The search for compounds that stimulate thermogenesis in obesity management: From pharmaceuticals to functional food ingredients

Obesity Reviews

Volumn 12, Issue 10, 2011, Pages 866-883

  Dulloo, A G ^a  

^a UNIVERSITY OF FRIBOURG   (Switzerland)

Author keywords

Bioactive food ingredients; Functional foods; Obesity; Thermogenesis

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; AMINO ACID DERIVATIVE; BETA 3 ADRENERGIC RECEPTOR STIMULATING AGENT; CALCITRIOL; CAPSAICIN; CAPSAICIN DERIVATIVE; CAPSIATE; CARBOHYDRATE DERIVATIVE; CHLOROGENIC ACID; CURCUMIN; DIHYDROCAPSAICIN; DIHYDROCAPSIATE; FATTY ACID DERIVATIVE; GALACTOSE; GINGEROL; ISOFLAVONE DERIVATIVE; KAEMPFEROL; LACTOSE; METHYLXANTHINE DERIVATIVE; MINERAL; NORDIHYDROCAPSIATE; NUTRACEUTICAL; OLEUROPEIN; POLYPHENOL DERIVATIVE; PROTEIN DERIVATIVE; QUERCETIN; RESVERATROL; SHOGAOL; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZINGERONE;

ADRENERGIC STIMULATION; ARTICLE; BROWN ADIPOSE TISSUE; DIET SUPPLEMENTATION; ENERGY EXPENDITURE; ENZYME INHIBITION; FATTY ACID OXIDATION; FOOD INDUSTRY; FOOD SAFETY; FUNCTIONAL FOOD; HUMAN; NONHUMAN; OBESITY; PROGNOSIS; SKELETAL MUSCLE; THERMOGENESIS;

ANTI-OBESITY AGENTS; DRUG DISCOVERY; FUNCTIONAL FOOD; HUMANS; OBESITY; THERMOGENESIS;

EID: 80053160831     PISSN: 14677881     EISSN: 1467789X     Source Type: Journal    
DOI: 10.1111/j.1467-789X.2011.00909.x     Document Type: Article

References (168)

1. Dulloo AG, Jacquet J, Solinas G, Montani JP, Schutz Y. Body composition phenotypes in pathways to obesity and the metabolic syndrome. Int J Obes 2010; 34(Suppl. 2): S4-S17.
2. Ravussin E, Gautier JF. Metabolic predictors of weight gain. Int J Obes 1999; 23(Suppl. 1): 37-41.
3. Stock MJ. Gluttony and thermogenesis revisited. Int J Obes 1999; 23: 1105-1117.
4. Astrup A, Raben A, Buemann B, Toubro S. Fat metabolism in the predisposition to obesity. Ann N Y Acad Sci 1997; 827: 417-430.
5. Blundell JE, Cooling J. Routes to obesity: phenotypes, food choices and activity. Br J Nutr 2000; 83(Suppl. 1): S33-S38.
6. Dulloo AG. Strategies to counteract readjustments toward lower metabolic rates during obesity management. Nutrition 1993; 9: 366-372.
7. Major GC, Doucet E, Trayhurn P, Astrup A, Tremblay A. Clinical significance of adaptive thermogenesis. Int J Obes 2007; 31: 204-212.
8. Dulloo AG. Suppressed thermogenesis as a cause for resistance to slimming and obesity rebound: adaptation or illusion? Int J Obes 2007; 31: 201-203.
9. Rosenbaum M, Hirsch J, Gallagher DA, Leibel RL. Long-term persistence of adaptive thermogenesis in subjects who have maintained a reduced body weight. Am J Clin Nutr 2008; 88: 906-912.
10. Dulloo AG, Seydoux J, Jacquet J. Adaptive thermogenesis and uncoupling proteins: a reappraisal of their roles in fat metabolism and energy balance. Physiol Behav 2004; 83: 587-602.
11. Bray GA, Greenway FL. Current and potential drugs for treatment of obesity. Endocr Rev 1999; 20: 805-875.
12. Dulloo AG, Miller DS. Obesity: a disorder of the sympathetic nervous system. World Rev Nutr Diet 1987; 50: 1-56.
13. Higgins HL, Means JH. The effect of certain drugs on the respiratory and gaseous metabolism in normal human subjects. J Pharmacol Exp Ther 1915; 7: 1-9.
14. Chen KK, Schmidt CF. Ephedrine and related substances. Medecine 1930; 9: 117-130.
15. Landsberg L, Young JB. Sympathoadrenal activity and obesity: physiological rationale for the use of adrenergic thermogenic drugs. Int J Obes 1992; 17(Suppl. 1): S29-S34.
