-
1
-
-
0028212937
-
Apoptosis and its role in human disease
-
Barr PJ,Tomei LD.Apoptosis and its role in human disease.Biotechnology (N Y). 1994;12:487-93.
-
(1994)
Biotechnology (N Y)
, vol.12
, pp. 487-493
-
-
Barr, P.J.1
Tomei, L.D.2
-
2
-
-
0026053958
-
Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18)
-
McDonnell TJ,Korsmeyer SJ.Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18).Nature. 1991;349:254-6.
-
(1991)
Nature
, vol.349
, pp. 254-256
-
-
McDonnell, T.J.1
Korsmeyer, S.J.2
-
3
-
-
0025939204
-
Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease
-
Strasser A,Whittingham S,Vaux DL, et al.Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease.Proc Natl Acad Sci U S A. 1991;88:8661-5.
-
(1991)
Proc Natl Acad Sci U S A
, vol.88
, pp. 8661-8665
-
-
Strasser, A.1
Whittingham, S.2
Vaux, D.L.3
-
4
-
-
0028943734
-
Apoptosis in the pathogenesis and treatment of disease
-
Thompson CB.Apoptosis in the pathogenesis and treatment of disease.Science. 1995;267:1456-62.
-
(1995)
Science
, vol.267
, pp. 1456-1462
-
-
Thompson, C.B.1
-
5
-
-
0026568919
-
Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis
-
Watanabe-Fukunaga R,Brannan CI,Copeland NG,Jenkins NA,Nagata S.Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis.Nature. 1992;356:314-7.
-
(1992)
Nature
, vol.356
, pp. 314-317
-
-
Watanabe-Fukunaga, R.1
Brannan, C.I.2
Copeland, N.G.3
Jenkins, N.A.4
Nagata, S.5
-
6
-
-
67649386107
-
Life and death by death receptors
-
Guicciardi ME,Gores GJ.Life and death by death receptors.FASEB J. 2009;23:1625-37.
-
(2009)
FASEB J
, vol.23
, pp. 1625-1637
-
-
Guicciardi, M.E.1
Gores, G.J.2
-
7
-
-
41149152733
-
How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?
-
Chipuk JE,Green DR.How do BCL-2 proteins induce mitochondrial outer membrane permeabilization?.Trends Cell Biol. 2008;18:157-64.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 157-164
-
-
Chipuk, J.E.1
Green, D.R.2
-
8
-
-
69249100500
-
Human caspases: activation, specificity, and regulation
-
Pop C,Salvesen GS.Human caspases: activation, specificity, and regulation.J Biol Chem. 2009;284:21777-81.
-
(2009)
J Biol Chem
, vol.284
, pp. 21777-21781
-
-
Pop, C.1
Salvesen, G.S.2
-
9
-
-
75949105922
-
The BCL-2 family reunion
-
Chipuk JE,Moldoveanu T,Llambi F,Parsons MJ,Green DR.The BCL-2 family reunion.Mol Cell. 2010;37:299-310.
-
(2010)
Mol Cell
, vol.37
, pp. 299-310
-
-
Chipuk, J.E.1
Moldoveanu, T.2
Llambi, F.3
Parsons, M.J.4
Green, D.R.5
-
11
-
-
0022379447
-
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining
-
Tsujimoto Y,Gorham J,Cossman J,Jaffe E,Croce CM.The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining.Science. 1985;229:1390-3.
-
(1985)
Science
, vol.229
, pp. 1390-1393
-
-
Tsujimoto, Y.1
Gorham, J.2
Cossman, J.3
Jaffe, E.4
Croce, C.M.5
-
12
-
-
0023786047
-
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells
-
Vaux DL,Cory S,Adams JM.Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells.Nature. 1988;335:440-2.
-
(1988)
Nature
, vol.335
, pp. 440-442
-
-
Vaux, D.L.1
Cory, S.2
Adams, J.M.3
-
13
-
-
0029760303
-
Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types
-
Zhu W,Cowie A,Wasfy GW,Penn LZ,Leber B,Andrews DW.Bcl-2 mutants with restricted subcellular location reveal spatially distinct pathways for apoptosis in different cell types.EMBO J. 1996;15:4130-41.
-
(1996)
EMBO J
, vol.15
, pp. 4130-4141
-
-
Zhu, W.1
Cowie, A.2
Wasfy, G.W.3
Penn, L.Z.4
Leber, B.5
Andrews, D.W.6
-
14
-
-
52149113769
-
Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands
-
Kvansakul M,Yang H,Fairlie WD, et al.Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligands.Cell Death Differ. 2008;15:1564-71.
-
(2008)
Cell Death Differ
, vol.15
, pp. 1564-1571
-
-
Kvansakul, M.1
Yang, H.2
Fairlie, W.D.3
-
15
-
-
0027166048
-
Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death
-
Oltvai ZN,Milliman CL,Korsmeyer SJ.Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death.Cell. 1993;74:609-19.
-
(1993)
Cell
, vol.74
, pp. 609-619
-
-
Oltvai, Z.N.1
Milliman, C.L.2
Korsmeyer, S.J.3
-
16
-
-
0028986876
-
Induction of apoptosis by the Bcl-2 homologue Bak
-
Chittenden T,Harrington EA,O'Connor R, et al.Induction of apoptosis by the Bcl-2 homologue Bak.Nature. 1995;374:733-6.
-
(1995)
Nature
, vol.374
, pp. 733-736
-
-
Chittenden, T.1
Harrington, E.A.2
O'Connor, R.3
-
17
-
-
33751544565
-
The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site
-
Moldoveanu T,Liu Q,Tocilj A,Watson M,Shore G,Gehring K.The X-ray structure of a BAK homodimer reveals an inhibitory zinc binding site.Mol Cell. 2006;24:677-88.
-
(2006)
Mol Cell
, vol.24
, pp. 677-688
-
-
Moldoveanu, T.1
Liu, Q.2
Tocilj, A.3
Watson, M.4
Shore, G.5
Gehring, K.6
-
18
-
-
0036850312
-
Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane
-
Kuwana T,Mackey MR,Perkins G, et al.Bid, Bax, and lipids cooperate to form supramolecular openings in the outer mitochondrial membrane.Cell. 2002;111:331-42.
