Expression of toll-like receptor 4 in uvea-resident tissue macrophages during endotoxin-induced uveitis

Molecular Vision

Volumn 15, Issue , 2009, Pages 619-628

  Chen, Wei ^a   Hu, Xiaofeng ^a   Zhao, Li ^a   Li, Shang ^a   Lu, Hong ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD163 ANTIGEN; ENDOTOXIN; TOLL LIKE RECEPTOR 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR EYE SEGMENT; ARTICLE; CELL COUNT; CELL DENSITY; CELL MEMBRANE; CELL STRUCTURE; CHOROID; CILIARY BODY; CONTROLLED STUDY; EYE INFLAMMATION; GRAM NEGATIVE BACTERIUM; MACROPHAGE; MALE; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; UVEITIS; VIBRIO CHOLERAE;

ANIMALS; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CELL COUNT; CELL SHAPE; CHOROID; CILIARY BODY; ENDOTOXINS; IMMUNOHISTOCHEMISTRY; IRIS; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; RATS; RATS, WISTAR; RECEPTORS, CELL SURFACE; TOLL-LIKE RECEPTOR 4; UVEA; UVEITIS;

EID: 65249123400     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Bloch-Michel E, Nussenblatt RB. International uveitis study group recommendations for the evaluation of intraocular inflammatory disease. Am J Ophthalmol 1987; 103:234-5.
2. Chang JH, Hampartzoumian T, Everett B, Lloyd A, McCluskey PJ, Wakefield D. Changes in Toll-like receptor (TLR)-2 and TLR4 expression and function but not polymorphisms are associated with acute anterior uveitis. Invest Ophthalmol Vis Sci 2007; 48:1711-7.
3. Chang JH, McCluskey PJ, Wakefield D. Acute anterior uveitis and HLA-B27. Surv Ophthalmol 2005; 50:364-88.
4. Rosenbaum JT, McDevitt HO, Guss RB, Egbert PR. Endotoxininduced uveitis in rats as a model for human disease. Nature 1980; 286:611-3.
5. Medzhitov R, Preston-Hurlburt P, Janeway CA Jr. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997; 388:394-7.
6. Takeda K, Kaisho T, Akira S. Toll-like receptors. Annu Rev Immunol 2003; 21:335-76.
7. Schnare M, Barton GM, Holt AC, Takeda K, Akira S, Medzhitov R. Toll-like receptors control activation of adaptive immune responses. Nat Immunol 2001; 2:947-50.
8. Takeda K, Akira S. Toll-like receptors in innate immunity. Int Immunol 2005; 17:1-14.
9. Poltorak A, He X, Smirnova I, Liu MY, Van Huffel C, Du X, Birdwell D, Alejos E, Silva M, Galanos C, Freudenberg M, Ricciardi-Castagnoli P, Layton B, Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282:2085-8.
10. Zarember KA, Godowski PJ. Tissue expression of human toll-like receptors and differential regulation of toll-like receptor mRNAs in leukocytes in response to microbes, their products, and cytokines. J Immunol 2002; 168:554-61.
11. Mita Y, Dobashi K, Endou K, Kawata T, Shimizu Y, Nakazawa T, Mori M. Toll-like receptor 4 surface expression on human monocytes and B cells is modulated by IL-2 and IL-4. Immunol Lett 2002; 81:71-5.
12. Pasterkamp G, Versteeg D, de Kleijn DP. Immune regulatory cells: circulating biomarker factories in cardiovascular disease. Clin Sci (Lond) 2008; 115:129-31.
13. Leon CG, Tory R, Jia J, Sivak O, Wasan KM. Discovery and development of toll-like receptor 4 (TLR4) antagonists: a new paradigm for treating sepsis and other diseases. Pharm Res 2008; 25:1751-61.
14. Parker LC, Prince LR, Sabroe I. Translational mini-review series on Toll-like receptors: networks regulated by Toll-like receptors mediate innate and adaptive immunity. Clin Exp Immunol 2007; 147:199-207.
15. Pouvreau I, Zech JC, Thillaye-Goldenberg B, Naud MC, Van Rooijen N, de Kozak Y. Effect of macrophage depletion by liposomes containing dichloromethylene-diphosphonate on endotoxin-induced uveitis. J Neuroimmunol 1998; 86:171-81.
16. Law SK, Micklem KJ, Shaw JM, Zhang XP, Dong Y, Willis AC, Mason DY. A new macrophage differentiation antigen which is a member of the scavenger receptor superfamily. Eur J Immunol 1993; 23:2320-5.
17. Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK, Moestrup SK. Identification of the hemoglobin scavenger receptor. Nature 2001; 409:198-201.
