메뉴 건너뛰기




Volumn 106, Issue 7, 2005, Pages 2580-2589

Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2)

Author keywords

[No Author keywords available]

Indexed keywords

FERROPORTIN 1; HEMOGLOBIN; IRON; IRON REGULATORY PROTEIN 2; MESSENGER RNA; TRANSFERRIN; TRANSFERRIN RECEPTOR;

EID: 27144467097     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-04-1365     Document Type: Article
Times cited : (191)

References (44)
  • 1
    • 2042546096 scopus 로고    scopus 로고
    • Balancing acts: Molecular control of mammalian iron metabolism
    • Hentze MW, Muckenthaler MU, Andrews NC. Balancing acts: molecular control of mammalian iron metabolism. Cell. 2004;117:285-297.
    • (2004) Cell , vol.117 , pp. 285-297
    • Hentze, M.W.1    Muckenthaler, M.U.2    Andrews, N.C.3
  • 2
    • 0030755366 scopus 로고    scopus 로고
    • Cloning and characterization of a mammalian proton-coupled metal-ion transporter
    • Gunshin H, Mackenzie B, Berger UV, et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature. 1997;388:482-488.
    • (1997) Nature , vol.388 , pp. 482-488
    • Gunshin, H.1    Mackenzie, B.2    Berger, U.V.3
  • 3
    • 0033861745 scopus 로고    scopus 로고
    • A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
    • McKie AT, Marciani P, Rolfs A, et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell. 2000;5:299-309.
    • (2000) Mol Cell , vol.5 , pp. 299-309
    • McKie, A.T.1    Marciani, P.2    Rolfs, A.3
  • 4
    • 0034733635 scopus 로고    scopus 로고
    • A novel mammalian iron-regulated protein involved in intracellular iron metabolism
    • Abboud S, Haile DJ. A novel mammalian ironregulated protein involved in intracellular iron metabolism. J Biol Chem. 2000;275:19906-19912.
    • (2000) J Biol Chem , vol.275 , pp. 19906-19912
    • Abboud, S.1    Haile, D.J.2
  • 5
    • 0034677467 scopus 로고    scopus 로고
    • Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
    • Donovan A, Brownlie A, Zhou Y, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000;403:776-781.
    • (2000) Nature , vol.403 , pp. 776-781
    • Donovan, A.1    Brownlie, A.2    Zhou, Y.3
  • 6
    • 0032875387 scopus 로고    scopus 로고
    • Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux
    • U S A
    • Harris ZL, Durley AP, Man TK, Gitlin JD. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci U S A. 1999;96:10812-10817.
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 10812-10817
    • Harris, Z.L.1    Durley, A.P.2    Man, T.K.3    Gitlin, J.D.4
  • 7
    • 0034575478 scopus 로고    scopus 로고
    • Iron metabolism: Iron deficiency and iron overload
    • Andrews NC. Iron metabolism: iron deficiency and iron overload. Annu Rev Genomics Hum Genet. 2000;1:75-98.
    • (2000) Annu Rev Genomics Hum Genet , vol.1 , pp. 75-98
    • Andrews, N.C.1
  • 8
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J. Hepcidin regulates iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090-2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3
  • 9
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002;110:1037-1044.
    • (2002) J Clin Invest , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3
  • 10
    • 0028881134 scopus 로고
    • Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinemia and cataract
    • Beaumont C, Leneuve P, Devaux I, et al. Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinemia and cataract. Nat Genet. 1995;11:444-446.
    • (1995) Nat Genet , vol.11 , pp. 444-446
    • Beaumont, C.1    Leneuve, P.2    Devaux, I.3
  • 11
    • 0028788201 scopus 로고
    • Molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome: A mutation in the iron-responsive element of ferritin L-subunit gene (the "Verona mutation")
    • Girelli D, Corrocher R, Bisceglia L, et al. Molecular basis for the recently described hereditary hyperferritinemia-cataract syndrome: a mutation in the iron-responsive element of ferritin L-subunit gene (the "Verona mutation"). Blood. 1995;86:4050-4053.
    • (1995) Blood , vol.86 , pp. 4050-4053
    • Girelli, D.1    Corrocher, R.2    Bisceglia, L.3
  • 12
    • 0034964604 scopus 로고    scopus 로고
    • A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload
    • Kato J, Fujikawa K, Kanda M, et al. A mutation, in the iron-responsive element of H ferritin mRNA, causing autosomal dominant iron overload. Am J Hum Genet. 2001;69:191-197.
    • (2001) Am J Hum Genet , vol.69 , pp. 191-197
    • Kato, J.1    Fujikawa, K.2    Kanda, M.3
  • 13
    • 0035138456 scopus 로고    scopus 로고
    • Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice
    • LaVaute T, Smith S, Cooperman S, et al. Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice. Nat Genet. 2001;27:209-214.
    • (2001) Nat Genet , vol.27 , pp. 209-214
    • LaVaute, T.1    Smith, S.2    Cooperman, S.3
  • 14
    • 0034531651 scopus 로고    scopus 로고
    • Iron regulatory proteins in pathobiology
    • Cairo G, Pietrangelo A. Iron regulatory proteins in pathobiology. Biochem J. 2000;352:241-250.
    • (2000) Biochem J , vol.352 , pp. 241-250
    • Cairo, G.1    Pietrangelo, A.2
  • 15
    • 0033826764 scopus 로고    scopus 로고
    • Iron regulatory proteins and the molecular control of mammalian iron metabolism
    • Eisenstein RS. Iron regulatory proteins and the molecular control of mammalian iron metabolism. Annu Rev Nutr. 2000;20:627-662.
    • (2000) Annu Rev Nutr , vol.20 , pp. 627-662
    • Eisenstein, R.S.1
  • 16
    • 1842608845 scopus 로고    scopus 로고
    • Iron metabolism and the IRE/IRP regulatory system: An update
    • Pantopoulos K. Iron metabolism and the IRE/IRP regulatory system: an update. Ann N Y Acad Sci. 2004;1012:1-13.
    • (2004) Ann N Y Acad Sci , vol.1012 , pp. 1-13
    • Pantopoulos, K.1
  • 17
    • 10744223491 scopus 로고    scopus 로고
    • Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis
    • Meyron-Holtz EG, Ghosh MC, Iwai K, et al. Genetic ablations of iron regulatory proteins 1 and 2 reveal why iron regulatory protein 2 dominates iron homeostasis. EMBO J. 2004;23:386-395.
    • (2004) EMBO J , vol.23 , pp. 386-395
    • Meyron-Holtz, E.G.1    Ghosh, M.C.2    Iwai, K.3
  • 18
    • 3042577347 scopus 로고    scopus 로고
    • Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo
    • Galy B, Ferring D, Benesova M, Benes V, Hentze MW. Targeted mutagenesis of the murine IRP1 and IRP2 genes reveals context-dependent RNA processing differences in vivo. RNA. 2004;10:1019-1025.
    • (2004) RNA , vol.10 , pp. 1019-1025
    • Galy, B.1    Ferring, D.2    Benesova, M.3    Benes, V.4    Hentze, M.W.5
  • 19
    • 11144353669 scopus 로고    scopus 로고
    • Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies
    • Smith SR, Cooperman S, Lavaute T, et al. Severity of neurodegeneration correlates with compromise of iron metabolism in mice with iron regulatory protein deficiencies. Ann N Y Acad Sci. 2004;1012:65-83.
    • (2004) Ann N Y Acad Sci , vol.1012 , pp. 65-83
    • Smith, S.R.1    Cooperman, S.2    Lavaute, T.3
  • 20
    • 0014267781 scopus 로고
    • A simple technique for measuring storage iron concentrations in formalinised liver samples
    • Torrance JD, Bothwell HT. A simple technique for measuring storage iron concentrations in formalinised liver samples. S Afr J Med Sci. 1968;33:9-15.
    • (1968) S Afr J Med Sci , vol.33 , pp. 9-15
    • Torrance, J.D.1    Bothwell, H.T.2
  • 21
    • 0036703490 scopus 로고    scopus 로고
    • Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury
    • Patel BN, Dunn RJ, Jeong SY, Zhu Q, Julien JP, David S. Ceruloplasmin regulates iron levels in the CNS and prevents free radical injury. J Neurosci. 2002;22:6578-6586.
    • (2002) J Neurosci , vol.22 , pp. 6578-6586
    • Patel, B.N.1    Dunn, R.J.2    Jeong, S.Y.3    Zhu, Q.4    Julien, J.P.5    David, S.6
  • 22
    • 0033539556 scopus 로고    scopus 로고
    • Experimental hemochromatosis due to MHC class I HFE deficiency: Immune status and iron metabolism
    • U S A
    • Bahram S, Gilfillan S, Kuhn LC, et al. Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism. Proc Natl Acad Sci U S A. 1999;96:13312-13317.
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 13312-13317
    • Bahram, S.1    Gilfillan, S.2    Kuhn, L.C.3
  • 23
    • 0036752147 scopus 로고    scopus 로고
    • Comparison of fluorescent tag DNA labeling methods used for expression analysis by DNA microarrays