-
(2002)
Cell
, vol.111
, pp. 331-342
-
-
Kuwana, T.1
Mackey, M.R.2
Perkins, G.3
-
19
-
-
0034508217
-
The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues
-
Lindsten T,Ross AJ,King A, et al.The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.Mol Cell. 2000;6:1389-99.
-
(2000)
Mol Cell
, vol.6
, pp. 1389-1399
-
-
Lindsten, T.1
Ross, A.J.2
King, A.3
-
20
-
-
0035957653
-
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
-
Wei MC,Zong WX,Cheng EH, et al.Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death.Science. 2001;292:727-30.
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
-
21
-
-
0033713002
-
Structure of Bax: coregulation of dimer formation and intracellular localization
-
Suzuki M,Youle RJ,Tjandra N.Structure of Bax: coregulation of dimer formation and intracellular localization.Cell. 2000;103:645-54.
-
(2000)
Cell
, vol.103
, pp. 645-654
-
-
Suzuki, M.1
Youle, R.J.2
Tjandra, N.3
-
22
-
-
33845486323
-
Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets
-
Hinds MG,Smits C,Fredericks-Short R, et al.Bim, Bad and Bmf: intrinsically unstructured BH3-only proteins that undergo a localized conformational change upon binding to prosurvival Bcl-2 targets.Cell Death Differ. 2007;14:128-36.
-
(2007)
Cell Death Differ
, vol.14
, pp. 128-136
-
-
Hinds, M.G.1
Smits, C.2
Fredericks-Short, R.3
-
23
-
-
0034663829
-
tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c
-
Wei MC,Lindsten T,Mootha VK, et al.tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c.Genes Dev. 2000;14:2060-71.
-
(2000)
Genes Dev
, vol.14
, pp. 2060-2071
-
-
Wei, M.C.1
Lindsten, T.2
Mootha, V.K.3
-
24
-
-
13944277343
-
BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly
-
Kuwana T,Bouchier-Hayes L,Chipuk JE, et al.BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly.Mol Cell. 2005;17:525-35.
-
(2005)
Mol Cell
, vol.17
, pp. 525-535
-
-
Kuwana, T.1
Bouchier-Hayes, L.2
Chipuk, J.E.3
-
25
-
-
0036728834
-
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics
-
Letai A,Bassik MC,Walensky LD,Sorcinelli MD,Weiler S,Korsmeyer SJ.Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics.Cancer Cell. 2002;2:183-92.
-
(2002)
Cancer Cell
, vol.2
, pp. 183-192
-
-
Letai, A.1
Bassik, M.C.2
Walensky, L.D.3
Sorcinelli, M.D.4
Weiler, S.5
Korsmeyer, S.J.6
-
26
-
-
69749112731
-
PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis
-
Chipuk JE,Green DR.PUMA cooperates with direct activator proteins to promote mitochondrial outer membrane permeabilization and apoptosis.Cell Cycle. 2009;8:2692-6.
-
(2009)
Cell Cycle
, vol.8
, pp. 2692-2696
-
-
Chipuk, J.E.1
Green, D.R.2
-
27
-
-
78649700978
-
BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program
-
Ren D,Tu HC,Kim H, et al.BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program.Science. 2010;330:1390-3.
-
(2010)
Science
, vol.330
, pp. 1390-1393
-
-
Ren, D.1
Tu, H.C.2
Kim, H.3
-
28
-
-
33846964621
-
Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak
-
Willis SN,Fletcher JI,Kaufmann T, et al.Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.Science. 2007;315:856-9.
-
(2007)
Science
, vol.315
, pp. 856-859
-
-
Willis, S.N.1
Fletcher, J.I.2
Kaufmann, T.3
-
29
-
-
0030970085
-
harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L)
-
Inohara N,Ding L,Chen S,Nunez G.harakiri, a novel regulator of cell death, encodes a protein that activates apoptosis and interacts selectively with survival-promoting proteins Bcl-2 and Bcl-X(L).EMBO J. 1997;16:1686-94.
-
(1997)
EMBO J
, vol.16
, pp. 1686-1694
-
-
Inohara, N.1
Ding, L.2
Chen, S.3
Nunez, G.4
-
30
-
-
0035265686
-
PUMA, a novel proapoptotic gene, is induced by p53
-
Nakano K,Vousden KH.PUMA, a novel proapoptotic gene, is induced by p53.Mol Cell. 2001;7:683-94.
-
(2001)
Mol Cell
, vol.7
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
31
-
-
0034640281
-
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
-
Oda E,Ohki R,Murasawa H, et al.Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis.Science. 2000;288:1053-8.
-
(2000)
Science
, vol.288
, pp. 1053-1058
-
-
Oda, E.1
Ohki, R.2
Murasawa, H.3
-
32
-
-
0035823238
-
Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis
-
Puthalakath H,Villunger A,O'Reilly LA, et al.Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis.Science. 2001;293:1829-32.
-
(2001)
Science
, vol.293
, pp. 1829-1832
-
-
Puthalakath, H.1
Villunger, A.2
O'Reilly, L.A.3
-
33
-
-
0028809209
-
Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death
-
Yang E,Zha J,Jockel J,Boise LH,Thompson CB,Korsmeyer SJ.Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death.Cell. 1995;80:285-91.
-
(1995)
Cell
, vol.80
, pp. 285-291
-
-
Yang, E.1
Zha, J.2
Jockel, J.3
Boise, L.H.4
Thompson, C.B.5
Korsmeyer, S.J.6
-
34
-
-
70449941949
-
Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices
-
Dewson G,Kratina T,Czabotar P,Day CL,Adams JM,Kluck RM.Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices.Mol Cell. 2009;36:696-703.
-
(2009)
Mol Cell
, vol.36
, pp. 696-703
-
-
Dewson, G.1
Kratina, T.2
Czabotar, P.3
Day, C.L.4
Adams, J.M.5
Kluck, R.M.6
-
35
-
-
0030780106
-
Movement of Bax from the cytosol to mitochondria during apoptosis
-
Wolter KG,Hsu YT,Smith CL,Nechushtan A,Xi XG,Youle RJ.Movement of Bax from the cytosol to mitochondria during apoptosis.J Cell Biol. 1997;139:1281-92.
