-
1
-
-
0038312385
-
Decreased liver hepcidin expression in the Hfe knockout mouse
-
Ahmad KA, Ahmann JR, Migas MC, Waheed A, Britton RS, et al. 2002. Decreased liver hepcidin expression in the Hfe knockout mouse. Blood Cells Mol. Dis. 29:361-66
-
(2002)
Blood Cells Mol. Dis.
, vol.29
, pp. 361-366
-
-
Ahmad, K.A.1
Ahmann, J.R.2
Migas, M.C.3
Waheed, A.4
Britton, R.S.5
-
2
-
-
0037103357
-
Regulation of iron absorption in Hfe mutant mice
-
DOI 10.1182/blood-2001-11-0037
-
Ajioka RS, Levy JE, Andrews NC, Kushner JP. 2002. Regulation of iron absorption in Hfe mutant mice. Blood 100:1465-69 (Pubitemid 34864306)
-
(2002)
Blood
, vol.100
, Issue.4
, pp. 1465-1469
-
-
Ajioka, R.S.1
Levy, J.E.2
Andrews, N.C.3
Kushner, J.P.4
-
3
-
-
33749638768
-
GAA repeat expansion mutation mouse models of Friedreich ataxia exhibit oxidative stress leading to progressive neuronal and cardiac pathology
-
DOI 10.1016/j.ygeno.2006.06.015, PII S0888754306001972
-
Al-Mahdawi S, Pinto RM, Varshney D, Lawrence L, Lowrie MB, et al. 2006. GAA repeat expansion mutation mouse models of Friedreich ataxia exhibit oxidative stress leading to progressive neuronal and cardiac pathology. Genomics 88:580-90 (Pubitemid 44540244)
-
(2006)
Genomics
, vol.88
, Issue.5
, pp. 580-590
-
-
Al-Mahdawi, S.1
Pinto, R.M.2
Varshney, D.3
Lawrence, L.4
Lowrie, M.B.5
Hughes, S.6
Webster, Z.7
Blake, J.8
Cooper, J.M.9
King, R.10
Pook, M.A.11
-
4
-
-
0032920837
-
Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A)
-
Allikmets R, RaskindWH,Hutchinson A, SchueckND, Dean M, KoellerDM. 1999. Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A). Hum. Mol. Genet. 8:743-49 (Pubitemid 29189041)
-
(1999)
Human Molecular Genetics
, vol.8
, Issue.5
, pp. 743-749
-
-
Allikmets, R.1
Raskind, W.H.2
Hutchinson, A.3
Schueck, N.D.4
Dean, M.5
Koeller, D.M.6
-
6
-
-
0034572933
-
Iron homeostasis: Insights from genetics and animal models
-
AndrewsNC. 2000. Iron homeostasis: insights from genetics and animal models. Nat. Rev. Genet. 1:208-17
-
(2000)
Nat. Rev. Genet.
, vol.1
, pp. 208-217
-
-
Andrews, N.C.1
-
7
-
-
0042810742
-
Animal models of hereditary iron transport disorders
-
Andrews NC. 2002. Animal models of hereditary iron transport disorders. Adv. Exp.Med. Biol. 509:1-17
-
(2002)
Adv. Exp.Med. Biol.
, vol.509
, pp. 1-17
-
-
Andrews, N.C.1
-
8
-
-
63449103712
-
BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism
-
Andriopoulos B Jr, Corradini E, Xia Y, Faasse SA, Chen S, et al. 2009. BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism. Nat. Genet. 41:482-87
-
(2009)
Nat. Genet.
, vol.41
, pp. 482-487
-
-
Andriopoulos Jr., B.1
Corradini, E.2
Xia, Y.3
Faasse, S.A.4
Chen, S.5
-
9
-
-
33646370235
-
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
-
Babitt JL,Huang FW,Wrighting DM, Xia Y, Sidis Y, et al. 2006. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 38:531-39
-
(2006)
Nat. Genet.
, vol.38
, pp. 531-539
-
-
Babitt, J.L.1
Huang, F.W.2
Wrighting, D.M.3
Xia, Y.4
Sidis, Y.5
-
10
-
-
0033539556
-
Experimental hemochromatosis due to MHC class i HFE deficiency: Immune status and iron metabolism
-
Bahram S, Gilfillan S, Kuhn LC, Moret R, Schulze JB, et al. 1999. Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism. Proc. Natl. Acad. Sci. USA 96:13312-17
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 13312-13317
-
-
Bahram, S.1
Gilfillan, S.2
Kuhn, L.C.3
Moret, R.4
Schulze, J.B.5
-
11
-
-
0015386010
-
Hereditary microcytic anaemia in the mouse: Studies in iron distribution and metabolism
-
Bannerman RM, Edwards JA, Kreimer-Birnbaum M, McFarland E, Russell ES. 1972. Hereditary microcytic anaemia in the mouse: studies in iron distribution and metabolism. Br. J. Haematol. 23:235-45
-
(1972)
Br. J. Haematol.
, vol.23
, pp. 235-245
-
-
Bannerman, R.M.1
Edwards, J.A.2
Kreimer-Birnbaum, M.3
McFarland, E.4
Russell, E.S.5
-
12
-
-
2142768213
-
Multigenic Control of Hepatic Iron Loading in a Murine Model of Hemochromatosis
-
DOI 10.1053/j.gastro.2004.01.021
-
Bensaid M, Fruchon S,Mazeres C, Bahram S, RothMP, Coppin H. 2004. Multigenic control of hepatic iron loading in a murine model of hemochromatosis. Gastroenterology 126:1400-8 (Pubitemid 38552803)
-
(2004)
Gastroenterology
, vol.126
, Issue.5
, pp. 1400-1408
-
-
Bensaid, M.1
Fruchon, S.2
Mazeres, C.3
Bahram, S.4
Roth, M.-P.5
Coppin, H.6
-
13
-
-
0023522698
-
Hereditary hypotranferrinemia with hemosiderosis, a murine disorder resembling human atransferrinemia
-
Bernstein SE. 1987. Hereditary hypotransferrinemia with hemosiderosis, a murine disorder resembling human atransferrinemia. J. Lab. Clin. Med. 110:690-705 (Pubitemid 18033263)
-
(1987)
Journal of Laboratory and Clinical Medicine
, vol.110
, Issue.6
, pp. 690-705
-
-
Bernstein, S.E.1
-
14
-
-
0023219279
-
Anemia of the Belgrade rat: Evidence for defective membrane transport of iron
-
Bowen BJ, Morgan EH. 1987. Anemia of the Belgrade rat: evidence for defective membrane transport of iron. Blood 70:38-44 (Pubitemid 17111238)
-
(1987)
Blood
, vol.70
, Issue.1
, pp. 38-44
-
-
Bowen, B.J.1
Morgan, E.H.2
-
15
-
-
0037460697
-
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
-
DOI 10.1016/S0140-6736(03)12602-5
-
Bridle KR, Frazer DM, Wilkins SJ, Dixon JL, Purdie DM, et al. 2003. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 361:669-73 (Pubitemid 36246550)
-
(2003)
Lancet
, vol.361
, Issue.9358
, pp. 669-673
-
-
Bridle, K.R.1
Frazer, D.M.2
Wilkins, S.J.3
Dixon, J.L.4
Purdie, D.M.5
Crawford, D.H.G.6
Subramaniam, V.N.7
Powell, L.W.8
Anderson, G.J.9
Ramm, G.A.10
-
16
-
-
51249119361
-
Recent advances in the understanding of inherited sideroblastic anaemia
-
Camaschella C. 2008. Recent advances in the understanding of inherited sideroblastic anaemia. Br. J. Haematol. 143:27-38
-
(2008)
Br. J. Haematol.
, vol.143
, pp. 27-38
-
-
Camaschella, C.1
-
17
-
-
0034022636
-
The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22
-
DOI 10.1038/75534
-
Camaschella C, Roetto A, Cali A, De Gobbi M, Garozzo G, et al. 2000. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat. Genet. 25:14-15 (Pubitemid 30257027)
-
(2000)
Nature Genetics
, vol.25
, Issue.1
, pp. 14-15
-
-
Camaschella, C.1
Roetto, A.2
Cali, A.3
De Gobbi, M.4
Garozzo, G.5
Carella, M.6
Majorano, N.7
Totaro, A.8
Gasparini, P.9
-
18
-
-
54349098472
-
Newand old players in the hepcidin pathway
-
Camaschella C, SilvestriL. 2008.Newand old players in the hepcidin pathway. Haematologica 93:1441-44
-
(2008)
Haematologica
, vol.93
, pp. 1441-1444
-
-
Camaschella, C.1
Silvestri, L.2
-
19
-
-
0034548853
-
The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border
-
Canonne-Hergaux F, Fleming MD, Levy JE, Gauthier S, Ralph T, et al. 2000. The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border. Blood 96:3964-70
-
(2000)
Blood
, vol.96
, pp. 3964-3970
-
-
Canonne-Hergaux, F.1
Fleming, M.D.2
Levy, J.E.3
Gauthier, S.4
Ralph, T.5
-
20
-
-
64049112236
-
Iron is essential for neuron development and memory function in mouse hippocampus
-
Carlson ES, Tkac I, Magid R, O'Connor MB, Andrews NC, et al. 2009. Iron is essential for neuron development and memory function in mouse hippocampus. J. Nutr. 139:672-79
-
(2009)
