Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis

Chemico-Biological Interactions

Volumn 179, Issue 2-3, 2009, Pages 297-303

  Basiglio, Cecilia L ^a   Sánchez Pozzi, Enrique J ^a   Mottino, Aldo D ^a   Roma, Marcelo G ^a  

^a UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

Bile salts; Plasma membrane; Silibinin; Silymarin; Tensioactives

Indexed keywords

ALANINE AMINOTRANSFERASE; LACTATE DEHYDROGENASE; SILIBININ; SILYMARIN; TAUROCHENODEOXYCHOLIC ACID; TRITON X 100;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ISOLATION; CELL PROTECTION; CONCENTRATION RESPONSE; CYTOLYSIS; DRUG EFFECT; LIPID BILAYER; LIVER CELL MEMBRANE; LIVER PROTECTION; MALE; MEMBRANE DAMAGE; MEMBRANE STABILIZATION; MICELLE; MOLECULAR MODEL; NONHUMAN; RAT;

ANIMALS; CELL MEMBRANE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HEPATOCYTES; MALE; OCTOXYNOL; RATS; RATS, WISTAR; SILYMARIN; TAUROCHENODEOXYCHOLIC ACID;

RATTUS;

EID: 62549116131     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2008.12.008     Document Type: Article

References (43)

1. Gazak R., Walterova D., and Kren V. Silybin and silymarin-new and emerging applications in medicine. Curr. Med. Chem. 14 (2007) 315-338
2. Wellington K., and Jarvis B. Silymarin: a review of its clinical properties in the management of hepatic disorders. BioDrugs 15 (2001) 465-489
3. Hoofnagle J.H. Milk thistle and chronic liver disease. Hepatology 42 (2005) 4
4. Crocenzi F.A., and Roma M.G. Silymarin as a new hepatoprotective agent in experimental cholestasis: new possibilities for an ancient medication. Curr. Med. Chem. 13 (2006) 1055-1074
5. Willard T. Textbook of Advanced Herbology (1992), Wild Rose College of Natural Healing Ltd., Calgary, Alberta, Canada
6. Sonnenbichler J., and Zetl I. Biochemical effects of the flavonolignane silibinin on RNA, protein and DNA synthesis in rat livers. Prog. Clin. Biol. Res. 213 (1986) 319-331
7. Pascual C., González R., Armesto J., and Muriel P. Effect of silymarin and silybinin on oxygen radicals. Drug Develop. Res. 29 (1993) 73-77
8. Boigk G., Stroedter L., Herbst H., Waldschmidt J., Riecken E.O., and Schuppan D. Silymarin retards collagen accumulation in early and advanced biliary fibrosis secondary to complete bile duct obliteration in rats. Hepatology 26 (1997) 643-649
9. Machicao F., and Sonnenbichler J. Mechanism of the stimulation of RNA synthesis in rat liver nuclei by silybin. Hoppe Seylers Z. Physiol. Chem. 358 (1977) 141-147
10. Nassuato G., Iemmolo R.M., Strazzabosco M., Lirussi F., Deana R., Francesconi M.A., Muraca M., Passera D., Fragosso A., Orlando R., Csomós G., and Okolicsányi L. Effect of Silibinin on biliary composition. Experimental and clinical study. J. Hepatol. 12 (1991) 290-295
11. Schriewer H., and Weinhold F. The influence of silybin from Silybum marianum (L.) Gaertn. On in vitro phosphatidyl choline biosynthesis in rat livers. Arzneimittelforschung 29 (1979) 791-792
12. Seeger R. Effect of silymarin on osmotic resistance of erythrocytes. Arzneimittelforschung 21 (1971) 1599-1605
13. Seeger R., Beck G., Gretzer K., and Heim A. Effect of silymarin-sodium on hemolysis of human erythrocytes by saponins, lysolecithin, sodium dodecylsulfate, phallolysin and theta-toxin from Clostridium welchi. Arzneimittelforschung 24 (1974) 868-873
14. Valenzuela A., Barria T., Guerra R., and Garrido A. Inhibitory effect of the flavonoid silymarin on the erythrocyte hemolysis induced by phenylhydrazine. Biochem. Biophys. Res. Commun. 126 (1985) 712-718
15. Lecomte J., and Damas J. Silybin effects on rat mastocytes. C. R. Seances Soc. Biol. Fil. 168 (1974) 1449-1451
16. Ramellini G., and Meldolesi J. Liver protection by silymarin: in vitro effect on dissociated rat hepatocytes. Arzneimittelforschung 26 (1976) 69-73
17. Ramellini G., and Meldolesi J. Stabilization of isolated rat liver plasma membranes by treatment in vitro with silymarin. Arzneimittelforschung 24 (1974) 806-808
18. Hofmann A.F. The continuing importance of bile acids in liver and intestinal disease. Arch. Intern. Med. 159 (1999) 2647-2658
19. Erlejman A.G., Verstraeten S.V., Fraga C.G., and Oteiza P.I. The interaction of flavonoids with membranes: potential determinant of flavonoid antioxidant effects. Free Radic. Res. 38 (2004) 1311-1320
