Toll-like receptor 2 signaling triggers fatal arrhythmias upon myocardial ischemia-reperfusion

Critical Care Medicine

Volumn 38, Issue 10, 2010, Pages 1927-1932

  Mersmann, Jan ^a,b   Koch, Alexander ^a   Tran, Nguyen ^a   Zimmermann, René ^a   Granja, Tiago F ^a   Larmann, Jan ^c   Herzog, Christine ^c   Theilmeier, Gregor ^c   Bornstein, Stefan R ^d   Kirschning, Carsten J ^e   Zacharowski, Kai ^a  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c HANNOVER MEDICAL SCHOOL   (Germany)

^d DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^e UNIVERSITY OF DUISBURG ESSEN   (Germany)

Author keywords

cardiac arrhythmias; connexin 43; heart rate turbulence; myocardial ischemia; reperfusion injury; toll like receptor 2

Indexed keywords

CONNEXIN 40; TOLL LIKE RECEPTOR 2; CONNEXIN 43; TROPONIN T;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GAP JUNCTION; HEART ARRHYTHMIA; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPERFUSION INJURY; SIGNAL TRANSDUCTION; SURVIVAL RATE; ANIMAL; BIOSYNTHESIS; BLOOD; C3H MOUSE; CHEMISTRY; DISEASE MODEL; ELECTROCARDIOGRAPHY; HEART MUSCLE; HEART RATE; KNOCKOUT MOUSE; MORTALITY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ARRHYTHMIAS, CARDIAC; CONNEXIN 43; DISEASE MODELS, ANIMAL; ELECTROCARDIOGRAPHY; GAP JUNCTIONS; HEART RATE; MALE; MICE; MICE, INBRED C3H; MICE, KNOCKOUT; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIUM; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 2; TROPONIN T;

EID: 77957231123     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0b013e3181ef455b     Document Type: Article

References (33)