-
(1997)
J Cell Biol
, vol.139
, pp. 1281-1292
-
-
Wolter, K.G.1
Hsu, Y.T.2
Smith, C.L.3
Nechushtan, A.4
Xi, X.G.5
Youle, R.J.6
-
36
-
-
33749846225
-
Role of Bax and Bak in mitochondrial morphogenesis
-
Karbowski M,Norris KL,Cleland MM,Jeong SY,Youle RJ.Role of Bax and Bak in mitochondrial morphogenesis.Nature. 2006;443:658-62.
-
(2006)
Nature
, vol.443
, pp. 658-662
-
-
Karbowski, M.1
Norris, K.L.2
Cleland, M.M.3
Jeong, S.Y.4
Youle, R.J.5
-
37
-
-
79953276389
-
Bcl-x(L) Retrotranslocates Bax from the mitochondria into the cytosol
-
Edlich F,Banerjee S,Suzuki M, et al.Bcl-x(L) Retrotranslocates Bax from the mitochondria into the cytosol.Cell. 2011;145:104-16.
-
(2011)
Cell
, vol.145
, pp. 104-116
-
-
Edlich, F.1
Banerjee, S.2
Suzuki, M.3
-
38
-
-
78149449341
-
BH3-triggered structural reorganization drives the activation of proapoptotic BAX
-
Gavathiotis E,Reyna DE,Davis ML,Bird GH,Walensky LD.BH3-triggered structural reorganization drives the activation of proapoptotic BAX.Mol Cell. 2010;40:481-92.
-
(2010)
Mol Cell
, vol.40
, pp. 481-492
-
-
Gavathiotis, E.1
Reyna, D.E.2
Davis, M.L.3
Bird, G.H.4
Walensky, L.D.5
-
39
-
-
70449091753
-
Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis
-
Kim H,Tu HC,Ren D, et al.Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.Mol Cell. 2009;36:487-99.
-
(2009)
Mol Cell
, vol.36
, pp. 487-499
-
-
Kim, H.1
Tu, H.C.2
Ren, D.3
-
40
-
-
57149135309
-
Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax
-
Lovell JF,Billen LP,Bindner S, et al.Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax.Cell. 2008;135:1074-84.
-
(2008)
Cell
, vol.135
, pp. 1074-1084
-
-
Lovell, J.F.1
Billen, L.P.2
Bindner, S.3
-
41
-
-
68149107692
-
BAD: undertaker by night, candyman by day
-
Danial NN.BAD: undertaker by night, candyman by day.Oncogene. 2008;27 (Suppl 1): S53-70.
-
(2008)
Oncogene
, vol.27
, Issue.SUPPL. 1
, pp. 53-70
-
-
Danial, N.N.1
-
42
-
-
0033635235
-
14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation
-
Datta SR,Katsov A,Hu L, et al.14-3-3 proteins and survival kinases cooperate to inactivate BAD by BH3 domain phosphorylation.Mol Cell. 2000;6:41-51.
-
(2000)
Mol Cell
, vol.6
, pp. 41-51
-
-
Datta, S.R.1
Katsov, A.2
Hu, L.3
-
43
-
-
1842333237
-
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt
-
del Peso L,Gonzalez-Garcia M,Page C,Herrera R,Nunez G.Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.Science. 1997;278:687-9.
-
(1997)
Science
, vol.278
, pp. 687-689
-
-
del Peso, L.1
Gonzalez-Garcia, M.2
Page, C.3
Herrera, R.4
Nunez, G.5
-
44
-
-
0037174934
-
JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery
-
Donovan N,Becker EB,Konishi Y,Bonni A.JNK phosphorylation and activation of BAD couples the stress-activated signaling pathway to the cell death machinery.J Biol Chem. 2002;277:40944-9.
-
(2002)
J Biol Chem
, vol.277
, pp. 40944-40949
-
-
Donovan, N.1
Becker, E.B.2
Konishi, Y.3
Bonni, A.4
-
45
-
-
0030584088
-
Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
-
Zha J,Harada H,Yang E,Jockel J,Korsmeyer SJ.Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L).Cell. 1996;87:619-28.
-
(1996)
Cell
, vol.87
, pp. 619-628
-
-
Zha, J.1
Harada, H.2
Yang, E.3
Jockel, J.4
Korsmeyer, S.J.5
-
46
-
-
0030827971
-
BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity
-
Zha J,Harada H,Osipov K,Jockel J,Waksman G,Korsmeyer SJ.BH3 domain of BAD is required for heterodimerization with BCL-XL and pro-apoptotic activity.J Biol Chem. 1997;272:24101-4.
-
(1997)
J Biol Chem
, vol.272
, pp. 24101-24104
-
-
Zha, J.1
Harada, H.2
Osipov, K.3
Jockel, J.4
Waksman, G.5
Korsmeyer, S.J.6
-
47
-
-
0041357164
-
BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis
-
Danial NN,Gramm CF,Scorrano L, et al.BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.Nature. 2003;424:952-6.
-
(2003)
Nature
, vol.424
, pp. 952-956
-
-
Danial, N.N.1
Gramm, C.F.2
Scorrano, L.3
-
48
-
-
38949140180
-
Dual role of proapoptotic BAD in insulin secretion and beta cell survival
-
Danial NN,Walensky LD,Zhang CY, et al.Dual role of proapoptotic BAD in insulin secretion and beta cell survival.Nat Med. 2008;14:144-53.
-
(2008)
Nat Med
, vol.14
, pp. 144-153
-
-
Danial, N.N.1
Walensky, L.D.2
Zhang, C.Y.3
-
49
-
-
0042424706
-
Bad-deficient mice develop diffuse large B cell lymphoma
-
Ranger AM,Zha J,Harada H, et al.Bad-deficient mice develop diffuse large B cell lymphoma.Proc Natl Acad Sci U S A. 2003;100:9324-9.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 9324-9329
-
-
Ranger, A.M.1
Zha, J.2
Harada, H.3
-
50
-
-
0032543578
-
The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136
-
Blume-Jensen P,Janknecht R,Hunter T.The kit receptor promotes cell survival via activation of PI 3-kinase and subsequent Akt-mediated phosphorylation of Bad on Ser136.Curr Biol. 1998;8:779-82.
-
(1998)
Curr Biol
, vol.8
, pp. 779-782
-
-
Blume-Jensen, P.1
Janknecht, R.2
Hunter, T.3
-
51
-
-
26644449670
-
The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells
-
She QB,Solit DB,Ye Q,O'Reilly KE,Lobo J,Rosen N.The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells.Cancer Cell. 2005;8:287-97.
