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Volumn 12, Issue 32, 2006, Pages 4135-4142

'Toll' gates for future immunotherapy

Author keywords

Immunological disorders; Interleukin 1 receptor associated kinase; Oligodeoxyribonucleic acids; TLR antagonists; TNF receptor associated factor 6

Indexed keywords

ANTIALLERGIC AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; CORTICOSTEROID; FREUND ADJUVANT; HEMOZOIN; IMMUNOLOGICAL ADJUVANT; MEMBRANE PROTEIN; MONOCLONAL ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT; OLIGODEOXYNUCLEOTIDE; PROFILIN; RECEPTOR BLOCKING AGENT; RESIQUIMOD; SMALL INTERFERING RNA; TAMM HORSFALL GLYCOPROTEIN; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TOLL LIKE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; VACCINE;

EID: 33750542135     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/138161206778743484     Document Type: Review
Times cited : (63)

References (89)
  • 2
    • 0030595339 scopus 로고    scopus 로고
    • The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults
    • Lemaitre B, Nicolas E, Michaut L, Reichhart JM, Hoffmann JA. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 1996; 86: 973-983.
    • (1996) Cell , vol.86 , pp. 973-983
    • Lemaitre, B.1    Nicolas, E.2    Michaut, L.3    Reichhart, J.M.4    Hoffmann, J.A.5
  • 3
    • 3142724031 scopus 로고    scopus 로고
    • Toll-like receptor signalling
    • Akira S, Takeda K. Toll-like receptor signalling. Nat Rev Immunol 2004; 4: 499-511.
    • (2004) Nat Rev Immunol , vol.4 , pp. 499-511
    • Akira, S.1    Takeda, K.2
  • 5
    • 2942627626 scopus 로고    scopus 로고
    • Hydrophobicity: An ancient damage-associated molecular pattern that initiates innate immune responses
    • Seong SY, Matzinger P. Hydrophobicity: an ancient damage-associated molecular pattern that initiates innate immune responses. Nat Rev Immunol 2004; 4: 469-478.
    • (2004) Nat Rev Immunol , vol.4 , pp. 469-478
    • Seong, S.Y.1    Matzinger, P.2
  • 7
    • 3142654210 scopus 로고    scopus 로고
    • Inferences, questions and possibilities in Toll-like receptor signalling
    • Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 2004; 430: 257-263.
    • (2004) Nature , vol.430 , pp. 257-263
    • Beutler, B.1
  • 8
    • 0346157331 scopus 로고    scopus 로고
    • TIR domain-containing adaptors define the specificity of TLR signaling
    • Yamamoto M, Takeda K, Akira S. TIR domain-containing adaptors define the specificity of TLR signaling. Mol Immunol 2004; 40: 861-868.
    • (2004) Mol Immunol , vol.40 , pp. 861-868
    • Yamamoto, M.1    Takeda, K.2    Akira, S.3
  • 9
    • 0033680737 scopus 로고    scopus 로고
    • Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction
    • Sato M, Suemori H, Hata N, Asagiri M, Ogasawara K, Nakao K, et al. Distinct and essential roles of transcription factors IRF-3 and IRF-7 in response to viruses for IFN-alpha/beta gene induction. Immunity 2000; 13: 539-548.
    • (2000) Immunity , vol.13 , pp. 539-548
    • Sato, M.1    Suemori, H.2    Hata, N.3    Asagiri, M.4    Ogasawara, K.5    Nakao, K.6
  • 10
    • 0035889228 scopus 로고    scopus 로고
    • Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
    • Kawai T, Takeuchi O, Fujita T, Inoue J, Muhlradt PF, Sato S, et al. Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes. J Immunol 2001; 167: 5887-5894.
    • (2001) J Immunol , vol.167 , pp. 5887-5894
    • Kawai, T.1    Takeuchi, O.2    Fujita, T.3    Inoue, J.4    Muhlradt, P.F.5    Sato, S.6
  • 11
    • 5444274514 scopus 로고    scopus 로고
    • Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6
    • Kawai T, Sato S, Ishii KJ, Coban C, Hemmi H, Yamamoto M, et al. Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6. Nat Immunol 2004; 5: 1061-1068.
