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Volumn 19, Issue 7, 2008, Pages 705-712

In-vitro synergism of m-TOR inhibitors, statins, and classical chemotherapy: Potential implications in acute leukemia

Author keywords

Acute leukemia; AKT; M TOR; Statin; Synergy

Indexed keywords

CYTARABINE; DAUNORUBICIN; EVEROLIMUS; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IDARUBICIN; MAMMALIAN TARGET OF RAPAMYCIN INHIBITOR; RAPAMYCIN; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; INDOLE DERIVATIVE; MAMMALIAN TARGET OF RAPAMYCIN; MONOUNSATURATED FATTY ACID; PROTEIN KINASE; PROTEIN KINASE B;

EID: 51049085142     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/CAD.0b013e328304ae19     Document Type: Article
Times cited : (35)

References (70)
  • 1
    • 0642336838 scopus 로고    scopus 로고
    • The latest treatment advances for acute myelogenous leukemia
    • Colvin GA, Elfenbein GJ. The latest treatment advances for acute myelogenous leukemia. Med Health R I 2003; 86:243-246.
    • (2003) Med Health R I , vol.86 , pp. 243-246
    • Colvin, G.A.1    Elfenbein, G.J.2
  • 2
    • 2342637719 scopus 로고    scopus 로고
    • Estey EH. Treatment of acute myelogenous leukemia. Oncology (Williston Park) 2002; 16:343-352, 355-356; discussion 357, 362, 365-366.
    • Estey EH. Treatment of acute myelogenous leukemia. Oncology (Williston Park) 2002; 16:343-352, 355-356; discussion 357, 362, 365-366.
  • 4
    • 0035066210 scopus 로고    scopus 로고
    • Uncertainties in the standard care of acute myelogenous leukemia
    • Rowe JM. Uncertainties in the standard care of acute myelogenous leukemia. Leukemia 2001; 15:677-679.
    • (2001) Leukemia , vol.15 , pp. 677-679
    • Rowe, J.M.1
  • 5
    • 0037365086 scopus 로고    scopus 로고
    • Molecular targets in acute myelogenous leukemia
    • Stirewalt DL, Meshinchi S, Radich JP. Molecular targets in acute myelogenous leukemia. Blood Rev 2003; 17:15-23.
    • (2003) Blood Rev , vol.17 , pp. 15-23
    • Stirewalt, D.L.1    Meshinchi, S.2    Radich, J.P.3
  • 6
    • 0032211844 scopus 로고    scopus 로고
    • Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction
    • Corvera S, Czech MP. Direct targets of phosphoinositide 3-kinase products in membrane traffic and signal transduction. Trends Cell Biol 1998; 8: 442-446.
    • (1998) Trends Cell Biol , vol.8 , pp. 442-446
    • Corvera, S.1    Czech, M.P.2
  • 7
    • 29444456417 scopus 로고    scopus 로고
    • Targeting the phosphatidylinositol-3 kinase/Akt pathway for the treatment of cancer
    • Kim D, Cheng GZ, Lindsley CW, Yang H, Cheng JQ. Targeting the phosphatidylinositol-3 kinase/Akt pathway for the treatment of cancer. Curr Opin Investig Drugs 2005; 6:1250-1258.
    • (2005) Curr Opin Investig Drugs , vol.6 , pp. 1250-1258
    • Kim, D.1    Cheng, G.Z.2    Lindsley, C.W.3    Yang, H.4    Cheng, J.Q.5
  • 8
    • 10744230387 scopus 로고    scopus 로고
    • Linking molecular diagnostics to molecular therapeutics: Targeting the PI3K pathway in breast cancer
    • Mills GB, Kohn E, Lu Y, Eder A, Fang X, Wang H, et al. Linking molecular diagnostics to molecular therapeutics: targeting the PI3K pathway in breast cancer. Semin Oncol 2003; 30:93-104.
