The putative effects of green tea on body fat: An evaluation of the evidence and a review of the potential mechanisms

British Journal of Nutrition

Volumn 106, Issue 9, 2011, Pages 1297-1309

  Thavanesan, Navamayooran ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Body fat; Green tea; Mechanisms; Obesity; Weight loss

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CAFFEINE; CATECHOL METHYLTRANSFERASE; FATTY ACID SYNTHASE; GLUCOSE; GREEN TEA EXTRACT; PLACEBO;

ADIPOCYTE; ARTICLE; BODY FAT; BODY WEIGHT; CELL DIFFERENTIATION; CELL PROLIFERATION; DISEASE MODEL; DRUG EFFECT; DRUG MECHANISM; ENERGY CONSUMPTION; ENZYME INHIBITION; FOOD INTAKE; GENETIC POLYMORPHISM; GLUCOSE METABOLISM; HOMEOSTASIS; HUMAN; LIPID ABSORPTION; LIPID METABOLISM; NONHUMAN; OBESITY; PROTEIN INTAKE; RANDOMIZED CONTROLLED TRIAL (TOPIC); THERMOGENESIS; WEIGHT REDUCTION;

ADIPOSE TISSUE; ANIMALS; ANTI-OBESITY AGENTS; CAMELLIA SINENSIS; DIETARY FATS; ENZYME INHIBITORS; HUMANS; OBESITY; PHYTOTHERAPY; PLANT EXTRACTS; POLYPHENOLS; TEA; WEIGHT LOSS;

EID: 80055027531     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114511003849     Document Type: Article

References (88)