16. Snitker S, Macdonald I, Ravussin E, Astrup A. The sympathetic nervous system and obesity: role in aetiology and treatment. Obes Rev 2000; 1: 5-15.
17. Schutz Y. The adjustment of energy expenditure and oxidation to energy intake: the role of carbohydrate and fat balance. Int J Obes Relat Metab Disord 1993; 17(Suppl. 3): S23-S27.
18. Dulloo AG, Seydoux J, Girardier L. Dietary and pharmacological effectiveness of thermogenic stimulation in obesity treatment. In: Oomura Y, Tarui S, Inoue S, Shimazu T (eds). Progress in Obesity Research 1990. John Libbey & Company Ltd: London, 1990, pp. 135-144.
19. Acheson KJ, Zahorska-Markiewicz B, Pittet PH, Anantharaman K, Jéquier E. Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals. Am J Clin Nutr 1980; 33: 989-997.
20. Jung RT, Shetty PS, James WP, Barrand MA, Callingham BA. Caffeine: its effect on catecholamines and metabolism in lean and obese humans. Clin Sci (Lond) 1981; 60: 527-535.
21. Dulloo AG, Geissler C, Horton T, Collins A, Miller DS. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and post-obese human volunteers. Am J Clin Nutr 1989; 49: 44-50.
22. Morgan JB, York DA, Wasilewska A, Portman J. A study of the thermic responses to a meal and to a sympathomimetic drug (ephedrine) in relation to energy balance in man. Br J Nutr 1982; 47: 21-32.
23. Astrup A, Lundsgaard C, Madsen J, Christensen NJ. Enhanced thermogenic responsiveness during chronic ephedrine treatment in man. Am J Clin Nutr 1985; 42: 83-94.
24. Dulloo AG, Miller DS. The thermogenic properties of ephedrine/methylxanthine mixtures: human studies. Int J Obes 1986; 10: 467-481.
25. Astrup A, Toubro S, Cannon S, Hein P, Madsen J. Thermogenic synergism between ephedrine and caffeine in healthy volunteers: a double-blind, placebo-controlled study. Metabolism 1991; 40: 323-329.
26. Dulloo AG, Miller DS. Ephedrine, caffeine and aspirin: 'over-the-counter' drugs that interact to stimulate thermogenesis in the obese. Nutrition 1989; 5: 7-9.
27. Horton TJ, Geissler CA. Aspirin potentiates the effect of ephedrine on the thermogenic response to a meal in obese but not lean women. Int J Obes 1991; 15: 359-366.
28. Dulloo AG. Ephedrine, xanthines and prostaglandin-inhibitors: actions and interactions in the stimulation of thermogenesis. Int J Obes 1993; 17(Suppl. 1): S35-S40.
29. Toubro S, Astrup AV, Breum L, Quaade F. Safety and efficacy of long-term treatment with ephedrine, caffeine and an ephedrine/caffeine mixture. Int J Obes Relat Metab Disord 1993; 17(Suppl. 1): S69-S72.
30. Daly PA, Krieger DR, Dulloo AG, Young JB, Landsberg L. Ephedrine, caffeine and aspirin: safety and efficacy for treatment of human obesity. Int J Obes 1993; 17(Suppl. 1): S73-S78.
31. Molnár D, Török K, Erhardt E, Jeges S. Safety and efficacy of treatment with an ephedrine/caffeine mixture. The first double-blind placebo-controlled pilot study in adolescents. Int J Obes 2000; 24: 1573-1578.
32. Greenway FL. The safety and efficacy of pharmaceutical and herbal caffeine and ephedrine use as a weight loss agent. Obes Rev 2001; 2: 199-211.
33. Arch JR, Ainsworth AT, Cawthorne MA, Piercy V, Sennitt MV, Thody VE etal. Atypical beta-adrenoceptor on brown adipocytes as target for anti-obesity drugs. Nature 1984; 309: 163-165.
34. Arch JR. The discovery of drugs for obesity, the metabolic effects of leptin and variable receptor pharmacology: perspectives from beta3-adrenoceptor agonists. Naunyn Schmiedebergs Arch Pharmacol 2008; 378: 225-240.
35. Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Müller C, Carling D etal. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002; 41: 339-343.
36. Abu-Elheiga L, Matzuk MM, Abo-Hashema KA, Wakil SJ. Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science 2001; 291: 2613-2616.
37. Choi CS, Savage DB, Abu-Elheiga L, Liu ZX, Kim S, Kulkarni A etal. Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity. Proc Natl Acad Sci U S A 2007; 104: 16480-16485.