    • (2003) Semin Oncol , vol.30 , pp. 93-104
    • Mills, G.B.1    Kohn, E.2    Lu, Y.3    Eder, A.4    Fang, X.5    Wang, H.6
  • 9
    • 0042744837 scopus 로고    scopus 로고
    • Survival of acute myeloid leukemia cells requires PI3 kinase activation
    • Xu Q, Simpson SE, Scialla TJ, Bagg A, Carroll M. Survival of acute myeloid leukemia cells requires PI3 kinase activation. Blood 2003; 102:972-980.
    • (2003) Blood , vol.102 , pp. 972-980
    • Xu, Q.1    Simpson, S.E.2    Scialla, T.J.3    Bagg, A.4    Carroll, M.5
  • 10
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307:1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 11
    • 33745304265 scopus 로고    scopus 로고
    • The PI3K/Akt/mTOR pathway: A new therapeutic target in the treatment of acute myeloid leukemia
    • Dos Santos C, Recher C, Demur C, Payrastre B. The PI3K/Akt/mTOR pathway: a new therapeutic target in the treatment of acute myeloid leukemia. Bull Cancer 2006; 93:445-447.
    • (2006) Bull Cancer , vol.93 , pp. 445-447
    • Dos Santos, C.1    Recher, C.2    Demur, C.3    Payrastre, B.4
  • 12
    • 1242285048 scopus 로고    scopus 로고
    • Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias
    • Zhao S, Konopleva M, Cabreira-Hansen M, Xie Z, Hu W, Milella M, et al. Inhibition of phosphatidylinositol 3-kinase dephosphorylates BAD and promotes apoptosis in myeloid leukemias. Leukemia 2004; 18:267-275.
    • (2004) Leukemia , vol.18 , pp. 267-275
    • Zhao, S.1    Konopleva, M.2    Cabreira-Hansen, M.3    Xie, Z.4    Hu, W.5    Milella, M.6
  • 13
    • 33747890445 scopus 로고    scopus 로고
    • Constitutive phosphorylation of the S6 ribosomal protein via mTOR and ERK signaling in the peripheral blasts of acute leukemia patients
    • Chow S, Minden MD, Hedley DW. Constitutive phosphorylation of the S6 ribosomal protein via mTOR and ERK signaling in the peripheral blasts of acute leukemia patients. Exp Hematol 2006; 34:1183-1191.
    • (2006) Exp Hematol , vol.34 , pp. 1183-1191
    • Chow, S.1    Minden, M.D.2    Hedley, D.W.3
  • 16
    • 29244459713 scopus 로고    scopus 로고
    • Mammalian target of rapamycin as a therapeutic target in leukemia
    • Giles FJ, Albitar M. Mammalian target of rapamycin as a therapeutic target in leukemia. Curr Mol Med 2005; 5:653-661.
    • (2005) Curr Mol Med , vol.5 , pp. 653-661
    • Giles, F.J.1    Albitar, M.2
  • 17
    • 40049092283 scopus 로고    scopus 로고
    • Exploiting the mammalian target of rapamycin pathway in hematologic malignancies
    • Altman JK, Platanias LC. Exploiting the mammalian target of rapamycin pathway in hematologic malignancies. Curr Opin Hematol 2008; 15: 88-94.
    • (2008) Curr Opin Hematol , vol.15 , pp. 88-94
    • Altman, J.K.1    Platanias, L.C.2
  • 18
    • 0345732640 scopus 로고    scopus 로고
    • mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E
    • Fingar DC, Richardson CJ, Tee AR, Cheatham L, Tsou C, Blenis J. mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol 2004; 24:200-216.
    • (2004) Mol Cell Biol , vol.24 , pp. 200-216
    • Fingar, D.C.1    Richardson, C.J.2    Tee, A.R.3    Cheatham, L.4    Tsou, C.5    Blenis, J.6
  • 20
    • 38049187096 scopus 로고    scopus 로고
    • Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: Rationale for therapeutic inhibition of both pathways
    • Tamburini J, Chapuis N, Bardet V, Park S, Sujobert P, Willems L, et al. Mammalian target of rapamycin (mTOR) inhibition activates phosphatidylinositol 3-kinase/Akt by up-regulating insulin-like growth factor-1 receptor signaling in acute myeloid leukemia: rationale for therapeutic inhibition of both pathways. Blood 2008; 111:379-382.
