-
1
-
-
38649103825
-
Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-κB pathway
-
Ahn, K. S., G. Sethi, and B. B. Aggarwal. 2008. Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-κB pathway. Biochem. Pharmacol. 75, 907-913.
-
(2008)
Biochem. Pharmacol.
, vol.75
, pp. 907-913
-
-
Ahn, K.S.1
Sethi, G.2
Aggarwal, B.B.3
-
2
-
-
58849117190
-
Safety and efficacy of statin therapy in patients switched from cyclosporine a to sirolimus after cardiac transplantation
-
Aliabadi, A. Z., et al. 2008. Safety and efficacy of statin therapy in patients switched from cyclosporine a to sirolimus after cardiac transplantation. Transplantation 86, 1771-1776.
-
(2008)
Transplantation
, vol.86
, pp. 1771-1776
-
-
Aliabadi, A.Z.1
-
3
-
-
38049169559
-
Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
-
Bissler, J. J., et al. 2008. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N. Engl. J. Med. 358, 140-151.
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 140-151
-
-
Bissler, J.J.1
-
4
-
-
0036192275
-
3- Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation
-
Blanco-Colio, L. M., et al. 2002. 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. Atherosclerosis 161, 17-26.
-
(2002)
Atherosclerosis
, vol.161
, pp. 17-26
-
-
Blanco-Colio, L.M.1
-
5
-
-
66449106340
-
Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition
-
Breuleux, M., et al. 2009. Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition. Mol. Cancer Ther. 8, 742-753.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 742-753
-
-
Breuleux, M.1
-
6
-
-
34250818154
-
Fluvastatin enhancement of trastuzumab and classical cytotoxic agents in defined breast cancer cell lines in vitro
-
Budman, D. R., J. Tai, and A. Calabro. 2007. Fluvastatin enhancement of trastuzumab and classical cytotoxic agents in defined breast cancer cell lines in vitro. Breast Cancer Res. Treat. 104, 93-101.
-
(2007)
Breast Cancer Res. Treat.
, vol.104
, pp. 93-101
-
-
Budman, D.R.1
Tai, J.2
Calabro, A.3
-
7
-
-
19844367157
-
Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells
-
Cafforio, P., F. Dammacco, A. Gernone, and F. Silvestris. 2005. Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis 26, 883-891.
-
(2005)
Carcinogenesis
, vol.26
, pp. 883-891
-
-
Cafforio, P.1
Dammacco, F.2
Gernone, A.3
Silvestris, F.4
-
8
-
-
51049085142
-
In- vitro synergism of m-TOR inhibitors, statins, and classical chemotherapy, potential implications in acute leukemia
-
Calabro, A., J. Tai, S. L. Allen, and D. R. Budman. 2008. In-vitro synergism of m-TOR inhibitors, statins, and classical chemotherapy, potential implications in acute leukemia. Anticancer Drugs 19, 705-712.
-
(2008)
Anticancer Drugs
, vol.19
, pp. 705-712
-
-
Calabro, A.1
Tai, J.2
Allen, S.L.3
Budman, D.R.4
-
9
-
-
0041356888
-
Rheb binds TSC2 and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
-
Castro, A. F., J. F. Rebhun, G. G. Clark, and L. A. Quilliam. 2003. Rheb binds TSC2 and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J. Biol. Chem. 278, 32493-32496.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 32493-32496
-
-
Castro, A.F.1
Rebhun, J.F.2
Clark, G.G.3
Quilliam, L.A.4
-
10
-
-
47049103366
-
Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice
-
Cho, S.-J., et al. 2008. Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int. J. Cancer 123, 951-957.
-
(2008)
Int. J. Cancer
, vol.123
, pp. 951-957
-
-
Cho, S.-J.1
-
12
-
-
62449266454
-
TORC-specific phosphorylation of mammalian target of rapamycin (mTOR), phospho-Ser2481 is a marker for intact mTOR signaling complex 2
-
Copp, J., G. Manning, and T. Hunter. 2009. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR), phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res. 69, 1821-1827.
-
(2009)
Cancer Res
, vol.69
, pp. 1821-1827
-
-
Copp, J.1
Manning, G.2
Hunter, T.3
-
13
-
-
0034601013
-
The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis
-
Costello, P. S., S. C. Cleverley, R. Galandrini, S. W. Henning, and D. A. Cantrell. 2000. The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis. J. Exp. Med. 192, 77-85.