38. Clapham JC. Fat oxidation in obesity: druggable or risky enterprise. Idrugs 2004; 7: 238-242.
39. Corbett JW. Review of recent acetyl-CoA carboxylase inhibitor patents: mid-2007-2008. Expert Opin Ther Pat 2009; 19: 943-956.
40. Hoehn KL, Turner N, Swarbrick MM, Wilks D, Preston E, Phua Y etal. Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity. Cell Metab 2010; 11: 70-76.
41. Harwood HJ Jr, Petras SF, Shelly LD, Zaccaro LM, Perry DA, Makowski MR etal. Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals. J Biol Chem 2003; 278: 37099-37111.
42. Savage DB, Choi CS, Samuel VT, Liu ZX, Zhang D, Wang A etal. Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2. J Clin Invest 2006; 116: 817-824.
43. Randle PJ, Garland P, Hales LN, Newsholme EA. The glucose fatty acid cycle, its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1963; 1: 785-789.
44. Kiens B, Alsted T, Jeppesen J. Exercise metabolism: regulation of fat metabolism and potential targets. Obes Rev 2011 (in press).
45. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med 2000; 343: 1833-1838.
46. Boozer CN, Nasser JA, Heymsfield SB, Wang V, Chen G, Solomon JL. An herbal supplement containing Ma Huang-Guarana for weight loss: a randomized, double-blind trial. Int J Obes 2001; 25: 316-324.
47. Boozer CN, Daly PA, Homel P, Solomon JL, Blanchard D, Nasser JA etal. Herbal Ephedra/Caffeine for weight loss: a 6-month randomized safety and efficacy trial. Int J Obes 2002; 26: 593-604.
48. Palamar J. How ephedrine escaped regulation in the United States: a historical review of misuse and associated policy. Health Policy 2011; 99: 1-9.
49. Gougeon R, Harrigan K, Tremblay JF, Hedrei P, Lamarche M, Morais JA. Increase in the thermic effect of food in women by adrenergic amines extracted from citrus aurantium. Obes Res 2005; 13: 1187-1194.
50. Preuss HG, DiFerdinando D, Bagchi M, Bagchi D. Citrus aurantium as a thermogenic, weight-reduction replacement for ephedra: an overview. J Med 2002; 33: 247-264.
51. Haaz S, Fontaine KR, Cutter G, Limdi N, Perumean-Chaney S, Allison DB. Citrus aurantium and synephrine alkaloids in the treatment of overweight and obesity: an update. Obes Rev 2006; 7: 79-88.
52. Preuss HG, Rao CV, Garis R, Bramble JD, Ohia SE, Bagchi M etal. An overview of the safety and efficacy of a novel, natural(-)-hydroxycitric acid extract (HCA-SX) for weight management. J Med 2004; 35: 33-48.
53. Sullivan AC, Hamilton JG, Miller ON, Wheatley VR. Inhibition of lipogenesis in rat liver by (-)-hydroxycitrate. Arch Biochem Biophys 1972; 150: 183-190.
54. Kriketos AD, Thompson HR, Greene H, Hill JO. (-)-hydroxycitric acid does not affect energy expenditure and substrate oxidation in adult males in post-absorptive state. Int J Obes 1999; 23: 867-873.
55. Heymsfield SB, Allison DB, Vasseli JR, Pietrobelli A, Greenfield D, Nunez C. Garcinia cambogia (hydroxycitric acid) as a potential anti-obesity agent. JAMA 1998; 280: 1596-1600.
56. Acheson KJ, Gremaud G, Meirim I, Montigon F, Krebs Y, Fay LB etal. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? Am J Clin Nutr 2004; 79: 40-46.
57. Groop LC, Bonadonna RC, Shank M, Petrides AS, DeFronzo RA. Role of free fatty acids and insulin in determining free fatty acid and lipid oxidation in man. J Clin Invest 1991; 87: 83-89.
58. Bracco D, Ferrarra JM, Arnaud MJ, Jéquier E, Schutz Y. Effects of caffeine on energy metabolism, heart rate, and methylxanthine metabolism in lean and obese women. Am J Physiol 1995; 269: E671-E678.
59. Dulloo AG, Duret C, Rohrer D, Girardier L, Mensi N, Fathi M etal. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24h energy expenditure and fat oxidation in humans. Am J Clin Nutr 1999; 70: 1040-1045.
60. Borchardt RT, Huber JA. Catechol O-methyltransferase. 5. Structure-activity relationships for inhibition by flavonoids. J Med Chem 1975; 18: 120-122.
61. Gugler R, Dengler HJ. Inhibition of human liver catechol-O-methyltransferase by flavonoids. Naunyn Schmiedebergs Arch Pharmacol 1973; 276: 223-233.