    • (2008) Blood , vol.111 , pp. 379-382
    • Tamburini, J.1    Chapuis, N.2    Bardet, V.3    Park, S.4    Sujobert, P.5    Willems, L.6
  • 21
    • 24944480788 scopus 로고    scopus 로고
    • The Akt-mTOR tango and its relevance to cancer
    • Hay N. The Akt-mTOR tango and its relevance to cancer. Cancer Cell 2005; 8:179-183.
    • (2005) Cancer Cell , vol.8 , pp. 179-183
    • Hay, N.1
  • 22
    • 17144373720 scopus 로고    scopus 로고
    • Inhibitors of the mammalian target of rapamycin
    • Dancey JE. Inhibitors of the mammalian target of rapamycin. Expert Opin Investig Drugs 2005; 14:313-328.
    • (2005) Expert Opin Investig Drugs , vol.14 , pp. 313-328
    • Dancey, J.E.1
  • 23
    • 18844409151 scopus 로고    scopus 로고
    • Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax: Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity
    • Tirado OM, Mateo-Lozano S, Notario V. Rapamycin induces apoptosis of JN-DSRCT-1 cells by increasing the Bax: Bcl-xL ratio through concurrent mechanisms dependent and independent of its mTOR inhibitory activity. Oncogene 2005; 24:3348-3357.
    • (2005) Oncogene , vol.24 , pp. 3348-3357
    • Tirado, O.M.1    Mateo-Lozano, S.2    Notario, V.3
  • 24
    • 33749002279 scopus 로고    scopus 로고
    • Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
    • Yee KW, Zeng Z, Konopleva M, Verstovsek S, Ravandi F, Ferrajoli A, et al. Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies. Clin Cancer Res 2006; 12:5165-5173.
    • (2006) Clin Cancer Res , vol.12 , pp. 5165-5173
    • Yee, K.W.1    Zeng, Z.2    Konopleva, M.3    Verstovsek, S.4    Ravandi, F.5    Ferrajoli, A.6
  • 26
    • 0038121035 scopus 로고    scopus 로고
    • Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses
    • Li HY, Appelbaum FR, Willman CL, Zager RA, Banker DE. Cholesterol-modulating agents kill acute myeloid leukemia cells and sensitize them to therapeutics by blocking adaptive cholesterol responses. Blood 2003; 101:3628-3634.
    • (2003) Blood , vol.101 , pp. 3628-3634
    • Li, H.Y.1    Appelbaum, F.R.2    Willman, C.L.3    Zager, R.A.4    Banker, D.E.5
  • 27
    • 0018181378 scopus 로고
    • Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells
    • Ho YK, Smith RG, Brown MS, Goldstein JL. Low-density lipoprotein (LDL) receptor activity in human acute myelogenous leukemia cells. Blood 1978; 52:1099-1114.
    • (1978) Blood , vol.52 , pp. 1099-1114
    • Ho, Y.K.1    Smith, R.G.2    Brown, M.S.3    Goldstein, J.L.4
  • 28
    • 4444257328 scopus 로고    scopus 로고
    • Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells
    • Banker DE, Mayer SJ, Li HY, Willman CL, Appelbaum FR, Zager RA. Cholesterol synthesis and import contribute to protective cholesterol increments in acute myeloid leukemia cells. Blood 2004; 104:1816-1824.
    • (2004) Blood , vol.104 , pp. 1816-1824
    • Banker, D.E.1    Mayer, S.J.2    Li, H.Y.3    Willman, C.L.4    Appelbaum, F.R.5    Zager, R.A.6
  • 30
    • 4644372454 scopus 로고    scopus 로고
    • Cholesterol is essential for mitosis progression and its deficiency induces polyploid cell formation
    • Fernandez C, Lobo Md Mdel V, Gomez-Coronado D, Lasuncion MA. Cholesterol is essential for mitosis progression and its deficiency induces polyploid cell formation. Exp Cell Res 2004; 300:109-120.