1. Cabrera C, Artacho R & Giménez R (2006) Beneficial effects of green tea-a review. J Am Coll Nutr 25, 79-99. (Pubitemid 46939847)
2. Wu C & Wei G (2002) Tea as a functional food for oral health. Nutrition 18, 443-444. (Pubitemid 34414981)
3. Hasegawa N, Yamda N & Mori M (2003) Powdered green tea has antilipogenic effect on Zucker rats fed a high-fat diet. Phytother Res 17, 477-480. (Pubitemid 36605897)
4. Tsuneki H, Ishizuka M, Terasawa M, et al. (2004) Effect of green tea on blood glucose levels and serum proteomic patterns in diabetic (db/db) mice and on glucose metabolism in healthy humans. BMC Pharmacol 4, 18.
5. Zaveri N (2006) Green tea and its polyphenolic catechins: medicinal uses in cancer and noncancer applications. Life Sci 78, 2073-2080.
6. Shiota S, Shimizu M, Mizushima T, et al. (1999) Marked reduction in the minimum inhibitory concentration (MIC) of beta-lactams in methicillin-resistant Staphylococcus aureus produced by epicatechin gallate, an ingredient of green tea (Camellia sinensis). Biol Pharm Bull 22, 1388-1390. (Pubitemid 30026657)
7. Nance C, Siwak E & Shearer W (2009) Preclinical development of the green tea catechin, epigallocatechin gallate, as an HIV-1 therapy. J Allergy Clin Immunol 123, 459-465.
8. Dulloo A, Duret C, Rohrer D, et al. (1999) Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am J Clin Nutr 70, 1040-1045.
9. Shixian Q, VanCrey B, Shi J, et al. (2006) Green tea extract thermogenesis-induced weight loss by epigallocatechin gallate inhibition of catechol-O-methyltransferase. J Med Food 9, 451-458. (Pubitemid 46095351)
10. Babu P & Liu D (2008) Green tea catechins and cardiovascular health: an update. Curr Med Chem 15, 1840-1850.
11. Muramatsu K, Fukuyo M & Hara Y (1986) Effect of green tea catechins on plasma cholesterol level in cholesterol-fed rats. J Nutr Sci Vitaminol (Tokyo) 32, 613-622.
12. Venables M, Hulston C, Cox H, et al. (2008) Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am J Clin Nutr 87, 778-784. (Pubitemid 351364561)
13. Dulloo A, Seydoux J, Girardier L, et al. (2000) Green tea and thermogenesis: interactions between catechin-polyphenols, caffeine and sympathetic activity. Int J Obes Relat Metab Disord 24, 252-258. (Pubitemid 30107577)
14. Boschmann M & Thielecke F (2007) The effects of epigallo-catechin-3- gallate on thermogenesis and fat oxidation in obese men: a pilot study. J Am Coll Nutr 26, 389S-395S. (Pubitemid 47579908)
15. Bérubé-Parent S, Pelletier C, Doré J, et al. (2005) Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men. Br J Nutr 94, 432-436. (Pubitemid 41404286)
16. Rudelle S, Ferruzzi M, Cristiani I, et al. (2007) Effect of a thermogenic beverage on 24-hour energy metabolism in humans. Obesity (Silver Spring) 15, 349-355. (Pubitemid 46407315)
17. Gregersen N, Bitz C, Krog-Mikkelsen I, et al. (2009) Effect of moderate intakes of different tea catechins and caffeine on acute measures of energy metabolism under sedentary conditions. Br J Nutr 102, 1187-1194.
18. Nagao T, Komine Y, Soga S, et al. (2005) Ingestion of a tea rich in catechins leads to a reduction in body fat and malon-dialdehyde-modified LDL in men. Am J Clin Nutr 81, 122-129. (Pubitemid 43073384)
19. Hill A, Coates A, Buckley J, et al. (2007) Can EGCG reduce abdominal fat in obese subjects? J Am Coll Nutr 26, 396S-402S. (Pubitemid 47579909)
20. Chantre P & Lairon D (2002) Recent findings of green tea extract AR25 (Exolise) and its activity for the treatment of obesity. Phytomedicine 9, 3-8. (Pubitemid 34184203)
21. Kajimoto O, Kajimoto Y, Yabune M, et al. (2005) Tea catechins with a galloyl moiety reduce body weight and fat. J Health Sci 51, 161-171. (Pubitemid 40628461)
22. Harada U, Chikama A, Saito S, et al. (2005) Effects of the long-term ingestion of tea catechins on energy expenditure and dietary fat oxidation in healthy subjects. J Health Sci 51, 248-252. (Pubitemid 40628475)
23. Auvichayapat P, Prapochanung M, Tunkamnerdthai O, et al. (2008) Effectiveness of green tea on weight reduction in obese Thais: a randomized, controlled trial. Physiol Behav 93, 486-491. (Pubitemid 351208430)
