Multiple sclerosis: A study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system

Journal of Neuroimmunology

Volumn 127, Issue 1-2, 2002, Pages 59-68

  Sorensen, Torben L ^a   Trebst, Corinna ^b   Kivisäkk, Pia ^b   Klaege, Karen L ^b   Majmudar, Amit ^b   Ravid, Rivka ^c   Lassmann, Hans ^d   Olsen, David B ^a   Strieter, Robert M ^e   Ransohoff, Richard M ^b   Sellebjerg, Finn ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b LERNER RESEARCH INSTITUTE   (United States)

^c NETHERLANDS BRAIN BANK   (Netherlands)

^d UNIVERSITY OF VIENNA   (Austria)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Central nervous system; CXCL10; CXCR3; Demyelination; Inflammation; Multiple sclerosis

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CXCL10; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON INDUCIBLE PROTEIN 10; LIGAND; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CENTRAL NERVOUS SYSTEM DISEASE; CEREBROSPINAL FLUID CYTOLOGY; CLINICAL ARTICLE; CONTROLLED STUDY; DEMYELINATION; FEMALE; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; T LYMPHOCYTE; TISSUE SECTION;

ADULT; AGED; ASTROCYTES; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CENTRAL NERVOUS SYSTEM; CEREBROSPINAL FLUID; CHEMOKINES, CXC; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; MYELITIS, TRANSVERSE; OPTIC NEURITIS; RECEPTORS, CHEMOKINE;

EID: 0036275625     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-5728(02)00097-8     Document Type: Article

References (43)

1. Involvement of the IP-10 chemokine in sarcoid granulomatous reactions
2. CXC chemokines IP-10 and mig expression and direct migration of pulmonary CD8+/CXCR3+ T cells in the lungs of patients with HIV infection and T-cell alveolitis
3. CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1α and IP-10 are expressed in demyelinating brain lesions
4. Oligodendrocytes in the early course of multiple sclerosis
5. Monocyte/macrophage differentiation in early multiple sclerosis lesions
6. Interferon-inducible T cell alpha chemoattractant (I-TAC): A novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3
7. The role of chemokines and chemokine receptors in CNS inflammation
8. CXCL10 (IFN-gamma-inducible protein-10) control of encephalitogenic CD4+ T cell accumulation in the central nervous system during experimental autoimmune encephalomyelitis
9. Differential expression of CXCR3 targeting chemokines CXCL10, CXCL9, and CXCL11 in different types of skin inflammation
10. Migratory activity and functional changes of green fluorescent effector cells before and during experimental autoimmune encephalomyelitis
11. Serum and CSF levels of MCP-1 and IP-10 in multiple sclerosis patients with acute and stable disease and undergoing immunomodulatory therapies
12. Demyelinating optic neuritis: Clinical features and differential diagnosis
13. Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis
14. Chemokine expression in murine experimental allergic encephalomyelitis
15. T-lymphocyte entry into the central nervous system
16. Chemokines and chemokine receptors in inflammation of the nervous system: Manifold roles and exquisite regulation
17. Chemokines and chemokine receptors in inflammatory demyelinating neuropathies - A central role for IP-10
18. Expression of Mig (monokine induced by interferon-gamma) is important in T lymphocyte recruitment and host defense following viral infection of the central nervous system
19. Neutralization of the chemokine cxcl10 reduces inflammatory cell invasion and demyelination and improves neurological function in a viral model of multiple sclerosis
20. Chemokine receptor specific for IP10 and mig: Structure, function, and expression in activated T-lymphocytes
21. Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination
22. Chemokines - Chemotactic cytokines that mediate inflammation
23. Recommended diagnostic criteria for multiple sclerosis: Guidelines from the international panel on the diagnosis of multiple sclerosis
24. Chemokine receptor expression on T cells in blood and cerebrospinal fluid at relapse and remission of multiple sclerosis: Imbalance of Th1/Th2-associated chemokine signaling
25. International union of pharmacology: XXII. Nomenclature for chemokine receptors
26. Progress in determining the causes and treatment of multiple sclerosis
27. MRI in the diagnosis of MS: A prospective study with comparison of clinical evaluation, evoked potentials, oligoclonal banding, and CT
28. Interferon-γ-inducible protein-10 is increased in the cerebrospinal fluid of patients with multiple sclerosis
29. The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions
30. Chemokine receptor responses on T cells are achieved through regulation of both receptor expression and signaling
31. Chemokine receptor antagonism as a new therapy for multiple sclerosis
32. Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis
33. Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity
34. Qualitative assessment of intrathecal IgG synthesis by isoelectric focusing and immunodetection: Interlaboratory reproducibility and interobserver agreement
35. Expression of the interferon-γ-inducible chemokines IP-10 and Mig and their receptor, CXCR3, in multiple sclerosis lesions
36. Etiology and pathogenesis of multiple sclerosis
37. Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients
38. Chemokines, CXCL10 and CCL2: Differential involvement in intrathecal inflammation in multiple sclerosis
39. In situ hybridization analysis of glial fibrillary acidic protein mRNA reveals evidence of biphasic astrocyte activation during acute experimental autoimmune encephalomyelitis
40. Investigating chemokines and chemokine receptors in patients with multiple sclerosis: Opportunities and challenges
41. CCR1+/CCR5+ mononuclear phagocytes accumulate in the central nervous system of patients with multiple sclerosis
42. Interaction of T lymphocytes with cerebral endothelial cells in vitro
43. Chemokines: A new classification system and their role in immunity