-
1
-
-
0038511317
-
IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway
-
Amrani Y, Tliba O, Choubey D, Huang CD, Krymskaya VP, Eszterhas A, Lazaar AL and Panettieri RA Jr (2003) IFN-gamma inhibits human airway smooth muscle cell proliferation by modulating the E2F-1/Rb pathway. Am J Physiol Lung Cell Mol Physiol 284:L1063-L1071.
-
(2003)
Am J Physiol Lung Cell Mol Physiol
, vol.284
-
-
Amrani, Y.1
Tliba, O.2
Choubey, D.3
Huang, C.D.4
Krymskaya, V.P.5
Eszterhas, A.6
Lazaar, A.L.7
Panettieri Jr, R.A.8
-
2
-
-
19044379044
-
Association between a high-expressing interferon-gamma allele and a lower frequency of kidney angiomyolipomas in TSC2 patients
-
Dabora SL, Roberts P, Nieto A, Perez R, Jozwiak S, Franz D, Bissler J, Thiele EA, Sims K, and Kwiatkowski DJ (2002) Association between a high-expressing interferon-gamma allele and a lower frequency of kidney angiomyolipomas in TSC2 patients. Am J Hum Genet 71:750-758.
-
(2002)
Am J Hum Genet
, vol.71
, pp. 750-758
-
-
Dabora, S.L.1
Roberts, P.2
Nieto, A.3
Perez, R.4
Jozwiak, S.5
Franz, D.6
Bissler, J.7
Thiele, E.A.8
Sims, K.9
Kwiatkowski, D.J.10
-
3
-
-
34547116656
-
Type I interferon receptors: Biochemistry and biological functions
-
de Weerd NA, Samarajiwa SA, and Hertzog PJ (2007) Type I interferon receptors: biochemistry and biological functions. J Biol Chem 282:20053-20057.
-
(2007)
J Biol Chem
, vol.282
, pp. 20053-20057
-
-
de Weerd, N.A.1
Samarajiwa, S.A.2
Hertzog, P.J.3
-
4
-
-
0036852241
-
Cancer immunoediting: From immunosurveillance to tumor escape
-
Dunn GP, Bruce AT, Ikeda H, Old LJ, and Schreiber RD (2002) Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol 3:991-998.
-
(2002)
Nat Immunol
, vol.3
, pp. 991-998
-
-
Dunn, G.P.1
Bruce, A.T.2
Ikeda, H.3
Old, L.J.4
Schreiber, R.D.5
-
5
-
-
24344479933
-
Interferon-{gamma}-Jak-Stat signaling in pulmonary lymphangioleiomyomatosis and renal angiomyolipoma: A potential therapeutic target
-
El-Hashemite N and Kwiatkowski DJ (2005) Interferon-{gamma}-Jak-Stat signaling in pulmonary lymphangioleiomyomatosis and renal angiomyolipoma: a potential therapeutic target. Am J Respir Cell Mol Biol 33:227-230.
-
(2005)
Am J Respir Cell Mol Biol
, vol.33
, pp. 227-230
-
-
El-Hashemite, N.1
Kwiatkowski, D.J.2
-
6
-
-
2442648035
-
Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: Synergistic effects of rapamycin-IFN-gamma treatment
-
El-Hashemite N, Zhang H, Walker V, Hoffmeister KM, and Kwiatkowski DJ (2004) Perturbed IFN-gamma-Jak-signal transducers and activators of transcription signaling in tuberous sclerosis mouse models: synergistic effects of rapamycin-IFN-gamma treatment. Cancer Res 64:3436-3443.
-
(2004)
Cancer Res
, vol.64
, pp. 3436-3443
-
-
El-Hashemite, N.1
Zhang, H.2
Walker, V.3
Hoffmeister, K.M.4
Kwiatkowski, D.J.5
-
7
-
-
0036073868
-
Phosphatidylinositol 3-kinase is required for proliferation and migration of human pulmonary vascular smooth muscle cells
-
Goncharova EA, Ammit AJ, Irani C, Carroll RG, Eszterhas AJ, Panettieri RA, and Krymskaya VP (2002a) Phosphatidylinositol 3-kinase is required for proliferation and migration of human pulmonary vascular smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 283:L354-L363.