24. Wang H, Wen Y, Du Y, et al. (2010) Effects of catechin enriched green tea on body composition. Obesity 18, 773-779.
25. Nagao T, Hase T & Tokimitsu I (2007) A green tea extract high in catechins reduces body fat and cardiovascular risks in humans. Obesity (Silver Spring) 15, 1473-1483. (Pubitemid 47110911)
26. Matsuyama T, Tanaka Y, Kamimaki I, et al. (2008) Catechin safely improved higher levels of fatness, blood pressure, and cholesterol in children. Obesity 16, 1338-1348. (Pubitemid 351770536)
27. Hsu C, Tsai T, Kao Y, et al. (2008) Effect of green tea extract on obese women: a randomized, double-blind, placebo-controlled clinical trial. Clin Nutr 27, 363-370.
28. Kovacs E, Lejeune M, Nijs I, et al. (2004) Effects of green tea on weight maintenance after body-weight loss. Br J Nutr 91, 431-437. (Pubitemid 38386907)
29. Diepvens K, Kovacs E, Nijs I, et al. (2005) Effect of green tea on resting energy expenditure and substrate oxidation during weight loss in overweight females. Br J Nutr 94, 1026-1034. (Pubitemid 43092437)
30. Westerterp-Plantenga M, Lejeune M & Kovacs E (2005) Body weight loss and weight maintenance in relation to habitual caffeine intake and green tea supplementation. Obes Res 13,1195-1204.
31. Shimotoyodome A, Haramizu S, Inaba M, et al. (2005) Exercise and green tea extract stimulate fat oxidation and prevent obesity in mice. Med Sci Sports Exerc 37, 1884-1892. (Pubitemid 41691830)
32. Murase T, Haramizu S, Shimotoyodome A, et al. (2006) Green tea extract improves running endurance in mice by stimulating lipid utilization during exercise. Am J Physiol Regul Integr Comp Physiol 290, R1550-R1556. (Pubitemid 43830819)
33. Murase T, Haramizu S, Shimotoyodome A, et al. (2005) Green tea extract improves endurance capacity and increases muscle lipid oxidation in mice. Am J Physiol Regul Integr Comp Physiol 288, R708-R715. (Pubitemid 40250583)
34. Klaus S, Pültz S, Thöne-Reineke C, et al. (2005) Epigallocate-chin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation. Int J Obes (Lond) 29, 615-623. (Pubitemid 40769483)
35. Bose M, Lambert JD, Ju J, et al. (2008) The major green tea polyphenol, (2)-epigallocatechin-3-gallate, inhibits obesity, metabolic syndrome, and fatty liver disease in high-fat-fed mice. J Nutr 138, 1677-1683.
36. Choo JJ (2003) Green tea reduces body fat accretion caused by high-fat diet in rats through beta-adrenoceptor activation of thermogenesis in brown adipose tissue. J Nutr Biochem 14, 671-676. (Pubitemid 37415270)
37. Ikeda I, Hamamoto R, Uzu K, et al. (2005) Dietary gallate esters of tea catechins reduce deposition of visceral fat, hepatic triacylglycerol, and activities of hepatic enzymes related to fatty acid synthesis in rats. Biosci Biotechnol Bio-chem 69, 1049-1053. (Pubitemid 41006986)
38. Murase T, Haramizu S, Ota N, et al. (2008) Tea catechin ingestion combined with habitual exercise suppresses the aging-associated decline in physical performance in senescence-accelerated mice. Am J Physiol Regul Integr Comp Physiol 295, R281-R289.
39. Ikeda I, Kobayashi M, Hamada T, et al. (2003) Heat-epimer-ized tea catechins rich in gallocatechin gallate and catechin gallate are more effective to inhibit cholesterol absorption than tea catechins rich in epigallocatechin gallate and epica-techin gallate. J Agric Food Chem 51, 7303-7307.
40. Seto R, Nakamura H, Nanjo F, et al. (1997) Preparation of epimers of tea catechins by heat treatment. Biosci Biotechnol Biochem 61, 1434-1439. (Pubitemid 127472958)
41. Yang B, Arai K & Kusu F (2000) Determination of catechins in human urine subsequent to tea ingestion by high-performance liquid chromatography with electrochemical detection. Anal Biochem 283, 77-82. (Pubitemid 30469753)
42. Suzuki M, Sano M, Yoshida R, et al. (2003) Epimerization of tea catechins and O-methylated derivatives of (2)-epigallo-catechin-3-O-gallate: relationship between epimerization and chemical structure. J Agric Food Chem 51, 510-514.
43. Yang C, Chen L, Lee M, et al. (1998) Blood and urine levels of tea catechins after ingestion of different amounts of green tea by human volunteers. Cancer Epidemiol Biomarkers Prev 7, 351-354. (Pubitemid 28354149)
