm Des 12 2006 4135 4142
    • (2006) Curr Pharm des , vol.12 , pp. 4135-4142
    • Ishii, K.J.1    Uematsu, S.2    Akira, S.3
  • 11
    • 75649087741 scopus 로고    scopus 로고
    • CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
    • C.R. Stewart, L.M. Stuart, K. Wilkinson, J.M. van Gils, J. Deng, and A. Halle CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer Nat Immunol 11 2010 155 161
    • (2010) Nat Immunol , vol.11 , pp. 155-161
    • Stewart, C.R.1    Stuart, L.M.2    Wilkinson, K.3    Van Gils, J.M.4    Deng, J.5    Halle, A.6
  • 12
    • 34548459868 scopus 로고    scopus 로고
    • Structure and function of Toll receptors and their ligands
    • N.J. Gay, and M. Gangloff Structure and function of Toll receptors and their ligands Annu Rev Biochem 76 2007 141 165
    • (2007) Annu Rev Biochem , vol.76 , pp. 141-165
    • Gay, N.J.1    Gangloff, M.2
  • 13
    • 30044442866 scopus 로고    scopus 로고
    • How Toll-like receptors signal: What we know and what we don't know
    • DOI 10.1016/j.coi.2005.11.012, PII S0952791505002050, Innate Immunity/Antigen Processing and Recognition
    • L.A. O'Neill How Toll-like receptors signal: what we know and what we don't know Curr Opin Immunol 18 2006 3 9 (Pubitemid 43049641)
    • (2006) Current Opinion in Immunology , vol.18 , Issue.1 , pp. 3-9
    • O'Neill, L.A.J.1
  • 14
    • 34548550594 scopus 로고    scopus 로고
    • Collaboration between the innate immune receptors dectin-1, TLRs, and Nods
    • DOI 10.1111/j.1600-065X.2007.00548.x
    • D.M. Underhill Collaboration between the innate immune receptors dectin-1, TLRs, and Nods Immunol Rev 219 2007 75 87 (Pubitemid 47390003)
    • (2007) Immunological Reviews , vol.219 , Issue.1 , pp. 75-87
    • Underhill, D.M.1
  • 15
    • 34548409654 scopus 로고    scopus 로고
    • Toll-like receptors in the brain and their potential roles in neuropathology
    • DOI 10.1038/sj.icb.7100103, PII 7100103
    • P.J. Crack, and P.J. Bray Toll-like receptors in the brain and their potential roles in neuropathology Immunol Cell Biol 85 2007 476 480 (Pubitemid 47367513)
    • (2007) Immunology and Cell Biology , vol.85 , Issue.6 , pp. 476-480
    • Crack, P.J.1    Bray, P.J.2
  • 16
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • S. Akira, and K. Takeda Toll-like receptor signalling Nat Rev Immunol 4 2004 499 511 (Pubitemid 38931765)
    • (2004) Nature Reviews Immunology , vol.4 , Issue.7 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 17
    • 34247566510 scopus 로고    scopus 로고
    • The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
    • DOI 10.1038/nri2079, PII NRI2079
    • L.A. O'Neill, and A.G. Bowie The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling Nat Rev Immunol 7 2007 353 364 (Pubitemid 46674493)
    • (2007) Nature Reviews Immunology , vol.7 , Issue.5 , pp. 353-364
    • O'Neill, L.A.J.1    Bowie, A.G.2
  • 19
    • 33947694370 scopus 로고    scopus 로고
    • TLR signaling
    • DOI 10.1016/j.smim.2006.12.004, PII S1044532306001242, TLR-Mediated Innate Immune Recognition
    • T. Kawai, and S. Akira TLR signaling Semin Immunol 19 2007 24 32 (Pubitemid 46498752)
    • (2007) Seminars in Immunology , vol.19 , Issue.1 , pp. 24-32
    • Kawai, T.1    Akira, S.2
  • 20
    • 0742324860 scopus 로고    scopus 로고
    • TLR signaling pathways
    • DOI 10.1016/j.smim.2003.10.003
    • K. Takeda, and S. Akira TLR signaling pathways Semin Immunol 16 2004 3 9 (Pubitemid 38147427)
    • (2004) Seminars in Immunology , vol.16 , Issue.1 , pp. 3-9
    • Takeda, K.1    Akira, S.2
  • 23
    • 5444262511 scopus 로고    scopus 로고
    • Toll-like receptor control of the adaptive immune responses
    • DOI 10.1038/ni1112
    • A. Iwasaki, and R. Medzhitov Toll-like receptor control of the adaptive immune responses Nat Immunol 5 2004 987 995 (Pubitemid 41057715)
    • (2004) Nature Immunology , vol.5 , Issue.10 , pp. 987-995
    • Iwasaki, A.1    Medzhitov, R.2
  • 24
    • 5444254408 scopus 로고    scopus 로고
    • Toll-like receptors in the pathogenesis of human disease
    • DOI 10.1038/ni1116
    • D.N. Cook, D.S. Pisetsky, and D.A. Schwartz Toll-like receptors in the pathogenesis of human disease Nat Immunol 5 2004 975 979 (Pubitemid 41057713)
    • (2004) Nature Immunology , vol.5 , Issue.10 , pp. 975-979
    • Cook, D.N.1    Pisetsky, D.S.2    Schwartz, D.A.3
  • 26
    • 34247881945 scopus 로고    scopus 로고
    • Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation
    • DOI 10.1016/j.imlet.2007.03.004, PII S0165247807000673
    • K.W. Kim, M.L. Cho, S.H. Lee, H.J. Oh, C.M. Kang, and J.H. Ju Human rheumatoid synovial fibroblasts promote osteoclastogenic activity by activating RANKL via TLR-2 and TLR-4 activation Immunol Lett 110 2007 54 64 (Pubitemid 46695759)
    • (2007) Immunology Letters , vol.110 , Issue.1 , pp. 54-64
    • Kim, K.-W.1    Cho, M.-L.2    Lee, S.-H.3    Oh, H.-J.4    Kang, C.-M.5    Ju, J.H.6    Min, S.-Y.7    Cho, Y.-G.8    Park, S.-H.9    Kim, H.-Y.10
  • 27
  • 28
    • 78650967552 scopus 로고    scopus 로고
    • Engagement of Toll-like receptor 3 induces vascular endothelial growth factor and interleukin-8 in human rheumatoid synovial fibroblasts
    • S.J. Moon, M.K. Park, H.J. Oh, S.Y. Lee, S.K. Kwok, and M.L. Cho Engagement of Toll-like receptor 3 induces vascular endothelial growth factor and interleukin-8 in human rheumatoid synovial fibroblasts Korean J Intern Med 25 2010 429 435
    • (2010) Korean J Intern Med , vol.25 , pp. 429-435
    • Moon, S.J.1    Park, M.K.2    Oh, H.J.3    Lee, S.Y.4    Kwok, S.K.5    Cho, M.L.6
  • 29
    • 77952483341 scopus 로고    scopus 로고
    • Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats
    • L. Meng, W. Zhu, C. Jiang, X. He, W. Hou, and F. Zheng Toll-like receptor 3 upregulation in macrophages participates in the initiation and maintenance of pristane-induced arthritis in rats Arthritis Res Ther 12 2010 R103
    • (2010) Arthritis Res Ther , vol.12 , pp. 103
    • Meng, L.1    Zhu, W.2    Jiang, C.3    He, X.4    Hou, W.5    Zheng, F.6
  • 30
    • 33244495503 scopus 로고    scopus 로고
    • Multiple toll-like receptor agonists act as potent adjuvants in the induction of autoimmunity
    • DOI 10.1016/j.jneuroim.2005.11.006, PII S0165572805004893
    • B.S. Hansen, R.Z. Hussain, A.E. Lovett-Racke, J.A. Thomas, and M.K. Racke Multiple Toll-like receptor agonists act as potent adjuvants in the induction of autoimmunity J Neuroimmunol 172 2006 94 103 (Pubitemid 43277494)
    • (2006) Journal of Neuroimmunology , vol.172 , Issue.1-2 , pp. 94-103
    • Hansen, B.S.1    Hussain, R.Z.2    Lovett-Racke, A.E.3    Thomas, J.A.4    Racke, M.K.5
