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Volumn 31, Issue 12, 2011, Pages 2484-2498

mTORC2 is required for proliferation and survival of TSC2-null cells

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 2; PROTEIN BCL 2; PROTEIN KINASE B; PUMA PROTEIN; RAPAMYCIN; RHEB PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SIMVASTATIN; SMALL INTERFERING RNA; TUBERIN;

EID: 79958068761     PISSN: 02707306     EISSN: 10985549     Source Type: Journal    
DOI: 10.1128/MCB.01061-10     Document Type: Article
Times cited : (107)

References (96)
  • 1
    • 38649103825 scopus 로고    scopus 로고
    • Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-κB pathway
    • Ahn, K. S., G. Sethi, and B. B. Aggarwal. 2008. Reversal of chemoresistance and enhancement of apoptosis by statins through down-regulation of the NF-κB pathway. Biochem. Pharmacol. 75, 907-913.
    • (2008) Biochem. Pharmacol. , vol.75 , pp. 907-913
    • Ahn, K.S.1    Sethi, G.2    Aggarwal, B.B.3
  • 2
    • 58849117190 scopus 로고    scopus 로고
    • Safety and efficacy of statin therapy in patients switched from cyclosporine a to sirolimus after cardiac transplantation
    • Aliabadi, A. Z., et al. 2008. Safety and efficacy of statin therapy in patients switched from cyclosporine a to sirolimus after cardiac transplantation. Transplantation 86, 1771-1776.
    • (2008) Transplantation , vol.86 , pp. 1771-1776
    • Aliabadi, A.Z.1
  • 3
    • 38049169559 scopus 로고    scopus 로고
    • Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis
    • Bissler, J. J., et al. 2008. Sirolimus for angiomyolipoma in tuberous sclerosis complex or lymphangioleiomyomatosis. N. Engl. J. Med. 358, 140-151.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 140-151
    • Bissler, J.J.1
  • 4
    • 0036192275 scopus 로고    scopus 로고
    • 3- Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation
    • Blanco-Colio, L. M., et al. 2002. 3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation. Atherosclerosis 161, 17-26.
    • (2002) Atherosclerosis , vol.161 , pp. 17-26
    • Blanco-Colio, L.M.1
  • 5
    • 66449106340 scopus 로고    scopus 로고
    • Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition
    • Breuleux, M., et al. 2009. Increased AKT S473 phosphorylation after mTORC1 inhibition is rictor dependent and does not predict tumor cell response to PI3K/mTOR inhibition. Mol. Cancer Ther. 8, 742-753.
    • (2009) Mol. Cancer Ther. , vol.8 , pp. 742-753
    • Breuleux, M.1
  • 6
    • 34250818154 scopus 로고    scopus 로고
    • Fluvastatin enhancement of trastuzumab and classical cytotoxic agents in defined breast cancer cell lines in vitro
    • Budman, D. R., J. Tai, and A. Calabro. 2007. Fluvastatin enhancement of trastuzumab and classical cytotoxic agents in defined breast cancer cell lines in vitro. Breast Cancer Res. Treat. 104, 93-101.
    • (2007) Breast Cancer Res. Treat. , vol.104 , pp. 93-101
    • Budman, D.R.1    Tai, J.2    Calabro, A.3
  • 7
    • 19844367157 scopus 로고    scopus 로고
    • Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells
    • Cafforio, P., F. Dammacco, A. Gernone, and F. Silvestris. 2005. Statins activate the mitochondrial pathway of apoptosis in human lymphoblasts and myeloma cells. Carcinogenesis 26, 883-891.
    • (2005) Carcinogenesis , vol.26 , pp. 883-891
    • Cafforio, P.1    Dammacco, F.2    Gernone, A.3    Silvestris, F.4
  • 8
    • 51049085142 scopus 로고    scopus 로고
    • In- vitro synergism of m-TOR inhibitors, statins, and classical chemotherapy, potential implications in acute leukemia
    • Calabro, A., J. Tai, S. L. Allen, and D. R. Budman. 2008. In-vitro synergism of m-TOR inhibitors, statins, and classical chemotherapy, potential implications in acute leukemia. Anticancer Drugs 19, 705-712.
    • (2008) Anticancer Drugs , vol.19 , pp. 705-712
    • Calabro, A.1    Tai, J.2    Allen, S.L.3    Budman, D.R.4
  • 9
    • 0041356888 scopus 로고    scopus 로고
    • Rheb binds TSC2 and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
    • Castro, A. F., J. F. Rebhun, G. G. Clark, and L. A. Quilliam. 2003. Rheb binds TSC2 and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J. Biol. Chem. 278, 32493-32496.
