메뉴 건너뛰기




Volumn 103, Issue 2, 2008, Pages 369-382

Pulmonary lymphangioleiomyomatosis (LAM): Progress and current challenges

Author keywords

Lung; Signal transduction; Smooth muscle; TSC1; TSC2; Tumor

Indexed keywords

GROWTH FACTOR; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; RAPAMYCIN; REGULATOR PROTEIN; S6 KINASE; TUBERIN; TUBEROUS SCLEROSIS 1 PROTEIN; UNCLASSIFIED DRUG;

EID: 38649143200     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.21419     Document Type: Review
Times cited : (43)

References (82)
  • 1
    • 0034014735 scopus 로고    scopus 로고
    • Mutational analysis of the tuberous sclerosis gene TSC2 in patients with pulmonary lymphangioleiomyomatosis
    • Astrinidis A, Khare L, Carsillo T, Smolareck T, Au KS, Northrup H, Henske EP. 2000. Mutational analysis of the tuberous sclerosis gene TSC2 in patients with pulmonary lymphangioleiomyomatosis. J Med Genet 37:55-57.
    • (2000) J Med Genet , vol.37 , pp. 55-57
    • Astrinidis, A.1    Khare, L.2    Carsillo, T.3    Smolareck, T.4    Au, K.S.5    Northrup, H.6    Henske, E.P.7
  • 2
    • 33750155593 scopus 로고    scopus 로고
    • Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase
    • Avruch J, Hara K, Lin Y, Liu M, Long X, Ortiz-Vega S, Yonezawa K. 2006. Insulin and amino-acid regulation of mTOR signaling and kinase activity through the Rheb GTPase. Oncogene 25:6361-6372.
    • (2006) Oncogene , vol.25 , pp. 6361-6372
    • Avruch, J.1    Hara, K.2    Lin, Y.3    Liu, M.4    Long, X.5    Ortiz-Vega, S.6    Yonezawa, K.7
  • 3
    • 34047095297 scopus 로고    scopus 로고
    • The Two TORCs and Akt
    • Bhaskar PT, Hay N. 2007. The Two TORCs and Akt. Dev Cell 12:487-502.
    • (2007) Dev Cell , vol.12 , pp. 487-502
    • Bhaskar, P.T.1    Hay, N.2
  • 4
    • 31544443860 scopus 로고    scopus 로고
    • TSC2, a key player in tumor suppression and cystic kidney disease
    • Cai S-L, Walker CL. 2006. TSC2, a key player in tumor suppression and cystic kidney disease. Nephrol Ther 2:S119-S122.
    • (2006) Nephrol Ther , vol.2
    • Cai, S.-L.1    Walker, C.L.2
  • 6
    • 0034705207 scopus 로고    scopus 로고
    • Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis
    • Carsillo T, Astrinidis A, Henske EP. 2000. Mutations in the tuberous sclerosis complex gene TSC2 are a cause of sporadic pulmonary lymphangioleiomyomatosis. Proc Natl Acad Sci U S A 97:6085-6090.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 6085-6090
    • Carsillo, T.1    Astrinidis, A.2    Henske, E.P.3
  • 9
    • 33748168778 scopus 로고    scopus 로고
    • Mind the GAP: Wnt Steps onto the mTORC1 Train
    • Choo AY, Roux PP, Blenis J. 2006. Mind the GAP: Wnt Steps onto the mTORC1 Train. Cell 126:834-836.
    • (2006) Cell , vol.126 , pp. 834-836
    • Choo, A.Y.1    Roux, P.P.2    Blenis, J.3
  • 10
    • 33746808398 scopus 로고    scopus 로고
    • Wnt/β-Catenin Signaling in Development and Disease
    • Clevers H. 2006. Wnt/β-Catenin Signaling in Development and Disease. Cell 127:469-480.
    • (2006) Cell , vol.127 , pp. 469-480
    • Clevers, H.1
  • 11
    • 15444362044 scopus 로고    scopus 로고
    • The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway
    • Corradetti MN, Inoki K, Guan K-L. 2005. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J Biol Chem 280:9769-9772.