  • 33
    • 33947697217 scopus 로고    scopus 로고
    • Synergistic interaction between Toll-like receptor agonists is required for induction of experimental autoimmune encephalomyelitis in Lewis rats
    • DOI 10.1016/j.jneuroim.2007.02.001, PII S0165572807000446
    • N.A. Wolf, T.K. Amouzegar, and R.H. Swanborg Synergistic interaction between Toll-like receptor agonists is required for induction of experimental autoimmune encephalomyelitis in Lewis rats J Neuroimmunol 185 2007 115 122 (Pubitemid 46497453)
    • (2007) Journal of Neuroimmunology , vol.185 , Issue.1-2 , pp. 115-122
    • Wolf, N.A.1    Amouzegar, T.K.2    Swanborg, R.H.3
  • 34
    • 33751571417 scopus 로고    scopus 로고
    • Cutting edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-β
    • T. Touil, D. Fitzgerald, G.X. Zhang, A. Rostami, and B. Gran Cutting edge: TLR3 stimulation suppresses experimental autoimmune encephalomyelitis by inducing endogenous IFN-beta J Immunol 177 2006 7505 7509 (Pubitemid 44846263)
    • (2006) Journal of Immunology , vol.177 , Issue.11 , pp. 7505-7509
    • Touil, T.1    Fitzgerald, D.2    Zhang, G.-X.3    Rostami, A.4    Gran, B.5
  • 37
    • 79953215626 scopus 로고    scopus 로고
    • Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: Relevance to therapeutic effects in models of multiple sclerosis
    • E.J. Downer, E. Clifford, B. Gran, H.J. Nel, P.G. Fallon, and P.N. Moynagh Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 (IRF3) activation and IFN-{beta} expression: relevance to therapeutic effects in models of multiple sclerosis J Biol Chem 286 2011 10316 10328
    • (2011) J Biol Chem , vol.286 , pp. 10316-10328
    • Downer, E.J.1    Clifford, E.2    Gran, B.3    Nel, H.J.4    Fallon, P.G.5    Moynagh, P.N.6
  • 38
    • 69049084375 scopus 로고    scopus 로고
    • Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE
    • M.F. Farez, F.J. Quintana, R. Gandhi, G. Izquierdo, M. Lucas, and H.L. Weiner Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE Nat Immunol 10 2009 958 964
    • (2009) Nat Immunol , vol.10 , pp. 958-964
    • Farez, M.F.1    Quintana, F.J.2    Gandhi, R.3    Izquierdo, G.4    Lucas, M.5    Weiner, H.L.6
  • 40
    • 33947204489 scopus 로고    scopus 로고
    • TLR ligands act directly upon T cells to restore proliferation in the absence of protein kinase C-θ signaling and promote autoimmune myocarditis
    • B.J. Marsland, C. Nembrini, K. Grun, R. Reissmann, M. Kurrer, and C. Leipner TLR ligands act directly upon T cells to restore proliferation in the absence of protein kinase C-theta signaling and promote autoimmune myocarditis J Immunol 178 2007 3466 3473 (Pubitemid 46417611)
    • (2007) Journal of Immunology , vol.178 , Issue.6 , pp. 3466-3473
    • Marsland, B.J.1    Nembrini, C.2    Grun, K.3    Reissmann, R.4    Kurrer, M.5    Leipner, C.6    Kopf, M.7
  • 41
    • 77952537201 scopus 로고    scopus 로고
    • Contribution of TLR7 and TLR9 signaling to the susceptibility of MyD88-deficient mice to myocarditis
    • P.P. Pagni, S. Traub, O. Demaria, L. Chasson, and L. Alexopoulou Contribution of TLR7 and TLR9 signaling to the susceptibility of MyD88-deficient mice to myocarditis Autoimmunity 43 2010 275 287
    • (2010) Autoimmunity , vol.43 , pp. 275-287
    • Pagni, P.P.1    Traub, S.2    Demaria, O.3    Chasson, L.4    Alexopoulou, L.5
  • 43
  • 45
    • 34247272370 scopus 로고    scopus 로고
    • Toll-like receptors: Emerging concepts in kidney disease
    • DOI 10.1097/MNH.0b013e32803fb767, PII 0004155220070500000002
    • H.J. Anders, and D. Schlondorff Toll-like receptors: emerging concepts in kidney disease Curr Opin Nephrol Hypertens 16 2007 177 183 (Pubitemid 46608524)
    • (2007) Current Opinion in Nephrology and Hypertension , vol.16 , Issue.3 , pp. 177-183
    • Anders, H.-J.1    Schlondorff, D.2
  • 47
    • 33745817481 scopus 로고    scopus 로고
    • Toll-like receptor 2 agonists exacerbate accelerated nephrotoxic nephritis
    • DOI 10.1681/ASN.2005111167
    • H.J. Brown, S.H. Sacks, and M.G. Robson Toll-like receptor 2 agonists exacerbate accelerated nephrotoxic nephritis J Am Soc Nephrol 17 2006 1931 1939 (Pubitemid 44036177)
    • (2006) Journal of the American Society of Nephrology , vol.17 , Issue.7 , pp. 1931-1939
    • Brown, H.J.1    Sacks, S.H.2    Robson, M.G.3
  • 48
    • 78649667341 scopus 로고    scopus 로고
    • Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis
    • S.A. Summers, B.S. van der Veen, K.M. O'Sullivan, P.Y. Gan, J.D. Ooi, and P. Heeringa Intrinsic renal cell and leukocyte-derived TLR4 aggravate experimental anti-MPO glomerulonephritis Kidney Int 78 2010 1263 1274
    • (2010) Kidney Int , vol.78 , pp. 1263-1274
    • Summers, S.A.1    Van Der Veen, B.S.2    O'Sullivan, K.M.3    Gan, P.Y.4    Ooi, J.D.5    Heeringa, P.6
  • 50
    • 34249915031 scopus 로고    scopus 로고
    • Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus
    • DOI 10.1681/ASN.2006101162
    • R.D. Pawar, A. Ramanjaneyulu, O.P. Kulkarni, M. Lech, S. Segerer, and H.J. Anders Inhibition of Toll-like receptor-7 (TLR-7) or TLR-7 plus TLR-9 attenuates glomerulonephritis and lung injury in experimental lupus J Am Soc Nephrol 18 2007 1721 1731 (Pubitemid 46870309)
    • (2007) Journal of the American Society of Nephrology , vol.18 , Issue.6 , pp. 1721-1731
    • Pawar, R.D.1    Ramanjaneyulu, A.2    Kulkarni, O.P.3    Lech, M.4    Segerer, S.5    Anders, H.-J.6
  • 51
    • 13444302229 scopus 로고    scopus 로고
    • Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB x NZW mice
    • DOI 10.1002/art.20810
    • L. Dong, S. Ito, K.J. Ishii, and D.M. Klinman Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB × NZW mice Arthritis Rheum 52 2005 651 658 (Pubitemid 40216332)
    • (2005) Arthritis and Rheumatism , vol.52 , Issue.2 , pp. 651-658
    • Dong, L.1    Ito, S.2    Ishii, K.J.3    Klinman, D.M.4
  • 52
    • 33748472865 scopus 로고    scopus 로고
    • Toll-like Receptor 7 and TLR9 Dictate Autoantibody Specificity and Have Opposing Inflammatory and Regulatory Roles in a Murine Model of Lupus
    • DOI 10.1016/j.immuni.2006.07.013, PII S1074761306003906
    • S.R. Christensen, J. Shupe, K. Nickerson, M. Kashgarian, R.A. Flavell, and M.J. Shlomchik Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus Immunity 25 2006 417 428 (Pubitemid 44354217)
    • (2006) Immunity , vol.25 , Issue.3 , pp. 417-428
    • Christensen, S.R.1    Shupe, J.2    Nickerson, K.3    Kashgarian, M.4    Flavell, RichardA.5    Shlomchik, M.J.6
  • 54
    • 31044440025 scopus 로고    scopus 로고