-
(2000)
J. Exp. Med.
, vol.192
, pp. 77-85
-
-
Costello, P.S.1
Cleverley, S.C.2
Galandrini, R.3
Henning, S.W.4
Cantrell, D.A.5
-
14
-
-
38049177875
-
Sirolimus therapy in tuberous sclerosis or sporadic lymphangioleiomyomatosis
-
Davies, D. M., et al. 2008. Sirolimus therapy in tuberous sclerosis or sporadic lymphangioleiomyomatosis. N. Engl. J. Med. 358, 200-203.
-
(2008)
N. Engl. J. Med.
, vol.358
, pp. 200-203
-
-
Davies, D.M.1
-
15
-
-
28844490054
-
Statins and cancer prevention
-
Demierre, M.-F., P. D. R. Higgins, S. B. Gruber, E. Hawk, and S. M. Lippman. 2005. Statins and cancer prevention. Nat. Rev. Cancer 5, 930-942.
-
(2005)
Nat. Rev. Cancer
, vol.5
, pp. 930-942
-
-
Demierre, M.-F.1
Higgins, P.D.R.2
Gruber, S.B.3
Hawk, E.4
Lippman, S.M.5
-
16
-
-
0037069690
-
Rho GTPases in cell biology
-
Etienne-Manneville, S., and A. Hall. 2002. Rho GTPases in cell biology. Nature 420, 629-635.
-
(2002)
Nature
, vol.420
, pp. 629-635
-
-
Etienne-Manneville, S.1
Hall, A.2
-
17
-
-
45849100932
-
Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/ cyclin E expression
-
Ferri, N., et al. 2008. Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/ cyclin E expression. Mol. Pharmacol. 74, 144-153.
-
(2008)
Mol. Pharmacol.
, vol.74
, pp. 144-153
-
-
Ferri, N.1
-
18
-
-
35448961560
-
Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity
-
Finlay, G. A., et al. 2007. Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity. Cancer Res. 67, 9878-9886.
-
(2007)
Cancer Res
, vol.67
, pp. 9878-9886
-
-
Finlay, G.A.1
-
19
-
-
0031843339
-
Toxin-induced activation of Rho GTP-binding protein increases Bcl-2 expression and influences mitochondrial homeostasis
-
Fiorentini, C., et al. 1998. Toxin-induced activation of Rho GTP-binding protein increases Bcl-2 expression and influences mitochondrial homeostasis. Exp. Cell Res. 242, 341-350.
-
(1998)
Exp. Cell Res.
, vol.242
, pp. 341-350
-
-
Fiorentini, C.1
-
20
-
-
77952007543
-
Mammalian Target of Rapamycin (mTOR), conducting the cellular signaling symphony
-
Foster, K. G., and D. C. Fingar. 2010. Mammalian Target of Rapamycin (mTOR), conducting the cellular signaling symphony. J. Biol. Chem. 285, 4071-14077.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 14071-14077
-
-
Foster, K.G.1
Fingar, D.C.2
-
21
-
-
33644827461
-
Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
-
Franz, D. N., et al. 2006. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann. Neurol. 59, 490-498.
-
(2006)
Ann. Neurol.
, vol.59
, pp. 490-498
-
-
Franz, D.N.1
-
22
-
-
33749637920
-
RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42//p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation
-
Fromigué, O., et al. 2006. RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42//p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. Cell Death Differ. 13, 1845- 1856.
-
(2006)
Cell Death Differ
, vol.13
, pp. 1845-1856
-
-
Fromigué, O.1
-
23
-
-
50949103203
-
HMGCoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway
-
Fuchs, D., C. Berges, G. Opelz, V. Daniel, and C. Naujokat. 2008. HMGCoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway. Biochem. Biophys. Res. Commun. 374, 309-314.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.374
, pp. 309-314
-
-
Fuchs, D.1
Berges, C.2
Opelz, G.3
Daniel, V.4
Naujokat, C.5
-
24
-
-
0038433304
-
Insulin activation of Rheb, a mediator of mTOR/ S6K/4E-BP signaling, is inhibited by TSC1 and 2
-
Garami, A., et al. 2003. Insulin activation of Rheb, a mediator of mTOR/ S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell 11, 1457-1466.
