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Volumn 248, Issue 2, 1996, Pages 175-185

Bile acid conjugation in early stage cholestatic liver disease before and during treatment with ursodeoxycholic acid

Author keywords

bile acid conjugation efficiency; cholehepatic shunting; cholestasis; primary biliary cirrhosis; primary sclerosing cholangitis; unconjugated bile acids; ursodeoxycholic acid

Indexed keywords

BILE ACID CONJUGATE; LIDOFENIN TC 99M; URSODEOXYCHOLIC ACID;

EID: 0030003493     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/0009-8981(95)06252-1     Document Type: Article
Times cited : (6)

References (34)
  • 1
    • 0028293869 scopus 로고
    • Ursodeoxycholic therapy in chronic liver disease: A metaanalysis in primary biliary cirrhosis and in chronic hepatitis
    • Simko V, Michael S, Prego V. Ursodeoxycholic therapy in chronic liver disease: a metaanalysis in primary biliary cirrhosis and in chronic hepatitis. Am J Gastroenterol 1994;89:392-398.
    • (1994) Am J Gastroenterol , vol.89 , pp. 392-398
    • Simko, V.1    Michael, S.2    Prego, V.3
  • 2
    • 0028142266 scopus 로고
    • Ursodeoxycholic acid therapy in primary biliary cirrhosis
    • Leuschner U. Ursodeoxycholic acid therapy in primary biliary cirrhosis. Scand J Gastroenterol 1994;29(204):40-46.
    • (1994) Scand J Gastroenterol , vol.29 , Issue.204 , pp. 40-46
    • Leuschner, U.1
  • 3
    • 0000496970 scopus 로고
    • Hepatoprotective effect of ursodeoxycholate in experimental animals
    • Paumgartner G, Stiehl A, Barbara L, Roda E, eds. Dordrecht: Kluwer
    • Kitani K. Hepatoprotective effect of ursodeoxycholate in experimental animals. In: Paumgartner G, Stiehl A, Barbara L, Roda E, eds. Strategies for the treatment of hepatobiliary diseases. Dordrecht: Kluwer, 1990;43-56.
    • (1990) Strategies for the Treatment of Hepatobiliary Diseases , pp. 43-56
    • Kitani, K.1
  • 4
    • 0026086134 scopus 로고
    • Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts
    • Heuman D, Mills A, McCall J, Hylemon P, Pandak W, Vlahcevic ZR. Conjugates of ursodeoxycholate protect against cholestasis and hepatocellular necrosis caused by more hydrophobic bile salts. Gastroenterology 1991;100:203-211.
    • (1991) Gastroenterology , vol.100 , pp. 203-211
    • Heuman, D.1    Mills, A.2    McCall, J.3    Hylemon, P.4    Pandak, W.5    Vlahcevic, Z.R.6
  • 5
    • 0028084463 scopus 로고
    • Kinetics of hepatic bile acid handling in cholestatic liver disease: Effect of ursodeoxycholic acid
    • Jazrawi RP, de Caestecker JS, Goggin PM, et al. Kinetics of hepatic bile acid handling in cholestatic liver disease: effect of ursodeoxycholic acid. Gastroenterology 1994;106:134-142.
    • (1994) Gastroenterology , vol.106 , pp. 134-142
    • Jazrawi, R.P.1    De Caestecker, J.S.2    Goggin, P.M.3
  • 6
    • 0025098908 scopus 로고
    • Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: Effect of ursodeoxycholic acid
    • Calmus Y, Gane P, Rouger P, Poupon R. Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 1990;11:12-15.
    • (1990) Hepatology , vol.11 , pp. 12-15
    • Calmus, Y.1    Gane, P.2    Rouger, P.3    Poupon, R.4
  • 7
    • 0027221534 scopus 로고
    • Immunosuppressive effect of ursodeoxycholic acid: A comparative in vitro study on human peripheral blood mononuclear cells
    • Lacaille F and Paradis K. Immunosuppressive effect of ursodeoxycholic acid: a comparative in vitro study on human peripheral blood mononuclear cells. Hepatology 1993;18:165-172.
    • (1993) Hepatology , vol.18 , pp. 165-172
    • Lacaille, F.1    Paradis, K.2
  • 8
    • 0008069046 scopus 로고
    • Influence of ursodeoxycholic acid on bile secretion
    • Paumgartner G, Stiehl A, Barbara L, Roda E, eds. Dordrecht: Kluwer Academic