    • (2004) Nat Immunol , vol.5 , pp. 1061-1068
    • Kawai, T.1    Sato, S.2    Ishii, K.J.3    Coban, C.4    Hemmi, H.5    Yamamoto, M.6
  • 12
    • 7444250116 scopus 로고    scopus 로고
    • Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling
    • Honda K, Yanai H, Mizutani T, Negishi H, Shimada N, Suzuki N, et al. Role of a transductional-transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci USA 2004; 101: 15416-15421.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 15416-15421
    • Honda, K.1    Yanai, H.2    Mizutani, T.3    Negishi, H.4    Shimada, N.5    Suzuki, N.6
  • 13
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V, Rothenfusser S, Britsch S, Krug A, Jahrsdorfer B, Giese T, et al. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J Immunol 2002; 168: 4531-4537.
    • (2002) J Immunol , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6
  • 14
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens
    • Kadowaki N, Ho S, Antonenko S, Malefyt RW, Kastelein RA, Bazan F, et al. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J Exp Med 2001; 194: 863-869.
    • (2001) J Exp Med , vol.194 , pp. 863-869
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3    Malefyt, R.W.4    Kastelein, R.A.5    Bazan, F.6
  • 15
    • 4444340990 scopus 로고    scopus 로고
    • Direct bacterial protein PAMPs recognition by human NK cells involves TLRs and triggers {alpha}-defensin production
    • Chalifour A, Jeannin P, Gauchat JF, Blaecke A, Malissard M, N'Guyen T, et al. Direct bacterial protein PAMPs recognition by human NK cells involves TLRs and triggers {alpha}-defensin production. Blood 2004; 104: 1778-1783.
    • (2004) Blood , vol.104 , pp. 1778-1783
    • Chalifour, A.1    Jeannin, P.2    Gauchat, J.F.3    Blaecke, A.4    Malissard, M.5    N'Guyen, T.6
  • 17
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001; 413: 732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 18
    • 0033583034 scopus 로고    scopus 로고
    • Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes
    • Zhang FX, Kirschning CJ, Mancinelli R, Xu XP, Jin Y, Faure E, et al. Bacterial lipopolysaccharide activates nuclear factor-kappaB through interleukin-1 signaling mediators in cultured human dermal endothelial cells and mononuclear phagocytes. J Biol Chem 1999; 274: 7611-7614.
    • (1999) J Biol Chem , vol.274 , pp. 7611-7614
    • Zhang, F.X.1    Kirschning, C.J.2    Mancinelli, R.3    Xu, X.P.4    Jin, Y.5    Faure, E.6
  • 19
    • 85047690873 scopus 로고    scopus 로고
    • Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes
    • Meng G, Rutz M, Schiemann M, Metzger J, Grabiec A, Schwandner R, et al. Antagonistic antibody prevents toll-like receptor 2-driven lethal shock-like syndromes. J Clin Invest 2004; 113: 1473-1481.
    • (2004) J Clin Invest , vol.113 , pp. 1473-1481
    • Meng, G.1    Rutz, M.2    Schiemann, M.3    Metzger, J.4    Grabiec, A.5    Schwandner, R.6
  • 20
    • 17044423406 scopus 로고    scopus 로고
    • Suppressive oligode-oxynucleotides protect mice from lethal endotoxic shock
    • Shirota H, Gursel I, Gursel M, Klinman DM. Suppressive oligode-oxynucleotides protect mice from lethal endotoxic shock. J Immunol 2005; 174: 4579-4583.
    • (2005) J Immunol , vol.174 , pp. 4579-4583
    • Shirota, H.1    Gursel, I.2    Gursel, M.3    Klinman, D.M.4
  • 21
    • 0142059241 scopus 로고    scopus 로고
    • Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains
    • Tanabe M, Kurita-Taniguchi M, Takeuchi K, Takeda M, Ayata M, Ogura H, et al. Mechanism of up-regulation of human Toll-like receptor 3 secondary to infection of measles virus-attenuated strains. Biochem Biophys Res Commun 2003; 311: 39-48.