-
(2005)
Cancer Cell
, vol.8
, pp. 287-297
-
-
She, Q.B.1
Solit, D.B.2
Ye, Q.3
O'Reilly, K.E.4
Lobo, J.5
Rosen, N.6
-
52
-
-
12844266796
-
Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding: a site-directed spin labeling study
-
Oh KJ,Barbuto S,Meyer N,Kim RS,Collier RJ,Korsmeyer SJ.Conformational changes in BID, a pro-apoptotic BCL-2 family member, upon membrane binding: a site-directed spin labeling study.J Biol Chem. 2005;280:753-67.
-
(2005)
J Biol Chem
, vol.280
, pp. 753-767
-
-
Oh, K.J.1
Barbuto, S.2
Meyer, N.3
Kim, R.S.4
Collier, R.J.5
Korsmeyer, S.J.6
-
53
-
-
0034534795
-
Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis
-
Zha J,Weiler S,Oh KJ,Wei MC,Korsmeyer SJ.Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis.Science. 2000;290:1761-5.
-
(2000)
Science
, vol.290
, pp. 1761-1765
-
-
Zha, J.1
Weiler, S.2
Oh, K.J.3
Wei, M.C.4
Korsmeyer, S.J.5
-
54
-
-
34247497716
-
Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes
-
Leber B,Lin J,Andrews DW.Embedded together: the life and death consequences of interaction of the Bcl-2 family with membranes.Apoptosis. 2007;12:897-911.
-
(2007)
Apoptosis
, vol.12
, pp. 897-911
-
-
Leber, B.1
Lin, J.2
Andrews, D.W.3
-
55
-
-
0033525749
-
Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists
-
McDonnell JM,Fushman D,Milliman CL,Korsmeyer SJ,Cowburn D.Solution structure of the proapoptotic molecule BID: a structural basis for apoptotic agonists and antagonists.Cell. 1999;96:625-34.
-
(1999)
Cell
, vol.96
, pp. 625-634
-
-
McDonnell, J.M.1
Fushman, D.2
Milliman, C.L.3
Korsmeyer, S.J.4
Cowburn, D.5
-
56
-
-
0037023739
-
tBID Homooligomerizes in the mitochondrial membrane to induce apoptosis
-
Grinberg M,Sarig R,Zaltsman Y, et al.tBID Homooligomerizes in the mitochondrial membrane to induce apoptosis.J Biol Chem. 2002;277:12237-45.
-
(2002)
J Biol Chem
, vol.277
, pp. 12237-12245
-
-
Grinberg, M.1
Sarig, R.2
Zaltsman, Y.3
-
58
-
-
0034799401
-
Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8
-
Desagher S,Osen-Sand A,Montessuit S, et al.Phosphorylation of bid by casein kinases I and II regulates its cleavage by caspase 8.Mol Cell. 2001;8:601-11.
-
(2001)
Mol Cell
, vol.8
, pp. 601-611
-
-
Desagher, S.1
Osen-Sand, A.2
Montessuit, S.3
-
59
-
-
44949233264
-
Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress
-
Upton JP,Austgen K,Nishino M, et al.Caspase-2 cleavage of BID is a critical apoptotic signal downstream of endoplasmic reticulum stress.Mol Cell Biol. 2008;28:3943-51.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 3943-3951
-
-
Upton, J.P.1
Austgen, K.2
Nishino, M.3
-
60
-
-
33745739717
-
Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death
-
Bonzon C,Bouchier-Hayes L,Pagliari LJ,Green DR,Newmeyer DD.Caspase-2-induced apoptosis requires bid cleavage: a physiological role for bid in heat shock-induced death.Mol Biol Cell. 2006;17:2150-7.
-
(2006)
Mol Biol Cell
, vol.17
, pp. 2150-2157
-
-
Bonzon, C.1
Bouchier-Hayes, L.2
Pagliari, L.J.3
Green, D.R.4
Newmeyer, D.D.5
-
61
-
-
23944498161
-
Proapoptotic BID is an ATM effector in the DNA-damage response
-
Kamer I,Sarig R,Zaltsman Y, et al.Proapoptotic BID is an ATM effector in the DNA-damage response.Cell. 2005;122:593-603.
-
(2005)
Cell
, vol.122
, pp. 593-603
-
-
Kamer, I.1
Sarig, R.2
Zaltsman, Y.3
-
63
-
-
2442453730
-
The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress
-
Tinel A,Tschopp J.The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.Science. 2004;304:843-6.
-
(2004)
Science
, vol.304
, pp. 843-846
-
-
Tinel, A.1
Tschopp, J.2
-
64
-
-
34147141585
-
The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest
-
Kaufmann T,Tai L,Ekert PG, et al.The BH3-only protein bid is dispensable for DNA damage- and replicative stress-induced apoptosis or cell-cycle arrest.Cell. 2007;129:423-33.
-
(2007)
Cell
, vol.129
, pp. 423-433
-
-
Kaufmann, T.1
Tai, L.2
Ekert, P.G.3
-
65
-
-
0037439151
-
Proapoptotic BID is required for myeloid homeostasis and tumor suppression
-
Zinkel SS,Ong CC,Ferguson DO, et al.Proapoptotic BID is required for myeloid homeostasis and tumor suppression.Genes Dev. 2003;17:229-39.
-
(2003)
Genes Dev
, vol.17
, pp. 229-239
-
-
Zinkel, S.S.1
Ong, C.C.2
Ferguson, D.O.3
-
66
-
-
23944445368
-
A role for proapoptotic BID in the DNA-damage response
-
Zinkel SS,Hurov KE,Ong C,Abtahi FM,Gross A,Korsmeyer SJ.A role for proapoptotic BID in the DNA-damage response.Cell. 2005;122:579-91.
-
(2005)
Cell
, vol.122
, pp. 579-591
-
-
Zinkel, S.S.1
Hurov, K.E.2
Ong, C.3
Abtahi, F.M.4
Gross, A.5
Korsmeyer, S.J.6
-
67
-
-
79957962932
-
Non-apoptotic role of BID in inflammation and innate immunity
-
Yeretssian G,Correa RG,Doiron K, et al.Non-apoptotic role of BID in inflammation and innate immunity.Nature. 2011;474:96-9.