J. Nutr.
, vol.139
, pp. 672-679
-
-
Carlson, E.S.1
Tkac, I.2
Magid, R.3
O'Connor, M.B.4
Andrews, N.C.5
-
21
-
-
70349479539
-
Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria
-
Chen W, Paradkar PN, Li L, Pierce EL, Langer NB, et al. 2009. Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc. Natl. Acad. Sci. USA 106:16263-68
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 16263-16268
-
-
Chen, W.1
Paradkar, P.N.2
Li, L.3
Pierce, E.L.4
Langer, N.B.5
-
22
-
-
23044503950
-
Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2
-
Cooperman SS, Meyron-Holtz EG, Olivierre-Wilson H, Ghosh MC, McConnell JP, Rouault TA. 2005. Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2. Blood 106:1084-91
-
Blood
, vol.106
, pp. 1084-1091
-
-
Cooperman, S.S.1
Meyron-Holtz, E.G.2
Olivierre-Wilson, H.3
Ghosh, M.C.4
McConnell, J.P.5
Rouault, T.A.6
-
23
-
-
70349494083
-
Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis
-
Corradini E, Garuti C, Montosi G, Ventura P, Andriopoulos B Jr, et al. 2009. Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis. Gastroenterology 137:1489-97
-
(2009)
Gastroenterology
, vol.137
, pp. 1489-1497
-
-
Corradini, E.1
Garuti, C.2
Montosi, G.3
Ventura, P.4
Andriopoulos Jr., B.5
-
24
-
-
10744226568
-
Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice
-
DOI 10.1016/j.bcmd.2003.11.003, PII S1079979603002869
-
Courselaud B, Troadec MB, Fruchon S, Ilyin G, Borot N, et al. 2004. Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice. Blood Cells Mol. Dis. 32:283-89 (Pubitemid 38296692)
-
(2004)
Blood Cells, Molecules, and Diseases
, vol.32
, Issue.2
, pp. 283-289
-
-
Courselaud, B.1
Troadec, M.-B.2
Fruchon, S.3
Ilyin, G.4
Borot, N.5
Leroyer, P.6
Coppin, H.7
Brissot, P.8
Roth, M.-P.9
Loreal, O.10
-
25
-
-
34250800318
-
Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin
-
DOI 10.1038/sj.emboj.7601735, PII 7601735
-
De Domenico I, Ward DM, di Patti MC, Jeong SY, David S, et al. 2007. Ferroxidase activity is required for the stability of cell surface ferroportin in cells expressing GPI-ceruloplasmin. EMBO J. 26:2823-31 (Pubitemid 46975784)
-
(2007)
EMBO Journal
, vol.26
, Issue.12
, pp. 2823-2831
-
-
De Domenico, I.1
Ward, D.M.2
Di Patti, M.C.B.3
Jeong, S.Y.4
David, S.5
Musci, G.6
Kaplan, J.7
-
26
-
-
0028176811
-
Iron overload in beta 2-microglobulin-deficient mice
-
de Sousa M, Reimao R, Lacerda R, Hugo P, Kaufmann SH, Porto G. 1994. Iron overload in beta 2-microglobulin-deficient mice. Immunol. Lett. 39:105-11
-
(1994)
Immunol. Lett.
, vol.39
, pp. 105-111
-
-
De Sousa, M.1
Reimao, R.2
Lacerda, R.3
Hugo, P.4
Kaufmann, S.H.5
Porto, G.6
-
27
-
-
20444416123
-
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
-
DOI 10.1016/j.cmet.2005.01.003, PII S1550413105000306
-
Donovan A, Lima CA, Pinkus JL, PinkusGS, Zon LI, et al. 2005. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 1:191-200 (Pubitemid 43960600)
-
(2005)
Cell Metabolism
, vol.1
, Issue.3
, pp. 191-200
-
-
Donovan, A.1
Lima, C.A.2
Pinkus, J.L.3
Pinkus, G.S.4
Zon, L.I.5
Robine, S.6
Andrews, N.C.7
-
28
-
-
33846164453
-
Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3
-
DOI 10.1152/ajpgi.00278.2006
-
Drake SF, Morgan EH, Herbison CE, Delima R, Graham RM, et al. 2007. Iron absorption and hepatic iron uptake are increased in a transferrin receptor 2 (Y245X) mutant mouse model of hemochromatosis type 3. Am. J. Physiol. Gastrointest. Liver Physiol. 292:G323-28 (Pubitemid 46090274)
-
(2007)
American Journal of Physiology - Gastrointestinal and Liver Physiology
, vol.292
, Issue.1
-
-
Drake, S.F.1
Morgan, E.H.2
Herbison, C.E.3
Delima, R.4
Graham, R.M.5
Chua, A.C.G.6
Leedman, P.J.7
Fleming, R.E.8
Bacon, B.R.9
Olynyk, J.K.10
Trinder, D.11
-
29
-
-
44449177930
-
The serine protease TMPRSS6 is required to sense iron deficiency
-
DOI 10.1126/science.1157121
-
Du X, She E, Gelbart T, Truksa J, Lee P, et al. 2008. The serine protease TMPRSS6 is required to sense iron deficiency. Science 320:1088-92 (Pubitemid 351929552)
-
(2008)
Science
, vol.320
, Issue.5879
, pp. 1088-1092
-
-
Du, X.1
She, E.2
Gelbart, T.3
Truksa, J.4
Lee, P.5
Xia, Y.6
Khovananth, K.7
Mudd, S.8
Mann, N.9
Moresco, E.M.Y.10
Beutler, E.11
Beutler, B.12
-
30
-
-
0036182842
-
Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains
-
Dupic F, Fruchon S, Bensaid M, Borot N, Radosavljevic M, et al. 2002. Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains. Gastroenterology 122:745-51 (Pubitemid 34173826)
-
(2002)
Gastroenterology
, vol.122
, Issue.3
, pp. 745-751
-
-
Dupic, F.1
Fruchon, S.2
Bensaid, M.3
Borot, N.4
Radosavljevic, M.5
Loreal, O.6
Brissot, P.7
Gilfillan, S.8
Bahram, S.9
Coppin, H.10
Roth, M.11
-
31
-
-
0014866334
-
Hereditary defect of intestinal iron transport inmice with sex-linked anemia
-
Edwards JA, Bannerman RM. 1970. Hereditary defect of intestinal iron transport inmice with sex-linked anemia. J. Clin. Invest. 49:1869-71
-
(1970)
J. Clin. Invest.
, vol.49
, pp. 1869-1871
-
-
Edwards, J.A.1
Bannerman, R.M.2
-
32
-
-
0016750343
-
Red cell iron uptake in hereditary microcytic anemia
-
Edwards JA, Hoke JE. 1975. Red cell iron uptake in hereditary microcytic anemia. Blood 46:381-88
-
(1975)
Blood
, vol.46
, pp. 381-388
-
-
Edwards, J.A.1
Hoke, J.E.2
-
33
-
-
0018831028
-
Defective delivery of iron to the developing red cell of the Belgrade laboratory rat
-
Edwards JA, Sullivan AL, Hoke JE. 1980. Defective delivery of iron to the developing red cell of the Belgrade laboratory rat. Blood 55:645-48 (Pubitemid 10138849)
-
(1980)
Blood
, vol.55
, Issue.4
, pp. 645-648
-
-
Edwards, J.A.1
Sullivan, A.L.2
Hoke, J.E.3
-
34
-
-
84974183672
-
The genetics of sex-linked anaemia in the mouse
-
Falconer DS, Isaacson JH. 1962. The genetics of sex-linked anaemia in the mouse. Genet. Res. 3:248-50
-
(1962)
Genet. Res.
, vol.3
, pp. 248-250
-
-
Falconer, D.S.1
Isaacson, J.H.2
-
35
-
-
9344224529
-
A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
-
DOI 10.1038/ng0896-399
-
Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, et al. 1996. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat. Genet. 13:399-408 (Pubitemid 26256612)
-
(1996)
Nature Genetics
, vol.13
, Issue.4
, pp. 399-408
-
-
Feder, J.N.1
Gnirke, A.2
Thomas, W.3
Tsuchihashi, Z.4
Ruddy, D.A.5
Basava, A.6
Dormishian, F.7
Domingo Jr., R.8
Ellis, M.C.9
Fullan, A.10
Hinton, L.M.11
Jones, N.L.12
Kimmel, B.E.13
Kronmal, G.S.14
Lauer, P.15
Lee, V.K.16
Loeb, D.B.17
Mapa, F.A.18
McClelland, E.19
Meyer, N.C.20
Mintier, G.A.21
Moeller, N.22
Moore, T.23
Morikang, E.24
Prass, C.E.25
Quintana, L.26
Starnes, S.M.27
Schatzman, R.C.28
Brunke, K.J.29
Drayna, D.T.30
Risch, N.J.31
Bacon, B.R.32
Wolff, R.K.33
more..