    • (2003) Biochem Biophys Res Commun , vol.311 , pp. 39-48
    • Tanabe, M.1    Kurita-Taniguchi, M.2    Takeuchi, K.3    Takeda, M.4    Ayata, M.5    Ogura, H.6
  • 22
    • 15444380849 scopus 로고    scopus 로고
    • IFN-{alpha} Enhances TLR3-Mediated Antiviral Cytokine Expression in Human Endothelial and Epithelial Cells by Up-Regulating TLR3 Expression
    • Tissari J, Siren J, Meri S, Julkunen I, Matikainen S. IFN-{alpha} Enhances TLR3-Mediated Antiviral Cytokine Expression in Human Endothelial and Epithelial Cells by Up-Regulating TLR3 Expression. J Immunol 2005; 174: 4289-4294.
    • (2005) J Immunol , vol.174 , pp. 4289-4294
    • Tissari, J.1    Siren, J.2    Meri, S.3    Julkunen, I.4    Matikainen, S.5
  • 23
    • 0041331693 scopus 로고    scopus 로고
    • Subcellular localization of Toll-like receptor 3 in human dendritic cells
    • Matsumoto M, Funami K, Tanabe M, Oshiumi H, Shingai M, Seto Y, et al. Subcellular localization of Toll-like receptor 3 in human dendritic cells. J Immunol 2003; 171: 3154-3162.
    • (2003) J Immunol , vol.171 , pp. 3154-3162
    • Matsumoto, M.1    Funami, K.2    Tanabe, M.3    Oshiumi, H.4    Shingai, M.5    Seto, Y.6
  • 27
    • 0033592748 scopus 로고    scopus 로고
    • The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens
    • Underhill DM, Ozinsky A, Hajjar AM, Stevens A, Wilson CB, Bassetti M, et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature 1999; 401: 811-815.
    • (1999) Nature , vol.401 , pp. 811-815
    • Underhill, D.M.1    Ozinsky, A.2    Hajjar, A.M.3    Stevens, A.4    Wilson, C.B.5    Bassetti, M.6
  • 28
    • 0037099629 scopus 로고    scopus 로고
    • Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation
    • Ishii KJ, Takeshita F, Gursel I, Gursel M, Conover J, Nussenzweig A. et al. Potential role of phosphatidylinositol 3 kinase, rather than DNA-dependent protein kinase, in CpG DNA-induced immune activation. J Exp Med 2002; 196: 269-274.
    • (2002) J Exp Med , vol.196 , pp. 269-274
    • Ishii, K.J.1    Takeshita, F.2    Gursel, I.3    Gursel, M.4    Conover, J.5    Nussenzweig, A.6
  • 29
    • 9244234953 scopus 로고    scopus 로고
    • Targeting split vaccines to the endosome improves vaccination
    • Wagner H, Heit A, Schmitz F, Bauer S. Targeting split vaccines to the endosome improves vaccination. Curr Opin Biotechnol 2004; 15: 538-542.
    • (2004) Curr Opin Biotechnol , vol.15 , pp. 538-542
    • Wagner, H.1    Heit, A.2    Schmitz, F.3    Bauer, S.4
  • 31
    • 0042493163 scopus 로고    scopus 로고
    • Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases
    • O'Neill LA. Therapeutic targeting of Toll-like receptors for inflammatory and infectious diseases. Curr Opin Pharmacol 2003; 3: 396-403.
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 396-403
    • O'Neill, L.A.1
  • 32
    • 2642610290 scopus 로고    scopus 로고
    • Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells
    • Xu D, Chan WL, Leung BP, Huang F, Wheeler R, Piedrafita D, et al. Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J Exp Med 1998; 187: 787-794.
