Lack of Haptoglobin Affects Iron Transport Across Duodenum by Modulating Ferroportin Expression

Gastroenterology

Volumn 133, Issue 4, 2007, Pages

  Marro, Samuele ^a   Barisani, Donatella ^b   Chiabrando, Deborah ^a   Fagoonee, Sharmila ^a   Muckenthaler, Martina U ^c   Stolte, Jens ^d   Meneveri, Raffaella ^b   Haile, David ^e   Silengo, Lorenzo ^a   Altruda, Fiorella ^a   Tolosano, Emanuela ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

^c UNIVERSITY OF HEIDELBERG   (Germany)

^d EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^e UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FERROPORTIN 1; HAPTOGLOBIN; HEMOGLOBIN; HEPCIDIN; MESSENGER RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL STIMULATION; CONTROLLED STUDY; DUODENUM; DUODENUM MUCOSA; HOMEOSTASIS; IRON ABSORPTION; IRON STORAGE; IRON TRANSPORT; MACROPHAGE; MODULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; SPLEEN; TISSUE HOMOGENATE; UPREGULATION;

EID: 34848925133     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2007.07.004     Document Type: Article

References (36)

1. Latunde-Dada G.O., Simpson R.J., and McKie A.T. Recent advances in mammalian haem transport. Trends Biochem Sci 31 (2006) 182-188
2. Ascenzi P., Bocedi A., Visca P., et al. Hemoglobin and heme scavenging. IUBMB Life 57 (2005) 749-759
3. Wang Y., Kinzie E., Berger F.G., et al. Haptoglobin, an inflammation-inducible plasma protein. Redox Rep 6 (2001) 379-385
4. Kino K., Tsunoo H., Higa Y., et al. Kinetic aspects of hemoglobin-haptoglobin-receptor interaction in rat liver plasma membranes, isolated liver cells, and liver cells in primary culture. J Biol Chem 257 (1982) 4828-4833
5. Higa Y., Oshiro S., Kino K., et al. Catabolism of globin-haptoglobin in liver cells after intravenous administration of hemoglobin-haptoglobin to rats. J Biol Chem 256 (1981) 12322-12328
6. Kino K., Mizumoto K., Watanabe J., et al. Immunohistochemical studies on hemoglobin-haptoglobin and hemoglobin catabolism sites. J Histochem Cytochem 35 (1987) 381-386
7. Moestrup S.K., and Moller H.J. CD163: a regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. Ann Med 36 (2004) 347-354
8. Ship N.J., Toprak A., Lai R.P., et al. Binding of acellular, native and cross-linked human hemoglobins to haptoglobin: enhanced distribution and clearance in the rat. Am J Physiol Gastrointest Liver Physiol 288 (2005) G1301-G1309
9. Weinstein M.B., and Segal H.L. Uptake of free hemoglobin by rat liver parenchymal cells. Biochem Biophys Res Commun 123 (1984) 489-496
10. Kristiansen M., Graversen J.H., Jacobsen C., et al. Identification of the haemoglobin scavenger receptor. Nature 409 (2001) 198-201
11. Fagoonee S., Gburek J., Hirsch E., et al. Plasma protein haptoglobin modulates renal iron loading. Am J Pathol 166 (2005) 973-983
12. Delanghe J., Langlois M., and De Buyzere M. Congenital anhaptoglobinemia versus acquired hypohaptoglobinemia. Blood 91 (1998) 3524
13. Langlois M.R., and Delanghe J.R. Biological and clinical significance of haptoglobin polymorphism in humans. Clin Chem 42 (1996) 1589-1600
14. Kato G.J., McGowan V., Machado R.F., et al. Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease. Blood 107 (2006) 2279-2285
15. Tolosano E., Fagoonee S., Garuti C., et al. Haptoglobin modifies the hemochromatosis phenotype in mice. Blood 105 (2005) 3353-3355
16. Langlois M.R., Martin M.E., Boelaert J.R., et al. The haptoglobin 2-2 phenotype affects serum markers of iron status in healthy males. Clin Chem 46 (2000) 1619-1625
17. Van Vlierberghe H., Langlois M., Delanghe J., et al. Haptoglobin phenotype 2-2 overrepresentation in Cys282Tyr hemochromatotic patients. J Hepatol 35 (2001) 707-711
18. Lim S.K., Kim H., bin Ali A., et al. Increased susceptibility in Hp knockout mice during acute hemolysis. Blood 92 (1998) 1870-1877
19. Zhou X.Y., Tomatsu S., Fleming R.E., et al. HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc Natl Acad Sci U S A 95 (1998) 2492-2497
20. Pieroni L., Khalil L., Charlotte F., et al. Comparison of bathophenanthroline sulfonate and ferene as chromogens in colorimetric measurement of low hepatic iron concentration. Clin Chem 47 (2001) 2059-2061
21. Laftah A.H., Ramesh B., Simpson R.J., et al. Effect of hepcidin on intestinal iron absorption in mice. Blood 103 (2004) 3940-3944
22. Abboud S., and Haile D.J. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem 275 (2000) 19906-19912
23. Santambrogio P., Cozzi A., Levi S., et al. Functional and immunological analysis of recombinant mouse H- and L-ferritins from Escherichia coli. Protein Expr Purif 19 (2000) 212-218
24. Canonne-Hergaux F., Gruenheid S., Ponka P., et al. Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood 93 (1999) 4406-4417
25. Muckenthaler M., Roy C.N., Custodio A.O., et al. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet 34 (2003) 102-107
26. Ganz T., and Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol 290 (2006) G199-G203
27. Hentze M.W., Muckenthaler M.U., and Andrews N.C. Balancing acts; molecular control of Mammalian iron metabolism. Cell 117 (2004) 285-297
28. McKie A.T., Marciani P., Rolfs A., et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell 5 (2000) 299-309
29. Theurl I., Ludwiczek S., Eller P., et al. Pathways for the regulation of body iron homeostasis in response to experimental iron overload. J Hepatol 43 (2005) 711-719
30. Zoller H., Theurl I., Koch R., et al. Mechanisms of iron mediated regulation of the duodenal iron transporters divalent metal transporter 1 and ferroportin 1. Blood Cells Mol Dis 29 (2002) 488-497
31. Wessling-Resnick M. Iron imports. III. Transfer of iron from the mucosa into circulation. Am J Physiol Gastrointest Liver Physiol 290 (2006) G1-G6
32. Wrighting D.M., and Andrews N.C. Interleukin-6 induces hepcidin expression through STAT3. Blood 108 (2006) 3204-3209
33. Nemeth E., Tuttle M.S., Powelson J., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306 (2004) 2090-2093
34. Knutson M.D., Vafa M.R., Haile D.J., et al. Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages. Blood 102 (2003) 4191-4197
35. Gardenghi S., Marongiu M.F., Ramos P., et al. Ineffective erythropoiesis in (β)-thalassemia is characterized by increased iron absorption mediated by down-regulation of hepcidin and up-regulation of ferroportin. Blood 109 (2007) 5027-5035
36. Gburek J., Verroust P.J., Willnow T.E., et al. Megalin and cubilin are endocytic receptors involved in renal clearance of hemoglobin. J Am Soc Nephrol 13 (2002) 423-430