-
(2003)
Mol. Cell
, vol.11
, pp. 1457-1466
-
-
Garami, A.1
-
25
-
-
77951899665
-
Simvastatin induces derepression of PTEN expression via NFκB to inhibit breast cancer cell growth
-
Ghosh-Choudhury, N., C. C. Mandal, N. Ghosh-Choudhury, and G. Ghosh Choudhury. 2010. Simvastatin induces derepression of PTEN expression via NFκB to inhibit breast cancer cell growth. Cell. Signal. 22, 749-758.
-
(2010)
Cell. Signal.
, vol.22
, pp. 749-758
-
-
Ghosh-Choudhury, N.1
Mandal, C.C.2
Ghosh-Choudhury, N.3
Ghosh Choudhury, G.4
-
26
-
-
1842367878
-
Rho prevents apoptosis through Bcl-2 expression, implications for interleukin-2 receptor signal transduction
-
Gómez, J., C. Martínez-A. M. Giry, A. García, and A. Rebollo. 1997. Rho prevents apoptosis through Bcl-2 expression, implications for interleukin-2 receptor signal transduction. Eur. J. Immunol. 27, 2793-2799.
-
(1997)
Eur. J. Immunol.
, vol.27
, pp. 2793-2799
-
-
Gómez, J.1
Giry, M.-A.M.2
García, A.3
Rebollo, A.4
-
27
-
-
11244277987
-
TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase
-
Goncharova, E., D. Goncharov, D. Noonan, and V. P. Krymskaya. 2004. TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. J. Cell Biol. 167, 1171-1182.
-
(2004)
J. Cell Biol.
, vol.167
, pp. 1171-1182
-
-
Goncharova, E.1
Goncharov, D.2
Noonan, D.3
Krymskaya, V.P.4
-
28
-
-
40849097790
-
Interferon β augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation
-
Goncharova, E. A., et al. 2008. Interferon β augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation. Mol. Pharmacol. 73, 778-788.
-
(2008)
Mol. Pharmacol.
, vol.73
, pp. 778-788
-
-
Goncharova, E.A.1
-
29
-
-
70349331249
-
STAT3 is required for abnormal proliferation and survival of TSC2-deficient cells, relevance to pulmonary LAM
-
Goncharova, E. A., et al. 2009. STAT3 is required for abnormal proliferation and survival of TSC2-deficient cells, relevance to pulmonary LAM. Mol. Pharmacol. 76, 766-777.
-
(2009)
Mol. Pharmacol.
, vol.76
, pp. 766-777
-
-
Goncharova, E.A.1
-
30
-
-
0037163033
-
Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation, a role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)
-
Goncharova, E. A., et al. 2002. Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation, a role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J. Biol. Chem. 277, 30958-30967.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 30958-30967
-
-
Goncharova, E.A.1
-
31
-
-
33645685932
-
Modulation of cell migration and invasiveness by tumor suppressor TSC2 in lymphangioleiomyomatosis
-
Goncharova, E. A., D. A. Goncharov, P. N. Lim, D. Noonan, and V. P. Krymskaya. 2006. Modulation of cell migration and invasiveness by tumor suppressor TSC2 in lymphangioleiomyomatosis. Am. J. Respir. Cell Mol. Biol. 34, 473-480.
-
(2006)
Am. J. Respir. Cell Mol. Biol.
, vol.34
, pp. 473-480
-
-
Goncharova, E.A.1
Goncharov, D.A.2
Lim, P.N.3
Noonan, D.4
Krymskaya, V.P.5
-
32
-
-
33645695725
-
Abnormal smooth muscle cell growth in lymphangioleiomyomatosis (LAM), role for tumor suppressor TSC2
-
Goncharova, E. A., et al. 2006. Abnormal smooth muscle cell growth in lymphangioleiomyomatosis (LAM), role for tumor suppressor TSC2. Am. J. Respir. Cell Mol. Biol. 34, 561-572.
-
(2006)
Am. J. Respir. Cell Mol. Biol.
, vol.34
, pp. 561-572
-
-
Goncharova, E.A.1
-
33
-
-
38649143200
-
Pulmonary lymphangioleiomyomatosis (LAM), progress and current challenges
-
Goncharova, E. A., and V. P. Krymskaya. 2008. Pulmonary lymphangioleiomyomatosis (LAM), progress and current challenges. J. Cell. Biochem. 103, 69-382.