    • (2003) J. Biol. Chem. , vol.278 , pp. 32493-32496
    • Castro, A.F.1    Rebhun, J.F.2    Clark, G.G.3    Quilliam, L.A.4
  • 10
    • 47049103366 scopus 로고    scopus 로고
    • Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice
    • Cho, S.-J., et al. 2008. Simvastatin induces apoptosis in human colon cancer cells and in tumor xenografts, and attenuates colitis-associated colon cancer in mice. Int. J. Cancer 123, 951-957.
    • (2008) Int. J. Cancer , vol.123 , pp. 951-957
    • Cho, S.-J.1
  • 11
  • 12
    • 62449266454 scopus 로고    scopus 로고
    • TORC-specific phosphorylation of mammalian target of rapamycin (mTOR), phospho-Ser2481 is a marker for intact mTOR signaling complex 2
    • Copp, J., G. Manning, and T. Hunter. 2009. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR), phospho-Ser2481 is a marker for intact mTOR signaling complex 2. Cancer Res. 69, 1821-1827.
    • (2009) Cancer Res , vol.69 , pp. 1821-1827
    • Copp, J.1    Manning, G.2    Hunter, T.3
  • 14
    • 38049177875 scopus 로고    scopus 로고
    • Sirolimus therapy in tuberous sclerosis or sporadic lymphangioleiomyomatosis
    • Davies, D. M., et al. 2008. Sirolimus therapy in tuberous sclerosis or sporadic lymphangioleiomyomatosis. N. Engl. J. Med. 358, 200-203.
    • (2008) N. Engl. J. Med. , vol.358 , pp. 200-203
    • Davies, D.M.1
  • 16
    • 0037069690 scopus 로고    scopus 로고
    • Rho GTPases in cell biology
    • Etienne-Manneville, S., and A. Hall. 2002. Rho GTPases in cell biology. Nature 420, 629-635.
    • (2002) Nature , vol.420 , pp. 629-635
    • Etienne-Manneville, S.1    Hall, A.2
  • 17
    • 45849100932 scopus 로고    scopus 로고
    • Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/ cyclin E expression
    • Ferri, N., et al. 2008. Fluvastatin synergistically improves the antiproliferative effect of everolimus on rat smooth muscle cells by altering p27Kip1/ cyclin E expression. Mol. Pharmacol. 74, 144-153.
    • (2008) Mol. Pharmacol. , vol.74 , pp. 144-153
    • Ferri, N.1
  • 18
    • 35448961560 scopus 로고    scopus 로고
    • Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity
    • Finlay, G. A., et al. 2007. Selective inhibition of growth of tuberous sclerosis complex 2 null cells by atorvastatin is associated with impaired Rheb and Rho GTPase function and reduced mTOR/S6 kinase activity. Cancer Res. 67, 9878-9886.
    • (2007) Cancer Res , vol.67 , pp. 9878-9886
    • Finlay, G.A.1
  • 19
    • 0031843339 scopus 로고    scopus 로고
    • Toxin-induced activation of Rho GTP-binding protein increases Bcl-2 expression and influences mitochondrial homeostasis
    • Fiorentini, C., et al. 1998. Toxin-induced activation of Rho GTP-binding protein increases Bcl-2 expression and influences mitochondrial homeostasis. Exp. Cell Res. 242, 341-350.
    • (1998) Exp. Cell Res. , vol.242 , pp. 341-350
    • Fiorentini, C.1
  • 20
    • 77952007543 scopus 로고    scopus 로고
    • Mammalian Target of Rapamycin (mTOR), conducting the cellular signaling symphony
    • Foster, K. G., and D. C. Fingar. 2010. Mammalian Target of Rapamycin (mTOR), conducting the cellular signaling symphony. J. Biol. Chem. 285, 4071-14077.
    • (2010) J. Biol. Chem. , vol.285 , pp. 14071-14077
    • Foster, K.G.1    Fingar, D.C.2
  • 21
    • 33644827461 scopus 로고    scopus 로고
    • Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
    • Franz, D. N., et al. 2006. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann. Neurol. 59, 490-498.
    • (2006) Ann. Neurol. , vol.59 , pp. 490-498
    • Franz, D.N.1
  • 22
    • 33749637920 scopus 로고    scopus 로고
    • RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42//p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation
    • Fromigué, O., et al. 2006. RhoA GTPase inactivation by statins induces osteosarcoma cell apoptosis by inhibiting p42//p44-MAPKs-Bcl-2 signaling independently of BMP-2 and cell differentiation. Cell Death Differ. 13, 1845- 1856.
    • (2006) Cell Death Differ , vol.13 , pp. 1845-1856
    • Fromigué, O.1
  • 23
    • 50949103203 scopus 로고    scopus 로고
    • HMGCoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway
    • Fuchs, D., C. Berges, G. Opelz, V. Daniel, and C. Naujokat. 2008. HMGCoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway. Biochem. Biophys. Res. Commun. 374, 309-314.