    • (1998) J Exp Med , vol.187 , pp. 787-794
    • Xu, D.1    Chan, W.L.2    Leung, B.P.3    Huang, F.4    Wheeler, R.5    Piedrafita, D.6
  • 33
    • 2942721674 scopus 로고    scopus 로고
    • ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance
    • Brint EK, Xu D, Liu H, Dunne A, McKenzie AN, O'Neill LA, et al. ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol 2004; 5: 373-379.
    • (2004) Nat Immunol , vol.5 , pp. 373-379
    • Brint, E.K.1    Xu, D.2    Liu, H.3    Dunne, A.4    McKenzie, A.N.5    O'Neill, L.A.6
  • 34
    • 0042733592 scopus 로고    scopus 로고
    • SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling
    • Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, et al. SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 2003; 4: 920-927.
    • (2003) Nat Immunol , vol.4 , pp. 920-927
    • Wald, D.1    Qin, J.2    Zhao, Z.3    Qian, Y.4    Naramura, M.5    Tian, L.6
  • 37
    • 0036850946 scopus 로고    scopus 로고
    • SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
    • Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, Ohishi M, et al. SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 2002; 17: 583-591.
    • (2002) Immunity , vol.17 , pp. 583-591
    • Kinjyo, I.1    Hanada, T.2    Inagaki-Ohara, K.3    Mori, H.4    Aki, D.5    Ohishi, M.6
  • 38
    • 0024955886 scopus 로고
    • Approaching the asymptote? Evolution and revolution in immunology
    • Janeway CA Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb Symp Quant Biol 1989; 54(Pt 1): 1-13.
    • (1989) Cold Spring Harb Symp Quant Biol , vol.54 , Issue.PART 1 , pp. 1-13
    • Janeway Jr., C.A.1
  • 39
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg AM. CpG motifs in bacterial DNA and their immune effects. Annu Rev Immunol 2002; 20: 709-760.
    • (2002) Annu Rev Immunol , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 40
    • 1842631153 scopus 로고    scopus 로고
    • Immunotherapeutic uses of CpG oligodeoxynucleotides
    • Klinman DM. Immunotherapeutic uses of CpG oligodeoxynucleotides. Nat Rev Immunol 2004; 4: 249-258.
    • (2004) Nat Rev Immunol , vol.4 , pp. 249-258
    • Klinman, D.M.1
  • 41
    • 3142690381 scopus 로고    scopus 로고
    • Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents
    • Baldridge JR, McGowan P, Evans JT, Cluff C, Mossman S, Johnson D, et al. Taking a Toll on human disease: Toll-like receptor 4 agonists as vaccine adjuvants and monotherapeutic agents. Expert Opin Biol Ther 2004; 4: 1129-1138.
    • (2004) Expert Opin Biol Ther , vol.4 , pp. 1129-1138
    • Baldridge, J.R.1    McGowan, P.2    Evans, J.T.3    Cluff, C.4    Mossman, S.5    Johnson, D.6
  • 43
    • 0344009684 scopus 로고    scopus 로고
    • Role of toll-like receptors and their adaptors in adjuvant immunotherapy for cancer
    • Seya T, Akazawa T, Uehori J, Matsumoto M, Azuma I, Toyoshima K. Role of toll-like receptors and their adaptors in adjuvant immunotherapy for cancer. Anticancer Res 2003; 23: 4369-4376.
    • (2003) Anticancer Res , vol.23 , pp. 4369-4376
    • Seya, T.1    Akazawa, T.2    Uehori, J.3    Matsumoto, M.4    Azuma, I.5    Toyoshima, K.6
  • 44
    • 0033213590 scopus 로고    scopus 로고
    • Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components
    • Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, et al. Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components. Immunity 1999; 11: 443-451.
    • (1999) Immunity , vol.11 , pp. 443-451
    • Takeuchi, O.1    Hoshino, K.2    Kawai, T.3    Sanjo, H.4    Takada, H.5    Ogawa, T.6
  • 45
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004; 303: 1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis e Sousa, C.5
  • 46
    • 0042123694 scopus 로고    scopus 로고
    • Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells
    • Lund J, Sato A, Akira S, Medzhitov I, Iwasaki A. Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 2003; 198: 513-520.