    • Toll-like receptor 9 signaling protects against murine lupus
    • DOI 10.1002/art.21553
    • X. Wu, and S.L. Peng Toll-like receptor 9 signaling protects against murine lupus Arthritis Rheum 54 2006 336 342 (Pubitemid 43122217)
    • (2006) Arthritis and Rheumatism , vol.54 , Issue.1 , pp. 336-342
    • Wu, X.1    Peng, S.L.2
  • 56
    • 78149298238 scopus 로고    scopus 로고
    • Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis
    • S.A. Summers, O.M. Steinmetz, J.D. Ooi, P.Y. Gan, K.M. O'Sullivan, and K. Visvanathan Toll-like receptor 9 enhances nephritogenic immunity and glomerular leukocyte recruitment, exacerbating experimental crescentic glomerulonephritis Am J Pathol 177 2010 2234 2244
    • (2010) Am J Pathol , vol.177 , pp. 2234-2244
    • Summers, S.A.1    Steinmetz, O.M.2    Ooi, J.D.3    Gan, P.Y.4    O'Sullivan, K.M.5    Visvanathan, K.6
  • 60
    • 33745168605 scopus 로고    scopus 로고
    • Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication
    • DOI 10.1126/science.1124978
    • P. Pisitkun, J.A. Deane, M.J. Difilippantonio, T. Tarasenko, A.B. Satterthwaite, and S. Bolland Autoreactive B cell responses to RNA-related antigens due to TLR7 gene duplication Science 312 2006 1669 1672 (Pubitemid 43902669)
    • (2006) Science , vol.312 , Issue.5780 , pp. 1669-1672
    • Pisitkun, P.1    Deane, J.A.2    Difilippantonio, M.J.3    Tarasenko, T.4    Satterthwaite, A.B.5    Bolland, S.6
  • 62
    • 33645076274 scopus 로고    scopus 로고
    • TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE
    • M. Ehlers, H. Fukuyama, T.L. McGaha, A. Aderem, and J.V. Ravetch TLR9/MyD88 signaling is required for class switching to pathogenic IgG2a and 2b autoantibodies in SLE J Exp Med 203 2006 553 561
    • (2006) J Exp Med , vol.203 , pp. 553-561
    • Ehlers, M.1    Fukuyama, H.2    McGaha, T.L.3    Aderem, A.4    Ravetch, J.V.5
  • 64
    • 38649129409 scopus 로고    scopus 로고
    • Toll-like receptor 9 in murine lupus: More friend than foe!
    • DOI 10.1016/j.imbio.2007.08.002, PII S0171298507000927
    • P. Yu, P. Musette, and S.L. Peng Toll-like receptor 9 in murine lupus: more friend than foe! Immunobiology 213 2008 151 157 (Pubitemid 351164231)
    • (2008) Immunobiology , vol.213 , Issue.2 , pp. 151-157
    • Yu, P.1    Musette, P.2    Peng, S.L.3
  • 66
    • 33846597964 scopus 로고    scopus 로고
    • Opposing effects of Toll-like receptor stimulation induce autoimmunity or tolerance
    • DOI 10.1016/j.it.2006.12.006, PII S1471490606003528
    • M. Ehlers, and J.V. Ravetch Opposing effects of Toll-like receptor stimulation induce autoimmunity or tolerance Trends Immunol 28 2007 74 79 (Pubitemid 46176735)
    • (2007) Trends in Immunology , vol.28 , Issue.2 , pp. 74-79
    • Ehlers, M.1    Ravetch, J.V.2
  • 67
    • 4043060025 scopus 로고    scopus 로고
    • A vitamin D analog down-regulates proinflammatory chemokine production by pancreatic islets inhibiting T cell recruitment and type 1 diabetes development
    • N. Giarratana, G. Penna, S. Amuchastegui, R. Mariani, K.C. Daniel, and L. Adorini A vitamin D analog down-regulates proinflammatory chemokine production by pancreatic islets inhibiting T cell recruitment and type 1 diabetes development J Immunol 173 2004 2280 2287 (Pubitemid 39063083)
    • (2004) Journal of Immunology , vol.173 , Issue.4 , pp. 2280-2287
    • Giarratana, N.1    Penna, G.2    Amuchastegui, S.3    Mariani, R.4    Daniel, K.C.5    Adorini, L.6
  • 68
    • 22644447473 scopus 로고    scopus 로고
    • Toll-like receptor 3 gene polymorphisms in South African blacks with type 1 diabetes
    • DOI 10.1111/j.1399-0039.2005.00454.x
    • F.J. Pirie, R. Pegoraro, A.A. Motala, S. Rauff, L. Rom, and T. Govender Toll-like receptor 3 gene polymorphisms in South African Blacks with type 1 diabetes Tissue Antigens 66 2005 125 130 (Pubitemid 41025934)
    • (2005) Tissue Antigens , vol.66 , Issue.2 , pp. 125-130
    • Pirie, F.J.1    Pegoraro, R.2    Motala, A.A.3    Rauff, S.4    Rom, L.5    Govender, T.6    Esterhuizen, T.M.7
  • 69
    • 0035879105 scopus 로고    scopus 로고
    • Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice
    • J. Tian, D. Zekzer, L. Hanssen, Y. Lu, A. Olcott, and D.L. Kaufman Lipopolysaccharide-activated B cells down-regulate Th1 immunity and prevent autoimmune diabetes in nonobese diabetic mice J Immunol 167 2001 1081 1089 (Pubitemid 32660868)
    • (2001) Journal of Immunology , vol.167 , Issue.2 , pp. 1081-1089
    • Tian, J.1    Zekzer, D.2    Hanssen, L.3    Lu, Y.4    Olcott, A.5    Kaufman, D.L.6
  • 70
    • 0037111430 scopus 로고    scopus 로고
    • DNA vaccination with heat shock protein 60 inhibits cyclophosphamide- accelerated diabetes
    • F.J. Quintana, P. Carmi, and I.R. Cohen DNA vaccination with heat shock protein 60 inhibits cyclophosphamide-accelerated diabetes J Immunol 169 2002 6030 6035 (Pubitemid 35291711)
    • (2002) Journal of Immunology , vol.169 , Issue.10 , pp. 6030-6035
    • Quintana, F.J.1    Carmi, P.2    Cohen, I.R.3
  • 71
    • 67650682810 scopus 로고    scopus 로고
    • Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes
    • S. Devaraj, M.R. Dasu, S.H. Park, and I. Jialal Increased levels of ligands of Toll-like receptors 2 and 4 in type 1 diabetes Diabetologia 52 2009 1665 1668
    • (2009) Diabetologia , vol.52 , pp. 1665-1668
    • Devaraj, S.1    Dasu, M.R.2    Park, S.H.3    Jialal, I.4
  • 72
    • 78751650117 scopus 로고    scopus 로고
    • Demonstration of increased Toll-like receptor 2 and Toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications
    • S. Devaraj, I. Jialal, J.M. Yun, and A. Bremer Demonstration of increased Toll-like receptor 2 and Toll-like receptor 4 expression in monocytes of type 1 diabetes mellitus patients with microvascular complications Metabolism 60 2011 256 259
    • (2011) Metabolism , vol.60 , pp. 256-259
    • Devaraj, S.1    Jialal, I.2    Yun, J.M.3    Bremer, A.4
  • 73
    • 77955653584 scopus 로고    scopus 로고
    • Toll-like receptors regulate B cell cytokine production in patients with diabetes
    • M. Jagannathan, M. McDonnell, Y. Liang, H. Hasturk, J. Hetzel, and D. Rubin Toll-like receptors regulate B cell cytokine production in patients with diabetes Diabetologia 53 2010 1461 1471
    • (2010) Diabetologia , vol.53 , pp. 1461-1471
    • Jagannathan, M.1    McDonnell, M.2    Liang, Y.3    Hasturk, H.4    Hetzel, J.5    Rubin, D.6
  • 74
    • 57549113882 scopus 로고    scopus 로고
    • Advanced glycation end-product of low density lipoprotein activates the Toll-like 4 receptor pathway implications for diabetic atherosclerosis