    • (2008) Biochem. Biophys. Res. Commun. , vol.374 , pp. 309-314
    • Fuchs, D.1    Berges, C.2    Opelz, G.3    Daniel, V.4    Naujokat, C.5
  • 24
    • 0038433304 scopus 로고    scopus 로고
    • Insulin activation of Rheb, a mediator of mTOR/ S6K/4E-BP signaling, is inhibited by TSC1 and 2
    • Garami, A., et al. 2003. Insulin activation of Rheb, a mediator of mTOR/ S6K/4E-BP signaling, is inhibited by TSC1 and 2. Mol. Cell 11, 1457-1466.
    • (2003) Mol. Cell , vol.11 , pp. 1457-1466
    • Garami, A.1
  • 25
    • 77951899665 scopus 로고    scopus 로고
    • Simvastatin induces derepression of PTEN expression via NFκB to inhibit breast cancer cell growth
    • Ghosh-Choudhury, N., C. C. Mandal, N. Ghosh-Choudhury, and G. Ghosh Choudhury. 2010. Simvastatin induces derepression of PTEN expression via NFκB to inhibit breast cancer cell growth. Cell. Signal. 22, 749-758.
    • (2010) Cell. Signal. , vol.22 , pp. 749-758
    • Ghosh-Choudhury, N.1    Mandal, C.C.2    Ghosh-Choudhury, N.3    Ghosh Choudhury, G.4
  • 26
    • 1842367878 scopus 로고    scopus 로고
    • Rho prevents apoptosis through Bcl-2 expression, implications for interleukin-2 receptor signal transduction
    • Gómez, J., C. Martínez-A. M. Giry, A. García, and A. Rebollo. 1997. Rho prevents apoptosis through Bcl-2 expression, implications for interleukin-2 receptor signal transduction. Eur. J. Immunol. 27, 2793-2799.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 2793-2799
    • Gómez, J.1    Giry, M.-A.M.2    García, A.3    Rebollo, A.4
  • 27
    • 11244277987 scopus 로고    scopus 로고
    • TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase
    • Goncharova, E., D. Goncharov, D. Noonan, and V. P. Krymskaya. 2004. TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. J. Cell Biol. 167, 1171-1182.
    • (2004) J. Cell Biol. , vol.167 , pp. 1171-1182
    • Goncharova, E.1    Goncharov, D.2    Noonan, D.3    Krymskaya, V.P.4
  • 28
    • 40849097790 scopus 로고    scopus 로고
    • Interferon β augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation
    • Goncharova, E. A., et al. 2008. Interferon β augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation. Mol. Pharmacol. 73, 778-788.
    • (2008) Mol. Pharmacol. , vol.73 , pp. 778-788
    • Goncharova, E.A.1
  • 29
    • 70349331249 scopus 로고    scopus 로고
    • STAT3 is required for abnormal proliferation and survival of TSC2-deficient cells, relevance to pulmonary LAM
    • Goncharova, E. A., et al. 2009. STAT3 is required for abnormal proliferation and survival of TSC2-deficient cells, relevance to pulmonary LAM. Mol. Pharmacol. 76, 766-777.
    • (2009) Mol. Pharmacol. , vol.76 , pp. 766-777
    • Goncharova, E.A.1
  • 30
    • 0037163033 scopus 로고    scopus 로고
    • Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation, a role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)
    • Goncharova, E. A., et al. 2002. Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation, a role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J. Biol. Chem. 277, 30958-30967.
    • (2002) J. Biol. Chem. , vol.277 , pp. 30958-30967
    • Goncharova, E.A.1
  • 32
    • 33645695725 scopus 로고    scopus 로고
    • Abnormal smooth muscle cell growth in lymphangioleiomyomatosis (LAM), role for tumor suppressor TSC2
    • Goncharova, E. A., et al. 2006. Abnormal smooth muscle cell growth in lymphangioleiomyomatosis (LAM), role for tumor suppressor TSC2. Am. J. Respir. Cell Mol. Biol. 34, 561-572.
    • (2006) Am. J. Respir. Cell Mol. Biol. , vol.34 , pp. 561-572
    • Goncharova, E.A.1
  • 33
    • 38649143200 scopus 로고    scopus 로고
    • Pulmonary lymphangioleiomyomatosis (LAM), progress and current challenges
    • Goncharova, E. A., and V. P. Krymskaya. 2008. Pulmonary lymphangioleiomyomatosis (LAM), progress and current challenges. J. Cell. Biochem. 103, 69-382.
    • (2008) J. Cell. Biochem. , vol.103 , pp. 369-382
    • Goncharova, E.A.1    Krymskaya, V.P.2
  • 34
    • 34548830141 scopus 로고    scopus 로고
    • Assays for in vitro monitoring proliferation of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cells
    • Goncharova, E. A., P. Lin, D. A. Goncharov, A. Eszterhas, R. A. Panettieri, Jr., and V. P. Krymskaya. 2006. Assays for in vitro monitoring proliferation of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cells. Nat. Protoc. 1, 2905-2908.