    • (2003) J Exp Med , vol.198 , pp. 513-520
    • Lund, J.1    Sato, A.2    Akira, S.3    Medzhitov, I.4    Iwasaki, A.5
  • 47
    • 12144286763 scopus 로고    scopus 로고
    • Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection
    • Tabeta K, Georgel P, Janssen E, Du X, Hoebe K, Crozat K, et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc Natl Acad Sci USA 2004; 101: 3516-3521.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3516-3521
    • Tabeta, K.1    Georgel, P.2    Janssen, E.3    Du, X.4    Hoebe, K.5    Crozat, K.6
  • 48
    • 7944219649 scopus 로고    scopus 로고
    • Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides
    • Ishii KJ, Gursel I, Gursel M, Klinman DM. Immunotherapeutic utility of stimulatory and suppressive oligodeoxynucleotides. Curr Opin Mol Ther 2004; 6: 166-174.
    • (2004) Curr Opin Mol Ther , vol.6 , pp. 166-174
    • Ishii, K.J.1    Gursel, I.2    Gursel, M.3    Klinman, D.M.4
  • 49
    • 2542620714 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides improve the survival of pregnant and fetal mice following Listeria monocytogenes infection
    • Ito S, Ishii KJ, Shirota H, Klinman DM. CpG oligodeoxynucleotides improve the survival of pregnant and fetal mice following Listeria monocytogenes infection. Infect Immun 2004; 72: 3543-3548.
    • (2004) Infect Immun , vol.72 , pp. 3543-3548
    • Ito, S.1    Ishii, K.J.2    Shirota, H.3    Klinman, D.M.4
  • 50
    • 0037407856 scopus 로고    scopus 로고
    • CpG Oligodeoxynucleotides Protect Normal and SIV-Infected Macaques from Leishmania Infection
    • Verthelyi D, Gursel M, Kenney RT, Lifson JD, Liu S, Mican J, et al. CpG Oligodeoxynucleotides Protect Normal and SIV-Infected Macaques from Leishmania Infection. J Immunol 2003; 170: 4717-4723.
    • (2003) J Immunol , vol.170 , pp. 4717-4723
    • Verthelyi, D.1    Gursel, M.2    Kenney, R.T.3    Lifson, J.D.4    Liu, S.5    Mican, J.6
  • 51
    • 0037136537 scopus 로고    scopus 로고
    • The effect of infections on susceptibility to autoimmune and allergic diseases
    • Bach JF. The effect of infections on susceptibility to autoimmune and allergic diseases. N Engl J Med 2002; 347: 911-920.
    • (2002) N Engl J Med , vol.347 , pp. 911-920
    • Bach, J.F.1
  • 53
    • 2942515020 scopus 로고    scopus 로고
    • Antigen-immunostimulatory oligonucleatide conjugates: Mechanisms and applications
    • Datta SK, Cho HJ, Takabayashi K, Horner AA, Raz E. Antigen-immunostimulatory oligonucleatide conjugates: mechanisms and applications. Immunol Rev 2004; 199: 217-226.
    • (2004) Immunol Rev , vol.199 , pp. 217-226
    • Datta, S.K.1    Cho, H.J.2    Takabayashi, K.3    Horner, A.A.4    Raz, E.5
  • 54
  • 55
    • 0037450746 scopus 로고    scopus 로고
    • Control of immune responses by naturally arising CD4+ regulatory T cells that express toll-like receptors
    • Sakaguchi S. Control of immune responses by naturally arising CD4+ regulatory T cells that express toll-like receptors. J Exp Med 2003; 197: 397-401.
    • (2003) J Exp Med , vol.197 , pp. 397-401
    • Sakaguchi, S.1
  • 56
    • 0037317763 scopus 로고    scopus 로고
    • Innate immune sensing and its roots: The story of endotoxin
    • Beutler B, Rietschel ET. Innate immune sensing and its roots: the story of endotoxin. Nat Rev Immunol 2003; 3: 169-176.