-
(2011)
Nature
, vol.474
, pp. 96-99
-
-
Yeretssian, G.1
Correa, R.G.2
Doiron, K.3
-
68
-
-
0032518787
-
Bim: a novel member of the Bcl-2 family that promotes apoptosis
-
O'Connor L,Strasser A,O'Reilly LA, et al.Bim: a novel member of the Bcl-2 family that promotes apoptosis.EMBO J. 1998;17:384-95.
-
(1998)
EMBO J
, vol.17
, pp. 384-395
-
-
O'Connor, L.1
Strasser, A.2
O'Reilly, L.A.3
-
69
-
-
0034609737
-
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
-
Dijkers PF,Medema RH,Lammers JW,Koenderman L,Coffer PJ.Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1.Curr Biol. 2000;10:1201-4.
-
(2000)
Curr Biol
, vol.10
, pp. 1201-1204
-
-
Dijkers, P.F.1
Medema, R.H.2
Lammers, J.W.3
Koenderman, L.4
Coffer, P.J.5
-
70
-
-
77953161581
-
Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer
-
Yang JY,Chang CJ,Xia W, et al.Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer.Cancer Res. 2010;70:4709-18.
-
(2010)
Cancer Res
, vol.70
, pp. 4709-4718
-
-
Yang, J.Y.1
Chang, C.J.2
Xia, W.3
-
71
-
-
34250758642
-
ER stress triggers apoptosis by activating BH3-only protein Bim
-
Puthalakath H,O'Reilly LA,Gunn P, et al.ER stress triggers apoptosis by activating BH3-only protein Bim.Cell. 2007;129:1337-49.
-
(2007)
Cell
, vol.129
, pp. 1337-1349
-
-
Puthalakath, H.1
O'Reilly, L.A.2
Gunn, P.3
-
72
-
-
0037418238
-
JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis
-
Lei K,Davis RJ.JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis.Proc Natl Acad Sci U S A. 2003;100:2432-7.
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 2432-2437
-
-
Lei, K.1
Davis, R.J.2
-
73
-
-
55849139095
-
Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic
-
Cragg MS,Jansen ES,Cook M,Harris C,Strasser A,Scott CL.Treatment of B-RAF mutant human tumor cells with a MEK inhibitor requires Bim and is enhanced by a BH3 mimetic.J Clin Invest. 2008;118:3651-9.
-
(2008)
J Clin Invest
, vol.118
, pp. 3651-3659
-
-
Cragg, M.S.1
Jansen, E.S.2
Cook, M.3
Harris, C.4
Strasser, A.5
Scott, C.L.6
-
74
-
-
35648953299
-
Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics
-
Cragg MS,Kuroda J,Puthalakath H,Huang DC,Strasser A.Gefitinib-induced killing of NSCLC cell lines expressing mutant EGFR requires BIM and can be enhanced by BH3 mimetics.PLoS Med. 2007;4:1681-89.
-
(2007)
PLoS Med
, vol.4
, pp. 1681-1689
-
-
Cragg, M.S.1
Kuroda, J.2
Puthalakath, H.3
Huang, D.C.4
Strasser, A.5
-
75
-
-
37549001026
-
Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion
-
Deng J,Shimamura T,Perera S, et al.Proapoptotic BH3-only BCL-2 family protein BIM connects death signaling from epidermal growth factor receptor inhibition to the mitochondrion.Cancer Res. 2007;67:11867-75.
-
(2007)
Cancer Res
, vol.67
, pp. 11867-11875
-
-
Deng, J.1
Shimamura, T.2
Perera, S.3
-
76
-
-
53249088373
-
Prognostic impact of bim, puma, and noxa expression in human colon carcinomas
-
Sinicrope FA,Rego RL,Okumura K, et al.Prognostic impact of bim, puma, and noxa expression in human colon carcinomas.Clin Cancer Res. 2008;14:5810-8.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 5810-5818
-
-
Sinicrope, F.A.1
Rego, R.L.2
Okumura, K.3
-
77
-
-
33846010700
-
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas
-
Mestre-Escorihuela C,Rubio-Moscardo F,Richter JA, et al.Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.Blood. 2007;109:271-80.
-
(2007)
Blood
, vol.109
, pp. 271-280
-
-
Mestre-Escorihuela, C.1
Rubio-Moscardo, F.2
Richter, J.A.3
-
78
-
-
0033607506
-
Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity
-
Bouillet P,Metcalf D,Huang DC, et al.Proapoptotic Bcl-2 relative Bim required for certain apoptotic responses, leukocyte homeostasis, and to preclude autoimmunity.Science. 1999;286:1735-8.
-
(1999)
Science
, vol.286
, pp. 1735-1738
-
-
Bouillet, P.1
Metcalf, D.2
Huang, D.C.3
-
80
-
-
0023574614
-
Immunologic competence of B cells subjected to constitutive c-myc oncogene expression in immunoglobulin heavy chain enhancer myc transgenic mice
-
Vaux DL,Adams JM,Alexander WS,Pike BL.Immunologic competence of B cells subjected to constitutive c-myc oncogene expression in immunoglobulin heavy chain enhancer myc transgenic mice.J Immunol. 1987;139:3854-60.
-
(1987)
J Immunol
, vol.139
, pp. 3854-3860
-
-
Vaux, D.L.1
Adams, J.M.2
Alexander, W.S.3
Pike, B.L.4
-
81
-
-
17644421083
-
Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy
-
Tan TT,Degenhardt K,Nelson DA, et al.Key roles of BIM-driven apoptosis in epithelial tumors and rational chemotherapy.Cancer Cell. 2005;7:227-38.
-
(2005)
Cancer Cell
, vol.7
, pp. 227-238
-
-
Tan, T.T.1
Degenhardt, K.2
Nelson, D.A.3
-
82
-
-
34247214984
-
Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis
-
Schmelzle T,Mailleux AA,Overholtzer M, et al.Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis.Proc Natl Acad Sci U S A. 2007;104:3787-92.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 3787-3792
-
-
Schmelzle, T.1
Mailleux, A.A.2
Overholtzer, M.3
-
83
-
-
77649210096
-
Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad
-
Frenzel A,Labi V,Chmelewskij W, et al.Suppression of B-cell lymphomagenesis by the BH3-only proteins Bmf and Bad.Blood. 2010;115:995-1005.