-
36
-
-
67651087324
-
The molecular basis of hepcidin-resistant hereditary hemochromatosis
-
Fernandes A, Preza GC, Phung Y, De Domenico I, Kaplan J, et al. 2009. The molecular basis of hepcidin-resistant hereditary hemochromatosis. Blood 114:437-43
-
(2009)
Blood
, vol.114
, pp. 437-443
-
-
Fernandes, A.1
Preza, G.C.2
Phung, Y.3
De Domenico, I.4
Kaplan, J.5
-
37
-
-
0034603062
-
Early embryonic lethality of H ferritin gene deletion in mice
-
DOI 10.1074/jbc.275.5.3021
-
Ferreira C, Bucchini D,MartinME, Levi S, Arosio P, et al. 2000. Early embryonic lethality ofHferritin gene deletion in mice. J. Biol. Chem. 275:3021-24 (Pubitemid 30082994)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.5
, pp. 3021-3024
-
-
Ferreira, C.1
Bucchini, D.2
Martin, M.-E.3
Levi, S.4
Arosio, P.5
Grandchamp, B.6
Beaumont, C.7
-
38
-
-
60249084746
-
Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism
-
Ferring-Appel D, Hentze MW, Galy B. 2009. Cell-autonomous and systemic context-dependent functions of iron regulatory protein 2 in mammalian iron metabolism. Blood 113:679-87
-
(2009)
Blood
, vol.113
, pp. 679-687
-
-
Ferring-Appel, D.1
Hentze, M.W.2
Galy, B.3
-
39
-
-
0032477866
-
Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport
-
DOI 10.1073/pnas.95.3.1148
-
FlemingMD, Romano MA, SuMA, Garrick LM, Garrick MD, Andrews NC. 1998. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc. Natl. Acad. Sci. USA 95:1148-53 (Pubitemid 28124927)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.3
, pp. 1148-1153
-
-
Fleming, M.D.1
Romano, M.A.2
Maureen, A.S.U.3
Garrick, L.M.4
Garrick, M.D.5
Andrews, N.C.6
-
40
-
-
0030763856
-
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
-
Fleming MD, Trenor CC 3rd, Su MA, Foernzler D, Beier DR, et al. 1997. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat. Genet. 16:383-86 (Pubitemid 27323306)
-
(1997)
Nature Genetics
, vol.16
, Issue.4
, pp. 383-386
-
-
Fleming, M.D.1
Trenor III, C.C.2
Su, M.A.3
Foernzler, D.4
Beier, D.R.5
Dietrich, W.E.6
Andrews, N.C.7
-
41
-
-
0036678091
-
Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
-
Fleming RE, Ahmann JR,Migas MC, Waheed A, Koeffler HP, et al. 2002. Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proc. Natl. Acad. Sci. USA 99:10653-58
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 10653-10658
-
-
Fleming, R.E.1
Ahmann, J.R.2
Migas, M.C.3
Waheed, A.4
Koeffler, H.P.5
-
42
-
-
0035956992
-
Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis
-
DOI 10.1073/pnas.051630898
-
Fleming RE, Holden CC, Tomatsu S, Waheed A, Brunt EM, et al. 2001. Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis. Proc. Natl. Acad. Sci. USA 98:2707-11 (Pubitemid 32209547)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.5
, pp. 2707-2711
-
-
Fleming, R.E.1
Holden, C.C.2
Tomatsu, S.3
Waheed, A.4
Brunt, E.M.5
Britton, R.S.6
Bacon, B.R.7
Roopenian, D.C.8
Sly, W.S.9
-
43
-
-
54349096688
-
Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis
-
Folgueras AR, de Lara FM, Pendas AM, Garabaya C, Rodriguez F, et al. 2008. Membrane-bound serine protease matriptase-2 (Tmprss6) is an essential regulator of iron homeostasis. Blood 112:2539-45
-
(2008)
Blood
, vol.112
, pp. 2539-2545
-
-
Folgueras, A.R.1
De Lara, F.M.2
Pendas, A.M.3
Garabaya, C.4
Rodriguez, F.5
-
44
-
-
37449009448
-
Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum
-
Galy B, Ferring-Appel D, Kaden S, GroneHJ, Hentze MW. 2008. Iron regulatory proteins are essential for intestinal function and control key iron absorption molecules in the duodenum. Cell Metab. 7:79-85
-
(2008)
Cell Metab.
, vol.7
, pp. 79-85
-
-
Galy, B.1
Ferring-Appel, D.2
Kaden, S.3
Grone, H.J.4
Hentze, M.W.5
-
45
-
-
30944449709
-
Generation of conditional alleles of the murine iron regulatory protein (IRP)-1 and -2 genes
-
DOI 10.1002/gene.20169
-
Galy B, Ferring D, Hentze MW. 2005. Generation of conditional alleles of the murine iron regulatory protein (IRP)-1 and-2 genes. Genesis 43:181-88 (Pubitemid 43117834)
-
(2005)
Genesis
, vol.43
, Issue.4
, pp. 181-188
-
-
Galy, B.1
Feering, D.2
Hentze, M.W.3
-
46
-
-
27144467097
-
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)
-
DOI 10.1182/blood-2005-04-1365
-
Galy B, Ferring D, Minana B, Bell O, Janser HG, et al. 2005. Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2). Blood 106:2580-89 (Pubitemid 41510837)
-
(2005)
Blood
, vol.106
, Issue.7
, pp. 2580-2589
-
-
Galy, B.1
Ferring, D.2
Minana, B.3
Bell, O.4
Janser, H.G.5
Muckenthaler, M.6
Schumann, K.7
Hentze, M.W.8
-
47
-
-
33748297526
-
Iron homeostasis in the brain: Complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse [4]
-
DOI 10.1038/ng0906-967, PII NG0906967
-
Galy B, Holter SM, Klopstock T, Ferring D, Becker L, et al. 2006. Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse. Nat. Genet. 38:967-69 (Pubitemid 44325914)
-
(2006)
Nature Genetics
, vol.38
, Issue.9
, pp. 967-969
-
-
Galy, B.1
Holter, S.M.2
Klopstock, T.3
Ferring, D.4
Becker, L.5
Kaden, S.6
Wurst, W.7
Grone, H.-J.8
Hentze, M.W.9
-
48
-
-
0041672570
-
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
-
DOI 10.1182/blood-2003-03-0672
-
Ganz T. 2003. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 102:783-88 (Pubitemid 36917762)
-
(2003)
Blood
, vol.102
, Issue.3
, pp. 783-788
-
-
Ganz, T.1
-
49
-
-
84974069733
-
A sex-linked anaemia in the mouse
-
Grewal MD. 1962. A sex-linked anaemia in the mouse. Genet. Res. 3:238-47
-
(1962)
Genet. Res.
, vol.3
, pp. 238-247
-
-
Grewal, M.D.1
-
50
-
-
0033103978
-
The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes
-
DOI 10.1084/jem.189.5.831
-
Gruenheid S, Canonne-Hergaux F, Gauthier S, Hackam DJ, Grinstein S, Gros P. 1999. The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. J. Exp. Med. 189:831-41 (Pubitemid 29189688)
-
(1999)
Journal of Experimental Medicine
, vol.189
, Issue.5
, pp. 831-841
-
-
Gruenheid, S.1
Canonne-Hergaux, F.2
Gauthier, S.3
Hackam, D.J.4
Grinstein, S.5
Gros, P.6
-
51
-
-
18244399587
-
Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver
-
DOI 10.1172/JCI200524356
-
Gunshin H, Fujiwara Y, Custodio AO, Direnzo C, Robine S, Andrews NC. 2005. Slc11a2 is required for intestinal iron absorption and erythropoiesis but dispensable in placenta and liver. J. Clin. Invest. 115:1258-66 (Pubitemid 40629044)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.5
, pp. 1258-1266
-
-
Gunshin, H.1
Fujiwara, Y.2
Custodio, A.O.3
DiRenzo, C.4
Robine, S.5
Andrews, N.C.6
-
52
-
-
0030755366
-
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
-
DOI 10.1038/41343
-
GunshinH,Mackenzie B, Berger UV,Gunshin Y, Romero MF, et al. 1997. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388:482-88 (Pubitemid 27328927)
-
(1997)
Nature
, vol.388
, Issue.6641
, pp. 482-488
-
-
Gunshin, H.1
Mackenzie, B.2
Berger, U.V.3
Gunshin, Y.4
Romero, M.F.5
Boron, W.F.6
Nussberger, S.7
Gollan, J.L.8
Hediger, M.A.9
-
53
-
-
27144507493
-
Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice
-
DOI 10.1182/blood-2005-02-0716
-
Gunshin H, Starr CN, Direnzo C, Fleming MD, Jin J, et al. 2005. Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. Blood 106:2879-83 (Pubitemid 41510768)
-
(2005)
Blood
, vol.106
, Issue.8
, pp. 2879-2883
-
-
Gunshin, H.1
Starr, C.N.2
DiRenzo, C.3
Fleming, M.D.4
Jin, J.5
Greer, E.L.6
Sellers, V.M.7
Galica, S.M.8
Andrews, N.C.9
-
54
-
-
47249131160
-
Ceruloplasmin/hephaestin knockout mice modelmorphologic and molecular features of AMD
-
Hadziahmetovic M, Dentchev T, Song Y, Haddad N, He X, et al. 2008. Ceruloplasmin/hephaestin knockout mice modelmorphologic and molecular features of AMD. Invest. Ophthalmol. Vis. Sci. 49:2728-36
-
(2008)
Invest. Ophthalmol. Vis. Sci.
