Toll-like receptor 4 (TLR4), but not TLR3 or TLR9, knock-out mice have neuroprotective effects against focal cerebral ischemia

Neuroscience

Volumn 171, Issue 1, 2010, Pages 258-267

  Hyakkoku, K ^a   Hamanaka, J ^a   Tsuruma, K ^a   Shimazawa, M ^a   Tanaka, H ^a   Uematsu, S ^b   Akira, S ^b   Inagaki, N ^a   Nagai, H ^a   Hara, H ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Cerebral ischemia; Inflammation; MCAO; Microglia; Toll like receptor

Indexed keywords

CD11B ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR RELA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CORPUS STRIATUM; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVOUS SYSTEM INFLAMMATION; NEUROPROTECTION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD11B; BRAIN ISCHEMIA; CELL COUNT; CEREBRAL INFARCTION; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NERVOUS SYSTEM DISEASES; NEUROGLIA; NEURONS; PHOSPHOPYRUVATE HYDRATASE; PROTEIN-SERINE-THREONINE KINASES; STATISTICS, NONPARAMETRIC; TIME FACTORS; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTOR 9;

EID: 77957858212     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.08.054     Document Type: Article

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