20. Bindoli A., Cavallini L., and Silipandri N. Inhibitory action of silymarin of lipid peroxide formation in rat liver mitochondria and microsomes. Biochem. Pharmacol. 26 (1977) 2405-2409
21. Bosisio E., Benelli C., and Pirola O. Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes. Pharmacol. Res. 25 (1992) 147-154
22. Carini R., Comoglio A., Albano E., and Poli G. Lipid peroxidation and irreversible damage in the rat hepatocyte model. Protection by the silybin-phospholipid complex IdB 1016. Biochem. Pharmacol. 43 (1992) 2111-2115
23. Muriel P., Garciapina T., Pérez Alvarez V., and Mourelle M. Silymarin protects against paracetamol-induced lipid peroxidation and liver damage. J. Appl. Toxicol. 12 (1992) 439-442
24. Kidd P., and Head K. A review of the bioavailability and clinical efficacy of milk thistle phytosome: a silybin-phosphatidylcholine complex (Siliphos). Altern. Med. Rev. 10 (2005) 193-203
25. Kvasnicka F., Biba B., Sevcik R., Voldrich M., and Kratka J. Analysis of the active components of silymarin. J. Chromatogr. A 990 (2003) 239-245
26. Meier P.J., Sztul E.S., Reuben A., and Boyer J.L. Structural and functional polarity of canalicular and basolateral plasma membrane vesicles isolated in high yield from rat liver. J. Cell Biol. 98 (1984) 991-1000
27. Carreras F.I., Lehmann G.L., Ferri D., Tioni M.F., Calamita G., and Marinelli R.A. Defective hepatocyte aquaporin-8 expression and reduced canalicular membrane water permeability in estrogen-induced cholestasis. Am. J. Physiol. Gastrointest. Liver Physiol. 292 (2007) G905-G912
28. Lowry O.H., Rosembrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
29. Domecq A., Disalvo E.A., Bernik D.L., Florenzano F., and Politi M.J. A stability test of liposome preparations using steady-state fluorescent measurements. Drug Deliv. 8 (2001) 155-160
30. MacDonald R.I. Characteristics of self-quenching of the fluorescence of lipid-conjugated rhodamine in membranes. J. Biol. Chem. 265 (1990) 13533-13539
31. Berry M.N., and Friend D.S. High-yield preparation of isolated rat liver parenchymal cells: a biochemical and fine structural study. J. Cell Biol. 43 (1969) 506-520
32. Guibert E.E., Morisoli L.S., Monti J.A., and Rodriguez Garay E.A. Effect of spironolactone on p-nitrophenol glucuronidation in isolated rat hepatocytes. Experientia 39 (1983) 527-528
33. Baur H., Kasperek S., and Pfaff E. Criteria of viability of isolated liver cells. Hoppe Seylers Z. Physiol. Chem. 356 (1975) 827-838
34. Buege J.A., and Aust S.D. Microsomal lipid peroxidation. Methods Enzymol. 52 (1978) 302-310
35. Borgognone M., Perez L.M., Basiglio C.L., Ochoa J.E., and Roma M.G. Signaling modulation of bile salt-induced necrosis in isolated rat hepatocytes. Toxicol. Sci. 83 (2005) 114-125
36. Fukunaga K., Suzuki T., and Takama K. Highly sensitive high-performance liquid chromatography for the measurement of malondialdehyde in biological samples. J. Chromatogr. 621 (1993) 77-81
37. Parasassi T., Martellucci A., Conti F., and Messina B. Drug-membrane interactions: silymarin, silibyn and microsomal membranes. Cell Biochem. Funct. 2 (1984) 12-17
38. Wesolowska O., Lania-Pietrzak B., Kuzdzal M., Stanczak K., Mosiadz D., Dobryszycki P., Ozyhar A., Komorowska M., Hendrich A.B., and Michalak K. Influence of silybin on biophysical properties of phospholipid bilayers. Acta Pharmacol. Sin. 28 (2007) 296-306
39. Shiao Y.J., Chen J.C., and Wang C.T. The solubilization and morphological change of human platelets in various detergents. Biochim. Biophys. Acta 980 (1989) 56-68
40. Huh N.W., Porter N.A., McIntosh T.J., and Simon S.A. The interaction of polyphenols with bilayers: conditions for increasing bilayer adhesion. Biophys. J. 71 (1996) 3261-3277
41. Kaler G.V., Rachkovskii L.I., and Okun' I.M. Erythrocyte hemolysis by detergents-a mathematical model and analysis of the concentration and kinetic curves. Tsitologiia 28 (1986) 954-963
42. Helenius A., and Simons K. Solubilization of membranes by detergents. Biochim. Biophys. Acta 415 (1975) 29-79
43. Shalel S., Streichman S., and Marmur A. The mechanism of hemolysis by surfactants: effect of solution composition. J. Colloid Interface Sci. 252 (2002) 66-76