    • C.P. Hodgkinson, R.C. Laxton, K. Patel, and S. Ye Advanced glycation end-product of low density lipoprotein activates the Toll-like 4 receptor pathway implications for diabetic atherosclerosis Arterioscler Thromb Vasc Biol 28 2008 2275 2281
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 2275-2281
    • Hodgkinson, C.P.1    Laxton, R.C.2    Patel, K.3    Ye, S.4
  • 75
    • 78650137830 scopus 로고    scopus 로고
    • Enhanced inflammatory responses to Toll-like receptor 2/4 stimulation in type 1 diabetic coronary artery endothelial cells: The effect of insulin
    • J. Li, C. Jin, J.C. Cleveland Jr., L. Ao, D. Xu, and D.A. Fullerton Enhanced inflammatory responses to Toll-like receptor 2/4 stimulation in type 1 diabetic coronary artery endothelial cells: the effect of insulin Cardiovasc Diabetol 9 2010 90
    • (2010) Cardiovasc Diabetol , vol.9 , pp. 90
    • Li, J.1    Jin, C.2    Cleveland Jr., J.C.3    Ao, L.4    Xu, D.5    Fullerton, D.A.6
  • 76
    • 77955369313 scopus 로고    scopus 로고
    • Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice
    • A. Aumeunier, F. Grela, A. Ramadan, L. Pham Van, E. Bardel, and A. Gomez Alcala Systemic Toll-like receptor stimulation suppresses experimental allergic asthma and autoimmune diabetes in NOD mice PLoS One 5 2010 e11484
    • (2010) PLoS One , vol.5 , pp. 11484
    • Aumeunier, A.1    Grela, F.2    Ramadan, A.3    Van, P.L.4    Bardel, E.5    Gomez Alcala, A.6
  • 80
    • 0035997390 scopus 로고    scopus 로고
    • Th1 and Th2 responses in pathogenesis and regulation of experimental autoimmune uveoretinitis
    • DOI 10.1080/08830180212063
    • R.R. Caspi Th1 and Th2 responses in pathogenesis and regulation of experimental autoimmune uveoretinitis Int Rev Immunol 21 2002 197 208 (Pubitemid 34791940)
    • (2002) International Reviews of Immunology , vol.21 , Issue.2-3 , pp. 197-208
    • Caspi, R.R.1
  • 81
    • 33746035677 scopus 로고    scopus 로고
    • Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways
    • DOI 10.1016/j.exphem.2006.04.025, PII S0301472X06003067
    • Z.Y. Wang, D. Yang, Q. Chen, C.A. Leifer, D.M. Segal, and S.B. Su Induction of dendritic cell maturation by pertussis toxin and its B subunit differentially initiate Toll-like receptor 4-dependent signal transduction pathways Exp Hematol 34 2006 1115 1124 (Pubitemid 44080388)
    • (2006) Experimental Hematology , vol.34 , Issue.8 , pp. 1115-1124
    • Wang, Z.Y.1    Yang, D.2    Chen, Q.3    Leifer, C.A.4    Segal, D.M.5    Su, S.B.6    Caspi, R.R.7    Howard, Z.O.M.8    Oppenheim, J.J.9
  • 82
    • 0042430414 scopus 로고    scopus 로고
    • Dissociating the enhancing and inhibitory effects of pertussis toxin on autoimmune disease
    • S.B. Su, P.B. Silver, P. Wang, C.C. Chan, and R.R. Caspi Dissociating the enhancing and inhibitory effects of pertussis toxin on autoimmune disease J Immunol 171 2003 2314 2319 (Pubitemid 37025536)
    • (2003) Journal of Immunology , vol.171 , Issue.5 , pp. 2314-2319
    • Su, S.B.1    Silver, P.B.2    Wang, P.3    Chan, C.-C.4    Caspi, R.R.5
  • 83
    • 0035399951 scopus 로고    scopus 로고
    • Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals
    • S.B. Su, P.B. Silver, M. Zhang, C.C. Chan, and R.R. Caspi Pertussis toxin inhibits induction of tissue-specific autoimmune disease by disrupting G protein-coupled signals J Immunol 167 2001 250 256 (Pubitemid 32567785)
    • (2001) Journal of Immunology , vol.167 , Issue.1 , pp. 250-256
    • Su, S.B.1    Silver, P.B.2    Zhang, M.3    Chan, C.-C.4    Caspi, R.R.5
  • 84
    • 77953246527 scopus 로고    scopus 로고
    • The role of TLR2, TRL3, TRL4, and TRL9 signaling in the pathogenesis of autoimmune disease in a retinal autoimmunity model
    • J. Fang, D. Fang, P.B. Silver, F. Wen, B. Li, and X. Ren The role of TLR2, TRL3, TRL4, and TRL9 signaling in the pathogenesis of autoimmune disease in a retinal autoimmunity model Invest Ophthalmol Vis Sci 51 2010 3092 3099
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 3092-3099
    • Fang, J.1    Fang, D.2    Silver, P.B.3    Wen, F.4    Li, B.5    Ren, X.6
  • 85
    • 79955870871 scopus 로고    scopus 로고
    • Toll-like receptor 3 ligand polyinosinic:polycytidylic acid enhances autoimmune disease in a retinal autoimmunity model
    • X. Ren, H. Zhou, B. Li, and S.B. Su Toll-like receptor 3 ligand polyinosinic:polycytidylic acid enhances autoimmune disease in a retinal autoimmunity model Int Immunopharmacol 11 2011 769 773
    • (2011) Int Immunopharmacol , vol.11 , pp. 769-773
    • Ren, X.1    Zhou, H.2    Li, B.3    Su, S.B.4
  • 86
    • 27744497439 scopus 로고    scopus 로고
    • Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity
    • S.B. Su, P.B. Silver, R.S. Grajewski, R.K. Agarwal, J. Tang, and C.C. Chan Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity J Immunol 175 2005 6303 6310 (Pubitemid 41598869)
    • (2005) Journal of Immunology , vol.175 , Issue.10 , pp. 6303-6310
    • Su, S.B.1    Silver, P.B.2    Grajewski, R.S.3    Agarwal, R.K.4    Tang, J.5    Chan, C.-C.6    Caspi, R.R.7
  • 88
    • 65249123400 scopus 로고    scopus 로고
    • Expression of Toll-like receptor 4 in uvea-resident tissue macrophages during endotoxin-induced uveitis
    • W. Chen, X. Hu, L. Zhao, S. Li, and H. Lu Expression of Toll-like receptor 4 in uvea-resident tissue macrophages during endotoxin-induced uveitis Mol Vis 15 2009 619 628
    • (2009) Mol Vis , vol.15 , pp. 619-628
    • Chen, W.1    Hu, X.2    Zhao, L.3    Li, S.4    Lu, H.5
  • 90
    • 77955716367 scopus 로고    scopus 로고
    • Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury
    • S. Ben Mkaddem, E. Pedruzzi, C. Werts, N. Coant, M. Bens, and F. Cluzeaud Heat shock protein gp96 and NAD(P)H oxidase 4 play key roles in Toll-like receptor 4-activated apoptosis during renal ischemia/reperfusion injury Cell Death Differ 17 2010 1474 1485
    • (2010) Cell Death Differ , vol.17 , pp. 1474-1485
    • Ben Mkaddem, S.1    Pedruzzi, E.2    Werts, C.3    Coant, N.4    Bens, M.5    Cluzeaud, F.6
  • 93
    • 72449200580 scopus 로고    scopus 로고
    • Hemorrhagic shock augments lung endothelial cell activation: Role of temporal alterations of TLR4 and TLR2
    • Y. Li, M. Xiang, Y. Yuan, G. Xiao, J. Zhang, and Y. Jiang Hemorrhagic shock augments lung endothelial cell activation: role of temporal alterations of TLR4 and TLR2 Am J Physiol Regul Integr Comp Physiol 297 2009 R1670 R1680
    • (2009) Am J Physiol Regul Integr Comp Physiol , vol.297
    • Li, Y.1    Xiang, M.2    Yuan, Y.3    Xiao, G.4    Zhang, J.5    Jiang, Y.6
  • 94
    • 77956405894 scopus 로고    scopus 로고