, vol.49
, pp. 2728-2736
-
-
Hadziahmetovic, M.1
Dentchev, T.2
Song, Y.3
Haddad, N.4
He, X.5
-
55
-
-
4644293303
-
Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration
-
DOI 10.1073/pnas.0405146101
-
Hahn P, Qian Y, Dentchev T, Chen L, Beard J, et al. 2004. Disruption of ceruloplasmin and hephaestin inmice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. Proc. Natl. Acad. Sci. USA 101:13850-55 (Pubitemid 39298496)
-
(2004)
Proceedings of the National Academy of Sciences of the United States of America
, vol.101
, Issue.38
, pp. 13850-13855
-
-
Hahn, P.1
Qian, Y.2
Dentchev, T.3
Chen, L.4
Beard, J.5
Harris, Z.L.6
Dunaief, J.L.7
-
56
-
-
0032875387
-
Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux
-
DOI 10.1073/pnas.96.19.10812
-
Harris ZL, Durley AP,Man TK, Gitlin JD. 1999. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc. Natl. Acad. Sci. USA 96:10812-17 (Pubitemid 29442226)
-
(1999)
Proceedings of the National Academy of Sciences of the United States of America
, vol.96
, Issue.19
, pp. 10812-10817
-
-
Harris, Z.L.1
Durley, A.P.2
Man, T.K.3
Gitlin, J.D.4
-
57
-
-
0028903259
-
Aceruloplasminemia: Molecular characterization of this disorder of iron metabolism
-
Harris ZL, Takahashi Y, Miyajima H, Serizawa M, MacGillivray RT, Gitlin JD. 1995. Aceruloplasminemia: molecular characterization of this disorder of iron metabolism. Proc. Natl. Acad. Sci. USA 92:2539-43
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 2539-2543
-
-
Harris, Z.L.1
Takahashi, Y.2
Miyajima, H.3
Serizawa, M.4
MacGillivray, R.T.5
Gitlin, J.D.6
-
58
-
-
37049019507
-
Brief report: Erythropoiesis and iron metabolism in dominant erythropoietic protoporphyria
-
DOI 10.1182/blood-2007-04-088120
-
Holme SA, Worwood M, Anstey AV, Elder GH, Badminton MN. 2007. Erythropoiesis and iron metabolism in dominant erythropoietic protoporphyria. Blood 110:4108-10 (Pubitemid 350248469)
-
(2007)
Blood
, vol.110
, Issue.12
, pp. 4108-4110
-
-
Holme, S.A.1
Worwood, M.2
Anstey, A.V.3
Elder, G.H.4
Badminton, M.N.5
-
59
-
-
23644460325
-
A mouse model of juvenile hemochromatosis
-
DOI 10.1172/JCI25049
-
Huang FW, Pinkus JL, Pinkus GS, Fleming MD, Andrews NC. 2005. A mouse model of juvenile hemochromatosis. J. Clin. Invest. 115:2187-91 (Pubitemid 41134160)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.8
, pp. 2187-2191
-
-
Huang, F.W.1
Pinkus, J.L.2
Pinkus, G.S.3
Fleming, M.D.4
Andrews, N.C.5
-
60
-
-
63149128149
-
Molecular basis of inheritedmicrocytic anemia due to defects in iron acquisition or heme synthesis
-
Iolascon A,De Falco L, Beaumont C. 2009. Molecular basis of inheritedmicrocytic anemia due to defects in iron acquisition or heme synthesis. Haematologica 94:395-408
-
(2009)
Haematologica
, vol.94
, pp. 395-408
-
-
Iolascon, A.1
De Falco, L.2
Beaumont, C.3
-
61
-
-
33748889489
-
Age-related changes in iron homeostasis and cell death in the cerebellum of ceruloplasmin-deficient mice
-
DOI 10.1523/JNEUROSCI.2922-06.2006
-
Jeong SY, David S. 2006. Age-related changes in iron homeostasis and cell death in the cerebellum of ceruloplasmin-deficient mice. J. Neurosci. 26:9810-19 (Pubitemid 44427720)
-
(2006)
Journal of Neuroscience
, vol.26
, Issue.38
, pp. 9810-9819
-
-
Suh, Y.J.1
David, S.2
-
62
-
-
70350494274
-
BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression
-
Kautz L, Meynard D, Besson-Fournier C, Darnaud V, Al Saati T, et al. 2009. BMP/Smad signaling is not enhanced in Hfe-deficient mice despite increased Bmp6 expression. Blood 114:2515-20
-
(2009)
Blood
, vol.114
, pp. 2515-2520
-
-
Kautz, L.1
Meynard, D.2
Besson-Fournier, C.3
Darnaud, V.4
Al Saati, T.5
-
63
-
-
19944427107
-
Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis
-
DOI 10.1182/blood-2004-04-1416
-
Kawabata H, Fleming RE, Gui D, Moon SY, Saitoh T, et al. 2005. Expression of hepcidin is downregulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood 105:376-81 (Pubitemid 40053107)
-
(2005)
Blood
, vol.105
, Issue.1
, pp. 376-381
-
-
Kawabata, H.1
Fleming, R.E.2
Gui, D.3
Moon, S.Y.4
Saitoh, T.5
O'Kelly, J.6
Umehara, Y.7
Wano, Y.8
Said, J.W.9
Koeffler, H.P.10
-
64
-
-
0033597780
-
Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family
-
Kawabata H, Yang R, Hirama T, Vuong PT, Kawano S, et al. 1999. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J. Biol. Chem. 274:20826-32
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 20826-20832
-
-
Kawabata, H.1
Yang, R.2
Hirama, T.3
Vuong, P.T.4
Kawano, S.5
-
65
-
-
38949097546
-
A heme export protein is required for red blood cell differentiation and iron homeostasis
-
DOI 10.1126/science.1151133
-
Keel SB, Doty RT, Yang Z, Quigley JG, Chen J, et al. 2008. A heme export protein is required for red blood cell differentiation and iron homeostasis. Science 319:825-28 (Pubitemid 351225875)
-
(2008)
Science
, vol.319
, Issue.5864
, pp. 825-828
-
-
Keel, S.B.1
Doty, R.T.2
Yang, Z.3
Quigley, J.G.4
Chen, J.5
Knoblaugh, S.6
Kingsley, P.D.7
De Domenico, I.8
Vaughn, M.B.9
Kaplan, J.10
Palis, J.11
Abkowitz, J.L.12
-
66
-
-
0035138456
-
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
-
DOI 10.1038/84859
-
LaVaute T, Smith S, Cooperman S, Iwai K, Land W, et al. 2001. Targeted deletion of the gene encoding iron regulatory protein-2 causesmisregulation of ironmetabolism and neurodegenerative disease inmice. Nat. Genet. 27:209-14 (Pubitemid 32157451)
-
(2001)
Nature Genetics
, vol.27
, Issue.2
, pp. 209-214
-
-
LaVaute, T.1
Smith, S.2
Cooperman, S.3
Iwai, K.4
Land, W.5
Meyron-Holtz, E.6
Drake, S.K.7
Miller, G.8
Abu-Asab, M.9
Tsokos, M.10
Switzer III, R.11
Grinberg, A.12
Love, P.13
Tresser, N.14
Rouault, T.A.15
-
67
-
-
0033644144
-
Conditional gene knockout using Cre recombinase
-
Le Y, Sauer B. 2000. Conditional gene knockout using Cre recombinase. Methods Mol. Biol. 136:477-85
-
(2000)
Methods Mol. Biol.
, vol.136
, pp. 477-485
-
-
Le, Y.1
Sauer, B.2
-
68
-
-
33745752870
-
Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis
-
DOI 10.1182/blood-2006-02-003376
-
Lesbordes-Brion JC, Viatte L, Bennoun M, Lou DQ, Ramey G, et al. 2006. Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood 108:1402-5 (Pubitemid 44232044)
-
(2006)
Blood
, vol.108
, Issue.4
, pp. 1402-1405
-
-
Lesbordes-Brion, J.-C.1
Viatte, L.2
Bennoun, M.3
Lou, D.-Q.4
Ramey, G.5
Houbron, C.6
Hamard, G.7
Kahn, A.8
Vaulont, S.9
-
69
-
-
0032959574
-
Transferrin receptor is necessary for development of erythrocytes and the nervous system
-
DOI 10.1038/7727
-
Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC. 1999. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat. Genet. 21:396-99 (Pubitemid 29159576)
-
(1999)
Nature Genetics
, vol.21
, Issue.4
, pp. 396-399
-
-
Levy, J.E.1
Jin, O.2
Fujiwara, Y.3
Kuo, F.4
Andrews, N.C.5
-
71
-
-
0033168767
-
The C282Y mutation causing hereditary hemochromatosis does not produce a null allele
-
Levy JE, Montross LK, Cohen DE, Fleming MD, Andrews NC. 1999. The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. Blood 94:9-11 (Pubitemid 29300128)
-
(1999)
Blood
, vol.94
, Issue.1
, pp. 9-11
-
-
Levy, J.E.1
Montross, L.K.2
Cohen, D.E.3
Fleming, M.D.4
Andrews, N.C.5
-
72
-
-
27644526967
-
A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice
-
DOI 10.1038/ng1659, PII N1659
-
Lim JE, Jin O, Bennett C, Morgan K, Wang F, et al. 2005. A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd ) mice. Nat. Genet. 37:1270-73 (Pubitemid 41568712)
-
(2005)
Nature Genetics
, vol.37
, Issue.11
, pp. 1270-1273
-
-
Lim, J.E.1
Jin, O.2
Bennett, C.3
Morgan, K.4
Wang, F.5
Trenor III, C.C.6
Fleming, M.D.7
Andrews, N.C.8
-
73
-
-
33846256111
-
Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice
-
DOI 10.1182/blood-2006-04-014142
-
Lyoumi S, Abitbol M, Andrieu V, Henin D, Robert E, et al. 2007. Increased plasma transferrin, altered body iron distribution, and microcytic hypochromic anemia in ferrochelatase-deficient mice. Blood 109:811-18 (Pubitemid 46105986)
-
(2007)
Blood
, vol.109
, Issue.2
, pp. 811-818
-
-
Lyoumi, S.1
Abitbol, M.2
Andrieu, V.3
Henin, D.4
Robert, E.5
Schmitt, C.6
Gouya, L.7
De Verneuil, H.8
Deybach, J.-C.9
Montagutelli, X.10
Beaumont, C.11
Puy, H.12
-
74
-
-
0037103294
-
An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria
-
DOI 10.1182/blood-2001-12-0283
-
Magness ST, Maeda N, Brenner DA. 2002. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. Blood 100:1470-77 (Pubitemid 34864307)
-
(2002)
Blood
, vol.100
, Issue.4
, pp. 1470-1477
-
-
Magness, S.T.1
Maeda, N.2
Brenner, D.A.3
-
75
-
-
0014984114
-
Intestinal iron-transport defect in the mouse with sex-linked anemia
-
Manis J. 1971. Intestinal iron-transport defect in the mouse with sex-linked anemia. Am. J. Physiol. 220:135-39
-
(1971)
Am. J. Physiol.