44. Chow H, Hakim I, Vining D, et al. (2005) Effects of dosing condition on the oral bioavailability of green tea catechins after single-dose administration of polyphenon E in healthy individuals. Clin Cancer Res 11, 4627-4633. (Pubitemid 40825654)
45. Nakagawa K, Okuda S & Miyazawa T (1997) Dose-dependent incorporation of tea catechins, (2)-epigallocatechin-3-gallate and (2)-epigallocatechin, into human plasma. Biosci Biotechnol Biochem 61, 1981-1985. (Pubitemid 127473054)
46. Mullen W, Borges G, Lean ME, et al. (2010) Identification of metabolites in human plasma and urine after consumption of a polyphenol-rich juice drink. J Agric Food Chem 58, 2586-2595.
47. Stalmach A, Mullen W, Steiling H, et al. (2010) Absorption, metabolism, and excretion of green tea flavan-3-ols in humans with an ileostomy. Mol Nutr Food Res 54, 323-334.
48. Stalmach A, Troufflard S, Serafini M, et al. (2009) Absorption, metabolism and excretion of Choladi green tea flavan-3-ols by humans. Mol Nutr Food Res 53, S44-S53.
49. Renouf M, Guy P, Marmet C, et al. (2010) Plasma appearance and correlation between coffee and green tea metabolites in human subjects. Br J Nutr 104, 1635-1640.
50. Williamson G & Clifford MN (2010) Colonic metabolites of berry polyphenols: the missing link to biological activity? Br J Nutr 104, S48-S66.
51. Borchardt R & Huber J (1975) Catechol O-methyltransferase. 5. Structure-activity relationships for inhibition by flavo-noids. J Med Chem 18, 120-122.
52. Holm C (2003) Molecular mechanisms regulating hormone-sensitive lipase and lipolysis. Biochem Soc Trans 31, 1120-1124. (Pubitemid 38030921)
53. Lu H, Meng X & Yang C (2003) Enzymology of methylation of tea catechins and inhibition of catechol-O-methyltransfer-ase by (2)-epigallocatechin gallate. Drug Metab Dispos 31, 572-579. (Pubitemid 36444166)
54. Dulloo A (2002) Biomedicine. A sympathetic defense against obesity. Science 297, 780-781. (Pubitemid 34839615)
55. Lafontan M & Langin D (2009) Lipolysis and lipid mobilization in human adipose tissue. Prog Lipid Res 48, 275-297.
56. Mochizuki M & Hasegawa N (2004) Effects of green tea catechin-induced lipolysis on cytosol glycerol content in differentiated 3T3-L1 cells. Phytother Res 18, 945-946. (Pubitemid 40052777)
57. Diepvens K, Westerterp K & Westerterp-Plantenga M (2007) Obesity and thermogenesis related to the consumption of caffeine, ephedrine, capsaicin, and green tea. Am J Physiol Regul Integr Comp Physiol 292, R77-R85. (Pubitemid 46089816)
58. Chen D, Wang CY, Lambert JD, et al. (2005) Inhibition of human liver catechol-O-methyltransferase by tea catechins and their metabolites: structure-activity relationship and molecular-modeling studies. Biochem Pharmacol 69, 1523-1531. (Pubitemid 40602453)
59. Zhu BT, Patel UK, Cai MX, et al. (2000) O-Methylation of tea polyphenols catalysed by human placental cytosolic cate-chol-O-methyltransferase. Drug Metab Disp 28, 1024-1030. (Pubitemid 30660355)
60. Zhu BT, Patel UK, Cai MX, et al. (2001) Rapid conversion of tea catechins to monomethylated products by rat liver cytosolic catechol-O-methyltransferase. Xenobiotica 31, 879-890. (Pubitemid 34074790)
61. Saggerson E & Carpenter C (1981) Effects of fasting and malonyl CoA on the kinetics of carnitine palmitoyltransferase and carnitine octanoyltransferase in intact rat liver mitochondria. FEBS Lett 132, 166-168. (Pubitemid 12174656)
62. Escrivá F, Pascual-Leone A, Hernández J, et al. (1987) Effect of feeding pattern on the sensitivity of hepatic carni-tine palmitoyl-transferase to inhibition by malonyl-CoA in the rat. Comp Biochem Physiol A Comp Physiol 87, 1041-1043.
63. Cook G (1984) Differences in the sensitivity of carnitine palmitoyltransferase to inhibition by malonyl-CoA are due to differences in Ki values. J Biol Chem 259, 12030-12033. (Pubitemid 14022134)
64. López-Viñas E, Bentebibel A, Gurunathan C, et al. (2007) Definition by functional and structural analysis of two malonyl-CoA sites in carnitine palmitoyltransferase 1A. J Biol Chem 282, 18212-18224. (Pubitemid 47100225)
65. Lin JK & Lin-Shiau SY (2006) Mechanisms of hypolipidemic and anti-obesity effects of tea and tea polyphenols. Mol Nutr Food Res 50, 211-217.