    • (2005) J Biol Chem , vol.280 , pp. 9769-9772
    • Corradetti, M.N.1    Inoki, K.2    Guan, K.-L.3
  • 15
    • 5444233787 scopus 로고    scopus 로고
    • Tsc2 is not a critical target of Akt during normal Drosophila development
    • Dong J, Pan D. 2004. Tsc2 is not a critical target of Akt during normal Drosophila development. Gene Dev 18:2479-2484.
    • (2004) Gene Dev , vol.18 , pp. 2479-2484
    • Dong, J.1    Pan, D.2
  • 16
    • 37849011347 scopus 로고    scopus 로고
    • Growth control under stress
    • Ellisen LW. 2005. Growth control under stress. Cell Cycle 4:e58-e60.
    • (2005) Cell Cycle , vol.4
    • Ellisen, L.W.1
  • 17
    • 12344279947 scopus 로고    scopus 로고
    • TSC 1-2tumor suppressor and regulation of mTOR signalling: Linking cell growth and proliferation?
    • Findlay GM, Harrington LS, Lamb RF. 2005. TSC 1-2tumor suppressor and regulation of mTOR signalling: linking cell growth and proliferation? Curr Opin Genet Dev 15:69-76.
    • (2005) Curr Opin Genet Dev , vol.15 , pp. 69-76
    • Findlay, G.M.1    Harrington, L.S.2    Lamb, R.F.3
  • 19
    • 23744454765 scopus 로고    scopus 로고
    • Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control
    • Gan B, Melkoumian ZK, Wu X, Guan K-L, Guan J-L. 2005. Identification of FIP200 interaction with the TSC1-TSC2 complex and its role in regulation of cell size control. J Cell Biol 170:379-389.
    • (2005) J Cell Biol , vol.170 , pp. 379-389
    • Gan, B.1    Melkoumian, Z.K.2    Wu, X.3    Guan, K.-L.4    Guan, J.-L.5
  • 20
    • 33749562122 scopus 로고    scopus 로고
    • Role of FIP200 in cardiac and liver development and its regulation of TNFα and TSC-mTOR signaling pathways
    • Gan B, Peng X, Nagy T, Alcaraz A, Gu H, Guan J-L. 2006a. Role of FIP200 in cardiac and liver development and its regulation of TNFα and TSC-mTOR signaling pathways. J Cell Biol 175:121-133.
    • (2006) J Cell Biol , vol.175 , pp. 121-133
    • Gan, B.1    Peng, X.2    Nagy, T.3    Alcaraz, A.4    Gu, H.5    Guan, J.-L.6
  • 21
    • 33845981498 scopus 로고    scopus 로고
    • Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of S6 kinase activation and cell growth
    • Gan B, Yoo Y, Guan J-L. 2006b. Association of focal adhesion kinase with tuberous sclerosis complex 2 in the regulation of S6 kinase activation and cell growth. J Biol Chem 281:37321-37329.
    • (2006) J Biol Chem , vol.281 , pp. 37321-37329
    • Gan, B.1    Yoo, Y.2    Guan, J.-L.3
  • 23
    • 11244277987 scopus 로고    scopus 로고
    • TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase
    • Goncharova E, Goncharov D, Noonan D, Krymskaya VP. 2004. TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. J Cell Biol 167:1171-1182.
    • (2004) J Cell Biol , vol.167 , pp. 1171-1182
    • Goncharova, E.1    Goncharov, D.2    Noonan, D.3    Krymskaya, V.P.4
  • 24
    • 34548845557 scopus 로고    scopus 로고
    • Assays for in vitro monitoring of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cell migration
    • Goncharova EA, Goncharov DA, Krymskaya VP. 2006a. Assays for in vitro monitoring of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cell migration. Nat Protoc 1:2933-2939.
    • (2006) Nat Protoc , vol.1 , pp. 2933-2939
    • Goncharova, E.A.1    Goncharov, D.A.2    Krymskaya, V.P.3
  • 28
    • 33646566510 scopus 로고    scopus 로고
    • Functional genomics identifies TOR-regulated genes that control growth and division
    • Guertin DA, Guntur KVP, Bell GW, Thoreen CC, Sabatini DM. 2006a. Functional genomics identifies TOR-regulated genes that control growth and division. Curr Biol 16:958-970.