    • (2004) Exp Cell Res , vol.300 , pp. 109-120
    • Fernandez, C.1    Lobo, M.2    Mdel, V.3    Gomez-Coronado, D.4    Lasuncion, M.A.5
  • 31
    • 36148968399 scopus 로고    scopus 로고
    • P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholesterol deprivation and by HMG-CoA reductase inhibitors
    • Connelly-Smith L, Pattinson J, Grundy M, Shang S, Seedhouse C, Russell N, et al. P-glycoprotein is downregulated in KG1a-primitive leukemia cells by LDL cholesterol deprivation and by HMG-CoA reductase inhibitors. Exp Hematol 2007; 35:1793-1800.
    • (2007) Exp Hematol , vol.35 , pp. 1793-1800
    • Connelly-Smith, L.1    Pattinson, J.2    Grundy, M.3    Shang, S.4    Seedhouse, C.5    Russell, N.6
  • 32
    • 0028535302 scopus 로고
    • Selective inhibition of primary acute myeloid leukaemia cell growth by simvastatin
    • Newman A, Clutterbuck RD, Powles RL, Millar JL. Selective inhibition of primary acute myeloid leukaemia cell growth by simvastatin. Leukemia 1994; 8:2023-2029.
    • (1994) Leukemia , vol.8 , pp. 2023-2029
    • Newman, A.1    Clutterbuck, R.D.2    Powles, R.L.3    Millar, J.L.4
  • 33
    • 0031871164 scopus 로고    scopus 로고
    • Inhibitory effect of simvastatin on the proliferation of human myeloid leukaemia cells in severe combined immunodeficient (SCID) mice
    • Clutterbuck RD, Millar BC, Powles RL, Newman A, Catovsky D, Jarman M, et al. Inhibitory effect of simvastatin on the proliferation of human myeloid leukaemia cells in severe combined immunodeficient (SCID) mice. Br J Haematol 1998; 102:522-527.
    • (1998) Br J Haematol , vol.102 , pp. 522-527
    • Clutterbuck, R.D.1    Millar, B.C.2    Powles, R.L.3    Newman, A.4    Catovsky, D.5    Jarman, M.6
  • 35
    • 14744273421 scopus 로고    scopus 로고
    • Lovastatin alters the isoprenoid biosynthetic pathway in acute myelogenous leukemia cells in vivo
    • Lewis KA, Holstein SA, Hohl RJ. Lovastatin alters the isoprenoid biosynthetic pathway in acute myelogenous leukemia cells in vivo. Leuk Res 2005; 29:527-533.
    • (2005) Leuk Res , vol.29 , pp. 527-533
    • Lewis, K.A.1    Holstein, S.A.2    Hohl, R.J.3
  • 36
    • 0034857309 scopus 로고    scopus 로고
    • Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells
    • Xia Z, Tan MM, Wong WW, Dimitroulakos J, Minden MD, Penn LZ. Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells. Leukemia 2001; 15:1398-1407.
    • (2001) Leukemia , vol.15 , pp. 1398-1407
    • Xia, Z.1    Tan, M.M.2    Wong, W.W.3    Dimitroulakos, J.4    Minden, M.D.5    Penn, L.Z.6
  • 37
    • 27744475074 scopus 로고    scopus 로고
    • In vitro profiling of the sensitivity of pediatric leukemia cells to tipifarnib:identification of T-cell ALL and FAB M5 AML as the most sensitive subsets
    • Goemans BF, Zwaan CM, Harlow A, Loonen AH, Gibson BE, Hahlen K, et al. In vitro profiling of the sensitivity of pediatric leukemia cells to tipifarnib:identification of T-cell ALL and FAB M5 AML as the most sensitive subsets. Blood 2005; 106:3532-3537.
    • (2005) Blood , vol.106 , pp. 3532-3537
    • Goemans, B.F.1    Zwaan, C.M.2    Harlow, A.3    Loonen, A.H.4    Gibson, B.E.5    Hahlen, K.6
  • 38
    • 33947594969 scopus 로고    scopus 로고
    • Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: A phase 1 study
    • Kornblau SM, Banker DE, Stirewalt D, Shen D, Lemker E, Verstovsek S, et al. Blockade of adaptive defensive changes in cholesterol uptake and synthesis in AML by the addition of pravastatin to idarubicin + high-dose Ara-C: a phase 1 study. Blood 2007; 109:2999-3006.