62. Chen D, Wang CY, Lambert JD, Ai N, Welsh WJ, Yang CS. Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies. Biochem Pharmacol 2005; 69: 1523-1531.
63. Dulloo AG, Seydoux J, Girardier L, Chantre P, Vandermander J. Green tea and thermogenesis: interaction between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes 2000; 24: 252-258.
64. Rumpler W, Seale J, Clevidence B, Judd J, Wiley E, Yamamoto S etal. Oolong tea increases metabolic rate and fat oxidation in men. J Nutr 2001; 131: 2848-2852.
65. Bérubé-Parent S, Pelletier C, Doré J, Tremblay A. Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24h energy expenditure and fat oxidation in men. Br J Nutr 2005; 94: 432-436.
66. Rudelle S, Ferruzzi MG, Cristiani I, Moulin J, Macé K, Acheson KJ etal. Effect of a thermogenic beverage on 24-hour energy metabolism in humans. Obesity (Silver Spring) 2007; 15: 349-355.
67. Venables MC, Hulston CJ, Cox HR, Jeukendrup AE. Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am J Clin Nutr 2008; 87: 778-784.
68. Thielecke F, Rahn G, Böhnke J, Adams F, Birkenfeld AL, Jordan J etal. Epigallocatechin-3-gallate and postprandial fat oxidation in overweight/obese male volunteers: a pilot study. Eur J Clin Nutr 2010; 64: 704-713.
69. Lonac MC, Richards JC, Schweder MM, Johnson TK, Bell C. Influence of short-term consumption of the caffeine-free, epigallocatechin-3-gallate supplement, Teavigo, on resting metabolism and the thermic effect of feeding. Obesity (Silver Spring) 2011; 19: 298-304.
70. Ravussin E, Lillioja S, Anderson TE, Christin L, Bogardus C. Determinants of 24-hour energy expenditure in man. Methods and results using a respiratory chamber. J Clin Invest 1986; 78: 1568-1578.
71. Gregersen NT, Bitz C, Krog-Mikkelsen I, Hels O, Kovacs EM, Rycroft JA etal. Effect of moderate intakes of different tea catechins and caffeine on acute measures of energy metabolism under sedentary conditions. Br J Nutr 2009; 102: 1187-1194.
72. Hursel R, Viechtbauer W, Dulloo AG, Tremblay A, Tappy L, Rumpler W etal. The effects of catechin rich teas and caffeine on energy expenditure and fat oxidation: a meta-analysis. Obes Rev 2011; 12: e573-e581.
73. Hursel R, Viechtbauer W, Westerterp-Plantenga MS. The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int J Obes 2009; 33: 956-961.
74. Phung OJ, Baker WL, Matthews LJ, Lanosa M, Thorne A, Coleman CI. Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis. Am J Clin Nutr 2010; 91: 73-81.
75. Hursel R, Westerterp-Plantenga MS. Green tea catechin plus caffeine supplementation to a high-protein diet has no additional effect on body weight maintenance after weight loss. Am J Clin Nutr 2009; 89: 822-830.
76. Thavanesan N. The putative effects of green tea on body fat: an evaluation of the evidence and a review of the potential mechanisms. Br J Nutr 2011; doi: 10.1017/S00071145110038490011
77. Gruendel S, Garcia AL, Otto B, Mueller C, Steiniger J, Weickert MO etal. Carob pulp preparation rich in insoluble dietary fiber and polyphenols enhances lipid oxidation and lowers postprandial acylated ghrelin in humans. J Nutr 2006; 136: 1533-1538.
78. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A etal. Resveratrol improves health and survival of mice on a high-calorie diet. Nature 2006; 444: 337-342.
79. Nieman DC, Williams AS, Shanely RA, Jin F, McAnulty SR, Triplett NT etal. Quercetin's influence on exercise performance and muscle mitochondrial biogenesis. Med Sci Sports Exerc 2010; 42: 338-345.
80. Davis JM, Carlstedt CJ, Chen S, Carmichael MD, Murphy EA. The dietary flavonoid quercetin increases VO(2max) and endurance capacity. Int J Sport Nutr Exerc Metab 2010; 20: 56-62.
81. Décordé K, Teissèdre PL, Sutra T, Ventura E, Cristol JP, Rouanet JM. Chardonnay grape seed procyanidin extract supplementation prevents high-fat diet-induced obesity in hamsters by improving adipokine imbalance and oxidative stress markers. Mol Nutr Food Res 2009; 53: 659-666.
82. Hollis JH, Houchins JA, Blumberg JB, Mattes RD. Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults. J Am Coll Nutr 2009; 28: 574-582.
