Glycine intake decreases plasma free fatty acids, adipose cell size, and blood pressure in sucrose-fed rats

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 287, Issue 6 56-6, 2004, Pages

  El Hafidi, Mohammed ^a   Pérez, Israel ^a   Zamora, Jose ^a   Soto, Virgilia ^a   Carvajal Sandoval, Guillermo ^b   Baños, Guadalupe ^a  

^a INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^b SECRETARÍA DE SALUD   (Mexico)

Author keywords

Fatty acid oxidation; Mitochondrial oxygen uptake; Obesity

Indexed keywords

DRINKING WATER; FATTY ACID; GLYCINE; OCTANOIC ACID; PALMITOYLCARNITINE; SUCROSE; TRIACYLGLYCEROL;

ADIPOSE TISSUE CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; CELL SIZE; CONTROLLED STUDY; FATTY ACID BLOOD LEVEL; FATTY ACID OXIDATION; HYPERTENSION; LIPID STORAGE; LIVER METABOLISM; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ADIPOSE TISSUE; ANIMALS; CELL SIZE; DIETARY SUCROSE; FATTY ACIDS, NONESTERIFIED; GLYCINE; LIVER; MALE; RATS; RATS, WISTAR; SUCROSE;

EID: 8844284363     PISSN: 03636119     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpregu.00159.2004     Document Type: Article

References (52)

