The Nramp2/DMT1 iron transporter is induced in the duodenum of microcytic anemia mk mice but is not properly targeted to the intestinal brush border

Blood

Volumn 96, Issue 12, 2000, Pages 3964-3970

  Canonne Hergaux, F ^a   Fleming, M D ^a   Levy, J E ^a   Gauthier, S ^a   Ralph, T ^a   Picard, V ^a   Andrews, N C ^a   Gros, P ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

DMT1 PROTEIN; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEEDBACK SYSTEM; GENE MUTATION; IMMUNOHISTOCHEMISTRY; INTESTINE BRUSH BORDER; INTESTINE CELL; IRON ABSORPTION; IRON DEFICIENCY; IRON METABOLISM; IRON TRANSPORT; MICROCYTIC ANEMIA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ALLELES; ANEMIA; ANIMALS; BIOLOGICAL TRANSPORT; CARRIER PROTEINS; CATION TRANSPORT PROTEINS; DUODENUM; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IRON, DIETARY; IRON-BINDING PROTEINS; MEMBRANE PROTEINS; MICE; MICE, MUTANT STRAINS; MICROVILLI; RNA, MESSENGER; TISSUE DISTRIBUTION;

EID: 0034548853     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (34)

1. The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells
2. Absorption of iron
3. Iron homeostasis
4. Biochemistry of nonheme iron in man. II. Absorption of iron
5. Disorders of iron metabolism
6. Cloning and characterization of a mammalian proton-coupled metal-ion transporter
7. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
8. Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport
9. Defective iron uptake by the duodenum of Belgrade rats fed diets of different iron contents
10. The human Nramp2 gene: Characterization of the gene structure, alternative splicing, promoter region and polymorphisms
11. Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron
12. Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: Increased duodenal expression of the iron transporter DMT1
13. Nramp defines a family of membrane proteins
14. Mycobacterium tuberculosis expresses a novel pH-dependent divalent cation transporter belonging to the Nramp family
15. The Nramp1 protein and its role in resistance to infection and macrophage function
16. Natural resistance to infection with intracellular pathogens: The Nramp1 protein is recruited to the membrane of the phagosome
17. Host resistance to intracellular infection: Mutation of natural resistance-associated macrophage protein 1 (Nramp1) impairs phagosomal acidification
18. Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg
19. The Ity/Lsh/Bcg locus: Natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene
20. The G185R mutation disrupts function of the iron transporter Nramp2
21. Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains
22. Characterization of cell lines showing growth control isolated from both the wild type and a leucyl-tRNA synthetase mutant of Chinese hamster ovary cells
23. Functional complementation of the yeast divalent cation transporter family SMF by NRAMP2, a member of the mammalian natural resistance-associated macrophage protein family
24. The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes
25. Identification and characterization of a second mouse Nramp gene
26. Expression of the Bgp gene and characterization of mouse colon biliary glycoprotein isoforms
27. The expression of mouse biliary glycoprotein, a carcinoembryonic antigen-related gene, is down-regulated in malignant mouse tissues
28. Biliary glycoprotein 1 expression during embryogenesis: Correlation with events of epithelial differentiation, mesenchymal-epithelial interactions, absorption, and myogenesis
29. Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress
30. Regulation of iron metabolism in eukaryotes
31. Iron proteins of duodenal enterocytes isolated from mice with genetically and experimentally altered iron metabolism
32. Iron regulatory protein as an endogenous sensor of iron in rat intestinal mucosa. Possible implications for the regulation of iron absorption
33. Positional cloning of zebrafish ferroportin 1 identifies a conserved vertebrate iron exporter
34. Cloning and characterization of a second human NRAMP gene on chromosome 12q13