Isozyme-nonselective N-substituted bipiperidylcarboxamide acetyl-CoA carboxylase inhibitors reduce tissue malonyl-CoA concentrations, inhibit fatty acid synthesis, and increase fatty acid oxidation in cultured cells and in experimental animals

Journal of Biological Chemistry

Volumn 278, Issue 39, 2003, Pages 37099-37111

  Harwood Jr , H James ^a   Petras, Stephen F ^a   Shelly, Lorraine D ^a   Zaccaro, Lawrence M ^a   Perry, David A ^a   Makowski, Michael R ^a   Hargrove, Diane M ^a   Martin, Kelly A ^a   Tracey, W Ross ^a   Chapman, Justin G ^a   Magee, William P ^a   Dalvie, Deepak K ^a   Soliman, Victor F ^a   Martin, William H ^a   Mularski, Christian J ^a   Eisenbeis, Shane A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYLATION; CARDIOVASCULAR SYSTEM; METABOLISM; MUSCLE; ORGANIC COMPOUNDS; OXIDATION; SYNTHESIS (CHEMICAL);

RISK FACTORS;

ENZYMES;

ACETYL COENZYME A; ACETYL COENZYME A CARBOXYLASE; ADENOSINE TRIPHOSPHATE; AMIDE; APOLIPOPROTEIN B; BICARBONATE; BIPIPERIDYLCARBOXAMIDE; CARBOXYL GROUP; CHOLESTEROL; CITRIC ACID; CP 497485; CP 610431; CP 610432; CP 640186; FATTY ACID; ISOENZYME; LIGASE INHIBITOR; MALONYL COENZYME A; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOCHEMISTRY; CARDIOVASCULAR RISK; CELL CULTURE; CELL SECRETION; CELL STRAIN HEPG2; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; ENZYME MECHANISM; EXPERIMENTAL ANIMAL; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; HEART MUSCLE; HUMAN; HUMAN CELL; IC 50; LIPOGENESIS; LIVER; MALE; METABOLIC DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SKELETAL MUSCLE; TISSUE LEVEL;

ACETYL-COA CARBOXYLASE; ADIPOSE TISSUE; ANIMALS; CELLS, CULTURED; ENZYME INHIBITORS; FATTY ACIDS; ISOENZYMES; LIVER; MALE; MALONYL COENZYME A; MICE; MICE, INBRED C3H; MUSCLE, SKELETAL; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES;

ANIMALIA;

EID: 0141510051     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304481200     Document Type: Article

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