Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: The switch between apoptosis and necrosis

Toxicological Sciences

Volumn 79, Issue 1, 2004, Pages 196-204

  Rolo, Anabela P ^a   Palmeira, Carlos M ^a   Holy, Jon M ^b   Wallace, Kendall B ^b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Apoptosis; Chenodeoxycholic acid; Combination; Mitochondria; Necrosis; Ursodeoxycholic acid

Indexed keywords

ADENOSINE TRIPHOSPHATE; BILE ACID; CASPASE 9; CHENODEOXYCHOLIC ACID; HOE 33342; POLY(ADENOSINE DIPHOSPHATE RIBOSE); URSODEOXYCHOLIC ACID;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL MEMBRANE PERMEABILITY; CELL PROLIFERATION; CELL STRAIN HEPG2; CONTROLLED STUDY; CYTOTOXICITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GROWTH INHIBITION; HUMAN; HUMAN CELL; INCUBATION TIME; NECROSIS; PROTEIN DEGRADATION; PROTEIN DEPLETION;

ADENOSINE TRIPHOSPHATE; APOPTOSIS; BILE ACIDS AND SALTS; BROMODEOXYURIDINE; CASPASE 9; CASPASES; CELL CYCLE; CELL DIVISION; CELL LINE; CELL MEMBRANE PERMEABILITY; CELL SURVIVAL; CHENODEOXYCHOLIC ACID; CHROMATIN; CYTOCHROMES C; DNA; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; HUMANS; MITOCHONDRIAL DISEASES; NECROSIS; POLY(ADP-RIBOSE) POLYMERASES; TAUROCHENODEOXYCHOLIC ACID; TIME FACTORS; TUBULIN; URSODEOXYCHOLIC ACID;

EID: 2442644019     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfh078     Document Type: Article

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