Haptoglobin modifies the hemochromatosis phenotype in mice

Blood

Volumn 105, Issue 8, 2005, Pages 3353-3355

  Tolosano, Emanuela ^a   Fagoonee, Sharmila ^a   Garuti, Cinzia ^a   Valli, Linda ^a   Andrews, Nancy C ^a   Altruda, Fiorella ^a   Pietrangelo, Antonello ^b  

^a Biol and Biochem ^*

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

HAPTOGLOBIN; HEME; HEMOGLOBIN; IRON;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; GENE MUTATION; GENETIC DISORDER; HEMOCHROMATOSIS; IRON BLOOD LEVEL; IRON METABOLISM; IRON OVERLOAD; LIVER LEVEL; MOUSE; MOUSE MUTANT; MOUSE STRAIN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; STATISTICAL SIGNIFICANCE;

EID: 17044421761     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-07-2814     Document Type: Article

References (23)

1. Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet. 1996;13:399-408.
2. Zhou XY, Tomatsu S, Fleming RE, et al. HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc Natl Acad Sci U S A. 1998;95:2492-2497.
3. Levy JE, Montross LK, Cohen DE, Fleming MD, Andrews NC. The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. Blood. 1999;94:9-11.
4. Beutler E. The HFE Cys282Tyr mutation as a necessary but not sufficient cause of clinical hereditary hemochromatosis. Blood. 2003;101:3347-3350.
5. Pietrangelo A. Hereditary hemochromatosis: a new look at an old disease. N Engl J Med. 2004;350:2383-2397.
6. Fleming RE, Holden CC, Tomatsu S, et al. Mouse strain differences determine severity of iron accumulation in Hfe knockout model of hereditary hemochromatosis. Proc Natl Acad Sci U S A. 2001;98:2707-2711.
7. Dupic F, Fruchon S, Bensaid M, et al. Inactivation of the hemochromatosis gene differentially regulates duodenal expression of iron-related mRNAs between mouse strains. Gastroenterology. 2002;122:745-751.
8. Levy JE, Montross LK, Andrews NC. Genes that modify the hemochromatosis phenotype in mice. J Clin Invest. 2000;105:1209-1216.
9. Jacolot S, Le Gac G, Scotet V, Quere I, Mura C, Ferec C. HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype. Blood. 2004;103:2835-2840.
10. Nicolas G, Andrews NC, Kahn A, Vaulont S. Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice. Blood. 2004;103:2841-2843.
11. Wang Y, Kinzie E, Berger FG, Lim SK, Baumann H. Haptoglobin, an inflammation-inducible plasma protein. Redox Rep. 2001;6:379-385.
12. Kristiansen M, Graversen JH, Jacobsen C, et al. Identification of the haemoglobin scavenger receptor. Nature. 2001;409:198-201.
13. Delanghe JR, Langlois MR. Haptoglobin polymorphism and body iron stores. Clin Chem Lab Med. 2002;40:212-216.
14. Langlois MR, Martin ME, Boelaert JR, et al. The haptoglobin 2-2 phenotype affects serum markers of iron status in healthy males. Clin Chem. 2000;46:1619-1625.
15. Van Vlierberghe H, Langlois M, Delanghe J, et al. Haptoglobin phenotype 2-2 overrepresentation in Cys282Tyr hemochromatotic patients. J Hepatol. 2001;35:707-711.
16. Beutler E, Gelbart T, Lee P. Haptoglobin polymorphism and iron homeostasis. Clin Chem. 2002;48:2232-2235.
17. Carter K, Bowen DJ, McCune CA, Worwood M. Haptoglobin type neither influences iron accumulation in normal subjects nor predicts clinical presentation in HFE C282Y haemochromatosis: phenotype and genotype analysis. Br J Haematol. 2003;122:326-332.
18. Lim SK, Kim H, bin Ali A, et al. Increased susceptibility in Hp knockout mice during acute hemolysis. Blood. 1998;92:1870-1877.
19. Fleming RE, Migas MC, Zhou X, et al. Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1. Proc Natl Acad Sci U S A. 1999;96:3143-3148.
20. Pieroni L, Khalil L, Charlotte F, et al. Comparison of bathophenanthroline sulfonate and ferene as chromogens in colorimetric measurement of low hepatic iron concentration. Clin Chem. 2001;47:2059-2061.
21. Nguyen-Legros J, Bizot J, Bolesse M, Pulicani JP. ["Diaminobenzidine black" as a new histochemical demonstration of exogenous iron (author's transl)]. Histochemistry. 1980;66:239-244.
22. Fagoonee S, Gburek J, Hirsch E, et al. Plasma protein haptoglobin modulates renal iron loading. Am J Pathol. 2005.
23. Bensaid M, Fruchon S, Mazeres C, Bahram S, Roth MP, Coppin H. Multigenic control of hepatic iron loading in a murine model of hemochromatosis. Gastroenterology. 2004;126:1400-1408.