, vol.220
, pp. 135-139
-
-
Manis, J.1
-
76
-
-
34848925133
-
Lack of haptoglobin affects iron transport across duodenum bymodulating ferroportin expression
-
Marro S, Barisani D, Chiabrando D, Fagoonee S, Muckenthaler MU, et al. 2007. Lack of haptoglobin affects iron transport across duodenum bymodulating ferroportin expression. Gastroenterology 133:1261-71
-
(2007)
Gastroenterology
, vol.133
, pp. 1261-1271
-
-
Marro, S.1
Barisani, D.2
Chiabrando, D.3
Fagoonee, S.4
Muckenthaler, M.U.5
-
77
-
-
59149096376
-
The role of Dcytb in iron metabolism: An update
-
McKie AT. 2008. The role of Dcytb in iron metabolism: an update. Biochem. Soc. Trans. 36:1239-41
-
(2008)
Biochem. Soc. Trans.
, vol.36
, pp. 1239-1241
-
-
McKie, A.T.1
-
78
-
-
63449122819
-
Lack of the bone morphogenetic protein BMP6 induces massive iron overload
-
Meynard D, Kautz L, Darnaud V, Canonne-Hergaux F, Coppin H, Roth MP. 2009. Lack of the bone morphogenetic protein BMP6 induces massive iron overload. Nat. Genet. 41:478-81
-
(2009)
Nat. Genet.
, vol.41
, pp. 478-481
-
-
Meynard, D.1
Kautz, L.2
Darnaud, V.3
Canonne-Hergaux, F.4
Coppin, H.5
Roth, M.P.6
-
79
-
-
10744223491
-
Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis
-
DOI 10.1038/sj.emboj.7600041
-
Meyron-Holtz EG, GhoshMC, Iwai K, LaVaute T, Brazzolotto X, et al. 2004. Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J. 23:386-95 (Pubitemid 38294503)
-
(2004)
EMBO Journal
, vol.23
, Issue.2
, pp. 386-395
-
-
Meyron-Holtz, E.G.1
Ghosh, M.C.2
Iwai, K.3
LaVaute, T.4
Brazzolotto, X.5
Berger, U.V.6
Land, W.7
Ollivierre-Wilson, H.8
Grinberg, A.9
Love, P.10
Rouault, T.A.11
-
80
-
-
18244408334
-
Frataxin knockin mouse
-
DOI 10.1016/S0014-5793(02)02251-2, PII S0014579302022512
-
Miranda CJ, Santos MM, Ohshima K, Smith J, Li L, et al. 2002. Frataxin knockin mouse. FEBS Lett. 512:291-97 (Pubitemid 34164497)
-
(2002)
FEBS Letters
, vol.512
, Issue.1-3
, pp. 291-297
-
-
Miranda, C.J.1
Santos, M.M.2
Ohshima, K.3
Smith, J.4
Li, L.5
Bunting, M.6
Cossee, M.7
Koenig, M.8
Sequeiros, J.9
Kaplan, J.10
Pandolfo, M.11
-
81
-
-
77449150120
-
Hemopexin affects iron distribution and ferritin expression in mouse brain
-
Morello N, Tonoli E, Logrand F, Fiorito V, Fagoonee S, et al. 2009. Hemopexin affects iron distribution and ferritin expression in mouse brain. J. Cell Mol. Med. 13:4192-204
-
(2009)
J. Cell Mol. Med.
, vol.13
, pp. 4192-204
-
-
Morello, N.1
Tonoli, E.2
Logrand, F.3
Fiorito, V.4
Fagoonee, S.5
-
82
-
-
50949102412
-
Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network
-
Muckenthaler MU, Galy B, Hentze MW. 2008. Systemic iron homeostasis and the iron-responsive element/iron-regulatory protein (IRE/IRP) regulatory network. Annu. Rev. Nutr. 28:197-213
-
(2008)
Annu. Rev. Nutr.
, vol.28
, pp. 197-213
-
-
Muckenthaler, M.U.1
Galy, B.2
Hentze, M.W.3
-
83
-
-
4143117032
-
Molecular analysis of iron overload in β2-microglobulin-deficient mice
-
DOI 10.1016/j.bcmd.2004.05.003, PII S1079979604001019
-
MuckenthalerMU, Rodrigues P,Macedo MG,Minana B, Brennan K, et al. 2004. Molecular analysis of iron overload in beta2-microglobulin-deficient mice. Blood Cells Mol. Dis. 33:125-31 (Pubitemid 39099293)
-
(2004)
Blood Cells, Molecules, and Diseases
, vol.33
, Issue.2
, pp. 125-131
-
-
Muckenthaler, M.U.1
Rodrigues, P.2
Macedo, M.G.3
Minana, B.4
Brennan, K.5
Cardoso, E.M.6
Hentze, M.W.7
De Sousa, M.8
-
84
-
-
0034059140
-
Cre recombinase: The universal reagent for genome tailoring
-
DOI 10.1002/(SICI)1526-968X(200002)26:2<99::AID-GENE1>3.0.CO;2-B
-
Nagy A. 2000. Cre recombinase: the universal reagent for genome tailoring. Genesis 26:99-109 (Pubitemid 30158089)
-
(2000)
Genesis
, vol.26
, Issue.2
, pp. 99-109
-
-
Nagy, A.1
-
85
-
-
33646754660
-
Transgenic rescue of erythroid 5-aminolevulinate synthase-deficient mice results in the formation of ring sideroblasts and siderocytes
-
DOI 10.1111/j.1365-2443.2006.00973.x
-
Nakajima O, Okano S, Harada H, Kusaka T, Gao X, et al. 2006. Transgenic rescue of erythroid 5-aminolevulinate synthase-deficient mice results in the formation of ring sideroblasts and siderocytes. Genes Cells 11:685-700 (Pubitemid 43744818)
-
(2006)
Genes to Cells
, vol.11
, Issue.6
, pp. 685-700
-
-
Nakajima, O.1
Okano, S.2
Harada, H.3
Kusaka, T.4
Gao, X.5
Hosoya, T.6
Suzuki, N.7
Takahashi, S.8
Yamamoto, M.9
-
86
-
-
0006908742
-
The inheritance of "mick,"a new anemia in the house mouse
-
Nash DJ, Kent E, Dickie MM, Russell ES. 1964. The inheritance of "mick,"a new anemia in the house mouse. Am. Zool. 4:404-5
-
(1964)
Am. Zool.
, vol.4
, pp. 404-405
-
-
Nash, D.J.1
Kent, E.2
Dickie, M.M.3
Russell, E.S.4
-
87
-
-
70450214396
-
The role of hepcidin in iron metabolism
-
Nemeth E, Ganz T. 2009. The role of hepcidin in iron metabolism. Acta Haematol. 122:78-86
-
(2009)
Acta Haematol.