    • Erlinger S, Dumont M. Influence of ursodeoxycholic acid on bile secretion. In: Paumgartner G, Stiehl A, Barbara L, Roda E, eds. Strategies for the treatment of hepatobiliary diseases. Dordrecht: Kluwer Academic, 1990:35-42.
    • (1990) Strategies for the Treatment of Hepatobiliary Diseases , pp. 35-42
    • Erlinger, S.1    Dumont, M.2
  • 9
    • 17144458794 scopus 로고
    • Effects of individual taurine-conjugated bile acids on biliary secretion and sucrose clearance in the unanesthetized dog
    • Gilmore IT, Barnhart JL, Hofmann AF, Erlinger S. Effects of individual taurine-conjugated bile acids on biliary secretion and sucrose clearance in the unanesthetized dog. Am J Physiol 1982;5:G40-G46.
    • (1982) Am J Physiol , vol.5
    • Gilmore, I.T.1    Barnhart, J.L.2    Hofmann, A.F.3    Erlinger, S.4
  • 10
    • 0021663785 scopus 로고
    • Influence of bile acid structure on bile flow and biliary lipid secretion in the hamster
    • Gurantz D, Hofmann AF. Influence of bile acid structure on bile flow and biliary lipid secretion in the hamster. Am J Physiol 1984;247:G736-G748.
    • (1984) Am J Physiol , vol.247
    • Gurantz, D.1    Hofmann, A.F.2
  • 11
    • 0022981057 scopus 로고
    • Differing transport maxima values for taurine-conjugated bile salts in rats and hamsters
    • Kitani K, Kanai S, Ohta M, Sato Y. Differing transport maxima values for taurine-conjugated bile salts in rats and hamsters. Am J Physiol 1986;251:G852-G858.
    • (1986) Am J Physiol , vol.251
    • Kitani, K.1    Kanai, S.2    Ohta, M.3    Sato, Y.4
  • 12
    • 0022650127 scopus 로고
    • Effect of side-chain shortening on the physiologic properties of bile acids: Hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents
    • Yoon YB, Hagey LR, Hofmann AF, Gurantz D, Michelotti EL, Steinbach JH. Effect of side-chain shortening on the physiologic properties of bile acids: hepatic transport and effect on biliary secretion of 23-nor-ursodeoxycholate in rodents. Gastroenterology 1986;90:837-852.
    • (1986) Gastroenterology , vol.90 , pp. 837-852
    • Yoon, Y.B.1    Hagey, L.R.2    Hofmann, A.F.3    Gurantz, D.4    Michelotti, E.L.5    Steinbach, J.H.6
  • 13
    • 0019294767 scopus 로고
    • Hypercholeresis induced by ursodeoxycholic acid and 7-ketolithocolic acid in the rat: Possible role of bicarbonate transport
    • Dumont M, Erlinger S, Uchman S. Hypercholeresis induced by ursodeoxycholic acid and 7-ketolithocolic acid in the rat: possible role of bicarbonate transport. Gastroenterology 1980;79:82-89.
    • (1980) Gastroenterology , vol.79 , pp. 82-89
    • Dumont, M.1    Erlinger, S.2    Uchman, S.3
  • 14
    • 0021816123 scopus 로고
    • Ursodeoxycholate-induced choleresis in taurine-deprived and taurine-supplemented rats
    • Kitani K, Kanai S. Ursodeoxycholate-induced choleresis in taurine-deprived and taurine-supplemented rats. Jpn J Physiol 1985;35:443-462.
    • (1985) Jpn J Physiol , vol.35 , pp. 443-462
    • Kitani, K.1    Kanai, S.2
  • 15
    • 0025352101 scopus 로고
    • Hypercholeretic bile acids: A clue to the mechanism?
    • Erlinger S. Hypercholeretic bile acids: a clue to the mechanism? Hepatology 1990;11:888-890.
    • (1990) Hepatology , vol.11 , pp. 888-890
    • Erlinger, S.1
  • 16
    • 0003158872 scopus 로고
    • The cholehepatic circulation of unconjugated bile acids: An update
    • Paumgartner G, Stiehl A, Gerok W, eds. Boston: Kluwer Academic Publishers
    • Hofmann AF. The cholehepatic circulation of unconjugated bile acids: an update. In: Paumgartner G, Stiehl A, Gerok W, eds. Bile acids and the hepatobiliary system. Boston: Kluwer Academic Publishers 1993;143-160.
    • (1993) Bile Acids and the Hepatobiliary System , pp. 143-160
    • Hofmann, A.F.1
  • 17
    • 0022913264 scopus 로고