    • (2003) Nat Rev Immunol , vol.3 , pp. 169-176
    • Beutler, B.1    Rietschel, E.T.2
  • 57
    • 0034083632 scopus 로고    scopus 로고
    • Pathophysiological roles of interleukin-18 in inflammatory liver diseases
    • Tsutsui H, Matsui K, Okamura H, Nakanishi K. Pathophysiological roles of interleukin-18 in inflammatory liver diseases. Immunol Rev 2000; 174: 192-209.
    • (2000) Immunol Rev , vol.174 , pp. 192-209
    • Tsutsui, H.1    Matsui, K.2    Okamura, H.3    Nakanishi, K.4
  • 58
    • 3042548183 scopus 로고    scopus 로고
    • Toll-like Receptor 9-Dependent and -Independent Dendritic Cell Activation by Chromatin-Immunoglobulin G Complexes
    • Boule MW, Broughton C, Mackay F, Akira S, Marshak-Rothstein A, Rifkin IR. Toll-like Receptor 9-Dependent and -Independent Dendritic Cell Activation by Chromatin-Immunoglobulin G Complexes. J Exp Med 2004; 199: 1631-1640.
    • (2004) J Exp Med , vol.199 , pp. 1631-1640
    • Boule, M.W.1    Broughton, C.2    Mackay, F.3    Akira, S.4    Marshak-Rothstein, A.5    Rifkin, I.R.6
  • 59
    • 0033038486 scopus 로고    scopus 로고
    • Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis
    • Deng GM, Nilsson IM, Verdrengh M, Collins LV, Tarkowski A. Intra-articularly localized bacterial DNA containing CpG motifs induces arthritis. Nat Med 1999; 5: 702-705.
    • (1999) Nat Med , vol.5 , pp. 702-705
    • Deng, G.M.1    Nilsson, I.M.2    Verdrengh, M.3    Collins, L.V.4    Tarkowski, A.5
  • 61
    • 2342491490 scopus 로고    scopus 로고
    • Suppressive oligonucleotides protect against collagen-induced arthritis in mice
    • Dong L, Ito S, Ishii KJ, Klinman DM. Suppressive oligonucleotides protect against collagen-induced arthritis in mice. Arthritis Rheum 2004; 50: 1686-1689.
    • (2004) Arthritis Rheum , vol.50 , pp. 1686-1689
    • Dong, L.1    Ito, S.2    Ishii, K.J.3    Klinman, D.M.4
  • 62
    • 13444302229 scopus 로고    scopus 로고
    • Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB x NZW mice
    • Dong L, Ito S, Ishii KJ, Klinman DM. Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus-prone NZB x NZW mice. Arthritis Rheum 2005; 52: 651-658.
    • (2005) Arthritis Rheum , vol.52 , pp. 651-658
    • Dong, L.1    Ito, S.2    Ishii, K.J.3    Klinman, D.M.4
  • 63
    • 3242728901 scopus 로고    scopus 로고
    • Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways
    • Bjorkbacka H, Kunjathoor VV, Moore KJ, Koehn S, Ordija CM, Lee MA, et al. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways. Nat Med 2004; 10: 416-421.
    • (2004) Nat Med , vol.10 , pp. 416-421
    • Bjorkbacka, H.1    Kunjathoor, V.V.2    Moore, K.J.3    Koehn, S.4    Ordija, C.M.5    Lee, M.A.6
  • 64
    • 0036644042 scopus 로고    scopus 로고
    • Cutting edge: Role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins
    • Takeuchi O, Sato S, Horiuchi T, Hoshino K, Takeda K, Dong Z, et al. Cutting edge: role of Toll-like receptor 1 in mediating immune response to microbial lipoproteins. J Immunol 2002; 169: 10-14.
    • (2002) J Immunol , vol.169 , pp. 10-14
    • Takeuchi, O.1    Sato, S.2    Horiuchi, T.3    Hoshino, K.4    Takeda, K.5    Dong, Z.6
  • 67
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
    • Poltorak A, He X, Smimova I, Liu MY, Van Huffel C, Du X, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 1998; 282: 2085-2088.