83. Oi-Kano Y, Kawada T, Watanabe T, Koyama F, Watanabe K, Senbongi R etal. Oleuropein, a phenolic compound in extra virgin olive oil, increases uncoupling protein 1 content in brown adipose tissue and enhances noradrenaline and adrenaline secretions in rats. J Nutr Sci Vitaminol 2008; 54: 363-370.
84. Fukuchi Y, Hiramitsu M, Okada M, Hayashi S, Nabeno Y, Osawa T etal. Lemon polyphenols (hesperidin) suppress diet-induced obesity by up-regulation of mRNA levels of the enzymes involved in beta-oxidation in mouse white adipose tissue. J Clin Biochem Nutr 2008; 43: 201-209.
85. Ejaz A, Wu D, Kwan P, Meydani M. Curcumin inhibits adipogenesis in 3T3-L1 adipocytes and angiogenesis and obesity in C57/BL mice. J Nutr 2009; 139: 919-925.
86. Cho AS, Jeon SM, Kim MJ, Yeo J, Seo KI, Choi MS etal. Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice. Food Chem Toxicol 2010; 48: 937-943.
87. Ørgaard A, Jensen L. The effects of soy isoflavones on obesity. Exp Biol Med (Maywood) 2008; 233: 1066-1080.
88. Cederroth CR, Vinciguerra M, Kühne F, Madani R, Doerge DR, Visser TJ etal. A phytoestrogen-rich diet increases energy expenditure and decreases adiposity in mice. Environ Health Perspect 2007; 115: 1467-1473.
89. da-Silva WS, Harney JW, Kim BW, Li J, Bianco SD, Crescenzi A etal. The small polyphenolic molecule kaempferol increases (skeletal muscle myocyte) cellular energy expenditure and thyroid hormone activation. Diabetes 2007; 56: 767-776.
90. Hughes LA, Arts IC, Ambergen T, Brants HA, Dagnelie PC, Goldbohm RA etal. Higher dietary flavone, flavonol, and catechin intakes are associated with less of an increase in BMI over time in women: a longitudinal analysis from the Netherlands Cohort Study. Am J Clin Nutr 2008; 88: 1341-1352.
91. Henry CJK, Emery P. Effects of spiced food on metabolic rate. Hum Nutr Clin Nutr 1986; 40C: 165-168.
92. Yoshioka M, St-Pierre S, Suzuki M, Tremblay A. Effects of red pepper added to high-fat and high-carbohydrate meals on energy metabolism and substrate utilization in Japanese women. Br J Nutr 1998; 80: 503-510.
93. Westerterp-Plantenga M, Diepvens K, Joosen AM, Bérubé-Parent S, Tremblay A. Metabolic effects of spices, teas, and caffeine. Physiol Behav 2006; 89: 85-91.
94. Yoshioka M, Doucet E, Drapeau V, Dionne I, Tremblay A. Combined effects of red pepper and caffeine consumption on 24h energy balance in subjects given free access to foods. Br J Nutr 2001; 85: 203-211.
95. Ludy MJ, Mattes RD. The effects of hedonically acceptable red pepper doses on thermogenesis and appetite. Physiol Behav 2011; 102: 251-258.
96. Ohnuki K, Niwa S, Maeda S, Inoue N, Yazawa S, Fushiki T. CH-19 sweet, a non-pungent cultivar of red pepper, increased body temperature and oxygen consumption in humans. Biosci Biotechnol Biochem 2001; 65: 2033-2036.
97. Josse AR, Sherriffs SS, Holwerda AM, Andrews R, Staples AW, Phillips SM. Effects of capsinoid ingestion on energy expenditure and lipid oxidation at rest and during exercise. Nutr Metab (Lond) 2010; 7: 65.
98. Galgani JE, Ravussin E. Effect of dihydrocapsiate on resting metabolic rate in humans. Am J Clin Nutr 2010; 92: 1089-1093.
99. Snitker S, Fujishima Y, Shen H, Ott S, Pi-Sunyer X, Furuhata Y etal. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr 2009; 89: 45-50.
100. Zemel MB. The role of dairy foods in weight management. J Am Coll Nutr 2005; 24(Suppl.): 537S-546S.
101. Bortolotti M, Rudelle S, Schneiter P, Vidal H, Loizon E, Tappy L etal. Dairy calcium supplementation in overweight or obese persons: its effect on markers of fat metabolism. Am J Clin Nutr 2008; 88: 877-885.
102. Boon N, Hul GB, Stegen JH, Sluijsmans WE, Valle C, Langin D etal. An intervention study of the effects of calcium intake on faecal fat excretion, energy metabolism and adipose tissue mRNA expression of lipid-metabolism related proteins. Int J Obes 2007; 31: 1704-1712.