    • (2007) Blood , vol.109 , pp. 2999-3006
    • Kornblau, S.M.1    Banker, D.E.2    Stirewalt, D.3    Shen, D.4    Lemker, E.5    Verstovsek, S.6
  • 39
    • 33646783320 scopus 로고    scopus 로고
    • Zoledronic acid (Zometa) enhances the cytotoxic effect of gemcitabine and fluvastatin:in vitro isobologram studies with conventional and nonconventional cytotoxic agents
    • Budman DR, Calabro A. Zoledronic acid (Zometa) enhances the cytotoxic effect of gemcitabine and fluvastatin:in vitro isobologram studies with conventional and nonconventional cytotoxic agents. Oncology 2006; 70:147-153.
    • (2006) Oncology , vol.70 , pp. 147-153
    • Budman, D.R.1    Calabro, A.2
  • 40
    • 0034771920 scopus 로고    scopus 로고
    • In vitro effects of dexrazoxane (Zinecard) and classical acute leukemia therapy:time to consider expanded clinical trials?
    • Budman DR, Calabro A, Kreis W. In vitro effects of dexrazoxane (Zinecard) and classical acute leukemia therapy:time to consider expanded clinical trials? Leukemia 2001; 15:1517-1520.
    • (2001) Leukemia , vol.15 , pp. 1517-1520
    • Budman, D.R.1    Calabro, A.2    Kreis, W.3
  • 41
    • 0035988004 scopus 로고    scopus 로고
    • In vitro search for synergy and antagonism:evaluation of docetaxel combinations in breast cancer cell lines
    • Budman DR, Calabro A. In vitro search for synergy and antagonism:evaluation of docetaxel combinations in breast cancer cell lines. Breast Cancer Res Treat 2002; 74:41-46.
    • (2002) Breast Cancer Res Treat , vol.74 , pp. 41-46
    • Budman, D.R.1    Calabro, A.2
  • 42
    • 8344281385 scopus 로고    scopus 로고
    • Studies of synergistic and antagonistic combinations of conventional cytotoxic agents with the multiple eico-sanoid pathway modulator LY 293111
    • Budman DR, Calabro A. Studies of synergistic and antagonistic combinations of conventional cytotoxic agents with the multiple eico-sanoid pathway modulator LY 293111. Anti-Cancer Drugs 2004; 15:877-881.
    • (2004) Anti-Cancer Drugs , vol.15 , pp. 877-881
    • Budman, D.R.1    Calabro, A.2
  • 43
    • 34250818154 scopus 로고    scopus 로고
    • Fluvastatin enhancement of trastuzumab and classical cytotoxic agents in defined breast cancer cell lines in vitro
    • Budman D, Tai J, Calabro A. Fluvastatin enhancement of trastuzumab and classical cytotoxic agents in defined breast cancer cell lines in vitro. Breast Cancer Res Treat 2007; 104:97-101.
    • (2007) Breast Cancer Res Treat , vol.104 , pp. 97-101
    • Budman, D.1    Tai, J.2    Calabro, A.3
  • 44
    • 0029008635 scopus 로고
    • Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines
    • Bailly JD, Muller C, Jaffrezou JP, Demur C, Gassar G, Bordier C, et al. Lack of correlation between expression and function of P-glycoprotein in acute myeloid leukemia cell lines. Leukemia 1995; 9:799-807.
    • (1995) Leukemia , vol.9 , pp. 799-807
    • Bailly, J.D.1    Muller, C.2    Jaffrezou, J.P.3    Demur, C.4    Gassar, G.5    Bordier, C.6
  • 46
    • 7144264382 scopus 로고    scopus 로고
    • Wt-p53 action in human leukaemia cell lines corresponding to different stages of differentiation
    • Rizzo MG, Zepparoni A, Cristofanelli B, Scardigli R, Crescenzi M, Blandino G, et al. Wt-p53 action in human leukaemia cell lines corresponding to different stages of differentiation. Br J Cancer 1998; 77:1429-1438.