, vol.122
, pp. 78-86
-
-
Nemeth, E.1
Ganz, T.2
-
88
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
DOI 10.1126/science.1104742
-
Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, et al. 2004. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306:2090-93 (Pubitemid 40007660)
-
(2004)
Science
, vol.306
, Issue.5704
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
Vaughn, M.D.4
Donovan, A.5
Ward, D.M.6
Ganz, T.7
Kaplan, J.8
-
89
-
-
0035902605
-
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
-
DOI 10.1073/pnas.151179498
-
Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, et al. 2001. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc. Natl. Acad. Sci. USA 98:8780-85 (Pubitemid 32678104)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.15
, pp. 8780-8785
-
-
Nicolas, G.1
Bennoun, M.2
Devaux, I.3
Beaumont, C.4
Grandchamp, B.5
Kahn, A.6
Vaulont, S.7
-
90
-
-
0037007064
-
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
-
DOI 10.1073/pnas.072632499
-
Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, et al. 2002. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc. Natl. Acad. Sci. USA 99:4596-601 (Pubitemid 34286030)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.7
, pp. 4596-4601
-
-
Nicolas, G.1
Bennoun, M.2
Porteu, A.3
Mativet, S.4
Beaumont, C.5
Grandchamp, B.6
Sirito, M.7
Sawadogo, M.8
Kahn, A.9
Vaulont, S.10
-
91
-
-
0036791486
-
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
-
Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, et al. 2002. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 110:1037-44
-
(2002)
J. Clin. Invest.
, vol.110
, pp. 1037-1044
-
-
Nicolas, G.1
Chauvet, C.2
Viatte, L.3
Danan, J.L.4
Bigard, X.5
-
92
-
-
23644444316
-
Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
-
DOI 10.1172/JCI25683
-
Niederkofler V, Salie R, Arber S. 2005. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J. Clin. Invest. 115:2180-86 (Pubitemid 41134159)
-
(2005)
Journal of Clinical Investigation
, vol.115
, Issue.8
, pp. 2180-2186
-
-
Niederkofler, V.1
Salie, R.2
Arber, S.3
-
93
-
-
27644570377
-
Nm1054: A spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse
-
DOI 10.1182/blood-2005-01-0379
-
Ohgami RS, Campagna DR, Antiochos B, Wood EB, Sharp JJ, et al. 2005. nm1054: a spontaneous, recessive, hypochromic, microcytic anemia mutation in the mouse. Blood 106:3625-31 (Pubitemid 41609203)
-
(2005)
Blood
, vol.106
, Issue.10
, pp. 3625-3631
-
-
Ohgami, R.S.1
Campagna, D.R.2
Antiochos, B.3
Wood, E.B.4
Sharp, J.J.5
Barker, J.E.6
Fleming, M.D.7
-
94
-
-
27644455133
-
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
-
DOI 10.1038/ng1658, PII N1658
-
Ohgami RS, Campagna DR, Greer EL, Antiochos B, McDonald A, et al. 2005. Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat. Genet. 37:1264-69 (Pubitemid 41568711)
-
(2005)
Nature Genetics
, vol.37
, Issue.11
, pp. 1264-1269
-
-
Ohgami, R.S.1
Campagna, D.R.2
Greer, E.L.3
Antiochos, B.4
McDonald, A.5
Chen, J.6
Sharp, J.J.7
Fujiwara, Y.8
Barker, J.E.9
Fleming, M.D.10
-
96
-
-
51549106718
-
Hereditary hemochromatosis in the post-HFE era
-
Olynyk JK, Trinder D, Ramm GA, Britton RS, Bacon BR. 2008. Hereditary hemochromatosis in the post-HFE era. Hepatology 48:991-1001
-
(2008)
Hepatology
, vol.48
, pp. 991-1001
-
-
Olynyk, J.K.1
Trinder, D.2
Ramm, G.A.3
Britton, R.S.4
Bacon, B.R.5
-
97
-
-
59449083869
-
Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2
-
Paradkar PN, Zumbrennen KB, Paw BH, Ward DM, Kaplan J. 2009. Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Mol. Cell Biol. 29:1007-16
-
(2009)
Mol. Cell Biol.
, vol.29
, pp. 1007-1016
-
-
Paradkar, P.N.1
Zumbrennen, K.B.2
Paw, B.H.3
Ward, D.M.4
Kaplan, J.5
-
98
-
-
0036703490
-
Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury
-
Patel BN, Dunn RJ, Jeong SY, Zhu Q, Julien JP, David S. 2002. Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J. Neurosci. 22:6578-86 (Pubitemid 35386414)
-
(2002)
Journal of Neuroscience
, vol.22
, Issue.15
, pp. 6578-6586
-
-
Patel, B.N.1
Dunn, R.J.2
Jeong, S.Y.3
Zhu, Q.4
Julien, J.-P.5
David, S.6
-
100
-
-
28444436913
-
Non-HFE hemochromatosis
-
DOI 10.1055/s-2005-923316
-
Pietrangelo A. 2005. Non-HFE hemochromatosis. Semin. Liver Dis. 25:450-60 (Pubitemid 41741261)
-
(2005)
Seminars in Liver Disease
, vol.25
, Issue.4
, pp. 450-460
-
-
Pietrangelo, A.1
-
101
-
-
36349028180
-
Hemochromatosis: An endocrine liver disease
-
DOI 10.1002/hep.21886
-
Pietrangelo A. 2007. Hemochromatosis: an endocrine liver disease. Hepatology 46:1291-301 (Pubitemid 350144793)
-
(2007)
Hepatology
, vol.46
, Issue.4
, pp. 1291-1301
-
-
Pietrangelo, A.1
-
102
-
-
0035896581
-
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
-
Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, et al. 2001. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276:7811-19
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 7811-7819
-
-
Pigeon, C.1
Ilyin, G.2
Courselaud, B.3
Leroyer, P.4
Turlin, B.5
-
103
-
-
33644772614
-
The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis
-
DOI 10.1093/hmg/ddl012
-
Pondarre C, Antiochos BB, Campagna DR, Clarke SL, Greer EL, et al. 2006. The mitochondrial ATPbinding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum. Mol. Genet. 15:953-64 (Pubitemid 43338236)
-
(2006)
Human Molecular Genetics
, vol.15
, Issue.6
, pp. 953-964
-
-
Pondarre, C.1
Antiochos, B.B.2
Campagna, D.R.3
Clarke, S.L.4
Greer, E.L.5
Deck, K.M.6
McDonald, A.7
Han, A.-P.8
Medlock, A.9
Kutok, J.L.10
Anderson, S.A.11
Eisenstein, R.S.12
Fleming, M.D.13
-
104
-
-
34147158934
-
Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis
-
DOI 10.1182/blood-2006-04-015768
-
Pondarre C, Campagna DR, Antiochos B, Sikorski L, Mulhern H, Fleming MD. 2007. Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis. Blood 109:3567-69 (Pubitemid 46572551)
-
(2007)
Blood
, vol.109
, Issue.8
, pp. 3567-3569
-
-
Pondarre, C.1
Campagna, D.R.2
Antiochos, B.3
Sikorski, L.4
Mulhern, H.5
Fleming, M.D.6
-
106
-
-
62549107492
-
Multicellular models of Friedreich ataxia
-
Puccio H. 2009. Multicellular models of Friedreich ataxia. J. Neurol. 256(Suppl. 1):18-24
-
(2009)
J. Neurol.
, vol.256
, Issue.SUPPL. 1
, pp. 18-24
-
-
Puccio, H.1
-
107
-
-
0035138072
-
Mouse models for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits
-
DOI 10.1038/84818
-
Puccio H, SimonD,CosseeM,Criqui-FilipeP,Tiziano F, et al. 2001. Mousemodels for Friedreich ataxia exhibit cardiomyopathy, sensory nerve defect and Fe-S enzyme deficiency followed by intramitochondrial iron deposits. Nat. Genet. 27:181-86 (Pubitemid 32157445)
-
(2001)
Nature Genetics
, vol.27
, Issue.2
, pp. 181-186
-
-
Puccio, H.1
Simon, D.2
Cossee, M.3
Criqui-Filipe, P.4
Tiziano, F.5
Melki, J.6
Hindelang, C.7
Matyas, R.8
Rustin, P.9
Koenig, M.10
-
108
-
-
4544264523
-
Identification of a human heme exporter that is essential for erythropoiesis
-
DOI 10.1016/j.cell.2004.08.014, PII S0092867404007512
-
Quigley JG, Yang Z, Worthington MT, Phillips JD, Sabo KM, et al. 2004. Identification of a human heme exporter that is essential for erythropoiesis. Cell 118:757-66 (Pubitemid 39221734)
-
(2004)
Cell
, vol.118
, Issue.6
, pp. 757-766
-
-
Quigley, J.G.1
Yang, Z.2
Worthington, M.T.3
Phillips, J.D.4
Sabo, K.M.5
Sabath, D.E.6
Berg, C.L.7
Sassa, S.8
Wood, B.L.9
Abkowitz, J.L.10
-
109
-
-
20244388240
-
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
-
DOI 10.1038/ng1053
-
Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, et al. 2003. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat. Genet. 33:21-22 (Pubitemid 36068676)
-
(2003)
Nature Genetics
, vol.33
, Issue.1
, pp. 21-22
-
-
Roettol, A.1
Papanikolaou, G.2
Politou, M.3
Alberti, F.4
Girelli, D.5
Christakis, J.6
Loukopoulos, D.7
Camaschella, C.8
-
110
-
-
0029670047
-
Beta2 knockout mice develop parenchymal iron overload: A putative role for class i genes of the major histocompatibility complex in iron metabolism
-
Rothenberg BE, Voland JR. 1996. beta2 knockout mice develop parenchymal iron overload: a putative role for class I genes of the major histocompatibility complex in iron metabolism. Proc. Natl. Acad. Sci. USA 93:1529-34
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 1529-1534
-
-
Rothenberg, B.E.1
Voland, J.R.2
-
111
-
-
33746361251
-
The role of iron regulatory proteins in mammalian iron homeostasis and disease
-
DOI 10.1038/nchembio807, PII NCHEMBIO807
-
Rouault TA. 2006. The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat. Chem. Biol. 2:406-14 (Pubitemid 44114917)
-
(2006)
Nature Chemical Biology
, vol.2
, Issue.8
, pp. 406-414
-
-
Rouault, T.A.1
-
112
-
-
34247366783
-
Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation
-
DOI 10.1182/blood-2006-10-051755
-
Roy CN, Mak HH, Akpan I, Losyev G, Zurakowski D, Andrews NC. 2007. Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. Blood 109:4038-44 (Pubitemid 46641759)
-
(2007)
Blood
, vol.109
, Issue.9
, pp. 4038-4044
-
-
Roy, C.N.1
Mak, H.H.2
Akpan, I.3
Losyev, G.4
Zurakowski, D.5
Andrews, N.C.6
-
113
-
-
0037369165
-
2002 E. Mead Johnson Award for research in pediatrics lecture: The molecular biology of the anemia of chronic disease: A hypothesis
-
DOI 10.1203/01.PDR.0000049513.67410.2D
-
Roy CN, Weinstein DA, Andrews NC. 2003. 2002 E. Mead Johnson Award for Research in Pediatrics Lecture: the molecular biology of the anemia of chronic disease: a hypothesis. Pediatr. Res. 53:507-12 (Pubitemid 36237409)
-
(2003)
Pediatric Research
, vol.53
, Issue.3
, pp. 507-512
-
-
Roy, C.N.1
Weinstein, D.A.2
Andrews, N.C.3
-
114
-
-
0014647432
-
An additional house mouse mutant with anemia (hemoglobin deficiency)
-
Scheufler H. 1969. An additional house mouse mutant with anemia (hemoglobin deficiency). Z. Versuchstierkd. 11:348-53
-
(1969)