103. Chan She Ping-Delfos W, Soares M. Diet induced thermogenesis, fat oxidation and food intake following sequential meals: influence of calcium and vitamin D. Clin Nutr 2011; 30: 376-383 (Epub ahead of print).
104. Kaciuba-Uściłko H, Nazar K, Chwalbińska-Moneta J, Ziemba A, Kruk B, Szczepanik J etal. Effect of phosphate supplementation on metabolic and neuroendocrine responses to exercise and oral glucose load in obese women during weight reduction. J Physiol Pharmacol 1993; 44: 425-440.
105. Jaedig S, Henningsen NC. Increased metabolic rate in obese women after ingestion of potassium, magnesium- and phosphate-enriched orange juice or injection of ephedrine. Int J Obes 1991; 15: 429-436.
106. Jaedig S, Lindgärde F, Arborelius M. Increased postprandial energy expenditure in obese women after peroral K- and Mg-phosphate. Miner Electrolyte Metab 1994; 20: 147-152.
107. Wylie-Rosett J. Evaluation of protein in dietary management of diabetes mellitus. Diabetes Care 1988; 11: 143-148.
108. Velasquez MT, Bhathena SJ. Role of dietary soy protein in obesity. Int J Med Sci 2007; 4: 72-82.
109. Liaset B, Madsen L, Hao Q, Criales G, Mellgren G, Marschall HU etal. Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats. Biochim Biophys Acta 2009; 1791: 254-262.
110. Pilon G, Ruzzin J, Rioux LE, Lavigne C, White PJ, Frøyland L etal. Differential effects of various fish proteins in altering body weight, adiposity, inflammatory status, and insulin sensitivity in high-fat-fed rats. Metabolism 2011; 60: 1122-1130 (Epub ahead of print).
111. Pilvi TK, Harala S, Korpela R, Mervaala EM. Effects of high-calcium diets with different whey proteins on weight loss and weight regain in high-fat-fed C57BL/6J mice. Br J Nutr 2009; 102: 337-341.
112. Royle PJ, Mc Intosh GH, Clifton PM. Whey protein isolate and glycomacropeptide decrease weight gain and alter body composition in male Wistar rats. Br J Nutr 2008; 100: 88-93.
113. El Hafidi M, Pérez I, Zamora J, Soto V, Carvajal-Sandoval G, Baños G. Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats. Am J Physiol 2004; 287: R1387-R1393.
114. Opara EC, Petro A, Tevrizian A, Feinglos MN, Surwit RS. L-glutamine supplementation of a high fat diet reduces body weight and attenuates hyperglycemia and hyperinsulinemia in C57BL/6J mice. J Nutr 1996; 126: 273-279.
115. Layman DK, Walker DA. Potential importance of leucine in treatment of obesity and the metabolic syndrome. J Nutr 2006; 136(Suppl. 1): 319S-323S.
116. McKnight JR, Satterfield MC, Jobgen WS, Smith SB, Spencer TE, Meininger CJ etal. Beneficial effects of L-arginine on reducing obesity: potential mechanisms and important implications for human health. Amino Acids 2010; 39: 349-357.
117. Van Vught AJ, Heitmann BL, Nieuwenhuizen AG, Veldhorst MA, Brummer RJ, Westerterp-Plantenga MS. Association between dietary protein and change in body composition among children (EYHS). Clin Nutr 2009; 28: 684-688.
118. Van Vught AJ, Heitmann BL, Nieuwenhuizen AG, Veldhorst MA, Andersen LB, Hasselstrom H etal. Association between intake of dietary protein and 3-year-change in body growth among normal and overweight 6-year-old boys and girls (CoSCIS). Public Health Nutr 2010; 13: 647-653.
119. Mikkelsen PB, Toubro S, Astrup A. Effect of fat-reduced diets on 24-h energy expenditure: comparisons between animal protein, vegetable protein, and carbohydrate. Am J Clin Nutr 2000; 72: 1135-1141.
120. Acheson KJ, Blondel-Lubrano A, Oguey-Araymon S, Beaumont M, Emady-Azar S, Ammon-Zufferey C etal. Protein choices targeting thermogenesis and metabolism. Am J Clin Nutr 2011; 93: 525-534.
121. Alfenas Rde C, Bressan J, Paiva AC. Effects of protein quality on appetite and energy metabolism in normal weight subjects. Arq Bras Endocrinol Metabol 2010; 54: 45-51.
122. Wu G. Amino acids: metabolism, functions, and nutrition. Amino Acids 2009; 37: 1-17.
123. Sharief NN, Macdonald I. Differences in dietary-induced thermogenesis with various carbohydrates in normal and overweight men. Am J Clin Nutr 1982; 35: 267-272.
