3-Hydroxy-3-methyl-glutaryl coenzyme A reductase inhibitors, atorvastatin and simvastatin, induce apoptosis of vascular smooth muscle cells by downregulation of Bcl-2 expression and Rho A prenylation

Atherosclerosis

Volumn 161, Issue 1, 2002, Pages 17-26

  Blanco Colio, Luis Miguel ^a   Villa, Ana ^b   Ortego, Mónica ^a   Hernández Presa, Miguel Angel ^a   Pascual, Angel ^b   Plaza, Juan José ^a   Egido, Jesús ^a,b  

^a Instituto de Investigaciones Sanitarias   (Spain)

^b CSIC   (Spain)

Author keywords

Apoptosis; Bcl 2; Rho A; Statins

Indexed keywords

ALPHA HYDROXYFARNESYLPHOSPHONIC ACID; ATORVASTATIN; BENZYLOXYCARBONYLVALYLALANYLASPARTIC ACID FLUOROMETHYL KETONE; CASPASE 8; CASPASE 9; FARNESYL DIPHOSPHATE; FARNESYL TRANS TRANSFERASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; KETONE DERIVATIVE; MANUMYCIN; MANUMYCIN A; MEVALONIC ACID; PRAVASTATIN; PROTEIN BAX; PROTEIN BCL 2; RHO A FACTOR; RHO FACTOR; SIMVASTATIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; IMMUNOREACTIVITY; NONHUMAN; PRENYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; CASPASES; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; ENZYME ACTIVATION; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MEVALONIC ACID; MUSCLE, SMOOTH, VASCULAR; POLYISOPRENYL PHOSPHATES; PROTEIN ISOPRENYLATION; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRROLES; RABBITS; RATS; RHOA GTP-BINDING PROTEIN; SIMVASTATIN; TIME FACTORS;

EID: 0036192275     PISSN: 00219150     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0021-9150(01)00613-X     Document Type: Article

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