1. Frangogiannis NG: Chemokines in ischemia and reperfusion. Thromb Haemost 2007; 97: 738-747
2. Beutler B, Hoebe K, Du X, et al: How we detect microbes and respond to them: The toll-like receptors and their transducers. J Leukoc Biol 2003; 74:479-485
3. Vabulas RM, Ahmad-Nejad P, da Costa C, et al: Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells. J Biol Chem 2001; 276: 31332-31339
4. Akira S, Uematsu S, Takeuchi O: Pathogen recognition and innate immunity. Cell 2006; 124:783-801
5. Tsung A, Hoffman RA, Izuishi K, et al: Hepatic ischemia/reperfusion injury involves functional TLR4 signaling in nonparenchy-mal cells. J Immunol 2005; 175:7661-7668
6. Shigeoka AA, Holscher TD, King AJ, et al: TLR2 is constitutively expressed within the kidney and participates in ischemic renal injury through both MyD88-dependent and-independent pathways. J Immunol 2007; 178:6252-6258
7. Leemans JC, Stokman G, Claessen N, et al: Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney. J Clin Invest 2005; 2894-2903
8. Frantz S, Kelly RA, Bourcier T: Role of TLR-2 in the activation of nuclear factor kappaB by oxidative stress in cardiac myocytes. J Biol Chem 2001; 276:5197-5203
9. O'Neill LAJ, Bowie AG: The family of five: TIR-domain-containing adaptors in toll-like receptor signalling. Nat Rev Immunol 2007; 7:353-364
10. Sakata Y, Dong JW, Vallejo JG, et al: Toll-like receptor 2 modulates left ventricular function following ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol 2007; 292: H503-H509
11. Favre J, Musette P, Douin-Echinard V, et al: Toll-like receptors 2-deficient mice are protected against postischemic coronary endo-thelial dysfunction. Arterioscler Thromb Vasc Biol 2007; 27:1064-1071
12. Bolli R, Becker L, Gross G, et al: Myocardial protection at a crossroads: The need for translation into clinical therapy. Circ Res 2004; 95:125-134
13. Sholter DE, Armstrong PW: Adverse effects of corticosteroids on the cardiovascular system. Can J Cardiol 2000; 16:505-511
14. Chong AJ, Shimamoto A, Hampton CR, et al: Toll-like receptor 4 mediates ischemia/reperfusion injury of the heart. J Thorac Car-diovasc Surg 2004; 128:170-179
15. Oyama J, Blais C Jr, Liu X, et al: Reduced myocardial ischemia-reperfusion injury in toll-like receptor 4-deficient mice. Circulation 2004; 109:784-789
16. Kim SC, Ghanem A, Stapel H, et al: Toll-like receptor 4 deficiency: smaller infarcts, but no gain in function. BMC Physiol 2007; 7:5-5
17. Meng G, Rutz M, Schiemann M, et al: Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. J Clin Invest 2004; 113:1473-1481
18. Mersmann J, Berkels R, Zacharowski P, et al: Preconditioning by toll-like receptor 2 agonist Pam3CSK4 reduces CXCL1-dependent leukocyte recruitment in murine myocardial ischemia/reperfusion injury. Crit Care Med 2010; 38:903-909
19. Petzelbauer P, Zacharowski PA, Miyazaki Y, et al: The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Nat Med 2005; 11:298-304
20. Francis J, Watanabe MA, Schmidt G: Heart rate turbulence: A new predictor for risk of sudden cardiac death. Annals of Noninvasive Electrocardiology 2005; 10:102-109
21. Zacharowski K, Zacharowski PA, Koch A, et al: Toll-like receptor 4 plays a crucial role in the immune-adrenal response to systemic inflammatory response syndrome. Proc Nat Acad Sci\USA 2006; 103:6392-6397
22. Bornstein SR, Schumann RR, Rettori V, et al: Toll-like receptor 2 and toll-like receptor 4 expression in human adrenals. Horm Metab Res 2004; 36:470-473
23. Schmidt G, Malik M, Barthel P, et al: Heart-rate turbulence after ventricular premature beats as a predictor of mortality after acute myocardial infarction. Lancet 1999; 353: 1390-1396
24. Newby LK, Christenson RH, Ohman EM, et al: Value of serial troponin T measures for early and late risk stratification in patients with acute coronary syndromes The GUSTO-IIa Investigators. Circulation 1998; 98: 1853-1859
25. Van Domburg RT, Sonnenschein K, Nieuw-laat R, et al: Sustained benefit 20 years after reperfusion therapy in acute myocardial infarction. J Am Coll Cardiol 2005; 46:15-20
26. Jalife J, Morley GE, Vaidya D: Connexins and impulse propagation in the mouse heart. J Cardiovasc Electrophysiol 1999; 10: 1649-1663
27. Roell W, Lewalter T, Sasse P, et al: Engraft-ment of connexin 43-expressing cells prevents post-infarct arrhythmia. Nature 2007; 450:819-824
28. Danik SB, Liu F, Zhang J, et al: Modulation of cardiac gap junction expression and arrhythmic susceptibility. Circ Res 2004; 95: 1035-1041
29. Beardslee MA, Lerner DL, Tadros PN, et al: Dephosphorylation and intracellular redistribution of ventricular connexin43 during electrical uncoupling induced by ischemia. Circ Res 2000; 87:656-662
30. Ausma J, Thone F, Dispersyn GD, et al: Ded-ifferentiated cardiomyocytes from chronic hibernating myocardium are ischemia-tolerant. Mol Cell Biochem 1998; 186: 159-168
31. Chen C, Liu J, Hua D, et al: Impact of delayed reperfusion of myocardial hibernation on myocardial ultrastructure and function and their recoveries after reperfusion in a pig model of myocardial hibernation. Cardiovasc Pathol 2000; 9:67-84
32. Dispersyn GD, Ausma J, Thone F, et al: Car-diomyocyte remodelling during myocardial hibernation and atrial fibrillation: Prelude to apoptosis. Cardiovasc Res 1999; 43:947-957
33. Martin FJ, Prince AS: TLR2 regulates gap junction intercellular communication in airway cells. J Immunol 2008; 180:4986-4993