1. Baños G, Carvajal K, Cardoso G, Zamora J, and Franco M. Vascular reactivity and effect of plasma in a rat model of hypertension and hypertriglyceridemia. Am J Hypertens 10: 379-388, 1997.
2. Barrett-Connor E. Obesity, atherosclerosis and coronary artery disease. Ann Intern Med 103: 1010-1019, 1985.
3. Belzung F, Raclot T, and Groscolas R. Fish oil n-3 fatty acids selectively limit the hypertrophy of abdominal fat depots in growing rats fed high fat diets. Am J Physiol Regul Integr Comp Physiol 264: R1111-R1118, 1993.
4. Berger JJ and Bernard RJ. Effect of diet on fat cell size and hormone-sensitive lipase activity. J Appl Physiol 87: 227-232, 1999.
5. Bergeron R, Previs SF, Cline GW, Perret P, Russell RR, Young LH, and Shulman GI. Effect of 5-aminoimidazole-4-carboxamide-1-β-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats. Diabetes 50: 1076-1082, 2001.
6. Björntorp P. Abdominal fat and the development of non-insulin dependent diabetes mellitus. Diabetes Metab Rev 4: 615-622, 1988.
7. Boden G and Chen X. Effects of fat on glucose uptake and utilization in patients with non-insulin-dependent diabetes. J Clin Invest 96: 1261-1268, 1995.
8. Bouchard C, Després JP, Mauriege P, Marcotte M, Chagnon M, Dionne FT, and Belanger A. The genes in the constellation of determinants of regional fat distribution. Int J Obes 15: 9-18, 1991.
9. Bray GA. Complications of obesity. Ann Intern Med 103: 1052-1062, 1985.
10. Bulow J, Madsen J, and Hojgaard J. Reversibility of the effects on local circulation of high lipid concentrations in blood. Scand J Clin Lab Invest 50: 291-296, 1990.
11. + overload in the rat. Hepatology 26: 107-112, 1997.
12. Carvajal-Sandoval G, Juarez E, Ramos-Martinez G, Carvajal-Juarez ME, and Medina-Santillan R. Inhibition of hemoglobin glycation with glycine in induced diabetes mellitus in rats. Proc West Pharmacol Soc 42: 35-36, 1999.
13. Carvajal Sandoval G, Medina-Santillan R, Juarez E, Ramos-Martinez G, and Carvajal-Juarez ME. Effect of glycine on hemoglobin glycation in diabetic patients. Proc West Pharmacol Soc 42: 31-32, 1999.
14. Cassel MD, Yi H, and Talman WT. Glycine receptor (gephyrin) inmunoreactivity is present on cholinergic neurons in the dorsal vagal complex. Neuroscience 95: 489-497, 2000.
15. Commerford SR, Pagliassotti MJ, Melby CL, Wei Y, Gayles EC, and Hill JO. Fat oxidation, lipolysis, and free fatty acid cycling in obesity-prone and obesity-resistant rats. Am J Physiol Endocrinol Metab 279: E875-E885, 2000.
16. Davda RK, Stepniakowski KT, Lu G, Ullian ME, Goodfriend TL, and Egan BM. Oleic acid inhibits endothelial nitric oxide synthase by a protein kinase C-independent mechanism. Hypertension 26: 764-770, 1995.
17. Després JP, Moorjani S, Lupien PJ, Trembaly A, Nadeau A, and Bouchard C. Regional distribution of body fat, plasma lipoprotein and cardiovascular disease. Artheriosderosis 10: 497-511, 1990.
18. El Hafidi M, Cuéllar A, Ramírez J, and Baños G. Effect of sucrose addition to the drinking water, that induces hypertension in the rats, on liver microsomal Δ9 and Δ5-desaturase activity. J Nutr Biochem 12: 65-71, 2001.
19. El Hafidi M, Valdez R, and Baños G. Possible relationship between altered fatty acid composition of plasma, platelets and aorta and hypertension induced by sugar feeding in rats. Clin Exp Hypertens 22: 99-108, 2000.
20. Campagna FA, Balkau B, Simon D, Warnet JM, Claude JR, Ducimetière P, and Eschwège E. High free fatty acid concentration: an independent risk factor for hypertension in the Paris Prospective Study. Int J Epidemiol 27: 808-813, 1998.
21. Fain JN and Garcia-Sainz JA. Adrenergic regulation in adipose metabolism. J Lipid Res 24: 945-966, 1983.
22. Folch L, Lees M, and Sloane-Stanley CH. A simple method for the isolation and a purification of total lipid from animal tissues. J Biol Chem 22: 697-509, 1957.
23. Goodfriend TL and Egan BM. Nonesterified fatty acids in the pathogenesis of hypertension: theory and evidence. Prostaglandins Leukot Essent Fatty Acids 57: 57-63, 1997.
24. Grekin RJ, Vollmer AP, and Sider RS. Pressor effects of portal venous oleate infusion. A proposed mechanism for obesity hypertension. Hypertension 26: 193-198, 1995.
25. 1-adrenergic receptor-mediated pressor sensitivity. Hypertension 32: 693-698, 1998.
26. Hwang IS, Ho H, Hoffman BB, and Reaven GM. Fructose-induced insulin resistance and hypertension in rats. Hypertension 10: 512-516, 1987.
27. Ikejima K, Iimuro Y, Forman DT, and Thurman RG. A diet containing glycine improves survival in endotoxin shock in, the rat. Am J Physiol Gastrointest Liver Physiol 271: G97-G103, 1996.