    • (2006) Curr Biol , vol.16 , pp. 958-970
    • Guertin, D.A.1    Guntur, K.V.P.2    Bell, G.W.3    Thoreen, C.C.4    Sabatini, D.M.5
  • 29
    • 33751348056 scopus 로고    scopus 로고
    • Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1
    • Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, Brown M, Fitzgerald KJ, Sabatini DM. 2006b. Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCα, but Not S6K1. Dev Cell 11:859-871.
    • (2006) Dev Cell , vol.11 , pp. 859-871
    • Guertin, D.A.1    Stevens, D.M.2    Thoreen, C.C.3    Burds, A.A.4    Kalaany, N.Y.5    Moffat, J.6    Brown, M.7    Fitzgerald, K.J.8    Sabatini, D.M.9
  • 31
    • 0842325813 scopus 로고    scopus 로고
    • Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions
    • Han S, Santos TM, Puga A, Roy J, Thiele EA, McCollin M, Stemmer-Rachamimov A, Ramesh V. 2004. Phosphorylation of tuberin as a novel mechanism for somatic inactivation of the tuberous sclerosis complex proteins in brain lesions. Cancer Res 64:812-816.
    • (2004) Cancer Res , vol.64 , pp. 812-816
    • Han, S.1    Santos, T.M.2    Puga, A.3    Roy, J.4    Thiele, E.A.5    McCollin, M.6    Stemmer-Rachamimov, A.7    Ramesh, V.8
  • 32
    • 33847072201 scopus 로고    scopus 로고
    • AMP-activated protein kinase as a drug target
    • Hardie DG. 2007. AMP-activated protein kinase as a drug target. Annu Rev Pharmacol Toxicol 47:185-210.
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 185-210
    • Hardie, D.G.1
  • 33
    • 11844304072 scopus 로고    scopus 로고
    • Restraining PI3K: MTOR Signalling goes back to the membrane
    • Harrington LS, Findlay GM, Lamb RF. 2005. Restraining PI3K: mTOR Signalling goes back to the membrane. Trend Biochem Sci 30:35-42.
    • (2005) Trend Biochem Sci , vol.30 , pp. 35-42
    • Harrington, L.S.1    Findlay, G.M.2    Lamb, R.F.3
  • 34
    • 0344155279 scopus 로고    scopus 로고
    • Metastasis of benign tumor cells in tuberous sclerosis complex
    • Henske EP. 2003. Metastasis of benign tumor cells in tuberous sclerosis complex. Genes Chromosomes Cancer 38:376-381.
    • (2003) Genes Chromosomes Cancer , vol.38 , pp. 376-381
    • Henske, E.P.1
  • 35
    • 33847174115 scopus 로고    scopus 로고
    • Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase
    • Hsu Y-C, Chern JJ, Cai Y, Liu M, Choi K-W. 2007. Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. Nature 445:785-788.
    • (2007) Nature , vol.445 , pp. 785-788
    • Hsu, Y.-C.1    Chern, J.J.2    Cai, Y.3    Liu, M.4    Choi, K.-W.5
  • 36
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the TSC-mTOR pathway in human disease
    • Inoki K, Corradetti MN, Guan K-L. 2005a. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 37:19-24.
    • (2005) Nat Genet , vol.37 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.-L.3
  • 37
    • 14844363721 scopus 로고    scopus 로고
    • Signaling by target of rapamycin proteins in cell growth control
    • Inoki K, Ouyang H, Li Y, Guan K-L. 2005b. Signaling by target of rapamycin proteins in cell growth control. Microbiol Mol Biol Rev 69:79-100.
    • (2005) Microbiol Mol Biol Rev , vol.69 , pp. 79-100
    • Inoki, K.1    Ouyang, H.2    Li, Y.3    Guan, K.-L.4
  • 38
  • 39
    • 33749076673 scopus 로고    scopus 로고
    • SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
    • Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, Huang Q, Qin J, Su B. 2006. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 127:125-137.