-
(2002)
Am J Physiol Lung Cell Mol Physiol
, vol.283
-
-
Goncharova, E.A.1
Ammit, A.J.2
Irani, C.3
Carroll, R.G.4
Eszterhas, A.J.5
Panettieri, R.A.6
Krymskaya, V.P.7
-
8
-
-
0037163033
-
Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation: A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)
-
Goncharova EA, Goncharov DA, Eszterhas AJ, Hunter DS, Glassberg MK, Yeung RS, Walker CL, Noonan D, Kwiatkowski DJ, Chou MM, et al. (2002b) Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation: a role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM). J Biol Chem 277:30958-30967.
-
(2002)
J Biol Chem
, vol.277
, pp. 30958-30967
-
-
Goncharova, E.A.1
Goncharov, D.A.2
Eszterhas, A.J.3
Hunter, D.S.4
Glassberg, M.K.5
Yeung, R.S.6
Walker, C.L.7
Noonan, D.8
Kwiatkowski, D.J.9
Chou, M.M.10
-
9
-
-
11244277987
-
TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase
-
Goncharova EA, Goncharov DA, Noonan D, and Krymskaya VP (2004) TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. J Cell Biol 167:1171-1182.
-
(2004)
J Cell Biol
, vol.167
, pp. 1171-1182
-
-
Goncharova, E.A.1
Goncharov, D.A.2
Noonan, D.3
Krymskaya, V.P.4
-
10
-
-
33645695725
-
Abnormal smooth muscle cell growth in lymphangioleiomyomatosis (LAM): Role for tumor suppressor TSC2
-
Goncharova EA, Goncharov DA, Spaits M, Noonan D, Talovskaya E, Eszterhas A, and Krymskaya VP (2006a) Abnormal smooth muscle cell growth in lymphangioleiomyomatosis (LAM): role for tumor suppressor TSC2. Am J Respir Cell Mol Biol 34:561-572.
-
(2006)
Am J Respir Cell Mol Biol
, vol.34
, pp. 561-572
-
-
Goncharova, E.A.1
Goncharov, D.A.2
Spaits, M.3
Noonan, D.4
Talovskaya, E.5
Eszterhas, A.6
Krymskaya, V.P.7
-
11
-
-
38649143200
-
Pulmonary lymphangioleiomyomatosis (LAM): Progress and current challenges
-
in press
-
Goncharova EA and Krymskaya VP (2008) Pulmonary lymphangioleiomyomatosis (LAM): progress and current challenges. J Cell Biochem, in press.
-
(2008)
J Cell Biochem
-
-
Goncharova, E.A.1
Krymskaya, V.P.2
-
12
-
-
34548830141
-
Assays for in vitro monitoring proliferation of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cells
-
Goncharova EA, Lim P, Goncharov DA, Eszterhas A, Panettieri RA Jr, and Krymskaya VP (2006b) Assays for in vitro monitoring proliferation of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cells. Nat Protoc 1:2905-2908.
-
(2006)
Nat Protoc
, vol.1
, pp. 2905-2908
-
-
Goncharova, E.A.1
Lim, P.2
Goncharov, D.A.3
Eszterhas, A.4
Panettieri Jr, R.A.5
Krymskaya, V.P.6
-
13
-
-
34548700597
-
Rapamycin: Something old, something new, sometimes borrowed and now renewed
-
Hartford CM and Ratain MJ (2007) Rapamycin: something old, something new, sometimes borrowed and now renewed. Clin Pharmacol Ther 82:381-388.