    • (2006) Nat. Protoc. , vol.1 , pp. 2905-2908
    • Goncharova, E.A.1    Lin, P.2    Goncharov, D.A.3    Eszterhas, A.4    Panettieri Jr., R.A.5    Krymskaya, V.P.6
  • 35
    • 68149096799 scopus 로고    scopus 로고
    • The pharmacology of mTOR inhibition
    • Guertin, D. A., and D. M. Sabatini. 2009. The pharmacology of mTOR inhibition. Sci. Signal. 2, pe24.
    • (2009) Sci. Signal. , vol.2
    • Guertin, D.A.1    Sabatini, D.M.2
  • 36
    • 33751348056 scopus 로고    scopus 로고
    • Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKC[alpha], but not S6K1
    • Guertin, D. A., et al. 2006. Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKC[alpha], but not S6K1. Dev. Cell 11, 859-871.
    • (2006) Dev. Cell , vol.11 , pp. 859-871
    • Guertin, D.A.1
  • 37
    • 3342958797 scopus 로고    scopus 로고
    • The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
    • Harrington, L. S., et al. 2004. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J. Cell Biol. 166, 213-223.
    • (2004) J. Cell Biol. , vol.166 , pp. 213-223
    • Harrington, L.S.1
  • 38
    • 0029036505 scopus 로고
    • Rodent model of reproductive tract leiomyomata Establishment and characterization of tumor-derived cell lines
    • Howe, S. R., et al. 1995. Rodent model of reproductive tract leiomyomata. Establishment and characterization of tumor-derived cell lines. Am. J. Pathol. 146, 1568-1579.
    • (1995) Am. J. Pathol. , vol.146 , pp. 1568-1579
    • Howe, S.R.1
  • 39
    • 0001003612 scopus 로고    scopus 로고
    • Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members
    • Hsu, S. Y., A. I. Kaipia, E. McGee, M. Lomeli, and A. J. W. Hsueh. 1997. Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc. Natl. Acad. Sci. U. S. A. 94, 12401-12406.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 12401-12406
    • Hsu, S.Y.1    Kaipia, A.I.2    McGee, E.3    Lomeli, M.4    Hsueh, A.J.W.5
  • 40
    • 44949215822 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
    • Huang, J., C. C. Dibble, M. Matsuzaki, and B. D. Manning. 2008. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol. Cell. Biol. 28, 4104-4115.
    • (2008) Mol. Cell. Biol. , vol.28 , pp. 4104-4115
    • Huang, J.1    Dibble, C.C.2    Matsuzaki, M.3    Manning, B.D.4
  • 41
    • 36749068988 scopus 로고    scopus 로고
    • Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer
    • Huynh, H., C. Teo, and K. Soo. 2007. Bevacizumab and rapamycin inhibit tumor growth in peritoneal model of human ovarian cancer. Mol. Cancer Ther. , 2959-2966.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 2959-2966
    • Huynh, H.1    Teo, C.2    Soo, K.3
  • 43
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki, K., Y. Li, T. Xu, and K.-L. Guan. 2003. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17, 829- 1834.
    • (2003) Genes Dev , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.-L.4
  • 44
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • Jacinto, E., et al. 2004. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6, 1122-1128.
    • (2004) Nat. Cell Biol. , vol.6 , pp. 1122-1128
    • Jacinto, E.1
  • 45
    • 27944479854 scopus 로고    scopus 로고
    • RHO GTPASES, biochemistry and biology
    • Jaffe, A. B., and A. Hall. 2005. RHO GTPASES, biochemistry and biology. Annu. Rev. Cell Dev. Biol. 21, 247-269.
    • (2005) Annu. Rev. Cell Dev. Biol. , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 46
    • 33748780944 scopus 로고    scopus 로고
    • Lymphangioleiomyomatosis
    • Johnson, S. R. 2006. Lymphangioleiomyomatosis. Eur. Respir. J. 27, 1056- 1065.
    • (2006) Eur. Respir. J. , vol.27 , pp. 1056-1065
    • Johnson, S.R.1
  • 48
    • 1842788119 scopus 로고    scopus 로고
    • Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas
    • Katano, H., L. Pesnicak, and J. I. Cohen. 2004. Simvastatin induces apoptosis of Epstein-Barr virus (EBV)-transformed lymphoblastoid cell lines and delays development of EBV lymphomas. Proc. Natl. Acad. Sci. U. S. A. 101, 4960-4965.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , pp. 4960-4965
    • Katano, H.1    Pesnicak, L.2    Cohen, J.I.3
  • 49
    • 17744394863 scopus 로고    scopus 로고
    • Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma A randomized controlled trial
    • Kawata, S., et al. 2001. Effect of pravastatin on survival in patients with advanced hepatocellular carcinoma. A randomized controlled trial. Br. J. Cancer 84, 86-891.