    • (1998) Br J Cancer , vol.77 , pp. 1429-1438
    • Rizzo, M.G.1    Zepparoni, A.2    Cristofanelli, B.3    Scardigli, R.4    Crescenzi, M.5    Blandino, G.6
  • 47
    • 0034522728 scopus 로고    scopus 로고
    • Human mortalin (HSPA9):a candidate for the myeloid leukemia tumor suppressor gene on 5q31
    • Xie H, Hu Z, Chyna B, Horrigan SK, Westbrook CA. Human mortalin (HSPA9):a candidate for the myeloid leukemia tumor suppressor gene on 5q31. Leukemia 2000; 14:2128-2134.
    • (2000) Leukemia , vol.14 , pp. 2128-2134
    • Xie, H.1    Hu, Z.2    Chyna, B.3    Horrigan, S.K.4    Westbrook, C.A.5
  • 48
    • 0019142091 scopus 로고
    • Human myeloid leukemia cell lines:a review
    • Koeffler HP, Golde DW. Human myeloid leukemia cell lines:a review. Blood 1980; 56:344-350.
    • (1980) Blood , vol.56 , pp. 344-350
    • Koeffler, H.P.1    Golde, D.W.2
  • 49
    • 0018849854 scopus 로고
    • Responsiveness of a human myelogenous leukemia cell line (KG-1) to humoral factors in vivo
    • Niskanen E, Koeffler HP, Golde DW, Cline MJ. Responsiveness of a human myelogenous leukemia cell line (KG-1) to humoral factors in vivo. Leuk Res 1980; 4:203-208.
    • (1980) Leuk Res , vol.4 , pp. 203-208
    • Niskanen, E.1    Koeffler, H.P.2    Golde, D.W.3    Cline, M.J.4
  • 50
    • 0029991474 scopus 로고    scopus 로고
    • Regulation of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human myeloid leukemia cell line (AML-193) by interleukin-6
    • Li Y, Valeriote F, Chen B. Regulation of granulocyte-macrophage colony-stimulating factor (GM-CSF) receptors in a GM-CSF-dependent human myeloid leukemia cell line (AML-193) by interleukin-6. Exp Hematol 1996; 24:94-100.
    • (1996) Exp Hematol , vol.24 , pp. 94-100
    • Li, Y.1    Valeriote, F.2    Chen, B.3
  • 51
    • 0032846455 scopus 로고    scopus 로고
    • Modulation of in vitro chemosensitivity in acute myelogenous leukemia cell line by GM-CSF:opposing effects observed with different cytotoxic drugs and time exposure
    • Ciaiolo C, Ferrero D, Pugliese A, Ortolano B, Borrione P, Pileri A. Modulation of in vitro chemosensitivity in acute myelogenous leukemia cell line by GM-CSF:opposing effects observed with different cytotoxic drugs and time exposure. Leuk Res 1999; 23:931-938.
    • (1999) Leuk Res , vol.23 , pp. 931-938
    • Ciaiolo, C.1    Ferrero, D.2    Pugliese, A.3    Ortolano, B.4    Borrione, P.5    Pileri, A.6
  • 52
    • 0029998037 scopus 로고    scopus 로고
    • FLT3 receptor expression on the surface of normal and malignant human hematopoietic cells
    • Turner AM, Lin NL, Issarachai S, Lyman SD, Broudy VC. FLT3 receptor expression on the surface of normal and malignant human hematopoietic cells. Blood 1996; 88:3383-3390.
    • (1996) Blood , vol.88 , pp. 3383-3390
    • Turner, A.M.1    Lin, N.L.2    Issarachai, S.3    Lyman, S.D.4    Broudy, V.C.5
  • 53
    • 0037352906 scopus 로고    scopus 로고
    • High susceptibility of human leukemic cells to Fas-induced apoptosis is restricted to G1 phase of the cell cycle and can be increased by interferon treatment
    • Jedema I, Barge RM, Willemze R, Falkenburg JH. High susceptibility of human leukemic cells to Fas-induced apoptosis is restricted to G1 phase of the cell cycle and can be increased by interferon treatment. Leukemia 2003; 17:576-584.