    • (2006) Cell , vol.127 , pp. 125-137
    • Jacinto, E.1    Facchinetti, V.2    Liu, D.3    Soto, N.4    Wei, S.5    Jung, S.Y.6    Huang, Q.7    Qin, J.8    Su, B.9
  • 43
    • 0035019467 scopus 로고    scopus 로고
    • Tuberin-dependent membrane localization of polycystin-1: A functional link between polycystic kidney disease and the TSC2 tumor suppressor gene
    • Kleymenova E, Ibragimov-Beskrovnaya O, Kugoh H, Everitt J, Xu H, Kiguchi K, Landes G, Harris P, Walker C. 2001. Tuberin-dependent membrane localization of polycystin-1: A functional link between polycystic kidney disease and the TSC2 tumor suppressor gene. Mol Cell 7:823-832.
    • (2001) Mol Cell , vol.7 , pp. 823-832
    • Kleymenova, E.1    Ibragimov-Beskrovnaya, O.2    Kugoh, H.3    Everitt, J.4    Xu, H.5    Kiguchi, K.6    Landes, G.7    Harris, P.8    Walker, C.9
  • 44
    • 0028830856 scopus 로고
    • A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Ekert rat model of dominantly inherited cancer
    • Kobayashi E, Hirayama Y, Kobayashi E, Kubo Y, Hino O. 1995. A germline insertion in the tuberous sclerosis (Tsc2) gene gives rise to the Ekert rat model of dominantly inherited cancer. Nat Genet 9:70-74.
    • (1995) Nat Genet , vol.9 , pp. 70-74
    • Kobayashi, E.1    Hirayama, Y.2    Kobayashi, E.3    Kubo, Y.4    Hino, O.5
  • 45
    • 0033559663 scopus 로고    scopus 로고
    • Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice
    • Kobayashi E, Minowa O, Kuno J, Mitani H, Hino O, Noda T. 1999. Renal carcinogenesis, hepatic hemangiomatosis, and embryonic lethality caused by a germ-line Tsc2 mutation in mice. Cancer Res 59:1206-1211.
    • (1999) Cancer Res , vol.59 , pp. 1206-1211
    • Kobayashi, E.1    Minowa, O.2    Kuno, J.3    Mitani, H.4    Hino, O.5    Noda, T.6
  • 46
    • 0035902509 scopus 로고    scopus 로고
    • A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice
    • Kobayashi T, Minowa O, Sugitani Y, Takai S, Mitani H, Kobayashi E, Noda T, Hino O. 2001. A germ-line Tsc1 mutation causes tumor development and embryonic lethality that are similar, but not identical to, those caused by Tsc2 mutation in mice. Proc Natl Acad Sci U S A 98:8762-8767.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 8762-8767
    • Kobayashi, T.1    Minowa, O.2    Sugitani, Y.3    Takai, S.4    Mitani, H.5    Kobayashi, E.6    Noda, T.7    Hino, O.8
  • 47
    • 0037683087 scopus 로고    scopus 로고
    • Tumor suppressors hamartin and tuberin: Intracellular signaling
    • Krymskaya VP. 2003. Tumor suppressors hamartin and tuberin: Intracellular signaling. Cell Signal 15:729-739.
    • (2003) Cell Signal , vol.15 , pp. 729-739
    • Krymskaya, V.P.1
  • 48
    • 38649143284 scopus 로고    scopus 로고
    • Smooth muscle-like cells in lymphangioleiomyomatosis
    • In Press
    • Krymskaya VP. 2007. Smooth muscle-like cells in lymphangioleiomyomatosis. Proc Am Thorac Soc (In Press).
    • (2007) Proc Am Thorac Soc
    • Krymskaya, V.P.1
  • 49
    • 0037732711 scopus 로고    scopus 로고
    • Lymphangioleiomyomatosis: A complex tale of serum response factor-mediated tissue inhibitor of metalloproteinase-3 regulation
    • Krymskaya VP, Shipley JM. 2003. Lymphangioleiomyomatosis: A complex tale of serum response factor-mediated tissue inhibitor of metalloproteinase-3 regulation. Am J Respir Cell Mol Biol 28:546-550.