Z. Versuchstierkd.
, vol.11
, pp. 348-353
-
-
Scheufler, H.1
-
115
-
-
33644748145
-
Mitoferrin is essential for erythroid iron assimilation
-
DOI 10.1038/nature04512, PII N04512
-
Shaw GC, Cope JJ, Li L, Corson K, Hersey C, et al. 2006. Mitoferrin is essential for erythroid iron assimilation. Nature 440:96-100 (Pubitemid 43336274)
-
(2006)
Nature
, vol.440
, Issue.7080
, pp. 96-100
-
-
Shaw, G.C.1
Cope, J.J.2
Li, L.3
Corson, K.4
Hersey, C.5
Ackermann, G.E.6
Gwynn, B.7
Lambert, A.J.8
Wingert, R.A.9
Traver, D.10
Trede, N.S.11
Barut, B.A.12
Zhou, Y.13
Minet, E.14
Donovan, A.15
Brownlie, A.16
Balzan, R.17
Weiss, M.J.18
Peters, L.L.19
Kaplan, J.20
Zon, L.I.21
Paw, B.H.22
more..
-
117
-
-
56449096622
-
The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin
-
Silvestri L, Pagani A, Nai A, De Domenico I, Kaplan J, Camaschella C. 2008. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab. 8:502-11
-
(2008)
Cell Metab.
, vol.8
, pp. 502-511
-
-
Silvestri, L.1
Pagani, A.2
Nai, A.3
De Domenico, I.4
Kaplan, J.5
Camaschella, C.6
-
118
-
-
0014685771
-
A thalassemia-like disorder in Belgrade laboratory rats
-
Sladic-Simic D, Martinovitch PN, Zivkovic N, Pavic D, Martinovic J, et al. 1969. A thalassemia-like disorder in Belgrade laboratory rats. Ann. N. Y. Acad. Sci. 165:93-99
-
(1969)
Ann. N. Y. Acad. Sci.
, vol.165
, pp. 93-99
-
-
Sladic-Simic, D.1
Martinovitch, P.N.2
Zivkovic, N.3
Pavic, D.4
Martinovic, J.5
-
119
-
-
33645307993
-
Complete loss of iron regulatory proteins 1 and 2 prevents viability ofmurine zygotes beyond the blastocyst stage of embryonic development
-
Smith SR, Ghosh MC, Ollivierre-Wilson H, Hang Tong W, Rouault TA. 2006. Complete loss of iron regulatory proteins 1 and 2 prevents viability ofmurine zygotes beyond the blastocyst stage of embryonic development. Blood Cells Mol. Dis. 36:283-87
-
(2006)
Blood Cells Mol. Dis.
, vol.36
, pp. 283-287
-
-
Smith, S.R.1
Ghosh, M.C.2
Ollivierre-Wilson, H.3
Hang Tong, W.4
Rouault, T.A.5
-
120
-
-
0032530922
-
The G185R mutation disrupts function of the iron transporter Nramp2
-
Su MA, Trenor CC, Fleming JC, Fleming MD, Andrews NC. 1998. The G185R mutation disrupts function of the iron transporter Nramp2. Blood 92:2157-63 (Pubitemid 28446707)
-
(1998)
Blood
, vol.92
, Issue.6
, pp. 2157-2163
-
-
Su, M.A.1
Trenor III, C.C.2
Fleming, J.C.3
Fleming, M.D.4
Andrews, N.C.5
-
122
-
-
29644448054
-
Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice
-
DOI 10.1093/hmg/ddi410
-
Thierbach R, Schulz TJ, Isken F, Voigt A,Mietzner B, et al. 2005. Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum. Mol. Genet. 14:3857-64 (Pubitemid 43020087)
-
(2005)
Human Molecular Genetics
, vol.14
, Issue.24
, pp. 3857-3864
-
-
Thierbach, R.1
Schulz, T.J.2
Isken, F.3
Voigt, A.4
Mietzner, B.5
Drewes, G.6
Von Kleist-Retzow, J.-C.7
Wiesner, R.J.8
Magnuson, M.A.9
Puccio, H.10
Pfeiffer, A.F.H.11
Steinberg, P.12
Ristow, M.13
-
123
-
-
0037216723
-
Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress
-
DOI 10.1002/jnr.10463
-
Thompson K, Menzies S, Muckenthaler M, Torti FM, Wood T, et al. 2003. Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress. J. Neurosci. Res. 71:46-63 (Pubitemid 36008401)
-
(2003)
Journal of Neuroscience Research
, vol.71
, Issue.1
, pp. 46-63
-
-
Thompson, K.1
Menzies, S.2
Muckenthaler, M.3
Torti, F.M.4
Wood, T.5
Torti, S.V.6
Hentze, M.W.7
Beard, J.8
Connor, J.9
-
124
-
-
0036259938
-
Hemopexin: Structure, function, and regulation
-
DOI 10.1089/104454902753759717
-
Tolosano E, Altruda F. 2002. Hemopexin: structure, function, and regulation.DNACell Biol. 21:297-306 (Pubitemid 34594543)
-
(2002)
DNA and Cell Biology
, vol.21
, Issue.4
, pp. 297-306
-
-
Tolosano, E.1
Altruda, F.2
-
125
-
-
17044421761
-
Haptoglobin modifies the hemochromatosis phenotype in mice
-
Tolosano E, Fagoonee S, Garuti C, Valli L, Andrews NC, et al. 2005. Haptoglobin modifies the hemochromatosis phenotype in mice. Blood 105:3353-55
-
(2005)
Blood
, vol.105
, pp. 3353-3355
-
-
Tolosano, E.1
Fagoonee, S.2
Garuti, C.3
Valli, L.4
Andrews, N.C.5
-
126
-
-
0033485566
-
Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice
-
Tolosano E, Hirsch E, Patrucco E, Camaschella C, Navone R, et al. 1999. Defective recovery and severe renal damage after acute hemolysis in hemopexin-deficient mice. Blood 94:3906-14
-
(1999)
Blood
, vol.94
, pp. 3906-3914
-
-
Tolosano, E.1
Hirsch, E.2
Patrucco, E.3
Camaschella, C.4
Navone, R.5
-
127
-
-
9144248397
-
Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis
-
DOI 10.1073/pnas.2237037100
-
Tomatsu S, Orii KO, Fleming RE, Holden CC, Waheed A, et al. 2003. Contribution of the H63D mutation in HFE to murine hereditary hemochromatosis. Proc. Natl. Acad. Sci. USA 100:15788-93 (Pubitemid 38021068)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.26
, pp. 15788-15793
-
-
Tomatsu, S.1
Orii, K.O.2
Fleming, R.E.3
Holden, C.C.4
Waheed, A.5
Britton, R.S.6
Gutierrez, M.A.7
Velez-Castrillon, S.8
Bacon, B.R.9
Sly, W.S.10
-
128
-
-
0034254752
-
The molecular defect in hypotransferrinemic mice
-
Trenor CC 3rd, Campagna DR, Sellers VM, Andrews NC, Fleming MD. 2000. The molecular defect in hypotransferrinemic mice. Blood 96:1113-18 (Pubitemid 30616881)
-
(2000)
Blood
, vol.96
, Issue.3
, pp. 1113-1118
-
-
Trenor III, C.C.1
Campagna, D.R.2
Sellers, V.M.3
Andrews, N.C.4
Fleming, M.D.5
-
129
-
-
77956327702
-
Intestinal ferritin H is required for an accurate control of iron absorption
-
Vanoaica L, Darshan D, Richman L, Schumann K, Kuhn LC. 2010. Intestinal ferritin H is required for an accurate control of iron absorption. Cell Metab. 12:273-82
-
(2010)
Cell Metab.