-
(2010)
Blood
, vol.115
, pp. 995-1005
-
-
Frenzel, A.1
Labi, V.2
Chmelewskij, W.3
-
84
-
-
0035949470
-
Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals
-
Han J,Flemington C,Houghton AB, et al.Expression of bbc3, a pro-apoptotic BH3-only gene, is regulated by diverse cell death and survival signals.Proc Natl Acad Sci U S A. 2001;98:11318-23.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 11318-11323
-
-
Han, J.1
Flemington, C.2
Houghton, A.B.3
-
85
-
-
0037039319
-
Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
-
Kaeser MD,Iggo RD.Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo.Proc Natl Acad Sci U S A. 2002;99:95-100.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 95-100
-
-
Kaeser, M.D.1
Iggo, R.D.2
-
86
-
-
12844266066
-
Identification of a network involved in thapsigargin-induced apoptosis using a library of small interfering RNA expression vectors
-
Futami T,Miyagishi M,Taira K.Identification of a network involved in thapsigargin-induced apoptosis using a library of small interfering RNA expression vectors.J Biol Chem. 2005;280:826-31.
-
(2005)
J Biol Chem
, vol.280
, pp. 826-831
-
-
Futami, T.1
Miyagishi, M.2
Taira, K.3
-
87
-
-
33646373219
-
Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53
-
Li J,Lee B,Lee AS.Endoplasmic reticulum stress-induced apoptosis: multiple pathways and activation of p53-up-regulated modulator of apoptosis (PUMA) and NOXA by p53.J Biol Chem. 2006;281:7260-70.
-
(2006)
J Biol Chem
, vol.281
, pp. 7260-7270
-
-
Li, J.1
Lee, B.2
Lee, A.S.3
-
88
-
-
33745841375
-
FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal
-
You H,Pellegrini M,Tsuchihara K, et al.FOXO3a-dependent regulation of Puma in response to cytokine/growth factor withdrawal.J Exp Med. 2006;203:1657-63.
-
(2006)
J Exp Med
, vol.203
, pp. 1657-1663
-
-
You, H.1
Pellegrini, M.2
Tsuchihara, K.3
-
89
-
-
27744547091
-
Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma
-
Wu WS,Heinrichs S,Xu D, et al.Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma.Cell. 2005;123:641-53.
-
(2005)
Cell
, vol.123
, pp. 641-653
-
-
Wu, W.S.1
Heinrichs, S.2
Xu, D.3
-
90
-
-
79958753992
-
Phosphorylation of Puma modulates its apoptotic function by regulating protein stability
-
Fricker M,O'Prey J,Tolkovsky AM,Ryan KM.Phosphorylation of Puma modulates its apoptotic function by regulating protein stability.Cell Death Dis. 2010;1:e59.
-
(2010)
Cell Death Dis
, vol.1
-
-
Fricker, M.1
O'Prey, J.2
Tolkovsky, A.M.3
Ryan, K.M.4
-
91
-
-
62849097807
-
Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim
-
Jabbour AM,Heraud JE,Daunt CP, et al.Puma indirectly activates Bax to cause apoptosis in the absence of Bid or Bim.Cell Death Differ. 2009;16:555-63.
-
(2009)
Cell Death Differ
, vol.16
, pp. 555-563
-
-
Jabbour, A.M.1
Heraud, J.E.2
Daunt, C.P.3
-
92
-
-
58149511987
-
Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins
-
Chipuk JE,Fisher JC,Dillon CP,Kriwacki RW,Kuwana T,Green DR.Mechanism of apoptosis induction by inhibition of the anti-apoptotic BCL-2 proteins.Proc Natl Acad Sci U S A. 2008;105:20327-32.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 20327-20332
-
-
Chipuk, J.E.1
Fisher, J.C.2
Dillon, C.P.3
Kriwacki, R.W.4
Kuwana, T.5
Green, D.R.6
-
93
-
-
24644436766
-
PUMA couples the nuclear and cytoplasmic proapoptotic function of p53
-
Chipuk JE,Bouchier-Hayes L,Kuwana T,Newmeyer DD,Green DR.PUMA couples the nuclear and cytoplasmic proapoptotic function of p53.Science. 2005;309:1732-5.
-
(2005)
Science
, vol.309
, pp. 1732-1735
-
-
Chipuk, J.E.1
Bouchier-Hayes, L.2
Kuwana, T.3
Newmeyer, D.D.4
Green, D.R.5
-
94
-
-
10744228800
-
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways
-
Jeffers JR,Parganas E,Lee Y, et al.Puma is an essential mediator of p53-dependent and -independent apoptotic pathways.Cancer Cell. 2003;4:321-8.
-
(2003)
Cancer Cell
, vol.4
, pp. 321-328
-
-
Jeffers, J.R.1
Parganas, E.2
Lee, Y.3
-
95
-
-
3042601281
-
Suppression of tumorigenesis by the p53 target PUMA
-
Hemann MT,Zilfou JT,Zhao Z,Burgess DJ,Hannon GJ,Lowe SW.Suppression of tumorigenesis by the p53 target PUMA.Proc Natl Acad Sci U S A. 2004;101:9333-8.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 9333-9338
-
-
Hemann, M.T.1
Zilfou, J.T.2
Zhao, Z.3
Burgess, D.J.4
Hannon, G.J.5
Lowe, S.W.6
-
96
-
-
33845913794
-
Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction
-
Erlacher M,Labi V,Manzl C, et al.Puma cooperates with Bim, the rate-limiting BH3-only protein in cell death during lymphocyte development, in apoptosis induction.J Exp Med. 2006;203:2939-51.
-
(2006)
J Exp Med
, vol.203
, pp. 2939-2951
-
-
Erlacher, M.1
Labi, V.2
Manzl, C.3
-
97
-
-
34548096400
-
Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1
-
Wang YF,Jiang CC,Kiejda KA,Gillespie S,Zhang XD,Hersey P.Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1.Clin Cancer Res. 2007;13:4934-42.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 4934-4942
-
-
Wang, Y.F.1
Jiang, C.C.2
Kiejda, K.A.3
Gillespie, S.4
Zhang, X.D.5
Hersey, P.6
-
98
-
-
33646480058
-
The BH3-only protein, PUMA, is involved in oxaliplatin-induced apoptosis in colon cancer cells
-
Wang X,Li M,Wang J, et al.The BH3-only protein, PUMA, is involved in oxaliplatin-induced apoptosis in colon cancer cells.Biochem Pharmacol. 2006;71:1540-50.