-
(2008)
J. Cell. Biochem.
, vol.103
, pp. 369-382
-
-
Goncharova, E.A.1
Krymskaya, V.P.2
-
34
-
-
34548830141
-
Assays for in vitro monitoring proliferation of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cells
-
Goncharova, E. A., P. Lin, D. A. Goncharov, A. Eszterhas, R. A. Panettieri, Jr., and V. P. Krymskaya. 2006. Assays for in vitro monitoring proliferation of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cells. Nat. Protoc. 1, 2905-2908.
-
(2006)
Nat. Protoc.
, vol.1
, pp. 2905-2908
-
-
Goncharova, E.A.1
Lin, P.2
Goncharov, D.A.3
Eszterhas, A.4
Panettieri Jr., R.A.5
Krymskaya, V.P.6
-
35
-
-
68149096799
-
The pharmacology of mTOR inhibition
-
Guertin, D. A., and D. M. Sabatini. 2009. The pharmacology of mTOR inhibition. Sci. Signal. 2, pe24.
-
(2009)
Sci. Signal.
, vol.2
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
36
-
-
33751348056
-
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKC[alpha], but not S6K1
-
Guertin, D. A., et al. 2006. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKC[alpha], but not S6K1. Dev. Cell 11, 859-871.
-
(2006)
Dev. Cell
, vol.11
, pp. 859-871
-
-
Guertin, D.A.1
-
37
-
-
3342958797
-
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
-
Harrington, L. S., et al. 2004. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166, 213-223.
-
(2004)
J. Cell Biol.
, vol.166
, pp. 213-223
-
-
Harrington, L.S.1
-
38
-
-
0029036505
-
Rodent model of reproductive tract leiomyomata Establishment and characterization of tumor-derived cell lines
-
Howe, S. R., et al. 1995. Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines. Am. J. Pathol. 146, 1568-1579.
-
(1995)
Am. J. Pathol.
, vol.146
, pp. 1568-1579
-
-
Howe, S.R.1
-
39
-
-
0001003612
-
Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members
-
Hsu, S. Y., A. I. Kaipia, E. McGee, M. Lomeli, and A. J. W. Hsueh. 1997. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc. Natl. Acad. Sci. U. S. A. 94, 12401-12406.
-
(1997)
Proc. Natl. Acad. Sci. U. S. A.
, vol.94
, pp. 12401-12406
-
-
Hsu, S.Y.1
Kaipia, A.I.2
McGee, E.3
Lomeli, M.4
Hsueh, A.J.W.5
-
40
-
-
44949215822
-
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
-
Huang, J., C. C. Dibble, M. Matsuzaki, and B. D. Manning. 2008. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol. Cell. Biol. 28, 4104-4115.
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 4104-4115
-
-
Huang, J.1
Dibble, C.C.2
Matsuzaki, M.3
Manning, B.D.4
-
41
-
-
36749068988
-
Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer
-
Huynh, H., C. Teo, and K. Soo. 2007. Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer. Mol. Cancer Ther. , 2959-2966.
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 2959-2966
-
-
Huynh, H.1
Teo, C.2
Soo, K.3
-
43
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki, K., Y. Li, T. Xu, and K.-L. Guan. 2003. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17, 829- 1834.
-
(2003)
Genes Dev
, vol.17
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.-L.4
-
44
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto, E., et al. 2004. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6, 1122-1128.
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
-
45
-
-
27944479854
-
RHO GTPASES, biochemistry and biology
-
Jaffe, A. B., and A. Hall. 2005. RHO GTPASES, biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21, 247-269.
-
(2005)
Annu. Rev. Cell Dev. Biol.
, vol.21
, pp. 247-269
-
-
Jaffe, A.B.1
Hall, A.2
-
46
-
-
33748780944
-
Lymphangioleiomyomatosis
-
Johnson, S. R. 2006. Lymphangioleiomyomatosis. Eur. Respir. J. 27, 1056- 1065.
-
(2006)
Eur. Respir. J.
, vol.27
, pp. 1056-1065
-
-
Johnson, S.R.1
-
47
-
-
70349187211
-
Rho GTPase function in tumorigenesis
-
Karlsson, R., E. D. Pedersen, Z. Wang, and C. Brakebusch. 2009. Rho GTPase function in tumorigenesis. Biochim. Biophys. Acta 1796, 91-98.
-
(2009)
Biochim. Biophys. Acta
, vol.1796
, pp. 91-98
-
-
Karlsson, R.1
Pedersen, E.D.2
Wang, Z.3
Brakebusch, C.4
-
48
-
-
1842788119
-
Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas
-
Katano, H., L. Pesnicak, and J. I. Cohen. 2004. Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas. Proc. Natl. Acad. Sci. U. S. A. 101, 4960-4965.