    • (2001) Br. J. Cancer , vol.84 , pp. 886-891
    • Kawata, S.1
  • 50
    • 11144262151 scopus 로고    scopus 로고
    • Effects of rapamycin in the Eker rat model of tuberous sclerosis complex
    • Kenerson, H., T. A. Dundon, and R. S. Yeung. 2005. Effects of rapamycin in the Eker rat model of tuberous sclerosis complex. Pediatr. Res. 57, 67-75.
    • (2005) Pediatr. Res. , vol.57 , pp. 67-75
    • Kenerson, H.1    Dundon, T.A.2    Yeung, R.S.3
  • 51
    • 0034511179 scopus 로고    scopus 로고
    • Chasing the cancer demon
    • Knudson, A. G. 2000. Chasing the cancer demon. Annu. Rev. Genet. 34, 1-19.
    • (2000) Annu. Rev. Genet. , vol.34 , pp. 1-19
    • Knudson, A.G.1
  • 52
    • 78751484981 scopus 로고    scopus 로고
    • Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and re-duced prostate-specific antigen expression
    • Kochuparambil, S. T., B. Al-Husein, A. Goc, S. Soliman, and P. R. Somanath. 2011. Anticancer efficacy of simvastatin on prostate cancer cells and tumor xenografts is associated with inhibition of Akt and re-duced prostate-specific antigen expression. J. Pharmacol. Exp. Ther. 336, 496-505.
    • (2011) J. Pharmacol. Exp. Ther. , vol.336 , pp. 496-505
    • Kochuparambil, S.T.1    Al-Husein, B.2    Goc, A.3    Soliman, S.4    Somanath, P.R.5
  • 53
    • 0034834765 scopus 로고    scopus 로고
    • Population pharmacokinetics of everolimus in de novo renal transplant patients, impact of ethnicity and comedications
    • Kovarik, J. M., C. Hsu, L. McMahon, S. Berthier, and C. Rordorf. 2001. Population pharmacokinetics of everolimus in de novo renal transplant patients, impact of ethnicity and comedications. Clin. Pharmacol. Ther. 70, 247-254.
    • (2001) Clin. Pharmacol. Ther. , vol.70 , pp. 247-254
    • Kovarik, J.M.1    Hsu, C.2    McMahon, L.3    Berthier, S.4    Rordorf, C.5
  • 54
    • 59449101155 scopus 로고    scopus 로고
    • PI3K/mTORC1 activation in hamartoma syndromes, therapeutic prospects
    • Krymskaya, V. P., and E. A. Goncharova. 2009. PI3K/mTORC1 activation in hamartoma syndromes, therapeutic prospects. Cell Cycle 8, 403-413.
    • (2009) Cell Cycle , vol.8 , pp. 403-413
    • Krymskaya, V.P.1    Goncharova, E.A.2
  • 56
    • 0033775869 scopus 로고    scopus 로고
    • The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho
    • Lamb, R. F., et al. 2000. The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat. Cell Biol. 2, 81-287.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 281-287
    • Lamb, R.F.1
  • 57
    • 70350418625 scopus 로고    scopus 로고
    • mTOR signaling at a glance
    • Laplante, M., and D. M. Sabatini. 2009. mTOR signaling at a glance. J. Cell Sci. 122, 3589-3594.
    • (2009) J. Cell Sci. , vol.122 , pp. 3589-3594
    • Laplante, M.1    Sabatini, D.M.2
  • 58
    • 0033618378 scopus 로고    scopus 로고
    • 3- Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing Rho GTPase-induced down-regulation of p27Kip1
    • Laufs, U., D. Marra, K. Node, and J. K. Liao. 1999. 3-Hydroxy-3-methylglutaryl-CoA reductase inhibitors attenuate vascular smooth muscle proliferation by preventing Rho GTPase-induced down-regulation of p27Kip1. J. Biol. Chem. 274, 21926-21931.
    • (1999) J. Biol. Chem. , vol.274 , pp. 21926-21931
    • Laufs, U.1    Marra, D.2    Node, K.3    Liao, J.K.4
  • 59
    • 33748485814 scopus 로고    scopus 로고
    • Combination of a rapamycin analog (CCI-779) and interferon-gamma is more effective than single agents in treating a mouse model of tuberous sclerosis complex
    • Lee, L., P. Sudentas, and S. L. Dabora. 2006. Combination of a rapamycin analog (CCI-779) and interferon-gamma is more effective than single agents in treating a mouse model of tuberous sclerosis complex. Genes Chromosomes Cancer 45, 933-944.