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1540-1550
-
-
Wang, X.1
Li, M.2
Wang, J.3
-
99
-
-
34247211554
-
The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage
-
Wang P,Yu J,Zhang L.The nuclear function of p53 is required for PUMA-mediated apoptosis induced by DNA damage.Proc Natl Acad Sci U S A. 2007;104:4054-9.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 4054-4059
-
-
Wang, P.1
Yu, J.2
Zhang, L.3
-
100
-
-
0025012137
-
Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line
-
Hijikata M,Kato N,Sato T,Kagami Y,Shimotohno K.Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line.J Virol. 1990;64:4632-9.
-
(1990)
J Virol
, vol.64
, pp. 4632-4639
-
-
Hijikata, M.1
Kato, N.2
Sato, T.3
Kagami, Y.4
Shimotohno, K.5
-
101
-
-
0346655211
-
BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha
-
Kim JY,Ahn HJ,Ryu JH,Suk K,Park JH.BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor 1alpha.J Exp Med. 2004;199:113-24.
-
(2004)
J Exp Med
, vol.199
, pp. 113-124
-
-
Kim, J.Y.1
Ahn, H.J.2
Ryu, J.H.3
Suk, K.4
Park, J.H.5
-
102
-
-
0141818136
-
Integral role of Noxa in p53-mediated apoptotic response
-
Shibue T,Takeda K,Oda E, et al.Integral role of Noxa in p53-mediated apoptotic response.Genes Dev. 2003;17:2233-8.
-
(2003)
Genes Dev
, vol.17
, pp. 2233-2238
-
-
Shibue, T.1
Takeda, K.2
Oda, E.3
-
103
-
-
0242410719
-
p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa
-
Villunger A,Michalak EM,Coultas L, et al.p53- and drug-induced apoptotic responses mediated by BH3-only proteins puma and noxa.Science. 2003;302:1036-8.
-
(2003)
Science
, vol.302
, pp. 1036-1038
-
-
Villunger, A.1
Michalak, E.M.2
Coultas, L.3
-
104
-
-
67349129712
-
Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis
-
Michalak EM,Jansen ES,Happo L, et al.Puma and to a lesser extent Noxa are suppressors of Myc-induced lymphomagenesis.Cell Death Differ. 2009;16:684-96.
-
(2009)
Cell Death Differ
, vol.16
, pp. 684-696
-
-
Michalak, E.M.1
Jansen, E.S.2
Happo, L.3
-
105
-
-
34248180714
-
Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains
-
Olejniczak ET,Van Sant C,Anderson MG, et al.Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.Mol Cancer Res. 2007;5:331-9.
-
(2007)
Mol Cancer Res
, vol.5
, pp. 331-339
-
-
Olejniczak, E.T.1
van Sant, C.2
Anderson, M.G.3
-
107
-
-
0031907428
-
bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice
-
Jansen B,Schlagbauer-Wadl H,Brown BD, et al.bcl-2 antisense therapy chemosensitizes human melanoma in SCID mice.Nat Med. 1998;4:232-4.
-
(1998)
Nat Med
, vol.4
, pp. 232-234
-
-
Jansen, B.1
Schlagbauer-Wadl, H.2
Brown, B.D.3
-
108
-
-
0034691130
-
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells
-
Wang JL,Liu D,Zhang ZJ, et al.Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells.Proc Natl Acad Sci U S A. 2000;97:7124-9.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 7124-7129
-
-
Wang, J.L.1
Liu, D.2
Zhang, Z.J.3
-
109
-
-
0242475256
-
HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death
-
Lickliter JD,Wood NJ,Johnson L, et al.HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death.Leukemia. 2003;17:2074-80.
-
(2003)
Leukemia
, vol.17
, pp. 2074-2080
-
-
Lickliter, J.D.1
Wood, N.J.2
Johnson, L.3
-
110
-
-
33645059697
-
The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death
-
Manero F,Gautier F,Gallenne T, et al.The small organic compound HA14-1 prevents Bcl-2 interaction with Bax to sensitize malignant glioma cells to induction of cell death.Cancer Res. 2006;66:2757-64.
-
(2006)
Cancer Res
, vol.66
, pp. 2757-2764
-
-
Manero, F.1
Gautier, F.2
Gallenne, T.3
-
111
-
-
37649023004
-
Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis
-
Nguyen M,Marcellus RC,Roulston A, et al.Small molecule obatoclax (GX15-070) antagonizes MCL-1 and overcomes MCL-1-mediated resistance to apoptosis.Proc Natl Acad Sci U S A. 2007;104:19512-7.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 19512-19517
-
-
Nguyen, M.1
Marcellus, R.C.2
Roulston, A.3
-
112
-
-
77957029255
-
Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis
-
Parikh SA,Kantarjian H,Schimmer A, et al.Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis.Clin Lymphoma Myeloma Leuk. 2010;10:285-9.
-
(2010)
Clin Lymphoma Myeloma Leuk
, vol.10
, pp. 285-289
-
-
Parikh, S.A.1
Kantarjian, H.2
Schimmer, A.3
-
113
-
-
58149340656
-
A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies
-
Schimmer AD,O'Brien S,Kantarjian H, et al.A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies.Clin Cancer Res. 2008;14:8295-301.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 8295-8301
-
-
Schimmer, A.D.1
O'Brien, S.2
Kantarjian, H.3
-
114
-
-
44849133234
-
Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax)
-
Konopleva M,Watt J,Contractor R, et al.Mechanisms of antileukemic activity of the novel Bcl-2 homology domain-3 mimetic GX15-070 (obatoclax).Cancer Res. 2008;68:3413-20.
-
(2008)
Cancer Res
, vol.68
, pp. 3413-3420
-
-
Konopleva, M.1
Watt, J.2
Contractor, R.3
-
115
-
-
53349097246
-
BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis
-
Mott JL,Bronk SF,Mesa RA,Kaufmann SH,Gores GJ.BH3-only protein mimetic obatoclax sensitizes cholangiocarcinoma cells to Apo2L/TRAIL-induced apoptosis.Mol Cancer Ther. 2008;7:2339-47.