    • High-mobility group box 1 promotes metalloproteinase-9 upregulation through Toll-like receptor 4 after cerebral ischemia
    • J. Qiu, J. Xu, Y. Zheng, Y. Wei, X. Zhu, and E.H. Lo High-mobility group box 1 promotes metalloproteinase-9 upregulation through Toll-like receptor 4 after cerebral ischemia Stroke 41 2010 2077 2082
    • (2010) Stroke , vol.41 , pp. 2077-2082
    • Qiu, J.1    Xu, J.2    Zheng, Y.3    Wei, Y.4    Zhu, X.5    Lo, E.H.6
  • 95
    • 77949315708 scopus 로고    scopus 로고
    • The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway
    • H. Xu, Z. Su, J. Wu, M. Yang, J.M. Penninger, and C.M. Martin The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase gamma pathway J Immunol 184 2010 1492 1498
    • (2010) J Immunol , vol.184 , pp. 1492-1498
    • Xu, H.1    Su, Z.2    Wu, J.3    Yang, M.4    Penninger, J.M.5    Martin, C.M.6
  • 96
    • 76849099915 scopus 로고    scopus 로고
    • Dendritic cell activation in response to ischemia-reperfusion injury of the small intestine
    • S. Hagiwara, H. Iwasaka, A. Hasegawa, N. Asai, T. Uchida, and T. Noguchi Dendritic cell activation in response to ischemia-reperfusion injury of the small intestine Surg Today 40 2010 137 145
    • (2010) Surg Today , vol.40 , pp. 137-145
    • Hagiwara, S.1    Iwasaka, H.2    Hasegawa, A.3    Asai, N.4    Uchida, T.5    Noguchi, T.6
  • 97
    • 62549100072 scopus 로고    scopus 로고
    • Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation
    • B. Kruger, S. Krick, N. Dhillon, S.M. Lerner, S. Ames, and J.S. Bromberg Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation Proc Natl Acad Sci U S A 106 2009 3390 3395
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 3390-3395
    • Kruger, B.1    Krick, S.2    Dhillon, N.3    Lerner, S.M.4    Ames, S.5    Bromberg, J.S.6
  • 98
    • 67649613033 scopus 로고    scopus 로고
    • Mechanisms of Toll-like receptor 4 (TLR4)-mediated inflammation after cold ischemia/reperfusion in the heart
    • D.J. Kaczorowski, A. Nakao, R. Vallabhaneni, K.P. Mollen, R. Sugimoto, and J. Kohmoto Mechanisms of Toll-like receptor 4 (TLR4)-mediated inflammation after cold ischemia/reperfusion in the heart Transplantation 87 2009 1455 1463
    • (2009) Transplantation , vol.87 , pp. 1455-1463
    • Kaczorowski, D.J.1    Nakao, A.2    Vallabhaneni, R.3    Mollen, K.P.4    Sugimoto, R.5    Kohmoto, J.6
  • 99
    • 79551627378 scopus 로고    scopus 로고
    • HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling
    • Q.W. Yang, F.L. Lu, Y. Zhou, L. Wang, Q. Zhong, and S. Lin HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling J Cereb Blood Flow Metab 31 2011 593 605
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 593-605
    • Yang, Q.W.1    Lu, F.L.2    Zhou, Y.3    Wang, L.4    Zhong, Q.5    Lin, S.6
  • 100
    • 70349947384 scopus 로고    scopus 로고
    • Toll-like receptor 4-mediated myeloid differentiation factor 88-dependent signaling pathway is activated by cerebral ischemia-reperfusion in hippocampal CA1 region in mice
    • Y. Gao, X. Fang, H. Sun, Y. Wang, L.J. Yao, and J.P. Li Toll-like receptor 4-mediated myeloid differentiation factor 88-dependent signaling pathway is activated by cerebral ischemia-reperfusion in hippocampal CA1 region in mice Biol Pharm Bull 32 2009 1665 1671
    • (2009) Biol Pharm Bull , vol.32 , pp. 1665-1671
    • Gao, Y.1    Fang, X.2    Sun, H.3    Wang, Y.4    Yao, L.J.5    Li, J.P.6
  • 101
    • 77957858212 scopus 로고    scopus 로고
    • Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia
    • K. Hyakkoku, J. Hamanaka, K. Tsuruma, M. Shimazawa, H. Tanaka, and S. Uematsu Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia Neuroscience 171 2010 258 267
    • (2010) Neuroscience , vol.171 , pp. 258-267
    • Hyakkoku, K.1    Hamanaka, J.2    Tsuruma, K.3    Shimazawa, M.4    Tanaka, H.5    Uematsu, S.6
  • 102
    • 61849088960 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in mice
    • F. Hua, J. Ma, T. Ha, J.L. Kelley, R.L. Kao, and J.B. Schweitzer Differential roles of TLR2 and TLR4 in acute focal cerebral ischemia/reperfusion injury in mice Brain Res 1262 2009 100 108
    • (2009) Brain Res , vol.1262 , pp. 100-108
    • Hua, F.1    Ma, J.2    Ha, T.3    Kelley, J.L.4    Kao, R.L.5    Schweitzer, J.B.6
  • 103
    • 70350551801 scopus 로고    scopus 로고
    • Toll-like receptor 4 is a key mediator of murine steatotic liver warm ischemia/reperfusion injury
    • J.D. Ellett, Z.P. Evans, C. Atkinson, M.G. Schmidt, R.G. Schnellmann, and K.D. Chavin Toll-like receptor 4 is a key mediator of murine steatotic liver warm ischemia/reperfusion injury Liver Transpl 15 2009 1101 1109
    • (2009) Liver Transpl , vol.15 , pp. 1101-1109
    • Ellett, J.D.1    Evans, Z.P.2    Atkinson, C.3    Schmidt, M.G.4    Schnellmann, R.G.5    Chavin, K.D.6
  • 104
    • 78649703973 scopus 로고    scopus 로고
    • T-cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner
    • Y. Uchida, B. Ke, M.C. Freitas, H. Yagita, H. Akiba, and R.W. Busuttil T-cell immunoglobulin mucin-3 determines severity of liver ischemia/reperfusion injury in mice in a TLR4-dependent manner Gastroenterology 139 2010 2195 2206
    • (2010) Gastroenterology , vol.139 , pp. 2195-2206
    • Uchida, Y.1    Ke, B.2    Freitas, M.C.3    Yagita, H.4    Akiba, H.5    Busuttil, R.W.6
  • 105
    • 79952175742 scopus 로고    scopus 로고
    • Interferon regulatory factor-1 mediates acetylation and release of high mobility group box-1 from hepatocytes during murine liver ischemia-reperfusion injury
    • R. Dhupar, J.R. Klune, J. Evankovich, J. Cardinal, M. Zhang, M. Ross, N. Murase, D.A. Geller, T.R. Billiar, and A. Tsung Interferon regulatory factor-1 mediates acetylation and release of high mobility group box-1 from hepatocytes during murine liver ischemia-reperfusion injury Shock 35 2011 293 301
    • (2011) Shock , vol.35 , pp. 293-301
    • Dhupar, R.1    Klune, J.R.2    Evankovich, J.3    Cardinal, J.4    Zhang, M.5    Ross, M.6    Murase, N.7    Geller, D.A.8    Billiar, T.R.9    Tsung, A.10
  • 106
    • 77953736637 scopus 로고    scopus 로고
    • Protective effects of Toll-like receptor 4 inhibitor eritoran on renal ischemia-reperfusion injury
    • M. Liu, M. Gu, D. Xu, Q. Lv, W. Zhang, and Y. Wu Protective effects of Toll-like receptor 4 inhibitor eritoran on renal ischemia-reperfusion injury Transplant Proc 42 2010 1539 1544
    • (2010) Transplant Proc , vol.42 , pp. 1539-1544
    • Liu, M.1    Gu, M.2    Xu, D.3    Lv, Q.4    Zhang, W.5    Wu, Y.6
  • 107
    • 77953823158 scopus 로고    scopus 로고
