BH3 domain of BAD is required for heterodimerization with BCL-X(L) and pro-apoptotic activity

Journal of Biological Chemistry

Volumn 272, Issue 39, 1997, Pages 24101-24104

  Zha, Jiping ^a   Harada, Hisashi ^a   Osipov, Konstantin ^a   Jockel, Jennifer ^a   Waksman, Gabriel ^a   Korsmeyer, Stanley J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; LEUCINE; MEMBRANE RECEPTOR; PROTEIN BAX; PROTEIN BCL 2;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; DELETION MUTANT; DIMERIZATION; EMBRYO; FIBROBLAST; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BCL-ASSOCIATED DEATH PROTEIN; BCL-X PROTEIN; CARRIER PROTEINS; CELLS, CULTURED; DIMERIZATION; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTO-ONCOGENE PROTEINS C-BCL-2; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID;

ANIMALIA;

EID: 0030827971     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.39.24101     Document Type: Article

References (18)

1. Farrow, S. N., and Brown, R. (1996) Curr. Opin. Genet. Dev. 6, 45-49
2. Oltvai, Z. N., Milliman, C. L., and Korsmeyer, S. J. (1993) Cell 74, 609-619
3. Yin, X.-M., Oltvai, Z. N., and Korsmeyer, S. J. (1994) Nature 369, 321-323
4. Cheng, E. H., Levine, B., Boise, L. H., Thompson, C. B., and Hardwick, J. M. (1996) Nature 379, 554-556
5. Chittenden, T., Flemington, C., Houghton, A. B., Ebb, R. G., Gallo, G. J., Elangovan, B., Chinnadurai, G., and Lutz, R. J. (1995) EMBO J. 14, 5589-5596
6. Hunter, J. J., and Parslow, T. G. (1996) J. Biol. Chem. 271, 8521-8524
7. Zha, H., Aime-Sempe, C., Sato, T., and Reed, J. C. (1996) J. Biol. Chem. 271, 7440-7444
8. Boyd, J. M., Gallo, G. J., Elangovan, B., Houghton, A. B., Malstrom, S., Avery, B. J., Ebb, R. G., Subramanian, T., Chittenden, T., Luta, R. J., and Chinnadurai, G. (1995) Oncogene 11, 1921-1928
9. Han, J., Sabbatini, P., and White, E. (1996) Mol. Cell. Biol. 160, 5857-5864
10. Wang, K., Yin, X.-M., Chao, D. T., Milliman, C. L., and Korsmeyer, S. J. (1996) Genes Dev. 10, 2859-2869
11. Yang, E., Zha, J., Jockel, J., Boise, L. H., Thompson, C. B., and Korsmeyer, S. J. (1995) Cell 80, 285-291
12. Zha, J., Harada, H., Yang, E., Jockel, J., and Korsmeyer, S. J. (1996) Cell 87, 619-628
13. Blanar, M. A., and Rutter, W. J. (1992) Science 256, 1014-1018
14. Boise, L. H., Minn, A. J., Noel, P. J., June, C. H., Accavitti, M. A., Lindsten, T., and Thompson, C. B. (1995) Immunity 3, 87-98
15. Muchmore, S. W., Sattler, M., Liang, H., Meadows, R. P., Harlan, J. E., Yoon, H. S., Netteshelm, D., Chang, B. S., Thompson, C. B., Wong, S.-L., Ng, S.-C., and Fesik, S. W. (1996) Nature 381, 335-341
16. Sedlak, T. W., Oltvai, Z. N., Yang, E., Wang, K., Boise, L. H., Thompson, C. B., and Korsmeyer, S. J. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 7834-7838
17. Sattler, M., Liang, H., Nettheim, D., Meadows, R. P., Harlan, J. E., Eberstadt, M., Yoon, H. S., Shuker, S. B., Chang, B. S., Minn, A. J., Thompson, C. B., and Fesik, S. N. (1997) Science 275, 983-986
18. Nicholls, A., Sharp, K. A., and Honig, B. (1991) Protein Struct. Funct. Genet. 11, 281-296