-
(2007)
Clin Pharmacol Ther
, vol.82
, pp. 381-388
-
-
Hartford, C.M.1
Ratain, M.J.2
-
14
-
-
0038662963
-
Renal carcinogenesis: Genotype, phenotype and dramatype
-
Hino O, Kobayashi T, Momose S, Kikuchi Y, Adachi H, and Okimoto K (2003) Renal carcinogenesis: genotype, phenotype and dramatype. Cancer Sci 94:142-147.
-
(2003)
Cancer Sci
, vol.94
, pp. 142-147
-
-
Hino, O.1
Kobayashi, T.2
Momose, S.3
Kikuchi, Y.4
Adachi, H.5
Okimoto, K.6
-
15
-
-
11244297916
-
Dysregulation of the TSC-mTOR pathway in human disease
-
Inoki K, Corradetti MN, and Guan K-L (2005) Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 37:19-24.
-
(2005)
Nat Genet
, vol.37
, pp. 19-24
-
-
Inoki, K.1
Corradetti, M.N.2
Guan, K.-L.3
-
16
-
-
33748780944
-
Lymphangioleiomyomatosis
-
Johnson SR (2006) Lymphangioleiomyomatosis. Eur Respir J 27:1056-1065.
-
(2006)
Eur Respir J
, vol.27
, pp. 1056-1065
-
-
Johnson, S.R.1
-
18
-
-
0031766727
-
The structure of human interferon-beta: Implications for activity
-
Karpusas M, Whitty A, Runkel L, and Hochman P (1998) The structure of human interferon-beta: implications for activity. Cell Mol Life Sci 54:1203-1216.
-
(1998)
Cell Mol Life Sci
, vol.54
, pp. 1203-1216
-
-
Karpusas, M.1
Whitty, A.2
Runkel, L.3
Hochman, P.4
-
19
-
-
27944446526
-
Tsc2 expression increases the susceptibility of renal tumor cells to apoptosis
-
Kolb TM, Duan L, and Davis MA (2005) Tsc2 expression increases the susceptibility of renal tumor cells to apoptosis. Toxicol Sci 88:331-339.
-
(2005)
Toxicol Sci
, vol.88
, pp. 331-339
-
-
Kolb, T.M.1
Duan, L.2
Davis, M.A.3
-
20
-
-
0037683087
-
Tumour suppressors hamartin and tuberin: Intracellular signalling
-
Krymskaya VP (2003) Tumour suppressors hamartin and tuberin: intracellular signalling. Cell Signal 15:729-739.
-
(2003)
Cell Signal
, vol.15
, pp. 729-739
-
-
Krymskaya, V.P.1
-
21
-
-
37849033529
-
Smooth muscle-like cells in lymphangioleiomyomatosis
-
Krymskaya VP (2008) Smooth muscle-like cells in lymphangioleiomyomatosis. Proc Am Thorac Soc 5:119-126.
-
(2008)
Proc Am Thorac Soc
, vol.5
, pp. 119-126
-
-
Krymskaya, V.P.1
-
22
-
-
0035041349
-
Activation of class IA PI3K stimulates DNA synthesis in human airway smooth muscle cells
-
Krymskaya VP, Ammit AJ, Hoffman RK, Eszterhas AJ, and Panettieri RA Jr (2001) Activation of class IA PI3K stimulates DNA synthesis in human airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 280:L1009-L1018.
-
(2001)
Am J Physiol Lung Cell Mol Physiol
, vol.280
-
-
Krymskaya, V.P.1
Ammit, A.J.2
Hoffman, R.K.3
Eszterhas, A.J.4
Panettieri Jr, R.A.5
-
23
-
-
0037732711
-
Lymphangioleiomyomatosis: A complex tale of serum response factor-mediated tissue inhibitor of metalloproteinase-3 regulation
-
Krymskaya VP and Shipley JM (2003) Lymphangioleiomyomatosis: a complex tale of serum response factor-mediated tissue inhibitor of metalloproteinase-3 regulation. Am J Respir Cell Mol Biol 28:546-550.