    • Toll-like receptor 4 is protective against neonatal murine ischemia-reperfusion intestinal injury
    • P.M. Tatum Jr., C.M. Harmon, R.G. Lorenz, and R.A. Dimmitt Toll-like receptor 4 is protective against neonatal murine ischemia-reperfusion intestinal injury J Pediatr Surg 45 2010 1246 1255
    • (2010) J Pediatr Surg , vol.45 , pp. 1246-1255
    • Tatum Jr., P.M.1    Harmon, C.M.2    Lorenz, R.G.3    Dimmitt, R.A.4
  • 110
    • 79851515594 scopus 로고    scopus 로고
    • Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury
    • M. Lv, Y. Liu, J. Zhang, L. Sun, Z. Liu, S. Zhang, B. Wang, D. Su, and Z. Su Roles of inflammation response in microglia cell through Toll-like receptors 2/interleukin-23/interleukin-17 pathway in cerebral ischemia/reperfusion injury Neuroscience 176 2011 162 172
    • (2011) Neuroscience , vol.176 , pp. 162-172
    • Lv, M.1    Liu, Y.2    Zhang, J.3    Sun, L.4    Liu, Z.5    Zhang, S.6    Wang, B.7    Su, D.8    Su, Z.9
  • 111
    • 77951767694 scopus 로고    scopus 로고
    • Key role of CD36 in Toll-like receptor 2 signaling in cerebral ischemia
    • T. Abe, M. Shimamura, K. Jackman, H. Kurinami, J. Anrather, and P. Zhou Key role of CD36 in Toll-like receptor 2 signaling in cerebral ischemia Stroke 41 2010 898 904
    • (2010) Stroke , vol.41 , pp. 898-904
    • Abe, T.1    Shimamura, M.2    Jackman, K.3    Kurinami, H.4    Anrather, J.5    Zhou, P.6
  • 112
    • 77249096344 scopus 로고    scopus 로고
    • Preconditioning by Toll-like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia/reperfusion injury
    • J. Mersmann, R. Berkels, P. Zacharowski, N. Tran, A. Koch, and K. Iekushi Preconditioning by Toll-like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia/reperfusion injury Crit Care Med 38 2010 903 909
    • (2010) Crit Care Med , vol.38 , pp. 903-909
    • Mersmann, J.1    Berkels, R.2    Zacharowski, P.3    Tran, N.4    Koch, A.5    Iekushi, K.6
  • 113
    • 77951804977 scopus 로고    scopus 로고
    • Toll-like receptor 2 mediates mesenchymal stem cell-associated myocardial recovery and VEGF production following acute ischemia-reperfusion injury
    • A.M. Abarbanell, Y. Wang, J.L. Herrmann, B.R. Weil, J.A. Poynter, and M.C. Manukyan Toll-like receptor 2 mediates mesenchymal stem cell-associated myocardial recovery and VEGF production following acute ischemia-reperfusion injury Am J Physiol Heart Circ Physiol 298 2010 H1529 H1536
    • (2010) Am J Physiol Heart Circ Physiol , vol.298
    • Abarbanell, A.M.1    Wang, Y.2    Herrmann, J.L.3    Weil, B.R.4    Poynter, J.A.5    Manukyan, M.C.6
  • 114
    • 79151476348 scopus 로고    scopus 로고
    • Left ventricular dilation in Toll-like receptor 2 deficient mice after myocardial ischemia/reperfusion through defective scar formation
    • J. Mersmann, K. Habeck, K. Latsch, R. Zimmermann, C. Jacoby, and J.W. Fischer Left ventricular dilation in Toll-like receptor 2 deficient mice after myocardial ischemia/reperfusion through defective scar formation Basic Res Cardiol 106 2011 89 98
    • (2011) Basic Res Cardiol , vol.106 , pp. 89-98
    • Mersmann, J.1    Habeck, K.2    Latsch, K.3    Zimmermann, R.4    Jacoby, C.5    Fischer, J.W.6
  • 115
    • 77957231123 scopus 로고    scopus 로고
    • Toll-like receptor 2 signaling triggers fatal arrhythmias upon myocardial ischemia-reperfusion
    • J. Mersmann, A. Koch, N. Tran, R. Zimmermann, T.F. Granja, and J. Larmann Toll-like receptor 2 signaling triggers fatal arrhythmias upon myocardial ischemia-reperfusion Crit Care Med 38 2010 1927 1932
    • (2010) Crit Care Med , vol.38 , pp. 1927-1932
    • Mersmann, J.1    Koch, A.2    Tran, N.3    Zimmermann, R.4    Granja, T.F.5    Larmann, J.6
  • 116
    • 74549178528 scopus 로고    scopus 로고
    • Myocardial ischemia/reperfusion injury is mediated by leukocytic Toll-like receptor-2 and reduced by systemic administration of a novel anti-Toll-like receptor-2 antibody
    • F. Arslan, M.B. Smeets, L.A. O'Neill, B. Keogh, P. McGuirk, and L. Timmers Myocardial ischemia/reperfusion injury is mediated by leukocytic Toll-like receptor-2 and reduced by systemic administration of a novel anti-Toll-like receptor-2 antibody Circulation 121 2011 80 90
    • (2011) Circulation , vol.121 , pp. 80-90
    • Arslan, F.1    Smeets, M.B.2    O'Neill, L.A.3    Keogh, B.4    McGuirk, P.5    Timmers, L.6
  • 118
  • 119
    • 38349014249 scopus 로고    scopus 로고
    • Wound healing is impaired in MyD88-deficient mice: A role for MyD88 in the regulation of wound healing by adenosine A2A receptors
    • L. Macedo, G. Pinhal-Enfield, V. Alshits, G. Elson, B.N. Cronstein, and S.J. Leibovich Wound healing is impaired in MyD88-deficient mice: a role for MyD88 in the regulation of wound healing by adenosine A2A receptors Am J Pathol 171 2007 1774 1788
    • (2007) Am J Pathol , vol.171 , pp. 1774-1788
    • MacEdo, L.1    Pinhal-Enfield, G.2    Alshits, V.3    Elson, G.4    Cronstein, B.N.5    Leibovich, S.J.6
  • 120
    • 78049337495 scopus 로고    scopus 로고
    • TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice
    • M.R. Dasu, R.K. Thangappan, A. Bourgette, L.A. DiPietro, R. Isseroff, and I. Jialal TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice Lab Invest 90 2010 1628 1636
    • (2010) Lab Invest , vol.90 , pp. 1628-1636
    • Dasu, M.R.1    Thangappan, R.K.2    Bourgette, A.3    Dipietro, L.A.4    Isseroff, R.5    Jialal, I.6
  • 121
    • 78349239324 scopus 로고    scopus 로고
    • Accelerated wound healing mediated by activation of Toll-like receptor 9
    • T. Sato, M. Yamamoto, T. Shimosato, and D.M. Klinman Accelerated wound healing mediated by activation of Toll-like receptor 9 Wound Repair Regen 18 2010 586 593
    • (2010) Wound Repair Regen , vol.18 , pp. 586-593
    • Sato, T.1    Yamamoto, M.2    Shimosato, T.3    Klinman, D.M.4
  • 122
    • 78650409670 scopus 로고    scopus 로고
    • Plasmacytoid dendritic cells sense skin injury and promote wound healing through type i interferons
    • J. Gregorio, S. Meller, C. Conrad, A. Di Nardo, B. Homey, and A. Lauerma Plasmacytoid dendritic cells sense skin injury and promote wound healing through type I interferons J Exp Med 207 2010 2921 2930
    • (2010) J Exp Med , vol.207 , pp. 2921-2930
    • Gregorio, J.1    Meller, S.2    Conrad, C.3    Di Nardo, A.4    Homey, B.5    Lauerma, A.6
  • 123
    • 71549150339 scopus 로고    scopus 로고
    • Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury
    • Y. Lai, A. Di Nardo, T. Nakatsuji, A. Leichtle, Y. Yang, and A.L. Cogen Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury Nat Med 15 2009 1377 1382
    • (2009) Nat Med , vol.15 , pp. 1377-1382