-
(2004)
Proc. Natl. Acad. Sci. U. S. A.
, vol.101
, pp. 4960-4965
-
-
Katano, H.1
Pesnicak, L.2
Cohen, J.I.3
-
49
-
-
17744394863
-
Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma A randomized controlled trial
-
Kawata, S., et al. 2001. Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial. Br. J. Cancer 84, 86-891.
-
(2001)
Br. J. Cancer
, vol.84
, pp. 886-891
-
-
Kawata, S.1
-
50
-
-
11144262151
-
Effects of rapamycin in the Eker rat model of tuberous sclerosis complex
-
Kenerson, H., T. A. Dundon, and R. S. Yeung. 2005. Effects of rapamycin in the Eker rat model of tuberous sclerosis complex. Pediatr. Res. 57, 67-75.
-
(2005)
Pediatr. Res.
, vol.57
, pp. 67-75
-
-
Kenerson, H.1
Dundon, T.A.2
Yeung, R.S.3
-
51
-
-
0034511179
-
Chasing the cancer demon
-
Knudson, A. G. 2000. Chasing the cancer demon. Annu. Rev. Genet. 34, 1-19.
-
(2000)
Annu. Rev. Genet.
, vol.34
, pp. 1-19
-
-
Knudson, A.G.1
-
52
-
-
78751484981
-
Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and re-duced prostate-specific antigen expression
-
Kochuparambil, S. T., B. Al-Husein, A. Goc, S. Soliman, and P. R. Somanath. 2011. Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and re-duced prostate-specific antigen expression. J. Pharmacol. Exp. Ther. 336, 496-505.
-
(2011)
J. Pharmacol. Exp. Ther.
, vol.336
, pp. 496-505
-
-
Kochuparambil, S.T.1
Al-Husein, B.2
Goc, A.3
Soliman, S.4
Somanath, P.R.5
-
53
-
-
0034834765
-
Population pharmacokinetics of everolimus in de novo renal transplant patients, impact of ethnicity and comedications
-
Kovarik, J. M., C. Hsu, L. McMahon, S. Berthier, and C. Rordorf. 2001. Population pharmacokinetics of everolimus in de novo renal transplant patients, impact of ethnicity and comedications. Clin. Pharmacol. Ther. 70, 247-254.
-
(2001)
Clin. Pharmacol. Ther.
, vol.70
, pp. 247-254
-
-
Kovarik, J.M.1
Hsu, C.2
McMahon, L.3
Berthier, S.4
Rordorf, C.5
-
54
-
-
59449101155
-
PI3K/mTORC1 activation in hamartoma syndromes, therapeutic prospects
-
Krymskaya, V. P., and E. A. Goncharova. 2009. PI3K/mTORC1 activation in hamartoma syndromes, therapeutic prospects. Cell Cycle 8, 403-413.
-
(2009)
Cell Cycle
, vol.8
, pp. 403-413
-
-
Krymskaya, V.P.1
Goncharova, E.A.2
-
56
-
-
0033775869
-
The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
-
Lamb, R. F., et al. 2000. The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat. Cell Biol. 2, 81-287.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 281-287
-
-
Lamb, R.F.1
-
57
-
-
70350418625
-
mTOR signaling at a glance
-
Laplante, M., and D. M. Sabatini. 2009. mTOR signaling at a glance. J. Cell Sci. 122, 3589-3594.
-
(2009)
J. Cell Sci.
, vol.122
, pp. 3589-3594
-
-
Laplante, M.1
Sabatini, D.M.2
-
58
-
-
0033618378
-
3- Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing Rho GTPase-induced down-regulation of p27Kip1
-
Laufs, U., D. Marra, K. Node, and J. K. Liao. 1999. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing Rho GTPase-induced down-regulation of p27Kip1. J. Biol. Chem. 274, 21926-21931.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 21926-21931
-
-
Laufs, U.1
Marra, D.2
Node, K.3
Liao, J.K.4
-
59
-
-
33748485814
-
Combination of a rapamycin analog (CCI-779) and interferon-gamma is more effective than single agents in treating a mouse model of tuberous sclerosis complex
-
Lee, L., P. Sudentas, and S. L. Dabora. 2006. Combination of a rapamycin analog (CCI-779) and interferon-gamma is more effective than single agents in treating a mouse model of tuberous sclerosis complex. Genes Chromosomes Cancer 45, 933-944.