124. Macdonald I. Differences in dietary-induced thermogenesis following the ingestion of various carbohydrates. Ann Nutr Metab 1984; 28: 226-230.
125. Tappy L, Jéquier E. Fructose and dietary thermogenesis. Am J Clin Nutr 1993; 58(Suppl.): 766S-770S.
126. Blaak EE, Saris WH. Postprandial thermogenesis and substrate utilization after ingestion of different dietary carbohydrates. Metabolism 1996; 45: 1235-1242.
127. Bray GA. Fructose: pure, white, and deadly? Fructose, by any other name, is a health hazard. J Diabetes Sci Technol 2010; 4: 1003-1007.
128. Stanhope KL, Schwarz JM, Keim NL, Griffen SC, Bremer AA, Graham JL etal. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest 2009; 119: 1322-1334.
129. Dulloo AG, Eisa OA, Miller DS, Yudkin J. A comparative study of the effects of white sugar, unrefined sugar and starch on the efficiency of food utilization and thermogenesis. Am J Clin Nutr 1985; 42: 214-219.
130. Dulloo AG, Girardier L. Influence of dietary composition on energy expenditure during recovery of body weight in the rat: implications for catch-up growth and obesity relapse. Metabolism 1992; 41: 1336-1342.
131. Walgren MC, Young JB, Kaufman LN, Landsberg L. The effects of various carbohydrates on sympathetic activity in heart and interscapular brown adipose tissue of the rat. Metabolism 1987; 36: 585-594.
132. Young JB, Weiss J, Boufath N. Effects of dietary monosaccharides on sympathetic nervous system activity in adipose tissues of male rats. Diabetes 2004; 53: 1271-1278.
133. Goseki-Sone M, Maruyama R, Sogabe N, Hosoi T. Effects of dietary lactose on long-term high-fat-diet-induced obesity in rats. Obesity (Silver Spring) 2007; 15: 2605-2613.
134. Mohammad MA, Sunehag AL, Rodriguez LA, Haymond MW. Galactose promotes fat mobilization in obese lactating and nonlactating women. Am J Clin Nutr 2011; 93: 374-381.
135. Ryttig KR, Lammert O, Nielsen E, Garby L, Poulsen K. The effect of a soluble dietary fibre supplement on 24-hour energy expenditure during a standardized physical activity programme. Int J Obes 1990; 14: 451-455.
136. Poppitt SD, Livesey G, Elia M. Energy expenditure and net substrate utilization in men ingesting usual and high amounts of nonstarch polysaccharide. Am J Clin Nutr 1998; 68: 820-826.
137. DeLany JP, Windhauser MM, Champagne CM, Bray GA. Differential oxidation of individual dietary fatty acids in humans. Am J Clin Nutr 2000; 72: 905-911.
138. St-Onge MP, Jones PJ. Physiological effects of medium-chain triglycerides: potential agents in the prevention of obesity. J Nutr 2002; 132: 329-332.
139. Piers LS, Walker KZ, Stoney RM, Soares MJ, O'Dea K. The influence of the type of dietary fat on postprandial fat oxidation rates: monounsaturated (olive oil) vs saturated fat (cream). Int J Obes 2002; 26: 814-821.
140. Jones PJ, Jew S, AbuMweis S. The effect of dietary oleic, linoleic, and linolenic acids on fat oxidation and energy expenditure in healthy men. Metabolism 2008; 57: 1198-1203.
141. Casas-Agustench P, López-Uriarte P, Bulló M, Ros E, Gómez-Flores A, Salas-Salvadó J. Acute effects of three high-fat meals with different fat saturations on energy expenditure, substrate oxidation and satiety. Clin Nutr 2009; 28: 39-45.
142. Flint A, Helt B, Raben A, Toubro S, Astrup A. Effects of different dietary fat types on postprandial appetite and energy expenditure. Obes Res 2003; 11: 1449-1455.
143. Dulloo AG, Fathi M, Mensi N, Girardier L. Twenty-four hour energy expenditure and urinary catecholamines of humans consuming low-to-moderate amounts of medium-chain-triglycerides: a dose-response study in a respiratory chamber. Eur J Clin Nutr 1996; 50: 152-158.
144. St-Onge MP, Ross R, Parsons WD, Jones PJ. Medium-chain triglycerides increase energy expenditure and decrease adiposity in overweight men. Obes Res 2003; 11: 395-402.
145. St-Onge MP, Bosarge A, Goree LL, Darnell B. Medium chain triglyceride oil consumption as part of a weight loss diet does not lead to an adverse metabolic profile when compared to olive oil. Am Coll Nutr 2008; 27: 547-552.