    • Lai, Y.1    Di Nardo, A.2    Nakatsuji, T.3    Leichtle, A.4    Yang, Y.5    Cogen, A.L.6
  • 124
    • 79953167155 scopus 로고    scopus 로고
    • Impaired wound healing with defective expression of chemokines and recruitment of myeloid cells in TLR3-deficient mice
    • Q. Lin, D. Fang, J. Fang, X. Ren, X. Yang, F. Wen, and S.B. Su Impaired wound healing with defective expression of chemokines and recruitment of myeloid cells in TLR3-deficient mice J Immunol 186 2011 3710 3717
    • (2011) J Immunol , vol.186 , pp. 3710-3717
    • Lin, Q.1    Fang, D.2    Fang, J.3    Ren, X.4    Yang, X.5    Wen, F.6    Su, S.B.7
  • 126
    • 79960091121 scopus 로고    scopus 로고
    • Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis
    • M. Fukata, L. Shang, R. Santaolalla, J. Sotolongo, C. Pastorini, and C. Espana Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis Inflamm Bowel Dis 2010
    • (2010) Inflamm Bowel Dis
    • Fukata, M.1    Shang, L.2    Santaolalla, R.3    Sotolongo, J.4    Pastorini, C.5    Espana, C.6
  • 127
    • 77956245973 scopus 로고    scopus 로고
    • Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury
    • D. Hsu, M. Fukata, Y.G. Hernandez, J.P. Sotolongo, T. Goo, and J. Maki Toll-like receptor 4 differentially regulates epidermal growth factor-related growth factors in response to intestinal mucosal injury Lab Invest 90 2010 1295 1305
    • (2010) Lab Invest , vol.90 , pp. 1295-1305
    • Hsu, D.1    Fukata, M.2    Hernandez, Y.G.3    Sotolongo, J.P.4    Goo, T.5    Maki, J.6
  • 128
    • 67649231565 scopus 로고    scopus 로고
    • Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency
    • D.K. Podolsky, G. Gerken, A. Eyking, and E. Cario Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency Gastroenterology 137 2009 209 220
    • (2009) Gastroenterology , vol.137 , pp. 209-220
    • Podolsky, D.K.1    Gerken, G.2    Eyking, A.3    Cario, E.4
  • 129
    • 77955185168 scopus 로고    scopus 로고
    • Possible role of Toll-like receptor 4 in acute pancreatitis
    • X. Zhang, C. Zhu, D. Wu, and X. Jiang Possible role of Toll-like receptor 4 in acute pancreatitis Pancreas 39 2010 819 824
    • (2010) Pancreas , vol.39 , pp. 819-824
    • Zhang, X.1    Zhu, C.2    Wu, D.3    Jiang, X.4
  • 130
    • 66649119723 scopus 로고    scopus 로고
    • Impact of Toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice
    • R. Sharif, R. Dawra, K. Wasiluk, P. Phillips, V. Dudeja, and E. Kurt-Jones Impact of Toll-like receptor 4 on the severity of acute pancreatitis and pancreatitis-associated lung injury in mice Gut 58 2009 813 819
    • (2009) Gut , vol.58 , pp. 813-819
    • Sharif, R.1    Dawra, R.2    Wasiluk, K.3    Phillips, P.4    Dudeja, V.5    Kurt-Jones, E.6
  • 131
    • 77449142236 scopus 로고    scopus 로고
    • Betaine inhibits Toll-like receptor 4 expression in rats with ethanol-induced liver injury
    • Q.Z. Shi, L.W. Wang, W. Zhang, and Z.J. Gong Betaine inhibits Toll-like receptor 4 expression in rats with ethanol-induced liver injury World J Gastroenterol 16 2010 897 903
    • (2010) World J Gastroenterol , vol.16 , pp. 897-903
    • Shi, Q.Z.1    Wang, L.W.2    Zhang, W.3    Gong, Z.J.4
  • 132
    • 79251482742 scopus 로고    scopus 로고
    • Interferon regulatory factor 3 and type i interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells
    • J. Petrasek, A. Dolganiuc, T. Csak, B. Nath, I. Hritz, and K. Kodys Interferon regulatory factor 3 and type I interferons are protective in alcoholic liver injury in mice by way of crosstalk of parenchymal and myeloid cells Hepatology 53 2010 649 660
    • (2010) Hepatology , vol.53 , pp. 649-660
    • Petrasek, J.1    Dolganiuc, A.2    Csak, T.3    Nath, B.4    Hritz, I.5    Kodys, K.6
  • 134
    • 79251600358 scopus 로고    scopus 로고
    • Type i interferons protect from Toll-like receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice
    • e4
    • J. Petrasek, A. Dolganiuc, T. Csak, E.A. Kurt-Jones, and G. Szabo Type I interferons protect from Toll-like receptor 9-associated liver injury and regulate IL-1 receptor antagonist in mice Gastroenterology 140 2011 697 708 e4.
    • (2011) Gastroenterology , vol.140 , pp. 697-708
    • Petrasek, J.1    Dolganiuc, A.2    Csak, T.3    Kurt-Jones, E.A.4    Szabo, G.5
  • 135
    • 77957354899 scopus 로고    scopus 로고
    • Decreased pulmonary inflammation following ethanol and burn injury in mice deficient in TLR4 but not TLR2 signaling
    • M.D. Bird, A. Zahs, C. Deburghgraeve, L. Ramirez, M.A. Choudhry, and E.J. Kovacs Decreased pulmonary inflammation following ethanol and burn injury in mice deficient in TLR4 but not TLR2 signaling Alcohol Clin Exp Res 34 2010 1733 1741
    • (2010) Alcohol Clin Exp Res , vol.34 , pp. 1733-1741
    • Bird, M.D.1    Zahs, A.2    Deburghgraeve, C.3    Ramirez, L.4    Choudhry, M.A.5    Kovacs, E.J.6
  • 136
    • 77449153891 scopus 로고    scopus 로고
    • Inhibiting Toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: An experimental study
    • Z. He, Y. Zhu, and H. Jiang Inhibiting Toll-like receptor 4 signaling ameliorates pulmonary fibrosis during acute lung injury induced by lipopolysaccharide: an experimental study Respir Res 10 2009 126
    • (2009) Respir Res , vol.10 , pp. 126
    • He, Z.1    Zhu, Y.2    Jiang, H.3
  • 137
    • 77957005486 scopus 로고    scopus 로고
    • Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice
    • H. Li, X. Su, X. Yan, K. Wasserloos, W. Chao, and A.M. Kaynar Toll-like receptor 4-myeloid differentiation factor 88 signaling contributes to ventilator-induced lung injury in mice Anesthesiology 113 2010 619 629
    • (2010) Anesthesiology , vol.113 , pp. 619-629
    • Li, H.1    Su, X.2    Yan, X.3    Wasserloos, K.4    Chao, W.5    Kaynar, A.M.6
  • 138
  • 141
    • 78650813284 scopus 로고    scopus 로고
    • Toll-like receptor 2 agonists inhibit human fibrocyte differentiation
    • A.S. Maharjan, D. Pilling, and R.H. Gomer Toll-like receptor 2 agonists inhibit human fibrocyte differentiation Fibrogenesis Tissue Repair 3 2010 23
    • (2010) Fibrogenesis Tissue Repair , vol.3 , pp. 23
    • Maharjan, A.S.1    Pilling, D.2    Gomer, R.H.3
  • 143
    • 70350448767 scopus 로고    scopus 로고
    • High-mobility group box 1 protein induces tissue factor expression in vascular endothelial cells via activation of NF-kappaB and Egr-1
    • B. Lv, H. Wang, Y. Tang, Z. Fan, X. Xiao, and F. Chen High-mobility group box 1 protein induces tissue factor expression in vascular endothelial cells via activation of NF-kappaB and Egr-1 Thromb Haemost 102 2009 352 359
    • (2009) Thromb Haemost , vol.102 , pp. 352-359