-
(2003)
Am J Respir Cell Mol Biol
, vol.28
, pp. 546-550
-
-
Krymskaya, V.P.1
Shipley, J.M.2
-
24
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
-
Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Glogauer M, el-Hashemite N, and Onda H (2002) A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 11:525-534.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 525-534
-
-
Kwiatkowski, D.J.1
Zhang, H.2
Bandura, J.L.3
Heiberger, K.M.4
Glogauer, M.5
el-Hashemite, N.6
Onda, H.7
-
25
-
-
33748485814
-
Combination of a rapamycin analog (CCI-779) and interferon-gamma is more effective than single agents in treating a mouse model of tuberous sclerosis complex
-
Lee L, Sudentas P, and Dabora SL (2006) Combination of a rapamycin analog (CCI-779) and interferon-gamma is more effective than single agents in treating a mouse model of tuberous sclerosis complex. Genes Chromosomes Cancer 45:933-944.
-
(2006)
Genes Chromosomes Cancer
, vol.45
, pp. 933-944
-
-
Lee, L.1
Sudentas, P.2
Dabora, S.L.3
-
26
-
-
0033861013
-
The TSC1 gene product, hamartin, negatively regulates cell proliferation
-
Miloloza A, Rosner M, Nellist M, Halley D, Bernaschek G, and Hengstschlager M (2000) The TSC1 gene product, hamartin, negatively regulates cell proliferation. Human Molecular Genetics 9:1721-1727.
-
(2000)
Human Molecular Genetics
, vol.9
, pp. 1721-1727
-
-
Miloloza, A.1
Rosner, M.2
Nellist, M.3
Halley, D.4
Bernaschek, G.5
Hengstschlager, M.6
-
27
-
-
0037406263
-
The p38 mitogen-activated protein kinase pathway and its role in interferon signaling
-
Platanias LC (2003) The p38 mitogen-activated protein kinase pathway and its role in interferon signaling. Pharmacol Ther 98:129-142.
-
(2003)
Pharmacol Ther
, vol.98
, pp. 129-142
-
-
Platanias, L.C.1
-
28
-
-
18844457095
-
Mechanisms of type-I- and type-II-interferon-mediated signalling
-
Platanias LC (2005) Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat Rev Immunol 5:375-386.
-
(2005)
Nat Rev Immunol
, vol.5
, pp. 375-386
-
-
Platanias, L.C.1
-
29
-
-
0036831613
-
New aspects of natural-killer-cell surveillance and therapy of cancer
-
Smyth MJ, Hayakawa Y, Takeda K, and Yagita H (2002) New aspects of natural-killer-cell surveillance and therapy of cancer. Nat Rev Cancer 2:850-861.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 850-861
-
-
Smyth, M.J.1
Hayakawa, Y.2
Takeda, K.3
Yagita, H.4
-
30
-
-
0030663735
-
Role of the tuberous sclerosis gene-2 product in cell cycle control
-
Soucek T, Pusch O, Wienecke R, DeClue JE, and Hengstschlager M (1997) Role of the tuberous sclerosis gene-2 product in cell cycle control. J Biol Chem 272:29301-29308.
-
(1997)
J Biol Chem
, vol.272
, pp. 29301-29308
-
-
Soucek, T.1
Pusch, O.2
Wienecke, R.3
DeClue, J.E.4
Hengstschlager, M.5
-
31
-
-
0031657551
-
How cells respond to interferons
-
Stark GR, Kerr IM, Williams BRG, Silverman RH, and Schreiber RD (1998) How cells respond to interferons. Annu Rev Biochem 67:227-264.
-
(1998)
Annu Rev Biochem
, vol.67
, pp. 227-264
-
-
Stark, G.R.1
Kerr, I.M.2
Williams, B.R.G.3
Silverman, R.H.4
Schreiber, R.D.5
-
32
-
-
0038420703
-
New aspects of IFN-alpha/beta signalling in immunity, oncogenesis and bone metabolism
-
Takaoka A and Taniguchi T (2003) New aspects of IFN-alpha/beta signalling in immunity, oncogenesis and bone metabolism. Cancer Sci 94:405-411.