18. Philippidis P, Mason JC, Evans BJ, Nadra I, Taylor KM, Haskard DO, Landis RC. Hemoglobin scavenger receptor CD163 mediates interleukin-10 release and heme oxygenase-1 synthesis: antiinflammatory monocytemacrophage responses in vitro, in resolving skin blisters in vivo, and after cardiopulmonary bypass surgery. Circ Res 2004; 94:119-26.
19. Lajavardi L, Bochot A, Camelo S, Goldenberg B, Naud MC, Behar-Cohen F, Fattal E, de Kozak Y. Downregulation of endotoxin-induced uveitis by intravitreal injection of vasoactive intestinal Peptide encapsulated in liposomes. Invest Ophthalmol Vis Sci 2007; 48:3230-8.
20. Polfliet MM, Fabriek BO, Daniëls WP, Dijkstra CD, van den Berg TK. The rat macrophage scavenger receptor CD163: expression, regulation and role in inflammatory mediator production. Immunobiology 2006; 211:419-25.
21. McMenamin PG, Crewe J. Endotoxin-induced uveitis. Kinetics and phenotype of the inflammatory cell infiltrate and the response of the resident tissue macrophages and dendritic cells in the iris and ciliary body. Invest Ophthalmol Vis Sci 1995; 36:1949-59.
22. Chang JH, McCluskey P, Wakefield D. Expression of toll-like receptor 4 and its associated lipopolysaccharide receptor complex by resident antigen-presenting cells in the human uvea. Invest Ophthalmol Vis Sci 2004; 45:1871-8.
23. Brito BE, Zamora DO, Bonnah RA, Pan Y, Planck SR, Rosenbaum JT. Toll-like receptor 4 and CD14 expression in human ciliary body and TLR-4 in human iris endothelial cells. Exp Eye Res 2004; 79:203-8.
24. de Kozak Y, Omri B, Smith JR, Naud MC, Thillaye-Goldenberg B, Crisanti P. Protein kinase Czeta (PKCzeta) regulates ocular inflammation and apoptosis in endotoxin-induced uveitis (EIU): signaling molecules involved in EIU resolution by PKCzeta inhibitor and interleukin-13. Am J Pathol 2007; 170:1241-57.
25. McMenamin PG. Optimal Methods for Preparation and Immunostaining of Iris, Ciliary Body, and Choroidal Wholemounts. Invest Ophthalmol Vis Sci 2000; 41:3043-8.
26. Yang P, Alex F, Kijlstra A. Macrophages and MHC class II positive cells in the choroid during endotoxin induced uveitis. Br J Ophthalmol 1997; 81:396-401.
27. Steptoe RJ, Holt PG, McMenamin PG. Major histocompatibility complex (MHC) class II-positive dendritic cells in the rat iris. In situ development from MHC class II-negative precursors. Invest Ophthalmol Vis Sci 1997; 38:2639-48.
28. Bhattacherjee P, Williams RN, Eakins KE. An evaluation of ocular inflammation following the injection of bacterial endotoxin into the rat foot pad. Invest Ophthalmol Vis Sci 1983; 24:196-202.
29. Sandor F, Buc M. Toll-like Receptors. II. Distribution and Pathways Involved in TLR Signalling. Folia Biol (Praha) 2005; 51:188-97.
30. Mazzoni A, Segal DM. Controlling the Toll road to dendritic cell polarization. J Leukoc Biol 2004; 75:721-30.
31. Sporri R, Reis e Sousa C. Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function. Nat Immunol 2005; 6:163-70.
32. Iwasaki A, Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004; 5:987-95.
33. Roelofs MF, Boelens WC, Joosten LA. Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis. J Immunol 2006; 176:7021-7.
34. Matzinger P. Tolerance, danger, and the extended family. Annu Rev Immunol 1994; 12:991-1045.
35. Huhtinen M, Repo H, Laasila K, Jansson SE, Kautiainen H, Karma A, Leirisalo-Repo M. Systemic inflammation and innate immune response in patients with previous anterior uveitis. Br J Ophthalmol 2002; 86:412-7.
36. Verreck FA, de Boer T, Langenberg DM, van der Zanden L, Ottenhoff TH. Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFNgamma-and CD40L-mediated costimulation. J Leukoc Biol 2006; 79:285-93.
37. Yang P, de Vos AF, Kijlstra A. Macrophages in the retina of normal Lewis rats and their dynamics after injection of lipopolysaccharide. Invest Ophthalmol Vis Sci 1996; 37:77-85.
38. Yang P, de Vos AF, Kijlstra A. Interferon gamma immunoreactivity in iris nerve fibres during endotoxin induced uveitis in the rat. Br J Ophthalmol 1998; 82:695-9.