Biliary secretion of glutathione in estradiol 17β -D-glucuronide-induced cholestasis

Journal of Pharmacology and Experimental Therapeutics

Volumn 307, Issue 1, 2003, Pages 306-313

  Mottino, Aldo D ^b   Veggi, Luis M ^b   Wood, Marcie ^a   Vélez Román, Joyce M ^a   Vore, Mary ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

^b Immunology Area   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

BICARBONATE; BILE SALT; BILE SALT EXPORT PUMP; ESTRADIOL 17 GLUCURONIDE; ESTRADIOL 3 GLUCURONIDE; GLUTATHIONE; GLUTATHIONE DISULFIDE; MULTIDRUG RESISTANCE PROTEIN 2; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BILE FLOW; BILE SECRETION; CHOLESTASIS; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENDOCYTOSIS; FEMALE; INTRAHEPATIC BILE DUCT; ISOLATED LIVER; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANIONS; BILIARY TRACT; CHOLESTASIS; ESTRADIOL; FEMALE; GLUTATHIONE; GLUTATHIONE DISULFIDE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0141630543     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.054544     Document Type: Article

References (32)

1. Ballatori N and Clarkson TW (1985) Sulfobromophthalein inhibition of glutathione and methylmercury secretion into bile. Am J Physiol 248:G238-G245.
2. Ballatori N, Jacob R, and Boyer JL (1986) Intrabiliary glutathione hydrolysis. A source of glutamate in bile. J Biol Chem 261:7860-7865.
3. Ballatori N and Rebbeor JF (1998) Roles of MRP2 and oatp1 in hepatocellular export of reduced glutathione. Semin Liver Dis 18:377-387.
4. Ballatori N and Truong AT (1992) Glutathione as a primary osmotic driving force in hepatic bile formation. Am J Physiol 263:G617-G624.
5. Crocenzi FA, Mottino AD, Cao J, Veggi LM, Sánchez Pozzi EJ, Vore M, Coleman R, and Roma MG (2003) Estradiol 17-β-D-glueuronide induces endocytic internalization of Bsep in rats. Am J Physiol Gastrointest Liver Physiol 285:G449-G459.
6. Gerk PM, Li W, and Vore M (2003) Noncholestatic estrogen glucuronides interact with the multidrug resistance-associated protein 2 (Mrp2). FASEB J 17:A1027.
7. GerloffT, Stieger B, Hagenbuch B, Madon J, Landmann L, Roth J, Hofmann AF, and Meier PJ (1998) The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver. J Biol Chem 273:10046-10050.
8. Griffith OW (1980) Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine. Anal Biochem 106:207-212.
9. Hardison WG and Wood CA (1978) Importance of bicarbonate in bile salt independent fraction of bile flow. Am J Physiol 235:E158-E164.
10. Haussinger D, Schmitt M, Weiergraber O, and Kubitz R (2000) Short-term regulation of canalicular transport. Semin Liver Dis 20:307-321.
11. Ito K, Suzuki H, and Sugiyama Y (2001) Single amino acid substitution of rat MRP2 results in acquired transport activity for taurocholate. Am J Physiol 281:G1034-G1043.
12. Kamisako T, Leier I, Cui Y, Konig J, Buchholz U, Hummel-Eisenbeiss J, and Keppler D (1999) Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. Hepatology 30:485-490.
13. Kan KS, Monte MJ, Parslow RA, and Coleman R (1989) Oestradiol 17β-D-glucuronide increases tight-junctional permeability in rat liver. Biochem J 261:297-300.
14. Kaplowitz N, Fernandez-Checa JC, Kannan R, Garcia-Ruiz C, Ookhtens M, and Yi JR (1996) GSH transporters: molecular characterization and role in GSH homeostasis. Biol Chem Hoppe Seyler 377:267-273.
15. Kipp H and Arias IM (2002) Trafficking of canalicular ABC transporters in hepatocytes. Annu Rev Physiol 64:595-608.
16. Konig J, Nies AT, Cui Y, Leier I, and Keppler D (1999) Conjugate export pumps of the multidrug resistance protein (MRP) family: localization, substrate specificity and MRP2-mediated drug resistance. Biochim Biophys Acta 1461:377-394.
17. Leier I, Jedlitschky G, Buchholz U, Center M, Cole SPC, and Deeley RG (1996) ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump. Biochem J 314:433-437.
18. Li L, Meier PJ, and Ballatori N (2000) Oatp2 mediates bi-directional organic solute transport: a role for intracellular glutathione. Mol Pharmacol 58:335-340.
19. Mao Q, Deeley RG, and Cole SP (2000) Functional reconstitution of substrate transport by purified multidrug resistance protein MRP1 (ABCC1) in phospholipid vesicles. J Biol Chem 275:34166-34172.
20. Meier PJ, Knickelbein R, Moseley RH, Dobbins JW, and Boyer JL (1985) Evidence for carrier-mediated chloride/bicarbonate exchange in canalicular rat liver plasma membrane vesicles. J Clin Investig 75:1256-1263.
21. Meyers M, Slikker W, Pascoe G, and Vore M (1980) Characterization of cholestasis induced by estradiol-17-β-glucuronide in the rat. J Pharmacol Exp Ther 214:87-93.
22. Mottino AD, Cao J, Veggi LM, Crocenzi F, Roma MG, and Vore M (2002) Altered localization and activity of canalicular Mrp2 in estradiol-17β -D-glucuronide-induced cholestasis. Hepatology 35:1409-1419.
23. Nathanson MH and Boyer JL (1991) Mechanisms and regulation of bile secretion. Hepatology 14:551-566.
24. Oude Elferink RP, Meijer DK, Kuipers F, Jansen PL, Groen AK, and Groothuis GM (1995) Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport. Biochim Biophys Acta 1241:215-268.
25. Rebbeor JF, Connolly GC, and Ballatori N (2002) Inhibition of Mrp2- and Ycf1p-mediated transport by reducing agents: evidence for GSH transport on rat Mrp2. Biochim Biophys Acta 1559:171-178.
26. Rost D, Kartenbeck J, and Keppler D (1999) Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis. Hepatology 29:814-821.
27. Tietze F (1969) Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: applications to mammalian blood and other tissues. Anal Biochem 27:502-522.
28. Trauner M, Meier PJ, and Boyer JL (1998) Molecular pathogenesis of cholestasis. N Engl J Med 339:1217-1227.
29. Van Dyke RW, Stephens JE, and Scharschmidt BF (1982) Effects of ion substitution on bile acid-dependent and -independent bile formation by rat liver. J Clin Investig 70:505-517.
30. Vore M, Bauer J, and Pascucci V (1978) The effect of pregnancy on the metabolism of [14C]phenytoin in the isolated perfused rat liver. J Pharmacol Exp Ther 206:439-447.
31. Vore M and Slikker W (1985) Steroid D-ring glucuronides: a new class of cholestatic agents. Trends Pharm Sci 6:256-259.
32. Yang B and Hill CE (2001) Nifedipine modulation of biliary GSH and GSSG/conjugate efflux in normal and regenerating rat liver. Am J Physiol 281:G85-G94.