The effect of ursodeoxycholic acid on glycochenodeoxycholic acid-induced apoptosis in rat hepatocytes

Toxicology

Volumn 214, Issue 1-2, 2005, Pages 77-86

  Utanohara, Shinichi ^a   Tsuji, Mayumi ^a   Momma, Shusuke ^a   Morio, Yuri ^a   Oguchi, Katsuji ^a  

^a SHOWA UNIVERSITY   (Japan)

Author keywords

Apoptosis; Bile acid; Glycochenodeoxycholic acid; Hepatocytes; Ursodeoxycholic acid

Indexed keywords

CASPASE; CYTOCHROME C; DNA FRAGMENT; GLYCOCHENODEOXYCHOLIC ACID; LACTATE DEHYDROGENASE; URSODEOXYCHOLIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ISOLATION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME RELEASE; INCUBATION TIME; LIVER CELL; LONG TERM EXPOSURE; MALE; MEMBRANE POTENTIAL; MITOCHONDRIAL MEMBRANE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; CASPASES; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROMES C; DNA FRAGMENTATION; ELECTROPHORESIS, AGAR GEL; GLYCOCHENODEOXYCHOLIC ACID; HEPATOCYTES; MALE; MEMBRANE POTENTIALS; MITOCHONDRIA, LIVER; RATS; RATS, SPRAGUE-DAWLEY; URSODEOXYCHOLIC ACID;

EID: 25644448987     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2005.05.025     Document Type: Article

References (27)

1. B. Antonsson, S. Montessuit, B. Sanchez, and J.C. Martinou Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells J. Biol. Chem. 276 2001 11615 11623
2. U. Beuers, J.L. Boyer, and G. Paumgartner Ursodeoxycholic acid in cholestasis: potential mechanisms of action and therapeutic applications Hepatology 28 1998 1449 1453
3. D. Elena, P. Henning, C. Alexander, and D. Rolf Effect of bile acids on the proliferative activity and apoptosis of rat hepatocytes Exp. Toxic. Pathol. 53 2001 227 233
4. W.A. Faubion, M.E. Guicciardi, H. Miyoshi, S.F. Bronk, P.J. Roberts, P.A. Svingen, S.H. Kaufmann, and G.J. Gores Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas J. Clin. Invest. 103 1999 137 145
5. O.S. Furankfurt, and A. Krishan Enzyme-linked immunosorbent assay (ELISA) for the specific detection of apoptotic cells and its application to rapid drug screening J. Immunol. Methods 253 2001 133 143
6. J. Goulis, G. Leandro, and A.K. Burroughs Randomised controlled trials of ursodeoxycholic-acid therapy for primary biliary cirrhosis: a meta-analysis Lancet 354 1999 1053 1060
7. H. Greim, P. Czygan, F. Schaffner, and H. Popper Determination of bile acids in needle biopsies of human liver Biochem. Med. 8 1973 280 286
8. H. Greim, D. Trülzsch, J. Robos, K. Dressler, P. Czygan, F. Hutterer, F. Schaffner, and H. Popper Mechanism of cholestasis. 5. Bile acids in normal rat livers and in those after bile duct ligation Gastroenterology 63 1972 837 845
9. H. Greim, D. Trülzsch, P. Czygan, J. Rudick, F. Hutterer, F. Schaffner, and H. Popper Mechanism of cholestasis. 6. Bile acids in human livers with or without biliary obstruction Gastroenterology 63 1972 846 850
10. C. Korzeniewski, and D.M. Callewaert An enzyme-release assay for natural cytotoxicity J. Immunol. Methods 64 1983 313 320
11. H. Koseki, M. Tsuji, S. Utanohara, Y. Asano, H. Oyamada, M. Okazaki, and K. Oguchi Glycochenodeoxycholic acid induced apoptosis in RLN-8 hepatocytes J. Showa. Med. Assoc. 63 2003 405 414 (in Japanese)
12. C. Lemaire, K. Andréau, V. Souvannavong, and A. Adam Inhibition of caspase activity induces a switch from apoptosis to necrosis FEBS Lett. 425 1998 266 270
13. K.D. Lindor, M.A. Lacerda, R.A. Jorgensen, C.K. DeSotel, A.K. Batta, G. Salen, E.R. Dickson, S.S. Rossi, and A.F. Hofmann Relationship between biliary and serum bile acids and response to ursodeoxycholic acid in patients with primary biliary cirrhosis Am. J. Gastroenterol. 93 1998 1498 1504
14. J. Neuberger URSO-panacea or placebo? Hepatology 31 2000 1027 1028
15. K. Oyama, G. Shiota, H. Ito, Y. Murawaki, and H. Kawasaki Reduction of hepatocarcinogenesis by ursodeoxycholic acid in rats Carcinogenesis 23 2002 885 892
16. T. Patel, S.F. Bronk, and G.J. Gores Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes J. Clin. Invest. 94 1994 2183 2192
17. A. Pares, L. Caballeria, J. Rodes, M. Bruguera, L. Rodrigo, A. Garcia-Plaza, J. Berenguer, D. Rodriguez-Martinez, J. Mercader, and R. Velicia Long-term effects of ursodeoxycholic acid in primary biliary cirrhosis: results of a double-blind controlled multicentric trial J. Hepatol. 32 2000 561 566
18. R.E. Poupon, R. Poupon, and B. Balkau Ursodiol for the long-term treatment of primary biliary cirrhosis New Engl. J. Med. 330 1994 1342 1347
19. L. Qiao, A. Yacoub, E. Studer, S. Gupta, X.Y. Pei, S. Grant, P.B. Hylemon, and P. Dent Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes Hepatology 35 2002 779 789
20. C.M.P. Rodrigues, G. Fan, X. Ma, B.T. Kren, and C.J. Steer A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation J. Clin. Invest. 101 1998 2790 2799
21. C.M.P. Rodrigues, and C.J. Steer Bile acids and hepatocyte apoptosis: living/leaving life in the Fas lane Gastroenterology 117 1999 732 736
22. A.P. Rolo, C.M. Palmeira, and K.B. Wallace Mitochondrially mediated synergistic cell killing by bile acids Biochim. Biophys. Acta 1637 2003 127 132
23. A.P. Rolo, C.M. Palmeira, and K.B. Wallace Interactions of combined bile acids on hepatocyte viability: cytoprotection or synergism Toxicol. Lett. 126 2002 197 203
24. S. Salvioli, R. Maseroli, and T.L. Pazienza Use of flow cytometry as a tool to study mitochondrial membrane potential in isolated, living hepatocytes Biochemistry (Mosc) 63 1998 235 238
25. R.J. Sokol, M.S. Strata, R. Dahl, M.W. Devereaux, B. Yerushalmi, E. Gumpricht, N. Elkins, and G. Everson Role of oxidant stress in the permeability transition induced in rat hepatic mitochondria by hydrophobic bile acids Pediatr. Res. 49 2001 519 531
26. J.R. Spivey, S.F. Bronk, and G.J. Gores Glycochenodeoxycholate-induced lethal hepatocellular injury in rat hepatocytes. Role of ATP depletion and cytosolic free calcium J. Clin. Invest. 92 1993 17 24
27. M. Tsuji, K. Kodama, M. Okazaki, and K. Oguchi Hepatotoxicity of monoamine oxidase inhibitors in isolated and primary cultured hepatocytes of rat H. Yasuhara S.H. Parves K. Oguchi M. Sandler T. Nagatsu Monoamine Oxidase: Basic and Clinical Aspects 1993 VSP Utrecht 89 106