    • Richter A, Schwager C, Hentze S, Ansorge W, Hentze MW, Muckenthaler M. Comparison of fluorescent tag DNA labeling methods used for expression analysis by DNA microarrays. Biotechniques. 2002;33:620-630.
    • (2002) Biotechniques , vol.33 , pp. 620-630
    • Richter, A.1    Schwager, C.2    Hentze, S.3    Ansorge, W.4    Hentze, M.W.5    Muckenthaler, M.6
  • 24
    • 0037509928 scopus 로고    scopus 로고
    • Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis
    • Muckenthaler M, Roy CN, Custodio AO, et al. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet. 2003;34:102-107.
    • (2003) Nat Genet , vol.34 , pp. 102-107
    • Muckenthaler, M.1    Roy, C.N.2    Custodio, A.O.3
  • 25
    • 0028788316 scopus 로고
    • Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2
    • Iwai K, Klausner RD, Rouault TA. Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2. EMBO J. 1995;14:5350-5357.
    • (1995) EMBO J , vol.14 , pp. 5350-5357
    • Iwai, K.1    Klausner, R.D.2    Rouault, T.A.3
  • 26
    • 0034672236 scopus 로고    scopus 로고
    • Iron homeostasis: New tales from the crypt
    • Roy CN, Enns CA. Iron homeostasis: new tales from the crypt. Blood. 2000;96:4020-4027.
    • (2000) Blood , vol.96 , pp. 4020-4027
    • Roy, C.N.1    Enns, C.A.2
  • 27
    • 0037126002 scopus 로고    scopus 로고
    • Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function
    • U S A
    • Hubert N, Hentze MW. Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci U S A. 2002;99:12345-12350.
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 12345-12350
    • Hubert, N.1    Hentze, M.W.2
  • 28
    • 0032104739 scopus 로고    scopus 로고
    • The human Nramp2 gene: Characterization of the gene structure, alternative splicing, promoter region and polymorphisms
    • Lee PL, Gelbart T, West C, Halloran C, Beutler E. The human Nramp2 gene: characterization of the gene structure, alternative splicing, promoter region and polymorphisms. Blood Cells Mol Dis. 1998;24:199-215.
    • (1998) Blood Cells Mol Dis , vol.24 , pp. 199-215
    • Lee, P.L.1    Gelbart, T.2    West, C.3    Halloran, C.4    Beutler, E.5
  • 29
    • 0033564656 scopus 로고    scopus 로고
    • Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron
    • Canonne-Hergaux F, Gruenheid S, Ponka P, Gros P. Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood. 1999;93:4406-4417.
    • (1999) Blood , vol.93 , pp. 4406-4417
    • Canonne-Hergaux, F.1    Gruenheid, S.2    Ponka, P.3    Gros, P.4
  • 30
    • 10744224903 scopus 로고    scopus 로고
    • Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin
    • Herrmann T, Muckenthaler M, van der Hoeven F, et al. Iron overload in adult Hfe-deficient mice independent of changes in the steady-state expression of the duodenal iron transporters DMT1 and Ireg1/ferroportin. J Mol Med. 2004;82:39-48.
    • (2004) J Mol Med , vol.82 , pp. 39-48
    • Herrmann, T.1    Muckenthaler, M.2    Van Der Hoeven, F.3
  • 31
    • 0041438849 scopus 로고    scopus 로고
    • Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency
    • Chen H, Su T, Attieh ZK, et al. Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency. Blood. 2003;102:1893-1899.
    • (2003) Blood , vol.102 , pp. 1893-1899
    • Chen, H.1    Su, T.2    Attieh, Z.K.3
  • 32
    • 4644309964 scopus 로고    scopus 로고
    • Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis
    • Latunde-Dada GO, Vulpe CD, Anderson GJ, Simpson RJ, McKie AT. Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis. Biochim Biophys Acta. 2004;1690:169-176.
    • (2004) Biochim Biophys Acta , vol.1690 , pp. 169-176
    • Latunde-Dada, G.O.1    Vulpe, C.D.2    Anderson, G.J.3    Simpson, R.J.4    McKie, A.T.5
  • 33
    • 1642315903 scopus 로고    scopus 로고
    • Functional differences between hepcidin 1 and 2 in transgenic mice
    • Lou DQ, Nicolas G, Lesbordes JC, et al. Functional differences between hepcidin 1 and 2 in transgenic mice. Blood. 2004;103:2816-2821.
    • (2004) Blood , vol.103 , pp. 2816-2821
    • Lou, D.Q.1    Nicolas, G.2    Lesbordes, J.C.3
  • 34
    • 0038025679 scopus 로고    scopus 로고