    • Identification of unconjugated bile acids in human bile
    • Matoba N, Une M, Hoshita T. Identification of unconjugated bile acids in human bile. J Lipid Res 1986;27:1154-1162.
    • (1986) J Lipid Res , vol.27 , pp. 1154-1162
    • Matoba, N.1    Une, M.2    Hoshita, T.3
  • 18
    • 0027265104 scopus 로고
    • Effect of long-term treatment with ursodiol on clinical and biochemical features and biliary bile acid metabolism in patients with primary biliary cirrhosis
    • Batta AK, Salen G, Mirchandanir et al. Effect of long-term treatment with ursodiol on clinical and biochemical features and biliary bile acid metabolism in patients with primary biliary cirrhosis. Am J Gastroenterol 1993;88:691-700.
    • (1993) Am J Gastroenterol , vol.88 , pp. 691-700
    • Batta, A.K.1    Salen, G.2    Mirchandanir3
  • 19
    • 0000950507 scopus 로고
    • Enterohepatic circulation of bile acids
    • Schultz SG, ed. Bethesda: American Physiological Society
    • Hofmann AF. Enterohepatic circulation of bile acids. In: Schultz SG, ed. Handbook of physiology. Section on the Gastrointestinal System. Bethesda: American Physiological Society, 1989;567-596.
    • (1989) Handbook of Physiology. Section on the Gastrointestinal System , pp. 567-596
    • Hofmann, A.F.1
  • 20
    • 0015364180 scopus 로고
    • Metabolism of steroid and amino acid moieties of conjugated bile acids in man. II. Glycine-conjugated dihydroxy bile acids
    • Hepner GW, Hofmann AF, Thomas PJ. Metabolism of steroid and amino acid moieties of conjugated bile acids in man. II. Glycine-conjugated dihydroxy bile acids. J Clin Invest 1972;51:1898-1905.
    • (1972) J Clin Invest , vol.51 , pp. 1898-1905
    • Hepner, G.W.1    Hofmann, A.F.2    Thomas, P.J.3
  • 21
    • 0026787057 scopus 로고
    • Effect of ursodeoxycholic acid on the masses of biliary lipids and alkaline phosphatase within the gallbladder in chronic cholestatic liver disease
    • Fracchia M, Ferraris R, Petrarulo M, Secreto P, Dunn T, Galatola G. Effect of ursodeoxycholic acid on the masses of biliary lipids and alkaline phosphatase within the gallbladder in chronic cholestatic liver disease. Eur J Gastroenterol Hepatol 1992:4:843-848.
    • (1992) Eur J Gastroenterol Hepatol , vol.4 , pp. 843-848
    • Fracchia, M.1    Ferraris, R.2    Petrarulo, M.3    Secreto, P.4    Dunn, T.5    Galatola, G.6
  • 22
    • 0020010904 scopus 로고
    • Clinical-pathologic relations in primary biliary cirrhosis
    • Popper H, Schaffner F, eds. New York: Grune and Stratton
    • Schaffner F, Popper H. Clinical-pathologic relations in primary biliary cirrhosis. In: Popper H, Schaffner F, eds. Progress in liver diseases. Vol 7. New York: Grune and Stratton, 1982;529-545.
    • (1982) Progress in Liver Diseases , vol.7 , pp. 529-545
    • Schaffner, F.1    Popper, H.2
  • 23
  • 25
    • 0342385842 scopus 로고
    • Quantitative determination of bile acids in bile with reversed-phase high performance liquid chromatography
    • Nakayama F, Nakagaki M. Quantitative determination of bile acids in bile with reversed-phase high performance liquid chromatography. J Chromatogr 1980;105:407-410.
    • (1980) J Chromatogr , vol.105 , pp. 407-410
    • Nakayama, F.1    Nakagaki, M.2
  • 26
    • 0026352217 scopus 로고
    • Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration
    • Crosignani A, Podda M, Battezzati PM et al. Changes in bile acid composition in patients with primary biliary cirrhosis induced by ursodeoxycholic acid administration Hepatology 1991;14:1000-1007.
    • (1991) Hepatology , vol.14 , pp. 1000-1007
    • Crosignani, A.1    Podda, M.2    Battezzati, P.M.3
  • 27
    • 0022501201 scopus 로고
    • Effects of cholic acid, 7 beta-hydroxy-and 12 beta-hydroxy-isocholic acid on bile flow, lipid secretion and bile acid synthesis in the rat