    • (2006) Genes Chromosomes Cancer , vol.45 , pp. 933-944
    • Lee, L.1    Sudentas, P.2    Dabora, S.L.3
  • 60
    • 19944431403 scopus 로고    scopus 로고
    • Efficacy of a rapamycin analog (CCI-779) and IFNgamma in tuberous sclerosis mouse models
    • Lee, L., et al. 2005. Efficacy of a rapamycin analog (CCI-779) and IFNgamma in tuberous sclerosis mouse models. Genes Chromosomes Cancer 42, 213-27.
    • (2005) Genes Chromosomes Cancer , vol.42 , pp. 213-227
    • Lee, L.1
  • 61
    • 65449116467 scopus 로고    scopus 로고
    • Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models
    • Lee, N., et al. 2009. Rapamycin weekly maintenance dosing and the potential efficacy of combination sorafenib plus rapamycin but not atorvastatin or doxycycline in tuberous sclerosis preclinical models. BMC Pharmacol. 9, 8.
    • (2009) BMC Pharmacol , vol.9 , pp. 8
    • Lee, N.1
  • 62
    • 0030953045 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors Similarities and differences
    • Lennernäs, H., and G. Fager. 1997. Pharmacodynamics and pharmacokinetics of the HMG-CoA reductase inhibitors. Similarities and differences. Clin. Pharmacokinet. 32, 403-425.
    • (1997) Clin. Pharmacokinet. , vol.32 , pp. 403-425
    • Lennernäs, H.1    Fager, G.2
  • 64
    • 0036753494 scopus 로고    scopus 로고
    • Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
    • Loewith, R., et al. 2002. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10, 457-468.
    • (2002) Mol. Cell , vol.10 , pp. 457-468
    • Loewith, R.1
  • 65
    • 21244456553 scopus 로고    scopus 로고
    • Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency
    • Long, X., S. Ortiz-Vega, Y. Lin, and J. Avruch. 2005. Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J. Biol. Chem. 280, 23433-23436.
    • (2005) J. Biol. Chem. , vol.280 , pp. 23433-23436
    • Long, X.1    Ortiz-Vega, S.2    Lin, Y.3    Avruch, J.4
  • 66
    • 73449139398 scopus 로고    scopus 로고
    • Down-regulation of RhoA is involved in the cytotoxic action of lipophilic statins in HepG2 cells
    • Maeda, A., et al. 2010. Down-regulation of RhoA is involved in the cytotoxic action of lipophilic statins in HepG2 cells. Atherosclerosis 208, 112-118.
    • (2010) Atherosclerosis , vol.208 , pp. 112-118
    • Maeda, A.1
  • 67
    • 0034870203 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of sirolimus
    • Mahalati, K., and B. D. Kahan. 2001. Clinical pharmacokinetics of sirolimus. Clin. Pharmacokinet. 40, 573-585.
    • (2001) Clin. Pharmacokinet. , vol.40 , pp. 573-585
    • Mahalati, K.1    Kahan, B.D.2
  • 68
    • 38649092279 scopus 로고    scopus 로고
    • Tuberous sclerosis preclinical studies, timing of treatment, combination of a rapamycin analog (CCI-779) and interferon-gamma, and comparison of rapamycin to CCI-779
    • Messina, M. P., A. Rauktys, L. Lee, and S. L. Dabora. 2007. Tuberous sclerosis preclinical studies, timing of treatment, combination of a rapamycin analog (CCI-779) and interferon-gamma, and comparison of rapamycin to CCI-779. BMC Pharmacol. 7, 14.
    • (2007) BMC Pharmacol , vol.7 , pp. 14
    • Messina, M.P.1    Rauktys, A.2    Lee, L.3    Dabora, S.L.4
  • 69
    • 0030064388 scopus 로고    scopus 로고
    • The side effect profile of sirolimus, a phase I study in quiescent cyclosporine-prednisone-treated renal transplant patients
    • Murgia, M. G., S. Jordan, and B. D. Kahan. 1996. The side effect profile of sirolimus, a phase I study in quiescent cyclosporine-prednisone-treated renal transplant patients. Kidney Int. 49, 209-216.
    • (1996) Kidney Int , vol.49 , pp. 209-216
    • Murgia, M.G.1    Jordan, S.2    Kahan, B.D.3
  • 71
    • 57849128116 scopus 로고    scopus 로고
    • Role for protein geranylgeranylation in adult T-cell leukemia cell survival
    • Nonaka, M., et al. 2009. Role for protein geranylgeranylation in adult T-cell leukemia cell survival. Exp. Cell Res. 315, 141-150.