    • Lv, B.1    Wang, H.2    Tang, Y.3    Fan, Z.4    Xiao, X.5    Chen, F.6
  • 144
    • 77951190309 scopus 로고    scopus 로고
    • Extracellular high mobility group box-1 (HMGB1) inhibits enterocyte migration via activation of Toll-like receptor-4 and increased cell-matrix adhesiveness
    • S. Dai, C. Sodhi, S. Cetin, W. Richardson, M. Branca, and M.D. Neal Extracellular high mobility group box-1 (HMGB1) inhibits enterocyte migration via activation of Toll-like receptor-4 and increased cell-matrix adhesiveness J Biol Chem 285 2010 4995 5002
    • (2010) J Biol Chem , vol.285 , pp. 4995-5002
    • Dai, S.1    Sodhi, C.2    Cetin, S.3    Richardson, W.4    Branca, M.5    Neal, M.D.6
  • 145
    • 77950539231 scopus 로고    scopus 로고
    • Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
    • M. Maroso, S. Balosso, T. Ravizza, J. Liu, E. Aronica, and A.M. Iyer Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures Nat Med 16 2010 413 419
    • (2010) Nat Med , vol.16 , pp. 413-419
    • Maroso, M.1    Balosso, S.2    Ravizza, T.3    Liu, J.4    Aronica, E.5    Iyer, A.M.6
  • 146
    • 77954951851 scopus 로고    scopus 로고
    • TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells
    • D. Mittal, F. Saccheri, E. Venereau, T. Pusterla, M.E. Bianchi, and M. Rescigno TLR4-mediated skin carcinogenesis is dependent on immune and radioresistant cells EMBO J 29 2010 2242 2252
    • (2010) EMBO J , vol.29 , pp. 2242-2252
    • Mittal, D.1    Saccheri, F.2    Venereau, E.3    Pusterla, T.4    Bianchi, M.E.5    Rescigno, M.6
  • 148
    • 41049117932 scopus 로고    scopus 로고
    • Convergence and amplification of Toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)
    • J.R. van Beijnum, W.A. Buurman, and A.W. Griffioen Convergence and amplification of Toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1) Angiogenesis 11 2008 91 99
    • (2008) Angiogenesis , vol.11 , pp. 91-99
    • Van Beijnum, J.R.1    Buurman, W.A.2    Griffioen, A.W.3
  • 149
    • 77953568668 scopus 로고    scopus 로고
    • Fas (CD95) induces rapid, TLR4/IRAK4-dependent release of pro-inflammatory HMGB1 from macrophages
    • F. Wang, Z. Lu, M. Hawkes, H. Yang, K.C. Kain, and W.C. Liles Fas (CD95) induces rapid, TLR4/IRAK4-dependent release of pro-inflammatory HMGB1 from macrophages J Inflamm (Lond) 7 2010 30
    • (2010) J Inflamm (Lond) , vol.7 , pp. 30
    • Wang, F.1    Lu, Z.2    Hawkes, M.3    Yang, H.4    Kain, K.C.5    Liles, W.C.6
  • 150
    • 77955403878 scopus 로고    scopus 로고
    • A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
    • H. Yang, H.S. Hreggvidsdottir, K. Palmblad, H. Wang, M. Ochani, and J. Li A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release Proc Natl Acad Sci U S A 107 2010 11942 11947
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 11942-11947
    • Yang, H.1    Hreggvidsdottir, H.S.2    Palmblad, K.3    Wang, H.4    Ochani, M.5    Li, J.6
  • 153
    • 78049250350 scopus 로고    scopus 로고
    • Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands
    • X.Z. West, N.L. Malinin, A.A. Merkulova, M. Tischenko, B.A. Kerr, and E.C. Borden Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands Nature 467 2010 972 976
    • (2010) Nature , vol.467 , pp. 972-976
    • West, X.Z.1    Malinin, N.L.2    Merkulova, A.A.3    Tischenko, M.4    Kerr, B.A.5    Borden, E.C.6
  • 157
    • 77749304560 scopus 로고    scopus 로고
    • Toll-like receptor 4-deficient mice are resistant to chronic hypoxia-induced pulmonary hypertension
    • K.C. Young, S.M. Hussein, R. Dadiz, D. deMello, C. Devia, D. Hehre, and C. Suguihara Toll-like receptor 4-deficient mice are resistant to chronic hypoxia-induced pulmonary hypertension Exp Lung Res 36 2010 111 119
    • (2010) Exp Lung Res , vol.36 , pp. 111-119
    • Young, K.C.1    Hussein, S.M.2    Dadiz, R.3    Demello, D.4    Devia, C.5    Hehre, D.6    Suguihara, C.7
  • 158
    • 78650240246 scopus 로고    scopus 로고
    • The role of TLR2 in nerve injury-induced neuropathic pain is essentially mediated through macrophages in peripheral inflammatory response
    • X.Q. Shi, H. Zekki, and J. Zhang The role of TLR2 in nerve injury-induced neuropathic pain is essentially mediated through macrophages in peripheral inflammatory response Glia 59 2011 231 241
    • (2011) Glia , vol.59 , pp. 231-241
    • Shi, X.Q.1    Zekki, H.2    Zhang, J.3
  • 159
    • 77956968619 scopus 로고    scopus 로고
    • Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain
    • F.X. Wu, J.J. Bian, X.R. Miao, S.D. Huang, X.W. Xu, and D.J. Gong Intrathecal siRNA against Toll-like receptor 4 reduces nociception in a rat model of neuropathic pain Int J Med Sci 7 2010 251 259
    • (2010) Int J Med Sci , vol.7 , pp. 251-259
    • Wu, F.X.1    Bian, J.J.2    Miao, X.R.3    Huang, S.D.4    Xu, X.W.5    Gong, D.J.6
  • 160
    • 73649137143 scopus 로고    scopus 로고
    • Microglia activated with the Toll-like receptor 9 ligand CpG attenuate oligomeric amyloid beta neurotoxicity in in vitro and in vivo models of Alzheimer's disease
    • Y. Doi, T. Mizuno, Y. Maki, S. Jin, H. Mizoguchi, and M. Ikeyama Microglia activated with the Toll-like receptor 9 ligand CpG attenuate oligomeric amyloid beta neurotoxicity in in vitro and in vivo models of Alzheimer's disease Am J Pathol 175 2009 2121 2132
    • (2009) Am J Pathol , vol.175 , pp. 2121-2132
    • Doi, Y.1    Mizuno, T.2    Maki, Y.3    Jin, S.4    Mizoguchi, H.5    Ikeyama, M.6
  • 161
    • 78649526394 scopus 로고    scopus 로고
    • Sterile inflammation: Sensing and reacting to damage
    • G.Y. Chen, and G. Nunez Sterile inflammation: sensing and reacting to damage Nat Rev Immunol 10 2010 826 837
    • (2010) Nat Rev Immunol , vol.10 , pp. 826-837
    • Chen, G.Y.1    Nunez, G.2
  • 163
    • 33646522414 scopus 로고    scopus 로고
    • Intervention of Toll-like receptor-mediated human innate immunity and inflammation by synthetic compounds and naturally occurring products
    • S. Fasciano, and L. Li Intervention of Toll-like receptor-mediated human innate immunity and inflammation by synthetic compounds and naturally occurring products Curr Med Chem 13 2006 1389 1395
    • (2006) Curr Med Chem , vol.13 , pp. 1389-1395
    • Fasciano, S.1    Li, L.2
  • 164
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
    • DOI 10.1038/35099560
    • L. Alexopoulou, A.C. Holt, R. Medzhitov, and R.A. Flavell Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3 Nature 413 2001 732 738 (Pubitemid 33009951)
    • (2001) Nature , vol.413 , Issue.6857 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.