Tauroursodeoxycholic acid partially prevents apoptosis induced by 3-nitropropionic acid: Evidence for a mitochondrial pathway independent of the permeability transition

Journal of Neurochemistry

Volumn 75, Issue 6, 2000, Pages 2368-2379

  Rodrigues, Cecilia M P ^a   Stieers, Cheryle Linehan ^a   Keene, C Dirk ^a   Ma, Xiaoming ^b  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF LISBON   (Portugal)

Author keywords

Bax protein; Bile acids; Caspases; Cyclosporin A; Hepatocytes; Huntington's disease; Mitochondria; RN33B neuronal cells; Transmembrane potential

Indexed keywords

3 NITROPROPIONIC ACID; CASPASE; CYCLOSPORIN A; CYTOCHROME C; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; TAURINE; TAUROURSODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID;

ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; ENZYME ACTIVITY; ENZYME ANALYSIS; HUNTINGTON CHOREA; MEMBRANE DAMAGE; MEMBRANE PERMEABILITY; MITOCHONDRIAL MEMBRANE; NERVE CELL NECROSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELLS, CULTURED; CYTOCHROME C GROUP; HEPATOCYTES; HUNTINGTON DISEASE; INTRACELLULAR MEMBRANES; MITOCHONDRIA; MITOCHONDRIAL SWELLING; NEURONS; NITRO COMPOUNDS; PERMEABILITY; POLY(ADP-RIBOSE) POLYMERASES; PROPIONIC ACIDS; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; REACTIVE OXYGEN SPECIES; TAUROCHENODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID;

ANIMALIA;

EID: 0033769186     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0752368.x     Document Type: Article

References (72)