    • Borgstrom B, Barrowman J, Krabisch L, Lindstrom M, Lillienau J. Effects of cholic acid, 7 beta-hydroxy-and 12 beta-hydroxy-isocholic acid on bile flow, lipid secretion and bile acid synthesis in the rat. Scand J Clin Lab Invest 1986;46:167-175.
    • (1986) Scand J Clin Lab Invest , vol.46 , pp. 167-175
    • Borgstrom, B.1    Barrowman, J.2    Krabisch, L.3    Lindstrom, M.4    Lillienau, J.5
  • 28
    • 0026322035 scopus 로고
    • Hepatic and ileal transport and effect on biliary secretion of norursocholic acid and its conjugates in rats
    • Lillienau J, Hagey LR, Borgstrom B. Hepatic and ileal transport and effect on biliary secretion of norursocholic acid and its conjugates in rats. Am J Physiol 1991;261: G1057-G1064.
    • (1991) Am J Physiol , vol.261
    • Lillienau, J.1    Hagey, L.R.2    Borgstrom, B.3
  • 29
    • 0023751425 scopus 로고
    • + exchange in the rat is associated with decreased ursodeoxycholate hypercholeresis, decreased secretion of unconjugated ursodeoxycholate, and increased ursodeoxycholate glucuronidation
    • + exchange in the rat is associated with decreased ursodeoxycholate hypercholeresis, decreased secretion of unconjugated ursodeoxycholate, and increased ursodeoxycholate glucuronidation. Gastroenterology 1988;95:454-463.
    • (1988) Gastroenterology , vol.95 , pp. 454-463
    • Lake, J.R.1    Renner, E.L.2    Scharschmidt, B.F.3
  • 30
    • 0025203619 scopus 로고
    • Gallbladder motility in cholesterol gallstone disease. Effect of ursodeoxycholic acid administration and gallstone dissolution
    • Festi D, Fraboni R, Bazzoli F et al. Gallbladder motility in cholesterol gallstone disease. Effect of ursodeoxycholic acid administration and gallstone dissolution. Gastroenterology 1990;99:1779-1785.
    • (1990) Gastroenterology , vol.99 , pp. 1779-1785
    • Festi, D.1    Fraboni, R.2    Bazzoli, F.3
  • 31
    • 0026581555 scopus 로고
    • Fasting gallbladder volume, postprandial emptying, and cholecystokinin release in gallstone patients and normal subjects
    • Van Erpekum KJ, van Berge Henegouwen GP, Stolk MF, Hopman WP, Jansen JB and Lamers CB. Fasting gallbladder volume, postprandial emptying, and cholecystokinin release in gallstone patients and normal subjects. J Hepatol 1992;14:194-202.
    • (1992) J Hepatol , vol.14 , pp. 194-202
    • Van Erpekum, K.J.1    Van Berge Henegouwen, G.P.2    Stolk, M.F.3    Hopman, W.P.4    Jansen, J.B.5    Lamers, C.B.6
  • 32
    • 0024309202 scopus 로고
    • The effects of intraduodenal bile acid administration on biliary secretion of ionized calcium and carbonate in man
    • Knyrim K, Vakil N, Pfab R, Classen M. The effects of intraduodenal bile acid administration on biliary secretion of ionized calcium and carbonate in man. Hepatology 1989;10:134-142.
    • (1989) Hepatology , vol.10 , pp. 134-142
    • Knyrim, K.1    Vakil, N.2    Pfab, R.3    Classen, M.4
  • 33
    • 0024517292 scopus 로고
    • Determinants of bile secretion: Effect of bile salt structure on bile flow and biliary cation secretion
    • Loria P, Carulli N, Medici G et al. Determinants of bile secretion: effect of bile salt structure on bile flow and biliary cation secretion. Gastroenterology 1989;96:1142-1150.
    • (1989) Gastroenterology , vol.96 , pp. 1142-1150
    • Loria, P.1    Carulli, N.2    Medici, G.3
  • 34
    • 0343691036 scopus 로고
    • Novel metabolism and hypercholeretic effect of norursodeoxycholic acid in man
    • Zakko S, Lira M, Clerici C et al. Novel metabolism and hypercholeretic effect of norursodeoxycholic acid in man (Abstr). Gastroenterology 1987;92:1793.
    • (1987) Gastroenterology , vol.92 , pp. 1793
    • Zakko, S.1    Lira, M.2    Clerici, C.3


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