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smimova, I.3    Liu, M.Y.4    Van Huffel, C.5    Du, X.6
  • 68
    • 0034723186 scopus 로고    scopus 로고
    • Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol
    • Kawasaki K, Akashi S, Shimazu R, Yoshida T, Miyake K, Nishijima M. Mouse toll-like receptor 4.MD-2 complex mediates lipopolysaccharide-mimetic signal transduction by Taxol. J Biol Chem 2000; 275: 2251-2254.
    • (2000) J Biol Chem , vol.275 , pp. 2251-2254
    • Kawasaki, K.1    Akashi, S.2    Shimazu, R.3    Yoshida, T.4    Miyake, K.5    Nishijima, M.6
  • 69
    • 5944261457 scopus 로고    scopus 로고
    • Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus
    • Kurt-Jones EA, Popova L, Kwinn L, Haynes LM, Jones LP, Tripp RA, et al. Pattern recognition receptors TLR4 and CD14 mediate response to respiratory syncytial virus. Nat Immunol 2000; 1: 398-401.
    • (2000) Nat Immunol , vol.1 , pp. 398-401
    • Kurt-Jones, E.A.1    Popova, L.2    Kwinn, L.3    Haynes, L.M.4    Jones, L.P.5    Tripp, R.A.6
  • 70
    • 0034650427 scopus 로고    scopus 로고
    • Cutting edge: Heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex
    • Ohashi K, Burkart V, Flohe S, Kolb H. Cutting edge: heat shock protein 60 is a putative endogenous ligand of the toll-like receptor-4 complex. J Immunol 2000; 164: 558-561.
    • (2000) J Immunol , vol.164 , pp. 558-561
    • Ohashi, K.1    Burkart, V.2    Flohe, S.3    Kolb, H.4
  • 72
    • 0035451118 scopus 로고    scopus 로고
    • Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4
    • Smiley ST, King JA, Hancock WW. Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 2001; 167: 2887-2894.
    • (2001) J Immunol , vol.167 , pp. 2887-2894
    • Smiley, S.T.1    King, J.A.2    Hancock, W.W.3
  • 73
    • 20144373629 scopus 로고    scopus 로고
    • Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism
    • Saemann MD, Weichhart T, Zeyda M, Staffler G, Schunn M, Stuhlmeier KM, et al. Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. J Clin Invest 2005; 115: 468-475.
    • (2005) J Clin Invest , vol.115 , pp. 468-475
    • Saemann, M.D.1    Weichhart, T.2    Zeyda, M.3    Staffler, G.4    Schunn, M.5    Stuhlmeier, K.M.6
  • 74
    • 0035953543 scopus 로고    scopus 로고
    • The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
    • Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, et al. The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 2001; 410: 1099-1103.
    • (2001) Nature , vol.410 , pp. 1099-1103
    • Hayashi, F.1    Smith, K.D.2    Ozinsky, A.3    Hawn, T.R.4    Yi, E.C.5    Goodlett, D.R.6
  • 75
    • 0036008014 scopus 로고    scopus 로고
    • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, et al. Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol 2002; 3: 196-200.
    • (2002) Nat Immunol , vol.3 , pp. 196-200
    • Hemmi, H.1    Kaisho, T.2    Takeuchi, O.3    Sato, S.4    Sanjo, H.5    Hoshino, K.6
  • 76
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    • Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, et al. Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004; 303: 1526-1529.
    • (2004) Science , vol.303 , pp. 1526-1529
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3    Ampenberger, F.4    Kirschning, C.5    Akira, S.6
  • 78
    • 20144389695 scopus 로고    scopus 로고
    • Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7
    • Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, et al. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med 2005; 11: 263-270.