-
(2006)
Genes Chromosomes Cancer
, vol.45
, pp. 933-944
-
-
Lee, L.1
Sudentas, P.2
Dabora, S.L.3
-
60
-
-
19944431403
-
Efficacy of a rapamycin analog (CCI-779) and IFNgamma in tuberous sclerosis mouse models
-
Lee, L., et al. 2005. Efficacy of a rapamycin analog (CCI-779) and IFNgamma in tuberous sclerosis mouse models. Genes Chromosomes Cancer 42, 213-27.
-
(2005)
Genes Chromosomes Cancer
, vol.42
, pp. 213-227
-
-
Lee, L.1
-
61
-
-
65449116467
-
Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models
-
Lee, N., et al. 2009. Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models. BMC Pharmacol. 9, 8.
-
(2009)
BMC Pharmacol
, vol.9
, pp. 8
-
-
Lee, N.1
-
62
-
-
0030953045
-
Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors Similarities and differences
-
Lennernäs, H., and G. Fager. 1997. Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences. Clin. Pharmacokinet. 32, 403-425.
-
(1997)
Clin. Pharmacokinet.
, vol.32
, pp. 403-425
-
-
Lennernäs, H.1
Fager, G.2
-
63
-
-
0347318056
-
TSC2, filling the GAP in the mTOR signaling pathway
-
Li, Y., M. N. Corradetti, K. Inoki, and K.-L. Guan. 2004. TSC2, filling the GAP in the mTOR signaling pathway. Trends Biochem. Sci. 29, 32-38.
-
(2004)
Trends Biochem. Sci.
, vol.29
, pp. 32-38
-
-
Li, Y.1
Corradetti, M.N.2
Inoki, K.3
Guan, K.-L.4
-
64
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith, R., et al. 2002. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10, 457-468.
-
(2002)
Mol. Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
-
65
-
-
21244456553
-
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
-
Long, X., S. Ortiz-Vega, Y. Lin, and J. Avruch. 2005. Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J. Biol. Chem. 280, 23433-23436.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23433-23436
-
-
Long, X.1
Ortiz-Vega, S.2
Lin, Y.3
Avruch, J.4
-
66
-
-
73449139398
-
Down-regulation of RhoA is involved in the cytotoxic action of lipophilic statins in HepG2 cells
-
Maeda, A., et al. 2010. Down-regulation of RhoA is involved in the cytotoxic action of lipophilic statins in HepG2 cells. Atherosclerosis 208, 112-118.
-
(2010)
Atherosclerosis
, vol.208
, pp. 112-118
-
-
Maeda, A.1
-
67
-
-
0034870203
-
Clinical pharmacokinetics of sirolimus
-
Mahalati, K., and B. D. Kahan. 2001. Clinical pharmacokinetics of sirolimus. Clin. Pharmacokinet. 40, 573-585.
-
(2001)
Clin. Pharmacokinet.
, vol.40
, pp. 573-585
-
-
Mahalati, K.1
Kahan, B.D.2
-
68
-
-
38649092279
-
Tuberous sclerosis preclinical studies, timing of treatment, combination of a rapamycin analog (CCI-779) and interferon-gamma, and comparison of rapamycin to CCI-779
-
Messina, M. P., A. Rauktys, L. Lee, and S. L. Dabora. 2007. Tuberous sclerosis preclinical studies, timing of treatment, combination of a rapamycin analog (CCI-779) and interferon-gamma, and comparison of rapamycin to CCI-779. BMC Pharmacol. 7, 14.
-
(2007)
BMC Pharmacol
, vol.7
, pp. 14
-
-
Messina, M.P.1
Rauktys, A.2
Lee, L.3
Dabora, S.L.4
-
69
-
-
0030064388
-
The side effect profile of sirolimus, a phase I study in quiescent cyclosporine-prednisone-treated renal transplant patients
-
Murgia, M. G., S. Jordan, and B. D. Kahan. 1996. The side effect profile of sirolimus, a phase I study in quiescent cyclosporine-prednisone-treated renal transplant patients. Kidney Int. 49, 209-216.
-
(1996)
Kidney Int
, vol.49
, pp. 209-216
-
-
Murgia, M.G.1
Jordan, S.2
Kahan, B.D.3
-
70
-
-
52449135575
-
Statins and prostate cancer prevention, where we are now, and future directions
-
Murtola, T. J., T. Visakorpi, J. Lahtela, H. Syvala, and T. L. J. Tammela. 2008. Statins and prostate cancer prevention, where we are now, and future directions. Nat. Clin. Pract. Urol. 5, 376-387.