    • (2009) Exp. Cell Res. , vol.315 , pp. 141-150
    • Nonaka, M.1
  • 72
    • 67650077581 scopus 로고    scopus 로고
    • Equivalent benefit of mTORC1 blockade and combined PI3KmTOR blockade in a mouse model of tuberous sclerosis
    • Pollizzi, K., I. Malinowska-Kolodziej, M. Stumm, H. Lane, and D. Kwiatkowski. 2009. Equivalent benefit of mTORC1 blockade and combined PI3KmTOR blockade in a mouse model of tuberous sclerosis. Mol. Cancer 8, 38.
    • (2009) Mol. Cancer , vol.8 , pp. 38
    • Pollizzi, K.1    Malinowska-Kolodziej, I.2    Stumm, M.3    Lane, H.4    Kwiatkowski, D.5
  • 73
    • 31844436074 scopus 로고    scopus 로고
    • Rho/ROCK pathway as a target of tumor therapy
    • Rattan, R., S. Giri, A. K. Singh, and I. Singh. 2006. Rho/ROCK pathway as a target of tumor therapy. J. Neurosci. Res. 83, 243-255.
    • (2006) J. Neurosci. Res. , vol.83 , pp. 243-255
    • Rattan, R.1    Giri, S.2    Singh, A.K.3    Singh, I.4
  • 74
  • 75
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • Sarbassov, D. D., et al. 2004. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14, 1296-1302.
    • (2004) Curr. Biol. , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1
  • 76
    • 0034644525 scopus 로고    scopus 로고
    • TOR, a central controller of cell growth
    • Schmelzle, T., and M. N. Hall. 2000. TOR, a central controller of cell growth. Cell 103, 253-262.
    • (2000) Cell , vol.103 , pp. 253-262
    • Schmelzle, T.1    Hall, M.N.2
  • 77
    • 0030906569 scopus 로고    scopus 로고
    • The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2
    • Schmidt, A., M. Bickle, T. Beck, and M. N. Hall. 1997. The yeast phosphatidylinositol kinase homolog TOR2 activates RHO1 and RHO2 via the exchange factor ROM2. Cell 88, 531-542.
    • (1997) Cell , vol.88 , pp. 531-542
    • Schmidt, A.1    Bickle, M.2    Beck, T.3    Hall, M.N.4
  • 78
    • 21444448246 scopus 로고    scopus 로고
    • Retrospective analysis of hyperlipidemia management in a transplant population
    • Schonder, K. S., T. P. McKaveney, and K. J. Lynch. 2005. Retrospective analysis of hyperlipidemia management in a transplant population. harmacotherapy 25, 918-923.
    • (2005) Pharmacotherapy , vol.25 , pp. 918-923
    • Schonder, K.S.1    McKaveney, T.P.2    Lynch, K.J.3
  • 79
    • 0033006201 scopus 로고    scopus 로고
    • 3- Hydroxy-3-methylglutaryl CoA reductase inhibitors reduce serum triglyceride levels through modulation of apolipoprotein C-III and lipoprotein lipase
    • Schoonjans, K., et al. 1999. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors reduce serum triglyceride levels through modulation of apolipoprotein C-III and lipoprotein lipase. FEBS Lett. 452, 160-164.
    • (1999) FEBS Lett , vol.452 , pp. 160-164
    • Schoonjans, K.1
  • 80
    • 4544343980 scopus 로고    scopus 로고
    • Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies
    • Shah, O. J., Z. Wang, and T. Hunter. 2004. Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr. Biol. 14, 1650-1656.
    • (2004) Curr. Biol. , vol.14 , pp. 1650-1656
    • Shah, O.J.1    Wang, Z.2    Hunter, T.3
  • 81
    • 33748950810 scopus 로고    scopus 로고
    • Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
    • Shiota, C., J. Woo, J. Lindner, K. D. Shelton, and M. A. Magnuson. 2006. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev. Cell 11, 583-589.
    • (2006) Dev. Cell , vol.11 , pp. 583-589
    • Shiota, C.1    Woo, J.2    Lindner, J.3    Shelton, K.D.4    Magnuson, M.A.5
  • 82
    • 77950900079 scopus 로고    scopus 로고
    • mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action
    • Soliman, G. A., et al. 2010. mTOR Ser-2481 autophosphorylation monitors mTORC-specific catalytic activity and clarifies rapamycin mechanism of action. J. Biol. Chem. 285, 7866-7879.
    • (2010) J. Biol. Chem. , vol.285 , pp. 7866-7879
    • Soliman, G.A.1
  • 83
    • 23844438209 scopus 로고    scopus 로고
    • Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition
    • Sun, S. Y., et al. 2005. Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition. Cancer Res. 65, 052-7058.
    • (2005) Cancer Res , vol.65 , pp. 7052-7058
    • Sun, S.Y.1
  • 84
    • 33750468907 scopus 로고    scopus 로고
    • Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin
    • Takeda, N., et al. 2006. Role of RhoA inactivation in reduced cell proliferation of human airway smooth muscle by simvastatin. Am. J. Respir. Cell Mol. iol. 35, 722-729.