1. 3-Nitropropionic acid's lethal triplet: Cooperative pathways of neurodegeneration
2. Inhibition of Bax channel-forming activity by Bcl-2
3. Aging, energy, and oxidative stress in neurodegenerative diseases
4. Age-dependent striatal excitotoxicity lesions produced by the endogenous mitochondrial inhibitor malonate
5. Neurochemical and histologic characterization of excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid
6. 3-Nitropropionic acid induces apoptosis in cultured striatal and cortical neurons
7. Ursodeoxycholic acid for treatment of primary sclerosing cholangitis: A placebo-controlled trial
8. Ursodeoxycholic acid in cholestasis: Potential mechanisms of action and therapeutic applications
9. Behavioral pathology induced by repeated systemic injections of 3-nitropropionic acid mimics the motoric symptoms of Huntington's disease
10. 3-Nitropropionic acid animal model and Huntington's disease
11. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
12. Ursodeoxycholate (UDCA) inhibits the mitochondrial membrane permeability transition induced by glycochenodeoxycholate: A mechanism of UDCA cytoprotection
13. Regional mitochondrial respiratory activity in Huntington's disease
14. Survival and growth of hippocampal neurons in defined medium at low density: Advantages of a sandwich culture technique or low oxygen
15. Effects of chronic MPTP and 3-nitropropionic acid in nonhuman primates
16. Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates
17. Oxidative damage and metabolic dysfunction in Huntington's disease: Selective vulnerability of the basal ganglia
18. Spin labeling in disease
19. β-Amyloid peptide free radical fragments initiate synaptosomal lipoperoxidation in a sequence-specific fashion: Implications to Alzheimer's disease
20. Ursodeoxycholic acid as adjunctive therapy for problematic type 1 autoimmune hepatitis: A randomized placebo-controlled treatment trial
21. 2+ ions
22. Mitochondria and apoptosis
23. The endogenous cofactors, thiotic acid and dihydrolipoic acid, are neuroprotective against NMDA and malonic acid lesions of striatum
24. Inhibition of succinate dehydrogenase by malonic acid produces an 'excitotoxic' lesion in rat striatum
25. Enforced dimerization of BAX results in its translocation, mitochondrial dysfunction and apoptosis
26. Regional mitochondrial respiratory activity in Huntington's disease
27. Electron paramagnetic resonance investigations of free radical-induced alterations in neocortical synaptosomal membrane protein infrastructure
28. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
29. Cytosol-to-memhrane redistribution of Bax and Bcl-X(L) during apoptosis
30. A conformational change in cytochrome c of apoptotic and necrotic cells is detected by monoclonal antibody binding and mimicked by association of the native antigen with synthetic phospholipid vesicles
31. Bax directly induces release of cytochrome c from isolated mitochondria
32. Excitotoxicity is required for induction of oxidative stress and apoptosis in mouse striatum by the mitochondrial toxin, 3-nitropropionic acid
33. The release of cytochrome c from mitochondria: A primary site for Bcl-2 regulation of apoptosis
34. Investigation of the subcellular distribution of the Bcl-2 oncoprotein: Residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes
35. Mitochondrial permeability transition in the central nervous system: Induction by calcium cycling-dependent and -independent pathways
36. Mitochondrial implication in apoptosis. Towards an endosymbiont hypothesis of apoptosis evolution
37. The proto-oncogene Bcl-2 and its role in regulating apoptosis
38. 3-Nitropropionic acid induced in vivo protein oxidation in striatal and cortical synaptosomes: Insights into Huntington's disease
39. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade
40. Induction of apoptotic program in cell-free extracts: Requirement for dATP and cytochrome c
41. 3-Nitropropionic acid decreases cellular energy levels and causes neuronal degeneration in cortical explants
42. Mitochondrial permeability transition is a central coordinating event of apoptosis
43. Rapid synergistic interaction between thyroid hormone and carbohydrate on mRNA(S14) induction
44. Cell-free apoptosis in Xenopus egg extracts: Inhibition by Bcl-2 and requirement for an organelle fraction enriched in mitochondria
45. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1
46. Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease
47. Mechanisms of cell death induced by the mitochondrial toxin 3-nitropropionic acid: Excitotoxic necrosis and delayed apoptosis
48. Cyclosporin and carnitine prevent the anoxic death of cultured hepatocytes by inhibiting the mitochondrial permeability transition
49. Mitochondria and programmed cell death: Back to the future
50. The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex
51. A novel role for ursodeoxycholic acid in inhibiting apoptosis by modulating mitochondrial membrane perturbation
52. Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production
53. Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation
54. Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid
55. Decreased expression of bcl-2 and bcl-x mRNA coincides with apoptosis following intracerebral administration of 3-nitropropionic acid
56. Mitochondrial dysfunction in neurodegenerative disorders
57. Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2
58. Inhibition of neuronal nitric oxide synthase by 7-nitroindazole protects against MPTP-induced neurotoxicity in mice
59. Blockade of neuronal nitric oxide synthase protects against excitotoxicity in vivo
60. Oxidant injury to hepatic mitochondrial lipids in rats with dietary copper overload. Modification by vitamin E deficiency
61. 3-Nitropropionic acid induces poly(ADP-ribosyl)ation and apoptosis related gene expression in the striatum in vivo
62. Molecular characterization of mitochondrial apoptosis-inducing factor
63. Biochemical abnormalities and excitotoxicity in Huntington's disease
64. Caspases: Enemies within
65. Bcl-x(L) regulates the membrane potential and volume homeostasis of mitochondria
66. Altered cytochrome c display precedes apoptotic cell death in Drosophila
67. The role of the matrix calcium level in the enhancement of mitochondrial pyruvate carboxylation by glucagon pretreatment
68. Sequential reduction of mitochondrial transmembrane potential and generation of reactive oxygen species in early programmed cell death
69. Mitochondrial control of nuclear apoptosis
70. Inhibitors of permeability transition interfere with the disruption of the mitochondrial transmembrane potential during apoptosis
71. Subcellular and submitochondrial mode of action of Bcl-2-like oncoproteins
72. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3