Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 38, 2009, Pages 16263-16268

  Chen, Wen ^a,b   Paradkar, Prasad N ^c   Li, Liangtao ^c   Pierce, Eric L ^a,b   Langer, Nathaniel B ^a,b   Takahashi Makise, Naoko ^c   Hyde, Brigham B ^d   Shirihai, Orian S ^d   Ward, Diane M ^c   Kaplan, Jerry ^c   Paw, Barry H ^a,b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^d BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Abcb transporters; Erythropoiesis; Iron and heme metabolism; Protein complexes; Solute carriers

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER B10; CARRIER PROTEIN; MITOFERRIN 1; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; COMPLEX FORMATION; CONTROLLED STUDY; ERYTHROBLAST; ERYTHROID CELL; INTRACELLULAR TRANSPORT; IRON TRANSPORT; MITOCHONDRION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTEIN TARGETING; TRANSCRIPTION REGULATION;

ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; IMMUNOPRECIPITATION; IRON; LEUKEMIA, ERYTHROBLASTIC, ACUTE; MEMBRANE TRANSPORT PROTEINS; MICE; MICROSCOPY, CONFOCAL; MITOCHONDRIA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROTEIN BINDING; PROTEIN STABILITY; TRANSFECTION;

EID: 70349479539     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0904519106     Document Type: Article

References (34)

1. Hentze MW, Muckenthaler MU, Andrews NC (2004) Balancing acts: Molecular control of mammalian iron metabolism. Cell 117:285-297.
2. Andrews NC (2000) Iron metabolism: Iron deficiency and iron overload. Annu Rev Genomics Hum Genet 1:75-98.
3. Kaplan J (2002) Mechanism of cellular iron acquisition: Another iron in the fire. Cell 111:603-606.
4. Roy CN, Andrews NC (2001) Recent advances in disorders of iron metabolism: Mutations, mechanisms and modifiers. Hum Mol Genet 10:2181-2186.
5. Rouault TA (2006) The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat Chem Biol 2:406-414. (Pubitemid 44114917)
6. Andrews NC (2008) Forging a field: The golden age of iron biology. Blood 112:219-230.
7. Lim JE, et al. (2005) A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. Nat Genet 37:1270-1273.
8. White RA, et al. (2005) Iron metabolism mutant hbd mice have a deletion in Sec15l1, which has homology to a yeast gene for vesicle docking. Genomics 86:668-673.
9. Ohgami RS, et al. (2005) Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet 37:1264-1269.
10. Fleming MD, et al. (1997) Microcytic anemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 16:383-386.
11. Gushin H, et al. (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388:482-488. (Pubitemid 27328927)
12. Ponka P (1997) Tissue-specific regulation of iron metabolism and heme synthesis: Distinct control mechanisms in erythroid cells. Blood 89:1-25.
13. Napier I, Ponka P, Richardson DR (2005) Iron trafficking in the mitochondria: Novel pathways revealed by disease. Blood 105:1867-1874. (Pubitemid 40731766)
14. Zhang AS, Sheftel AD, Ponka P (2005) Intracellular kinetics of iron in reticulocytes: Evidence for endosome involvement in iron targeting to mitochondria. Blood 105:368-375.
15. Richardson DR, Ponka P, Vyoral D (1996) Distribution of iron in reticulocytes after inhibition of heme synthesis with succinylacetone: Examination of the intermediates involved in iron metabolism. Blood 87:3477-3488. (Pubitemid 26115381)
16. Sheftel AD, Zhang AS, Brown C, Shirihai OS, Ponka P (2007) Direct interorganellar transfer of iron from endosome to mitochondrion. Blood 110:125-132. (Pubitemid 47026827)
17. Foury F, Roganti T (2002) Deletion of the mitochondrial carrier genes MRS3 and MRS4 suppresses mitochondrial iron accumulation in a yeast frataxin-deficient strain. J Biol Chem 277:24475-24483. (Pubitemid 34951972)
18. Mühlenhoff U, et al. (2003) A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions. J Biol Chem 278:40612-40620. (Pubitemid 37280874)
19. Li L, Kaplan J (2004) A mitochondrial-vacuolar signaling pathway in yeast that affects iron and copper metabolism. J Biol Chem 279:33653-33661. (Pubitemid 39063015)
20. Zhang Y, Lyver ER, Knight SA, Lesuisse E, Dancis A (2005) Frataxin and mitochondrial carrier proteins, Mrs3p and Mrs4p, cooperate in providing iron for heme synthesis. J Biol Chem 280:19794-19807. (Pubitemid 41379505)
21. Zhang Y, et al. (2006) Mrs3p, Mrs4p, and frataxin provide iron for Fe-S cluster synthesis in mitochondria. J Biol Chem 281:22493-22502. (Pubitemid 44242278)
22. Shaw GC, et al. (2006) Mitoferrin is essential for erythroid iron assimilation. Nature 440:96-100.
23. Paw BH, et al. (2006) Targeted disruption of the mouse mitoferrin (Slc25A37) mitochondrial solute carrier results in defective primitive and definitive erythropoiesis. Blood 108:82A-83A.
24. Paradkar PN, et al. (2009) Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Mol Cell Biol 29:1007-1016.
25. Shirihai OS, Gregory T, Yu C, Orkin SH, Weiss MJ (2000) ABC-me: A novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. EMBO J 19:2492-2502. (Pubitemid 30323539)
26. Woo AJ, et al. (2008) Identification of ZBP-89 as a novel GATA-1-associated transcription factor involved in megakaryocytic and erythroid development. Mol Cell Biol 28:2675-2689.
27. Palmieri F (2004) The mitochondrial transporter family (SLC25): Physiological and pathological implications. Pflugers Arch 447:689-709.
28. Chen C, et al. (2004) Mitochondrial ATP synthasome: Three-dimensional structure by electron microscopy of the ATP synthase in complex formation with carriers for Pi and ADP/ATP. J Biol Chem 279:31761-33178. (Pubitemid 39037848)
29. Krishnamurthy PC, et al. (2006) Identification of a mammalian mitochondrial porphyrin transporter. Nature 443:586-589.
30. Amigo J, et al. (2008) Mitoferrin1 transgenic zebrafish line serves as a model to study erythroid cell fate during hematopoiesis. Blood 112(11):1223 (abstract 3576).
31. Young L, Leonhard K, Tatsuta T, Trowsdale J, Langer T (2001) Role of the ABC transporter Mdl1 in peptide export from mitochondria. Science 291:2135-2138. (Pubitemid 32224441)
32. Graf SA, Haigh SE, Corson ED, Shirihai OS (2004) Targeting, import, and dimerization of amammalian mitochondrial ATP binding cassette (ABC) transporter, ABCB10 (ABC-me). J Biol Chem 279:42954-42963.
33. Hyde BB, et al. (2008) ABC-Me (ABCB10) is required for erythroid development in the mouse embryo and is protective against mitochondrial oxidative stress. Blood 112(11):199.
34. Lill R, Mühlenhoff U (2008) Maturation of iron-sulfur proteins in eukaryotes: Mechanisms, connected processes, and diseases. Annu Rev Biochem 77:669-700.