메뉴 건너뛰기




Volumn 40, Issue 8, 2001, Pages 573-585

Clinical pharmacokinetics of sirolimus

Author keywords

[No Author keywords available]

Indexed keywords

16 O NORSIROLIMUS; 27,39 O DINORSIROLIMUS; 39 O NORSIROLIMUS; AZATHIOPRINE; CORTICOSTEROID; CYCLOSPORIN; CYTOCHROME P450 3A4; DIHYDROXYSIROLIMUS; DILTIAZEM; DRUG METABOLITE; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 2 RECEPTOR ANTIBODY; KETOCONAZOLE; LACTONE DERIVATIVE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; PREDNISONE; RAPAMYCIN; TACROLIMUS; UNCLASSIFIED DRUG;

EID: 0034870203     PISSN: 03125963     EISSN: None     Source Type: Journal    
DOI: 10.2165/00003088-200140080-00002     Document Type: Review
Times cited : (270)

References (60)
  • 2
    • 50549168496 scopus 로고
    • The rejection of renal homograft inhibition in dogs by 6-mercaptopurine
    • (1960) Lancet , vol.1 , pp. 417-418
    • Calne, R.Y.1
  • 9
    • 0002379569 scopus 로고    scopus 로고
    • Established immunosuppressive drugs: Clinical and toxic effects
    • Kahan BD, Ponticelli C, editors. Principles and practice of renal transplantation. London: Dunitz
    • (2000) , pp. 349-414
    • Kahan, B.D.1
  • 14
    • 0029738491 scopus 로고    scopus 로고
    • Sensitive and specific quantification of sirolimus (rapamycin) and its metabolites in blood of kidney graft recipients by HPLC/electrospray-mass spectrometry
    • (1996) Clin Chem , vol.42 , pp. 1417-1425
    • Streit, F.1    Christians, U.2    Schiebel, H.M.3
  • 18
    • 0032757545 scopus 로고    scopus 로고
    • Analytical performance of microparticle enzyme immunoassay and HPLC-tandem mass spectrometry in the determination of sirolimus in whole blood
    • (1999) Clin Chem , vol.45 , pp. 2278-2280
    • Salm, P.1    Taylor, P.J.2    Pillans, P.I.3
  • 21
    • 0034023133 scopus 로고    scopus 로고
    • Measurement of sirolimus in whole blood using high-performance liquid chromatography with ultraviolet detection
    • (2000) Clin Ther , vol.22 , pp. B38-B48
    • Holt, D.W.1    Lee, T.2    Johnston, A.3
  • 22
    • 0029829769 scopus 로고    scopus 로고
    • Routine clinical monitoring of sirolimus (rapamycin) whole-blood concentrations by HPLC with ultraviolet detection
    • (1996) Clin Chem , vol.42 , pp. 1943-1948
    • Napoli, K.L.1    Kahan, B.D.2
  • 23
    • 0030001227 scopus 로고    scopus 로고
    • Comparison of binding characteristics of four rapamycin metabolites to the 14 and 52 kDa immunophilins with their pharmacologic activity measured by the mixed-lymphocyte culture assay
    • (1996) Clin Biochem , vol.29 , pp. 309-313
    • Goodyear, N.1    Murthy, J.N.2    Gallant, H.L.3
  • 26
    • 0034080768 scopus 로고    scopus 로고
    • The quantification of sirolimus by high-performance liquid chromatography-tandem mass spectrometry and microparticle enzyme immunoassay in renal transplant recipients
    • (2000) Clin Ther , vol.22 , pp. B71-B85
    • Salm, P.1    Taylor, P.J.2    Pillans, P.I.3
  • 29
    • 9244240732 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled study of the safety, tolerance, and preliminary pharmacokinetics of ascending single doses of orally administered sirolimus (rapamycin) in stable renal transplant recipients
    • (1996) Transplant Proc , vol.28 , pp. 987
    • Johnson, E.M.1    Zimmerman, J.2    Duderstadt, K.3
  • 33
    • 4244174370 scopus 로고    scopus 로고
    • Sirolimus oral solution and tablets demonstrate equivalent safety and efficacy in renal allografts
    • American Society of Transplantation/American Society of Transplant Surgeons Joint Meeting; 2000 May 13-17; Chicago
    • (2000) Transplantation , vol.69 , pp. S153
    • Van Buren, C.T.1
  • 34
    • 4244174372 scopus 로고    scopus 로고
    • Comparison of the pharmacokinetics of sirolimus (Rapamune) in renal transplant recipients following administration of the liquid or solid table formations
    • (2000) Transplantation , vol.69 , pp. S154
    • Kelly, P.1    Napoli, K.L.2    Kahan, B.D.3
  • 36
    • 4243606204 scopus 로고    scopus 로고
    • A comparative study of the pharmacokinetic profiles of sirolimus oral solution and tablets in renal allograft patients
    • (2000) Transplantation , vol.69 , pp. S154
    • Zimmerman, J.1
  • 45
    • 0031786057 scopus 로고    scopus 로고
    • In vitro and in situ absorption of SDZRAD using a human intestinal cell line (Caco-2) and a single pass perfusion model in rats: Comparison with rapamycin
    • (1998) Pharm Res , vol.15 , pp. 1666-1672
    • Crowe, A.1    Lemaire, M.2
  • 50
    • 0029126123 scopus 로고
    • High performance liquid chromatographic isolation and spectroscopic characterization of three major metabolites from the plasma of rats receiving rapamycin (sirolimus) orally
    • (1995) J Liq Chromatogr , vol.18 , pp. 2259
    • Wang, C.P.1    Lim, H.K.2    Chan, K.W.3
  • 52
    • 33746530366 scopus 로고    scopus 로고
    • Sirolimus (Rapamune, rapamycin) is more effective than azathioprine to reduce the incidence of acute renal allograft rejection episodes when used in combination with cyclosporine and prednisone: A phase III U.S. multicenter trial
    • (2000) Lancet , vol.356 , pp. 194-202
    • Kahan, B.D.1
  • 56
    • 0033610638 scopus 로고    scopus 로고
    • Sirolimus reduces the incidence of acute rejection episodes despite lower cyclosporine doses in Caucasian recipients of mismatched primary renal allografts: A phase II trial
    • (1999) Transplantation , vol.68 , pp. 1526-1532
    • Kahan, B.D.1    Julian, B.A.2    Pescovitz, M.D.3
  • 57
    • 0345161813 scopus 로고    scopus 로고
    • Sirolimus European Renal Transplant Study Group. Sirolimus (rapamycin)-based therapy in human renal transplantation: Similar efficacy and different toxicity compared with cyclosporine
    • (1999) Transplantation , vol.67 , pp. 1036-1042
    • Groth, C.G.1    Backman, L.2    Morales, J.M.3
  • 59
    • 0033567982 scopus 로고    scopus 로고
    • Use of anti-CD25 monoclonal antibody in combination with rapamycin to eliminate cyclosporine treatment during the induction phase of immunosuppression [brief communication]
    • (1999) Transplantation , vol.68 , pp. 701-704
    • Hong, J.C.1    Kahan, B.D.2
  • 60
    • 0035086695 scopus 로고    scopus 로고
    • A calcineurin-free strategy for induction immunosuppression for delayed graft function in cadaveric kidney transplantation
    • (2001) Transplant Proc , vol.33 , pp. 1271-1272
    • Hong, J.C.1    Kahan, B.D.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.