146. Norris LE, Collene AL, Asp ML, Hsu JC, Liu LF, Richardson JR etal. Comparison of dietary conjugated linoleic acid with safflower oil on body composition in obese postmenopausal women with type 2 diabetes mellitus. Am J Clin Nutr 2009; 90: 468-476.
147. Yepuri G, Marcelino H, Shahkhalili Y, Aprikian O, Macé K, Seydoux J etal. Dietary modulation of body composition and insulin sensitivity during catch-up growth in rats: effects of oils rich in n-6 or n-3 PUFA. Br J Nutr 2011; 105: 1750-1763.
148. Rossmeisl M, Jelenik T, Jilkova Z, Slamova K, Kus V, Hensler M etal. Prevention and reversal of obesity and glucose intolerance in mice by DHA derivatives. Obesity (Silver Spring) 2009; 17: 1023-1031.
149. Yamashita J, Onai T, York DA, Bray GA. Relationship between food intake and metabolic rate in rats treated with beta-adrenoceptor agonists. Int J Obes 1994; 18: 429-433.
150. Egawa T, Hamada T, Ma X, Karaike K, Kameda N, Masuda S etal. Caffeine activates preferentially α1-isoform of 5'AMP-activated protein kinase in rat skeletal muscle. Acta Physiol (Oxf) 2011; 201: 227-238.
151. Kim DH, Joo JI, Choi JW, Yun JW. Differential expression of skeletal muscle proteins in high-fat diet-fed rats in response to capsaicin feeding. Proteomics 2010; 10: 2870-2881.
152. Hwang SL, Yang BK, Lee JY, Kim JH, Kim BD, Suh KH etal. Isodihydrocapsiate stimulates plasma glucose uptake by activation of AMP-activated protein kinase. Biochem Biophys Res Commun 2008; 371: 289-293.
153. Dular U, Dakshinamurti K. Effect of salicylates on acetyl coenzyme A carboxylase. Biochem Pharmacol 1979; 28: 715-718.
154. Murase T, Misawa K, Haramizu S, Hase T. Catechin-induced activation of the LKB1/AMP-activated protein kinase pathway. Biochem Pharmacol 2009; 78: 78-84.
155. Um JH, Park SJ, Kang H, Yang S, Foretz M, McBurney MW etal. AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes 2010; 59: 554-563.
156. Zheng J, Ramirez VD. Inhibition of mitochondrial proton F0F1-ATPase/ATP synthase by polyphenolic phytochemicals. Br J Pharmacol 2000; 130: 1115-1123.
157. Cederroth CR, Vinciguerra M, Gjinovci A, Kühne F, Klein M, Cederroth M etal. Dietary phytoestrogens activate AMP-activated protein kinase with improvement in lipid and glucose metabolism. Diabetes 2008; 57: 1176-1185.
158. Watt MJ, Steinberg GR, Chen ZP, Kemp BE, Febbraio MA. Fatty acids stimulate AMP-activated protein kinase and enhance fatty acid oxidation in L6 myotubes. J Physiol 2006; 574: 139-147.
159. Astrup A, Bülow J, Madsen J, Christensen NJ. Contribution of BAT and skeletal muscle to thermogenesis induced by ephedrine in man. Am J Physiol 1985; 248: E507-E515.
160. Kurpad AV, Khan K, Calder AG, Elia M. Muscle and whole body metabolism after norepinephrine. Am J Physiol 1994; 266: E877-E884.
161. Dulloo AG. A sympathetic defense against obesity. Science 2002; 297: 780-781.
162. Nedergaard J, Cannon B. The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab 2010; 11: 268-272.
163. Richard D, Carpentier AC, Doré G, Ouellet V, Picard F. Determinants of brown adipocyte development and thermogenesis. Int J Obes 2010; 34(Suppl. 2): S59-S66.
164. Lee P, Zhao JT, Swarbrick MM, Gracie G, Bova R, Greenfield JR etal. High prevalence of brown adipose tissue in adult humans. J Clin Endocrinol Metab 2011; doi: 1210/jc.2011-0487 (Epub ahead of print).
165. Li JJ, Huang CJ, Xie D. Anti-obesity effects of conjugated linoleic acid, docosahexaenoic acid, and eicosapentaenoic acid. Mol Nutr Food Res 2008; 52: 631-645.
166. Rothwell NJ, Stock MJ. Diet-induced thermogenesis. In: Girardier L, Stock MJ (eds). Mammalian Thermogenesis. Chapman and Hall Ltd: London, UK, 1983, pp. 208-233.
167. Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995; 332: 621-628.
168. Levine JA, Eberhardt NL, Jensen MD. Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science 1999; 283: 212-214.