    • (2003) Leukemia , vol.17 , pp. 576-584
    • Jedema, I.1    Barge, R.M.2    Willemze, R.3    Falkenburg, J.H.4
  • 54
    • 0026027166 scopus 로고
    • Growth regulation of the AML-193 leukemic cell line:evidence for autocrine production of granulocyte-macrophage colony-stimulating factor (GM-CSF), and inhibition of GM-CSF-dependent cell proliferation by interleukin-1 (IL-1) and tumor necrosis factor (TNF alpha)
    • Kindler V, Shields J, Ayer D, Mazzei GJ. Growth regulation of the AML-193 leukemic cell line:evidence for autocrine production of granulocyte-macrophage colony-stimulating factor (GM-CSF), and inhibition of GM-CSF-dependent cell proliferation by interleukin-1 (IL-1) and tumor necrosis factor (TNF alpha). Int J Cancer 1991; 47:450-454.
    • (1991) Int J Cancer , vol.47 , pp. 450-454
    • Kindler, V.1    Shields, J.2    Ayer, D.3    Mazzei, G.J.4
  • 55
    • 0025854356 scopus 로고
    • Two-step differentiation of AML-193 leukemic line:terminal maturation is induced by positive interaction of retinoic acid with granulocyte colony-stimulating factor (CSF) and vitamin D3 with monocyte CSF
    • Valtieri M, Boccoli G, Testa U, Barletta C, Peschle C. Two-step differentiation of AML-193 leukemic line:terminal maturation is induced by positive interaction of retinoic acid with granulocyte colony-stimulating factor (CSF) and vitamin D3 with monocyte CSF. Blood 1991; 77:1804-1812.
    • (1991) Blood , vol.77 , pp. 1804-1812
    • Valtieri, M.1    Boccoli, G.2    Testa, U.3    Barletta, C.4    Peschle, C.5
  • 56
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival:application to proliferation and cytotoxicity assays
    • Mosmann T. Rapid colorimetric assay for cellular growth and survival:application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65:55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 57
    • 34547133008 scopus 로고    scopus 로고
    • Phase 1 trial of everolimus and gefitinib in patients with advanced nonsmall-cell lung cancer
    • Milton DT, Riely GJ, Azzoli CG, Gomez JE, Heelan RT, Kris MG, et al. Phase 1 trial of everolimus and gefitinib in patients with advanced nonsmall-cell lung cancer. Cancer 2007; 110:599-605.
    • (2007) Cancer , vol.110 , pp. 599-605
    • Milton, D.T.1    Riely, G.J.2    Azzoli, C.G.3    Gomez, J.E.4    Heelan, R.T.5    Kris, M.G.6
  • 58
    • 10644257370 scopus 로고    scopus 로고
    • Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells
    • Liu X, Yue P, Zhou Z, Khuri FR, Sun SY. Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells. J Natl Cancer Inst 2004; 96:1769-1780.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1769-1780
    • Liu, X.1    Yue, P.2    Zhou, Z.3    Khuri, F.R.4    Sun, S.Y.5
  • 59
    • 26444567404 scopus 로고    scopus 로고
    • The role of therapeutic monitoring of everolimus in solid organ transplantation
    • Mabasa VH, Ensom MH. The role of therapeutic monitoring of everolimus in solid organ transplantation. Ther Drug Monit 2005; 27:666-676.
    • (2005) Ther Drug Monit , vol.27 , pp. 666-676
    • Mabasa, V.H.1    Ensom, M.H.2
  • 60
    • 0019882480 scopus 로고
    • Generalized equations for the analysis of inhibition of Michaelis-Menton and higher order kinetic systems with two or more mutually exclusive and non-exclusive inhibitors
    • Chou T, Talalay P. Generalized equations for the analysis of inhibition of Michaelis-Menton and higher order kinetic systems with two or more mutually exclusive and non-exclusive inhibitors. Eur J Biochem 1988; 115:207-216.