28. Jansson PA, Larsson A, and Lönnroth PN. Relationship between blood pressure, metabolic variables and blood flow in obese subjects with or without non-insulin-dependent diabetes mellitus. Eur J Clin Invest 28: 813-818, 1998.
29. Kanai H, Tokunaga K, Fujioka S, Yamashita S, Kameda-Takemura KK, and Matsuzawa Y. Decrease in intra-abdominal visceral fat may reduce blood pressure in obese hypertensive women. Hypertension 27: 125-129, 1996.
30. Kim JK, Wi JK, and Youn JH. Plasma free fatty acids decrease insulin stimulated skeletal muscle glucose uptake by suppressing glycolysis in conscious rats. Diabetes 45: 446-453, 1996.
31. Kopelman PG. Obesity as a medical problem. Nature 404: 635-643, 2000.
32. Lowry OH, Rosebrough NJ, Farr A, and Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275, 1951.
33. Martin ML and Jensen MD. Effects of body fat distribution on regional lipolysis in obesity. J Clin Invest 88: 609-613, 1991.
34. Matsuzawa Y, Shimomura I, Nakamura T, Keno Y, Kotani K, and Tokunaga K. Pathophysiology and pathogenesis of visceral fat obesity. Obes Res 3: 187S-194S, 1995.
35. McClelland GB, Hochachka PW, and Weber JM. Effect of high-altitude acclimation on NEFA turnover and lipid utilization during exercise in rats. Am J Physiol Endocrinol Metab 277: E1095-E1102, 1999.
36. Munday MR and Hemingway CJ. The regulation of acetyl-CoA carboxylase: a potential target for the action of hypolipidemic agents. Adv Enzyme Regul 39: 205-234, 1999.
37. Nägele U, Hägele EO, Sauer G, Wiedeman E, Lehmann P, Wahlefeld AW, and Gruber W. Reagent for the enzymatic determination of serum total triglycerides with improved lipolytic efficiency. J Clin Chem Clin Biochem 22: 165-174, 1984.
38. Narce M and Poisson JP. Polyunsaturated fatty acid biogenesis is impaired in spontaneously hypertensive rat in relation to the pathogenesis of hypertension. Arch Mal Coeur Vaiss 89: 1025-1028, 1996.
39. Nava P, Guarner V, Posadas R, Perez I, and Baños G. Insulin-induced endothelin release and vasoreactivity in hypertriglyceridemic and hypertensive rats. Am J Physiol Heart Circ Physiol 277: H399-H404, 1999.
40. Ratnayake WM, Sarwar G, and Laffey P. Influence of dietary protein and fat on serum lipids and metabolism of essential fatty acids in rats. Br J Nutr 78: 459-467, 1997.
41. Reaven GM, Risser TR, Chen YD, and Reaven EP. Characterization of a model of dietary-induced hypertriglyceridemia in young, nonobese rats. J Lipid Res 20: 371-8, 1979.
42. Rocchini AP, Mao HZ, Babu K, Marker P, and Rocchini AJ. Clonidine prevents insulin resistance and hypertension in obese dogs. Hypertension 33: 548-553, 1999.
43. Rosse RB, Theut SK, Banay-Schwartz M, Leighton M, Scarcella E, Cohen CG, and Deutsch SI. Glycine adjuvant therapy to conventional neuroleptic treatment in schizophrenia: an open-label, pilot study. Clin Neuropharmacol 12: 416-424, 1989.
44. Seidell JC. Environmental influences of regional fat distribution. Int J Obes 15: 31-35, 1991.
45. Stachlewitz RF, Seabra V, Bradford B, Bradham CA, Rusyn I, Germolec D, and Thurman RG. Glycine and uridine prevent D-galactosamine hepatotoxicity in the rats: role of Kupffer cells. Hepatology 29: 737-745, 1999.
46. Steinberg HO, Tarshoby M, Monestel R, Hook G, Cronin J, Johnson A, Bayazeed B, and Baron AD. Elevated circulating free fatty acid levels impair endothelium-dependent vasodilation. J Clin Invest 100: 1230-1239, 1997.
47. Stojiljkovic MP, Zang D, Lopes HF, Lee CG, Goodfriend TL, and Egan BM. Hemodynamic effects of lipids in humans. Am J Physiol Regul Integr Comp Physiol 280: R1674-R1679, 2001.
48. Talman WT and Robertson SC. Glycine, like glutamate, microinjected into the nucleus tractus solitarii of rat decreases arterial pressure and heart rate. Brain Res 477: 7-13, 1989.
49. Toida S, Takahashi M, Shimizu H, Sato N, Shimomura Y, and Kobayashi I. Effect of high sucrose feeding on fat accumulation in the male Wistar rat. Obes Res 4: 561-568, 1996.
50. Tserng KI, Kleigman RM, Mietenen EL, and Kalham SC. A rapid, simple and sensitive procedure for the determination of free fatty acid in plasma using glass capillary column liquid chromatography. J Lipid Res 22: 852-858, 1981.
51. Weinberg JM, Davis JA, Abaezua M, and Rajan T. Cytoprotective effects of glycine and glutathione against hypoxic injury in renal tubules. J Clin Invest 80: 1446-1454, 1987.
52. Wheeler MD, Rose ML, Yamashima S, Enomoto N, Seabra V, Madren J, and Thurman RG. Dietary glycine blunts lung inflammatory cell influx following acute endotoxin. Am J Physiol Lung Cell Mol Physiol 279: L390-L398, 2000.