    • (2006) Am. J. Respir. Cell Mol. Biol. , vol.35 , pp. 722-729
    • Takeda, N.1
  • 86
    • 0030010318 scopus 로고    scopus 로고
    • Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer
    • Thibault, A., et al. 1996. Phase I study of lovastatin, an inhibitor of the mevalonate pathway, in patients with cancer. Clin. Cancer Res. 2, 483-491.
    • (1996) Clin. Cancer Res. , vol.2 , pp. 483-491
    • Thibault, A.1
  • 87
    • 0034795339 scopus 로고    scopus 로고
    • Use of isogenic human cancer cells for high-throughput screening and drug discovery
    • Torrance, C. J., V. Agrawal, B. Vogelstein, and K. W. Kinzler. 2001. Use of isogenic human cancer cells for high-throughput screening and drug discovery. Nat. Biotechnol. 19, 940-945.
    • (2001) Nat. Biotechnol. , vol.19 , pp. 940-945
    • Torrance, C.J.1    Agrawal, V.2    Vogelstein, B.3    Kinzler, K.W.4
  • 88
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and dietinduced obesity while enhancing insulin sensitivity
    • Um, S. H., et al. 2004. Absence of S6K1 protects against age- and dietinduced obesity while enhancing insulin sensitivity. Nature 431, 200-205.
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1
  • 89
    • 4143055661 scopus 로고    scopus 로고
    • Update on statins: 2003
    • Vaughan, C. J., and A. M. Gotto, Jr. 2004. Update on statins, 2003. Circulation 110, 886-892.
    • (2004) Circulation , vol.110 , pp. 886-892
    • Vaughan, C.J.1    Gotto Jr., A.M.2
  • 90
    • 34447295155 scopus 로고    scopus 로고
    • Simvastatin-dependent apoptosis in Hodgkin's lymphoma cells and growth impairment of human Hodgkin's tumors in vivo
    • von Tresckow, B., et al. 2007. Simvastatin-dependent apoptosis in Hodgkin's lymphoma cells and growth impairment of human Hodgkin's tumors in vivo. Haematologica 92, 682-685.
    • (2007) Haematologica , vol.92 , pp. 682-685
    • von Tresckow, B.1
  • 91
    • 0036239832 scopus 로고    scopus 로고
    • HMG- CoA reductase inhibitors and the malignant cell, the statin family of drugs as triggers of tumor-specific apoptosis
    • Wong, W. W., J. Dimitroulakos, M. D. Minden, and L. Z. Penn. 2002. HMG-CoA reductase inhibitors and the malignant cell, the statin family of drugs as triggers of tumor-specific apoptosis. Leukemia 16, 508-519.
    • (2002) Leukemia , vol.16 , pp. 508-519
    • Wong, W.W.1    Dimitroulakos, J.2    Minden, M.D.3    Penn, L.Z.4
  • 92
    • 4644261860 scopus 로고    scopus 로고
    • Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis
    • Wu, J., W. W. Wong, F. Khosravi, M. D. Minden, and L. Z. Penn. 2004. Blocking the Raf/MEK/ERK pathway sensitizes acute myelogenous leukemia cells to lovastatin-induced apoptosis. Cancer Res. 64, 6461-6468.
    • (2004) Cancer Res , vol.64 , pp. 6461-6468
    • Wu, J.1    Wong, W.W.2    Khosravi, F.3    Minden, M.D.4    Penn, L.Z.5
  • 93
    • 0344155285 scopus 로고    scopus 로고
    • Multiple roles of the tuberous sclerosis complex genes
    • Yeung, R. S. 2003. Multiple roles of the tuberous sclerosis complex genes. Genes Chromosomes Cancer 38, 368-375.
    • (2003) Genes Chromosomes Cancer , vol.38 , pp. 368-375
    • Yeung, R.S.1
  • 94
    • 0347988005 scopus 로고    scopus 로고
    • Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR
    • Zhang, H., et al. 2003. Loss of Tsc1/Tsc2 activates mTOR and disrupts PI3K-Akt signaling through downregulation of PDGFR. J. Clin. Invest. 112, 1223-233.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1223-1233
    • Zhang, H.1
  • 95
    • 0038141979 scopus 로고    scopus 로고
    • Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
    • Zhang, Y., et al. 2003. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat. Cell Biol. 5, 578-581.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 578-581
    • Zhang, Y.1
  • 96
    • 33644697765 scopus 로고    scopus 로고
    • Exposure-response relationships and drug interactions of sirolimus
    • Zimmerman, J. J. 2004. Exposure-response relationships and drug interactions of sirolimus. AAPS J. 6, e28.
    • (2004) AAPS J , vol.6
    • Zimmerman, J.J.1


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