66. Kao Y, Chang H, Lee M, et al. (2006) Tea, obesity, and diabetes. Mol Nutr Food Res 50, 188-210. (Pubitemid 43325660)
67. Wang X, Song K, Guo Q, et al. (2003) The galloyl moiety of green tea catechins is the critical structural feature to inhibit fatty-acid synthase. Biochem Pharmacol 66, 2039-2047. (Pubitemid 37352867)
68. Wang X & Tian W (2001) Green tea epigallocatechin gallate: a natural inhibitor of fatty-acid synthase. Biochem Biophys Res Commun 288, 1200-1206. (Pubitemid 33131728)
69. Watanabe J, Kawabata J & Niki R (1998) Isolation and identification of acetyl-CoA carboxylase inhibitors from green tea (Camellia sinensis). Biosci Biotechnol Biochem 62, 532-534. (Pubitemid 128474960)
70. Murase T, Misawa K, Haramizu S, et al. (2009) Catechin-induced activation of the LKB1/AMP-activated protein kinase pathway. Biochem Pharmacol 78, 78-84.
71. Wolfram S, Wang Y & Thielecke F (2006) Anti-obesity effects of green tea: from bedside to bench. Mol Nutr Food Res 50, 176-187. (Pubitemid 43325659)
72. Juhel C, Armand M, Pafumi Y, et al. (2000) Green tea extract (AR25) inhibits lipolysis of triglycerides in gastric and duodenal medium in vitro. J Nutr Biochem 11, 45-51. (Pubitemid 30081719)
73. Shishikura Y, Khokhar S & Murray B (2006) Effects of tea polyphenols on emulsification of olive oil in a small intestine model system. J Agric Food Chem 54, 1906-1913.
74. Young S & Hui D (1999) Pancreatic lipase/colipase-mediated triacylglycerol hydrolysis is required for cholesterol transport from lipid emulsions to intestinal cells. Biochem J 339, 615-620. (Pubitemid 29243525)
75. Koo S & Noh S (2007) Green tea as inhibitor of the intestinal absorption of lipids: potential mechanism for its lipid-lowering effect. J Nutr Biochem 18, 179-183. (Pubitemid 46216812)
76. Ikeda I, Imasato Y, Sasaki E, et al. (1992) Tea catechins decrease micellar solubility and intestinal absorption of cholesterol in rats. Biochim Biophys Acta 1127, 141-146.
77. Wang S, Noh S & Koo S (2006) Green tea catechins inhibit pancreatic phospholipase A(2) and intestinal absorption of lipids in ovariectomized rats. J Nutr Biochem 17, 492-498. (Pubitemid 43867256)
78. Loftus T, Jaworsky D, Frehywot G, et al. (2000) Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288, 2379-2381. (Pubitemid 30448165)
79. Bouchard C (2000) Inhibition of food intake by inhibitors of fatty acid synthase. N Engl J Med 343, 1888-1889. (Pubitemid 32104137)
80. Yeh C, Chen W, Chiang C, et al. (2003) Suppression of fatty acid synthase in MCF-7 breast cancer cells by tea and tea polyphenols: a possible mechanism for their hypolipidemic effects. Pharmacogenomics J 3, 267-276. (Pubitemid 37428192)
81. Li B, Ma X, Wang Y, et al. (2005) Structure-activity relationship of polyphenols that inhibit fatty acid synthase. J Biochem 138, 679-685. (Pubitemid 43258861)
82. Hursel R, Viechtbauer W & Westerterp-Plantenga MS (2009) The effects of green tea on weight loss and weight maintenance: a meta-analysis. Int J Obes (Lond) 33, 956-961.
83. Cornelis MC, El-Sohemy A & Campos H (2007) Genetic polymorphism of the adenosine A2A receptor is associated with habitual caffeine consumption. Am J Clin Nutr 86, 240-244. (Pubitemid 47041616)
84. Palmatier MA, Kang AM & Kidd KK (1999) Global variation in the frequencies of functionally different catechol-O-methyltransferase alleles. Biol Psychiatry 46, 557-567. (Pubitemid 29370449)
85. Hursel R & Westerterp-Plantenga MS (2009) Green tea catechin plus caffeine supplementation to a high-protein diet has no additional effect on body weight maintenance after weight loss. Am J Clin Nutr 89, 822-830.
86. Hollman PC, Van Het Hof KH, Tijburg LB, et al. (2001) Addition of milk does not affect the absorption of flavonols from tea in man. Free Radic Res 34, 297-300. (Pubitemid 32331657)
87. Kyle JA, Morrice PC, McNeill G, et al. (2007) Effects of infusion time and addition of milk on content and absorption of polyphenols from black tea. J Agric Food Chem 55, 4889-4894. (Pubitemid 46960921)
88. Panza V, Wazlawik E, Ricardo Schütz G, et al. (2008) Consumption of green tea favorably affects oxidative stress markers in weight-trained men. Nutrition 24, 433-442.