The alarmin cytokine, high mobility group box 1, is produced by viable cardiomyocytes and mediates the lipopolysaccharide-induced myocardial dysfunction via a TLR4/phosphatidylinositol 3-kinase γ pathway

Journal of Immunology

Volumn 184, Issue 3, 2010, Pages 1492-1498

  Xu, Hu ^a,b   Su, Zhaoliang ^a,b   Wu, Jun ^a,b   Yang, Min ^a,b   Penninger, Josef M ^c   Martin, Claudio M ^a,d   Kvietys, Peter R ^a,b   Rui, Tao ^a,b,d  

^a LAWSON HEALTH RESEARCH INSTITUTE   (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^d LONDON HEALTH SCIENCES CENTRE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

5 (6 QUINOXALINYLMETHYLENE) 2,4 THIAZOLIDINEDIONE; ALARMIN; CYTOKINE; HIGH MOBILITY GROUP B1 PROTEIN; LIPOPOLYSACCHARIDE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG; ISOENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3-KINASE GAMMA; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENDOTOXEMIA; HEART DISEASE; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILITY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEPSIS; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CARDIOMYOPATHY; CELL CULTURE; CELL SURVIVAL; DISEASE MODEL; ENZYMOLOGY; GENETICS; HEART CONTRACTION; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; NEWBORN; PATHOPHYSIOLOGY; PHYSIOLOGY; SECRETION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANIMALS, NEWBORN; CARDIOMYOPATHIES; CELL SURVIVAL; CELLS, CULTURED; CYTOKINES; DISEASE MODELS, ANIMAL; ENDOTOXEMIA; HMGB1 PROTEIN; ISOENZYMES; LIPOPOLYSACCHARIDES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 4;

EID: 77949315708     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0902660     Document Type: Article

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