-
(2008)
Nat. Clin. Pract. Urol.
, vol.5
, pp. 376-387
-
-
Murtola, T.J.1
Visakorpi, T.2
Lahtela, J.3
Syvala, H.4
Tammela, T.L.J.5
-
71
-
-
57849128116
-
Role for protein geranylgeranylation in adult T-cell leukemia cell survival
-
Nonaka, M., et al. 2009. Role for protein geranylgeranylation in adult T-cell leukemia cell survival. Exp. Cell Res. 315, 141-150.
-
(2009)
Exp. Cell Res.
, vol.315
, pp. 141-150
-
-
Nonaka, M.1
-
72
-
-
67650077581
-
Equivalent benefit of mTORC1 blockade and combined PI3KmTOR blockade in a mouse model of tuberous sclerosis
-
Pollizzi, K., I. Malinowska-Kolodziej, M. Stumm, H. Lane, and D. Kwiatkowski. 2009. Equivalent benefit of mTORC1 blockade and combined PI3KmTOR blockade in a mouse model of tuberous sclerosis. Mol. Cancer 8, 38.
-
(2009)
Mol. Cancer
, vol.8
, pp. 38
-
-
Pollizzi, K.1
Malinowska-Kolodziej, I.2
Stumm, M.3
Lane, H.4
Kwiatkowski, D.5
-
73
-
-
31844436074
-
Rho/ROCK pathway as a target of tumor therapy
-
Rattan, R., S. Giri, A. K. Singh, and I. Singh. 2006. Rho/ROCK pathway as a target of tumor therapy. J. Neurosci. Res. 83, 243-255.
-
(2006)
J. Neurosci. Res.
, vol.83
, pp. 243-255
-
-
Rattan, R.1
Giri, S.2
Singh, A.K.3
Singh, I.4
-
75
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov, D. D., et al. 2004. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
-
76
-
-
0034644525
-
TOR, a central controller of cell growth
-
Schmelzle, T., and M. N. Hall. 2000. TOR, a central controller of cell growth. Cell 103, 253-262.
-
(2000)
Cell
, vol.103
, pp. 253-262
-
-
Schmelzle, T.1
Hall, M.N.2
-
77
-
-
0030906569
-
The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2
-
Schmidt, A., M. Bickle, T. Beck, and M. N. Hall. 1997. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88, 531-542.
-
(1997)
Cell
, vol.88
, pp. 531-542
-
-
Schmidt, A.1
Bickle, M.2
Beck, T.3
Hall, M.N.4
-
78
-
-
21444448246
-
Retrospective analysis of hyperlipidemia management in a transplant population
-
Schonder, K. S., T. P. McKaveney, and K. J. Lynch. 2005. Retrospective analysis of hyperlipidemia management in a transplant population. harmacotherapy 25, 918-923.
-
(2005)
Pharmacotherapy
, vol.25
, pp. 918-923
-
-
Schonder, K.S.1
McKaveney, T.P.2
Lynch, K.J.3
-
79
-
-
0033006201
-
3- Hydroxy-3-methylglutaryl CoA reductase inhibitors reduce serum triglyceride levels through modulation of apolipoprotein C-III and lipoprotein lipase
-
Schoonjans, K., et al. 1999. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors reduce serum triglyceride levels through modulation of apolipoprotein C-III and lipoprotein lipase. FEBS Lett. 452, 160-164.
-
(1999)
FEBS Lett
, vol.452
, pp. 160-164
-
-
Schoonjans, K.1
-
80
-
-
4544343980
-
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
-
Shah, O. J., Z. Wang, and T. Hunter. 2004. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14, 1650-1656.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1650-1656
-
-
Shah, O.J.1
Wang, Z.2
Hunter, T.3
-
81
-
-
33748950810
-
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
-
Shiota, C., J. Woo, J. Lindner, K. D. Shelton, and M. A. Magnuson. 2006. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev. Cell 11, 583-589.