    • (2005) Nat Med , vol.11 , pp. 263-270
    • Hornung, V.1    Guenthner-Biller, M.2    Bourquin, C.3    Ablasser, A.4    Schlee, M.5    Uematsu, S.6
  • 80
    • 11844290125 scopus 로고    scopus 로고
    • Cutting edge: Species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides
    • Roberts TL, Sweet MJ, Hume DA, Stacey KJ. Cutting edge: species-specific TLR9-mediated recognition of CpG and non-CpG phosphorothioate-modified oligonucleotides. J Immunol 2005; 174: 605-608.
    • (2005) J Immunol , vol.174 , pp. 605-608
    • Roberts, T.L.1    Sweet, M.J.2    Hume, D.A.3    Stacey, K.J.4
  • 81
    • 19944430901 scopus 로고    scopus 로고
    • Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin
    • Coban C, Ishii KJ, Kawai T, Hemmi H, Sato S, Uematsu S, et al. Toll-like receptor 9 mediates innate immune activation by the malaria pigment hemozoin. J Exp Med 2005; 201: 19-25.
    • (2005) J Exp Med , vol.201 , pp. 19-25
    • Coban, C.1    Ishii, K.J.2    Kawai, T.3    Hemmi, H.4    Sato, S.5    Uematsu, S.6
  • 82
    • 21044444274 scopus 로고    scopus 로고
    • Immunomodulatory oligonucleotides containing a cytosine-phosphate-2′-deoxy-7-deazaguanosine motif as potent Toll-like receptor 9 agonists
    • Kandimalla ER, Bhagat L, Li Y, Yu D, Wang D, Cong YP, et al. Immunomodulatory oligonucleotides containing a cytosine-phosphate-2′-deoxy-7-deazaguanosine motif as potent Toll-like receptor 9 agonists. Proc Natl Acad Sci USA 2005; 102: 6925-6930.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 6925-6930
    • Kandimalla, E.R.1    Bhagat, L.2    Li, Y.3    Yu, D.4    Wang, D.5    Cong, Y.P.6
  • 84
    • 8344250212 scopus 로고    scopus 로고
    • Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells
    • Marshak-Rothstein A, Busconi L, Lau CM, Tabor AS, Leadbetter EA, Akira S, et al. Comparison of CpG s-ODNs, chromatin immune complexes, and dsDNA fragment immune complexes in the TLR9-dependent activation of rheumatoid factor B cells. J Endotoxin Res 2004; 10: 247-251.
    • (2004) J Endotoxin Res , vol.10 , pp. 247-251
    • Marshak-Rothstein, A.1    Busconi, L.2    Lau, C.M.3    Tabor, A.S.4    Leadbetter, E.A.5    Akira, S.6
  • 87
    • 3042598056 scopus 로고    scopus 로고
    • Treatment of chronic hepatitis B: From research to clinical practice via the consensus conferences
    • Brunetto MR, Bonino F. Treatment of chronic hepatitis B: from research to clinical practice via the consensus conferences. Curr Pharm Des 2004; 10(17): 2063-75.
    • (2004) Curr Pharm Des , vol.10 , Issue.17 , pp. 2063-2075
    • Brunetto, M.R.1    Bonino, F.2
  • 88
    • 1842535286 scopus 로고    scopus 로고
    • Ex-vivo uses and applications of cytokines for adoptive immunotherapy in cancer
    • Foster AE, Forrester K, Li YC, Gottlieb DJ. Ex-vivo uses and applications of cytokines for adoptive immunotherapy in cancer. Curr Pharm Des 2004; 10(11): 1207-20.
    • (2004) Curr Pharm Des , vol.10 , Issue.11 , pp. 1207-1220
    • Foster, A.E.1    Forrester, K.2    Li, Y.C.3    Gottlieb, D.J.4
  • 89
    • 4644221287 scopus 로고    scopus 로고
    • Adjunctive immunotherapy of mycobacterial infections
    • Tomioka H. Adjunctive immunotherapy of mycobacterial infections. Curr Pharm Des 2004; 10(26): 3297-312.
    • (2004) Curr Pharm Des , vol.10 , Issue.26 , pp. 3297-3312
    • Tomioka, H.1


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