-
(2003)
Cancer Sci
, vol.94
, pp. 405-411
-
-
Takaoka, A.1
Taniguchi, T.2
-
33
-
-
0033870894
-
Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein
-
Talon J, Horvath CM, Polley R, Basler CF, Muster T, Palese P, and Garcia-Sastre A (2000) Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. J Virol 74:7989-7996.
-
(2000)
J Virol
, vol.74
, pp. 7989-7996
-
-
Talon, J.1
Horvath, C.M.2
Polley, R.3
Basler, C.F.4
Muster, T.5
Palese, P.6
Garcia-Sastre, A.7
-
34
-
-
0035805180
-
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation
-
Tapon N, Ito N, Dickson BJ, Treisman JE, and Hariharan IK (2001) The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell 105:345-355.
-
(2001)
Cell
, vol.105
, pp. 345-355
-
-
Tapon, N.1
Ito, N.2
Dickson, B.J.3
Treisman, J.E.4
Hariharan, I.K.5
-
36
-
-
2642527835
-
Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway
-
Thyrell L, Hjortsberg L, Arulampalam V, Panaretakis T, Uhles S, Dagnell M, Zhivotovsky B, Leibiger I, Grander D, and Pokrovskaja K (2004) Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway. J Biol Chem 279:24152-24162.
-
(2004)
J Biol Chem
, vol.279
, pp. 24152-24162
-
-
Thyrell, L.1
Hjortsberg, L.2
Arulampalam, V.3
Panaretakis, T.4
Uhles, S.5
Dagnell, M.6
Zhivotovsky, B.7
Leibiger, I.8
Grander, D.9
Pokrovskaja, K.10
-
37
-
-
0346749458
-
Tumor necrosis factor α modulates airway smooth muscle function via the autocrine action of interferon β
-
Tliba O, Tliba S, Da Huang C, Hoffman RK, DeLong P, Panettieri RA Jr, and Amrani Y (2003) Tumor necrosis factor α modulates airway smooth muscle function via the autocrine action of interferon β. J Biol Chem 278:50615-50623.
-
(2003)
J Biol Chem
, vol.278
, pp. 50615-50623
-
-
Tliba, O.1
Tliba, S.2
Da Huang, C.3
Hoffman, R.K.4
DeLong, P.5
Panettieri Jr, R.A.6
Amrani, Y.7
-
39
-
-
24944521057
-
Intrapulmonary IFN-{beta} gene therapy using an adenoviral vector is highly effective in a murine orthotopic model of bronchogenic adenocarcinoma of the lung
-
Wilderman MJ, Sun J, Jassar AS, Kapoor V, Khan M, Vachani A, Suzuki E, Kinniry PA, Sterman DH, Kaiser LR, et al. (2005) Intrapulmonary IFN-{beta} gene therapy using an adenoviral vector is highly effective in a murine orthotopic model of bronchogenic adenocarcinoma of the lung. Cancer Res 65:8379-8387.
-
(2005)
Cancer Res
, vol.65
, pp. 8379-8387
-
-
Wilderman, M.J.1
Sun, J.2
Jassar, A.S.3
Kapoor, V.4
Khan, M.5
Vachani, A.6
Suzuki, E.7
Kinniry, P.A.8
Sterman, D.H.9
Kaiser, L.R.10
-
40
-
-
33644516582
-
Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis
-
Yan H, Frost P, Shi Y, Hoang B, Sharma S, Fisher M, Gera JF, and Lichtenstein AK (2006) Mechanism by which mammalian target of rapamycin inhibitors sensitize multiple myeloma cells to dexamethasone-induced apoptosis. Cancer Res 66:2305-2313.
-
(2006)
Cancer Res
, vol.66
, pp. 2305-2313
-
-
Yan, H.1
Frost, P.2
Shi, Y.3
Hoang, B.4
Sharma, S.5
Fisher, M.6
Gera, J.F.7
Lichtenstein, A.K.8
|