-
(2006)
Dev. Cell
, vol.11
, pp. 583-589
-
-
Shiota, C.1
Woo, J.2
Lindner, J.3
Shelton, K.D.4
Magnuson, M.A.5
-
82
-
-
77950900079
-
mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action
-
Soliman, G. A., et al. 2010. mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. J. Biol. Chem. 285, 7866-7879.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 7866-7879
-
-
Soliman, G.A.1
-
83
-
-
23844438209
-
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
-
Sun, S. Y., et al. 2005. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res. 65, 052-7058.
-
(2005)
Cancer Res
, vol.65
, pp. 7052-7058
-
-
Sun, S.Y.1
-
84
-
-
33750468907
-
Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin
-
Takeda, N., et al. 2006. Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin. Am. J. Respir. Cell Mol. iol. 35, 722-729.
-
(2006)
Am. J. Respir. Cell Mol. Biol.
, vol.35
, pp. 722-729
-
-
Takeda, N.1
-
86
-
-
0030010318
-
Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer
-
Thibault, A., et al. 1996. Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer. Clin. Cancer Res. 2, 483-491.
-
(1996)
Clin. Cancer Res.
, vol.2
, pp. 483-491
-
-
Thibault, A.1
-
87
-
-
0034795339
-
Use of isogenic human cancer cells for high-throughput screening and drug discovery
-
Torrance, C. J., V. Agrawal, B. Vogelstein, and K. W. Kinzler. 2001. Use of isogenic human cancer cells for high-throughput screening and drug discovery. Nat. Biotechnol. 19, 940-945.
-
(2001)
Nat. Biotechnol.
, vol.19
, pp. 940-945
-
-
Torrance, C.J.1
Agrawal, V.2
Vogelstein, B.3
Kinzler, K.W.4
-
88
-
-
4544220704
-
Absence of S6K1 protects against age- and dietinduced obesity while enhancing insulin sensitivity
-
Um, S. H., et al. 2004. Absence of S6K1 protects against age- and dietinduced obesity while enhancing insulin sensitivity. Nature 431, 200-205.
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
-
90
-
-
34447295155
-
Simvastatin-dependent apoptosis in Hodgkin's lymphoma cells and growth impairment of human Hodgkin's tumors in vivo
-
von Tresckow, B., et al. 2007. Simvastatin-dependent apoptosis in Hodgkin's lymphoma cells and growth impairment of human Hodgkin's tumors in vivo. Haematologica 92, 682-685.
-
(2007)
Haematologica
, vol.92
, pp. 682-685
-
-
von Tresckow, B.1
-
91
-
-
0036239832
-
HMG- CoA reductase inhibitors and the malignant cell, the statin family of drugs as triggers of tumor-specific apoptosis
-
Wong, W. W., J. Dimitroulakos, M. D. Minden, and L. Z. Penn. 2002. HMG-CoA reductase inhibitors and the malignant cell, the statin family of drugs as triggers of tumor-specific apoptosis. Leukemia 16, 508-519.
-
(2002)
Leukemia
, vol.16
, pp. 508-519
-
-
Wong, W.W.1
Dimitroulakos, J.2
Minden, M.D.3
Penn, L.Z.4
-
92
-
-
4644261860
-
Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis
-
Wu, J., W. W. Wong, F. Khosravi, M. D. Minden, and L. Z. Penn. 2004. Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis. Cancer Res. 64, 6461-6468.
-
(2004)
Cancer Res
, vol.64
, pp. 6461-6468
-
-
Wu, J.1
Wong, W.W.2
Khosravi, F.3
Minden, M.D.4
Penn, L.Z.5
-
93
-
-
0344155285
-
Multiple roles of the tuberous sclerosis complex genes
-
Yeung, R. S. 2003. Multiple roles of the tuberous sclerosis complex genes. Genes Chromosomes Cancer 38, 368-375.
-
(2003)
Genes Chromosomes Cancer
, vol.38
, pp. 368-375
-
-
Yeung, R.S.1
-
94
-
-
0347988005
-
Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
-
Zhang, H., et al. 2003. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. J. Clin. Invest. 112, 1223-233.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 1223-1233
-
-
Zhang, H.1
-
95
-
-
0038141979
-
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
-
Zhang, Y., et al. 2003. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat. Cell Biol. 5, 578-581.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 578-581
-
-
Zhang, Y.1
-
96
-
-
33644697765
-
Exposure-response relationships and drug interactions of sirolimus
-
Zimmerman, J. J. 2004. Exposure-response relationships and drug interactions of sirolimus. AAPS J. 6, e28.
-
(2004)
AAPS J
, vol.6
-
-
Zimmerman, J.J.1
|