    • (1988) Eur J Biochem , vol.115 , pp. 207-216
    • Chou, T.1    Talalay, P.2
  • 61
    • 0029036955 scopus 로고
    • The search for synergy:a critical review from a response surface perspective
    • Greco WR, Bravo G, Parsons JC. The search for synergy:a critical review from a response surface perspective. Pharmacol Rev 1995; 47:331-385.
    • (1995) Pharmacol Rev , vol.47 , pp. 331-385
    • Greco, W.R.1    Bravo, G.2    Parsons, J.C.3
  • 63
    • 9744254768 scopus 로고    scopus 로고
    • Evaluation of combination chemotherapy:integration of nonlinear regression, curve shift, isobologram, and combination index analyses
    • Zhao L, Wientjes MG, Au JL. Evaluation of combination chemotherapy:integration of nonlinear regression, curve shift, isobologram, and combination index analyses. Clin Cancer Res 2004; 10:7994-8004.
    • (2004) Clin Cancer Res , vol.10 , pp. 7994-8004
    • Zhao, L.1    Wientjes, M.G.2    Au, J.L.3
  • 64
    • 0642379556 scopus 로고    scopus 로고
    • Preclinical models for defining efficacy of drug combinations:mapping the road to the clinic
    • Gitler MS, Monks A, Sausville EA. Preclinical models for defining efficacy of drug combinations:mapping the road to the clinic. Mol Cancer Ther 2003; 2:929-932.
    • (2003) Mol Cancer Ther , vol.2 , pp. 929-932
    • Gitler, M.S.1    Monks, A.2    Sausville, E.A.3
  • 65
    • 0036084351 scopus 로고    scopus 로고
    • Treatment of refractory and relapsed acute myelogenous leukemia
    • Stanisic S, Kalaycio M. Treatment of refractory and relapsed acute myelogenous leukemia. Expert Rev Anticancer Ther 2002; 2:287-295.
    • (2002) Expert Rev Anticancer Ther , vol.2 , pp. 287-295
    • Stanisic, S.1    Kalaycio, M.2
  • 66
    • 0842304369 scopus 로고    scopus 로고
    • Mammalian target of rapamycin inhibition as therapy for hematologic malignancies
    • Panwalkar A, Verstovsek S, Giles FJ. Mammalian target of rapamycin inhibition as therapy for hematologic malignancies. Cancer 2004; 100:657-666.
    • (2004) Cancer , vol.100 , pp. 657-666
    • Panwalkar, A.1    Verstovsek, S.2    Giles, F.J.3
  • 67
    • 27744507024 scopus 로고    scopus 로고
    • Recher C, Dos Santos C, Demur C, Payrastre B. mTOR, a new therapeutic target in acute myeloid leukemia. Cell Cycle 2005; 4:1540-1549.
    • Recher C, Dos Santos C, Demur C, Payrastre B. mTOR, a new therapeutic target in acute myeloid leukemia. Cell Cycle 2005; 4:1540-1549.
  • 68
    • 18144399578 scopus 로고    scopus 로고
    • mTOR-targeted therapy of cancer with rapamycin derivatives
    • Vignot S, Faivre S, Aguirre D, Raymond E. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol 2005; 16:525-537.
    • (2005) Ann Oncol , vol.16 , pp. 525-537
    • Vignot, S.1    Faivre, S.2    Aguirre, D.3    Raymond, E.4
  • 69
    • 14644424522 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage
    • Paajarvi G, Roudier E, Crisby M, Hogberg J, Stenius U. HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. Faseb J 2005; 19:476-478.
    • (2005) Faseb J , vol.19 , pp. 476-478
    • Paajarvi, G.1    Roudier, E.2    Crisby, M.3    Hogberg, J.4    Stenius, U.5
  • 70
    • 0344305708 scopus 로고    scopus 로고
    • Lancet JE. Management of acute myelogenous leukemia in the elderly
    • Rathnasabapathy R, Lancet JE. Management of acute myelogenous leukemia in the elderly. Cancer Control 2003; 10:469-477.
    • (2003) Cancer Control , vol.10 , pp. 469-477
    • Rathnasabapathy, R.1


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