-
(2008)
Mol Cancer Ther
, vol.7
, pp. 2339-2347
-
-
Mott, J.L.1
Bronk, S.F.2
Mesa, R.A.3
Kaufmann, S.H.4
Gores, G.J.5
-
116
-
-
0025313476
-
Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers
-
Benz CC,Keniry MA,Ford JM, et al.Biochemical correlates of the antitumor and antimitochondrial properties of gossypol enantiomers.Mol Pharmacol. 1990;37:840-7.
-
(1990)
Mol Pharmacol
, vol.37
, pp. 840-847
-
-
Benz, C.C.1
Keniry, M.A.2
Ford, J.M.3
-
117
-
-
42449147919
-
Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048)
-
Kitada S,Kress CL,Krajewska M,Jia L,Pellecchia M,Reed JC.Bcl-2 antagonist apogossypol (NSC736630) displays single-agent activity in Bcl-2-transgenic mice and has superior efficacy with less toxicity compared with gossypol (NSC19048).Blood. 2008;111:3211-9.
-
(2008)
Blood
, vol.111
, pp. 3211-3219
-
-
Kitada, S.1
Kress, C.L.2
Krajewska, M.3
Jia, L.4
Pellecchia, M.5
Reed, J.C.6
-
118
-
-
54249116969
-
ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells
-
Sun J,Li ZM,Hu ZY, et al.ApoG2 inhibits antiapoptotic Bcl-2 family proteins and induces mitochondria-dependent apoptosis in human lymphoma U937 cells.Anticancer Drugs. 2008;19:967-74.
-
(2008)
Anticancer Drugs
, vol.19
, pp. 967-974
-
-
Sun, J.1
Li, Z.M.2
Hu, Z.Y.3
-
119
-
-
52149098982
-
Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo
-
Sun Y,Wu J,Aboukameel A, et al.Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo.Cancer Biol Ther. 2008;7:1418-26.
-
(2008)
Cancer Biol Ther
, vol.7
, pp. 1418-1426
-
-
Sun, Y.1
Wu, J.2
Aboukameel, A.3
-
120
-
-
67749143838
-
SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status
-
Al-Katib AM,Sun Y,Goustin AS, et al.SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status.J Hematol Oncol. 2009;2:8.
-
(2009)
J Hematol Oncol
, vol.2
, pp. 8
-
-
Al-Katib, A.M.1
Sun, Y.2
Goustin, A.S.3
-
121
-
-
4444291734
-
Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix
-
Walensky LD,Kung AL,Escher I, et al.Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.Science. 2004;305:1466-70.
-
(2004)
Science
, vol.305
, pp. 1466-1470
-
-
Walensky, L.D.1
Kung, A.L.2
Escher, I.3
-
122
-
-
77955891885
-
The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer
-
Stewart ML,Fire E,Keating AE,Walensky LD.The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer.Nat Chem Biol. 2010;6:595-601.
-
(2010)
Nat Chem Biol
, vol.6
, pp. 595-601
-
-
Stewart, M.L.1
Fire, E.2
Keating, A.E.3
Walensky, L.D.4
-
123
-
-
20444486559
-
An inhibitor of Bcl-2 family proteins induces regression of solid tumours
-
Oltersdorf T,Elmore SW,Shoemaker AR, et al.An inhibitor of Bcl-2 family proteins induces regression of solid tumours.Nature. 2005;435:677-81.
-
(2005)
Nature
, vol.435
, pp. 677-681
-
-
Oltersdorf, T.1
Elmore, S.W.2
Shoemaker, A.R.3
-
124
-
-
33750834023
-
The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized
-
van Delft MF,Wei AH,Mason KD, et al.The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.Cancer Cell. 2006;10:389-99.
-
(2006)
Cancer Cell
, vol.10
, pp. 389-399
-
-
van Delft, M.F.1
Wei, A.H.2
Mason, K.D.3
-
125
-
-
33947227522
-
Programmed anuclear cell death delimits platelet life span
-
Mason KD,Carpinelli MR,Fletcher JI, et al.Programmed anuclear cell death delimits platelet life span.Cell. 2007;128:1173-86.
-
(2007)
Cell
, vol.128
, pp. 1173-1186
-
-
Mason, K.D.1
Carpinelli, M.R.2
Fletcher, J.I.3
-
126
-
-
44849112219
-
ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor
-
Tse C,Shoemaker AR,Adickes J, et al.ABT-263: a potent and orally bioavailable Bcl-2 family inhibitor.Cancer Res. 2008;68:3421-8.
-
(2008)
Cancer Res
, vol.68
, pp. 3421-3428
-
-
Tse, C.1
Shoemaker, A.R.2
Adickes, J.3
-
127
-
-
33750112776
-
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins
-
Wang G,Nikolovska-Coleska Z,Yang CY, et al.Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.J Med Chem. 2006;49:6139-42.
-
(2006)
J Med Chem
, vol.49
, pp. 6139-6142
-
-
Wang, G.1
Nikolovska-Coleska, Z.2
Yang, C.Y.3
-
128
-
-
0141569444
-
Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins
-
Kitada S,Leone M,Sareth S,Zhai D,Reed JC,Pellecchia M.Discovery, characterization, and structure-activity relationships studies of proapoptotic polyphenols targeting B-cell lymphocyte/leukemia-2 proteins.J Med Chem. 2003;46:4259-64.
-
(2003)
J Med Chem
, vol.46
, pp. 4259-4264
-
-
Kitada, S.1
Leone, M.2
Sareth, S.3
Zhai, D.4
Reed, J.C.5
Pellecchia, M.6
-
129
-
-
33847404358
-
Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL
-
Bruncko M,Oost TK,Belli BA, et al.Studies leading to potent, dual inhibitors of Bcl-2 and Bcl-xL.J Med Chem. 2007;50:641-62.
-
(2007)
J Med Chem
, vol.50
, pp. 641-662
-
-
Bruncko, M.1
Oost, T.K.2
Belli, B.A.3
-
130
-
-
33745872296
-
Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins
-
Zhai D,Jin C,Satterthwait AC,Reed JC.Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteins.Cell Death Differ. 2006;13:1419-21.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1419-1421
-
-
Zhai, D.1
Jin, C.2
Satterthwait, A.C.3
Reed, J.C.4
|