, vol.12
, pp. 273-282
-
-
Vanoaica, L.1
Darshan, D.2
Richman, L.3
Schumann, K.4
Kuhn, L.C.5
-
130
-
-
46749135674
-
Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload
-
DOI 10.2353/ajpath.2008.071130
-
Vinchi F, Gastaldi S, Silengo L, Altruda F, Tolosano E. 2008. Hemopexin prevents endothelial damage and liver congestion in a mouse model of heme overload. Am. J. Pathol. 173:289-99 (Pubitemid 351947975)
-
(2008)
American Journal of Pathology
, vol.173
, Issue.1
, pp. 289-299
-
-
Vinchi, F.1
Gastaldi, S.2
Silengo, L.3
Altruda, F.4
Tolosano, E.5
-
131
-
-
38649128515
-
Hfe acts in hepatocytes to prevent hemochromatosis
-
DOI 10.1016/j.cmet.2007.11.014, PII S1550413107003713
-
Vujic SpasicM,Kiss J,HerrmannT,Galy B, Martinache S, et al. 2008. Hfe acts in hepatocytes to prevent hemochromatosis. Cell Metab. 7:173-78 (Pubitemid 351168556)
-
(2008)
Cell Metabolism
, vol.7
, Issue.2
, pp. 173-178
-
-
Vujic Spasic, M.1
Kiss, J.2
Herrmann, T.3
Galy, B.4
Martinache, S.5
Stolte, J.6
Grone, H.-J.7
Stremmel, W.8
Hentze, M.W.9
Muckenthaler, M.U.10
-
132
-
-
34248374866
-
Physiologic systemic iron metabolism in mice deficient for duodenal Hfe
-
DOI 10.1182/blood-2006-07-036186
-
Vujic SpasicM,Kiss J,Herrmann T,Kessler R, Stolte J, et al. 2007. Physiologic systemic ironmetabolism in mice deficient for duodenal Hfe. Blood 109:4511-17 (Pubitemid 46743422)
-
(2007)
Blood
, vol.109
, Issue.10
, pp. 4511-4517
-
-
Spasic, M.V.1
Kiss, J.2
Herrmann, T.3
Kessler, R.4
Stolte, J.5
Galy, B.6
Rathkolb, B.7
Wolf, E.8
Stremmel, W.9
Hentze, M.W.10
Muckenthaler, M.U.11
-
133
-
-
0032909207
-
Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse
-
DOI 10.1038/5979
-
Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, et al. 1999. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat. Genet. 21:195-99 (Pubitemid 29070366)
-
(1999)
Nature Genetics
, vol.21
, Issue.2
, pp. 195-199
-
-
Vulpe, C.D.1
Kuo, Y.-M.2
Murphy, T.L.3
Cowley, L.4
Askwith, C.5
Libina, N.6
Gitschier, J.7
Anderson, G.I.8
-
134
-
-
0030732164
-
Hereditary hemochromatosis: Effects of C282Y andH63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells
-
Waheed A, Parkkila S, Zhou XY, Tomatsu S, Tsuchihashi Z, et al. 1997. Hereditary hemochromatosis: effects of C282Y andH63D mutations on association with beta2-microglobulin, intracellular processing, and cell surface expression of the HFE protein in COS-7 cells. Proc. Natl. Acad. Sci. USA 94:12384-89
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 12384-12389
-
-
Waheed, A.1
Parkkila, S.2
Zhou, X.Y.3
Tomatsu, S.4
Tsuchihashi, Z.5
-
135
-
-
73149083742
-
Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload
-
Wallace DF, Summerville L, Crampton EM, Frazer DM, Anderson GJ, Subramaniam VN. 2009. Combined deletion of Hfe and transferrin receptor 2 in mice leads to marked dysregulation of hepcidin and iron overload. Hepatology 50:1992-2000
-
(2009)
Hepatology
, vol.50
, pp. 1992-2000
-
-
Wallace, D.F.1
Summerville, L.2
Crampton, E.M.3
Frazer, D.M.4
Anderson, G.J.5
Subramaniam, V.N.6
-
136
-
-
21044434748
-
First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin
-
DOI 10.1136/gut.2004.062018
-
Wallace DF, Summerville L, Lusby PE, Subramaniam VN. 2005. First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin. Gut 54:980-86 (Pubitemid 40873913)
-
(2005)
Gut
, vol.54
, Issue.7
, pp. 980-986
-
-
Wallace, D.F.1
Summerville, L.2
Lusby, P.E.3
Subramaniam, V.N.4
-
137
-
-
33846225653
-
Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload
-
DOI 10.1053/j.gastro.2006.11.028, PII S0016508506024838
-
Wallace DF, Summerville L, Subramaniam VN. 2007. Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload. Gastroenterology 132:301-10 (Pubitemid 46108757)
-
(2007)
Gastroenterology
, vol.132
, Issue.1
, pp. 301-310
-
-
Wallace, D.F.1
Summerville, L.2
Subramaniam, V.N.3
-
138
-
-
33644876815
-
A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression
-
Wang RH, Li C, Xu X, Zheng Y, Xiao C, et al. 2005. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2:399-409
-
(2005)
Cell Metab.
, vol.2
, pp. 399-409
-
-
Wang, R.H.1
Li, C.2
Xu, X.3
Zheng, Y.4
Xiao, C.5
-
139
-
-
28644444443
-
Iron metabolism mutant hbd mice have a deletion in Sec15l1, which has homology to a yeast gene for vesicle docking
-
DOI 10.1016/j.ygeno.2005.09.015, PII S088875430500279X
-
White RA, Boydston LA, Brookshier TR, McNulty SG, Nsumu NN, et al. 2005. Iron metabolism mutant hbd mice have a deletion in Sec15l1, which has homology to a yeast gene for vesicle docking. Genomics 86:668-73 (Pubitemid 41752947)
-
(2005)
Genomics
, vol.86
, Issue.6
, pp. 668-673
-
-
White, R.A.1
Boydston, L.A.2
Brookshier, T.R.3
McNulty, S.G.4
Nsumu, N.N.5
Brewer, B.P.6
Blackmore, K.7
-
140
-
-
0032893958
-
Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency
-
Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, et al. 1999. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J. Clin. Invest. 103:129-35 (Pubitemid 29031171)
-
(1999)
Journal of Clinical Investigation
, vol.103
, Issue.1
, pp. 129-135
-
-
Yachie, A.1
Niida, Y.2
Wada, T.3
Igarashi, N.4
Kaneda, H.5
Toma, T.6
Ohta, K.7
Kasahara, Y.8
Koizumi, S.9
-
141
-
-
0034243386
-
Animal models for X-linked sideroblastic anemia
-
Yamamoto M, Nakajima O. 2000. Animal models for X-linked sideroblastic anemia. Int. J. Hematol. 72:157-64
-
(2000)
Int. J. Hematol.
, vol.72
, pp. 157-164
-
-
Yamamoto, M.1
Nakajima, O.2
-
142
-
-
33646104690
-
The anemia of "haemoglobin-deficit" (hbd/hbd ) mice is caused by a defect in transferrin cycling
-
Zhang AS, Sheftel AD, Ponka P. 2006. The anemia of "haemoglobin- deficit" (hbd/hbd ) mice is caused by a defect in transferrin cycling. Exp. Hematol. 34:593-98
-
(2006)
Exp. Hematol.
, vol.34
, pp. 593-598
-
-
Zhang, A.S.1
Sheftel, A.D.2
Ponka, P.3
-
143
-
-
0001376313
-
HFE gene knockout produces mouse model of hereditary hemochromatosis
-
DOI 10.1073/pnas.95.5.2492
-
Zhou XY, Tomatsu S, Fleming RE, Parkkila S, Waheed A, et al. 1998. HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc. Natl. Acad. Sci. USA 95:2492-97 (Pubitemid 28145969)
-
(1998)
Proceedings of the National Academy of Sciences of the United States of America
, vol.95
, Issue.5
, pp. 2492-2497
-
-
Zhou, X.Y.1
Tomatsu, S.2
Fleming, R.E.3
Parkkila, S.4
Waheed, A.5
Jiang, J.6
Fei, Y.7
Brunt, E.M.8
Ruddy, D.A.9
Prass, C.E.10
Schatzman, R.C.11
O'Neill, R.12
Britton, R.S.13
Bacon, B.R.14
Sly, W.S.15
-
144
-
-
34248343093
-
The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease
-
DOI 10.1182/blood-2007-01-066068
-
Zohn IE, De Domenico I, Pollock A, Ward DM, Goodman JF, et al. 2007. The flatiron mutation in mouse ferroportin acts as a dominant negative to cause ferroportin disease. Blood 109:4174-80 (Pubitemid 46743381)
-
(2007)
Blood
, vol.109
, Issue.10
, pp. 4174-4180
-
-
Zohn, I.E.1
De Domenico, I.2
Pollock, A.3
Ward, D.M.4
Goodman, J.F.5
Liang, X.6
Sanchez, A.J.7
Niswander, L.8
Kaplan, J.9
|