    • Comparative analysis of mouse hepcidin 1 and 2 genes: Evidence for different patterns of expression and co-inducibility during iron overload
    • Ilyin G, Courselaud B, Troadec MB, et al. Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload. FEBS Lett. 2003;542:22-26.
    • (2003) FEBS Lett , vol.542 , pp. 22-26
    • Ilyin, G.1    Courselaud, B.2    Troadec, M.B.3
  • 35
    • 10744226568 scopus 로고    scopus 로고
    • Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice
    • Courselaud B, Troadec MB, Fruchon S. Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice. Blood Cells Mol Dis. 2004;32:283-289.
    • (2004) Blood Cells Mol Dis , vol.32 , pp. 283-289
    • Courselaud, B.1    Troadec, M.B.2    Fruchon, S.3
  • 36
    • 0742272103 scopus 로고    scopus 로고
    • The ferroportin disease
    • Pietrangelo A. The ferroportin disease. Blood Cells Mol Dis. 2004;32:131-138.
    • (2004) Blood Cells Mol Dis , vol.32 , pp. 131-138
    • Pietrangelo, A.1
  • 37
    • 20444416123 scopus 로고    scopus 로고
    • The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
    • Donovan A, Lima CA, Pinkus JL, et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metabolism. 2005;1:191-200.
    • (2005) Cell Metabolism , vol.1 , pp. 191-200
    • Donovan, A.1    Lima, C.A.2    Pinkus, J.L.3
  • 38
    • 0032959574 scopus 로고    scopus 로고
    • Transferrin receptor is necessary for development of erythrocytes and the nervous system
    • Levy JE, Jin O, Fujiwara Y, Kuo F, Andrews NC. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet. 1999;21:396-399.
    • (1999) Nat Genet , vol.21 , pp. 396-399
    • Levy, J.E.1    Jin, O.2    Fujiwara, Y.3    Kuo, F.4    Andrews, N.C.5
  • 39
    • 0020607921 scopus 로고
    • Ultrastructural localization of the transferrin receptor and transferrin on marrow cell surfaces
    • Parmley RT, Hajdu I, Denys FR. Ultrastructural localization of the transferrin receptor and transferrin on marrow cell surfaces. Br J Haematol. 1983;54:633-641.
    • (1983) Br J Haematol , vol.54 , pp. 633-641
    • Parmley, R.T.1    Hajdu, I.2    Denys, F.R.3
  • 40
    • 2542560427 scopus 로고    scopus 로고
    • Hereditary hemochromatosis-a new look at an old disease
    • Pietrangelo A. Hereditary hemochromatosis-a new look at an old disease. N Engl J Med. 2004;350:2383-2397.
    • (2004) N Engl J Med , vol.350 , pp. 2383-2397
    • Pietrangelo, A.1
  • 41
    • 0001392285 scopus 로고
    • The control of iron balance by the intestinal mucosa
    • Crosby WH. The control of iron balance by the intestinal mucosa. Blood. 1963;22:441-449.
    • (1963) Blood , vol.22 , pp. 441-449
    • Crosby, W.H.1
  • 42
    • 23044503950 scopus 로고    scopus 로고
    • Microcytic anemia, erythropoietic protoporphyria and neurodegeneration in mice with targeted deletion of iron regulatory protein 2
    • Cooperman SS, Meyron-Holtz EG, Olivierre-Wilson H, Ghosh MC, McConnell JP, Rouault TA. Microcytic anemia, erythropoietic protoporphyria and neurodegeneration in mice with targeted deletion of iron regulatory protein 2. Blood. 2005;106:1084-1091.
    • (2005) Blood , vol.106 , pp. 1084-1091
    • Cooperman, S.S.1    Meyron-Holtz, E.G.2    Olivierre-Wilson, H.3    Ghosh, M.C.4    McConnell, J.P.5    Rouault, T.A.6
  • 43
    • 0012254102 scopus 로고    scopus 로고
    • Gene targeting, principles, and practice in mammalian cells
    • Joyner AL, ed. Oxford, United Kingdom: Oxford University Press
    • Hasty P, Abuin A, Bradley A. Gene targeting, principles, and practice in mammalian cells. In: Joyner AL, ed. Gene Targeting, A Practical Approach. 2nd ed. Oxford, United Kingdom: Oxford University Press; 2000:1-35.
    • (2000) Gene Targeting, A Practical Approach. 2nd Ed. , pp. 1-35
    • Hasty, P.1    Abuin, A.2    Bradley, A.3
  • 44
    • 0034623930 scopus 로고    scopus 로고
    • Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE
    • West AP Jr, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem. 2000;275:38135-38138.
    • (2000) J Biol Chem , vol.275 , pp. 38135-38138
    • West Jr., A.P.1    Bennett, M.J.2    Sellers, V.M.3    Andrews, N.C.4    Enns, C.A.5    Bjorkman, P.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.