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 546-550
    • Krymskaya, V.P.1    Shipley, J.M.2
  • 50
    • 0041758428 scopus 로고    scopus 로고
    • Tuberous sclerosis: From tubers to mTOR
    • Kwiatkowski DJ. 2003. Tuberous sclerosis: From tubers to mTOR. Ann Human Genet 67:87-96.
    • (2003) Ann Human Genet , vol.67 , pp. 87-96
    • Kwiatkowski, D.J.1
  • 51
    • 0036501277 scopus 로고    scopus 로고
    • A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
    • Kwiatkowski DJ, Zhang H, Bandura JL, Heiberger KM, Glogauer M, el-Hashemite N, Onda H. 2002. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum Mol Genet 11:525-534.
    • (2002) Hum Mol Genet , vol.11 , pp. 525-534
    • Kwiatkowski, D.J.1    Zhang, H.2    Bandura, J.L.3    Heiberger, K.M.4    Glogauer, M.5    el-Hashemite, N.6    Onda, H.7
  • 54
    • 0038190932 scopus 로고    scopus 로고
    • The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14- 3-3
    • Li Y, Inoki K, Vacratsis P, Guan K-L. 2003. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 gene product, and enhances its interaction with 14- 3-3. J Biol Chem 278:13663-13671.
    • (2003) J Biol Chem , vol.278 , pp. 13663-13671
    • Li, Y.1    Inoki, K.2    Vacratsis, P.3    Guan, K.-L.4
  • 55
    • 17444431201 scopus 로고    scopus 로고
    • Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis
    • Ma L, Chen Z, Erdjument-Bromage H, Tempst P, Pandolfi PP. 2005. Phosphorylation and functional inactivation of TSC2 by Erk: Implications for tuberous sclerosis and cancer pathogenesis. Cell 121:179-193.
    • (2005) Cell , vol.121 , pp. 179-193
    • Ma, L.1    Chen, Z.2    Erdjument-Bromage, H.3    Tempst, P.4    Pandolfi, P.P.5
  • 57
    • 0346463022 scopus 로고    scopus 로고
    • Pam and its ortholog highwire interact with and may negatively regulate the TSC1/TSC2 complex
    • Murthy V, Han S, Beauchamp RL, Smith N, Haddad LA, Ito N, Ramesh V. 2004. Pam and its ortholog highwire interact with and may negatively regulate the TSC1/TSC2 complex. J Biol Chem 279:1351-1358.
    • (2004) J Biol Chem , vol.279 , pp. 1351-1358
    • Murthy, V.1    Han, S.2    Beauchamp, R.L.3    Smith, N.4    Haddad, L.A.5    Ito, N.6    Ramesh, V.7
  • 58
    • 16544383044 scopus 로고    scopus 로고
    • The mTOR/S6K signaling pathway: The role of the TSC1/2 tumor suppressor complex and the proto-oncogene Rheb
    • Nobukini T, Thomas G. 2005. The mTOR/S6K signaling pathway: The role of the TSC1/2 tumor suppressor complex and the proto-oncogene Rheb. Novartis Found Symp 262:148-159.
    • (2005) Novartis Found Symp , vol.262 , pp. 148-159
    • Nobukini, T.1    Thomas, G.2
  • 59
    • 0032741978 scopus 로고    scopus 로고
    • Tsc2+/- mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background
    • Onda H, Lueck A, Marks PW, Warren HB, Kwiatkowski DJ. 1999. Tsc2+/- mice develop tumors in multiple sites that express gelsolin and are influenced by genetic background. J Clin Invest 104:687-695.
    • (1999) J Clin Invest , vol.104 , pp. 687-695
    • Onda, H.1    Lueck, A.2    Marks, P.W.3    Warren, H.B.4    Kwiatkowski, D.J.5
  • 60
    • 33748934979 scopus 로고    scopus 로고
    • mTORC2 Caught in a SINful Akt
    • Polak P, Hall MN. 2006. mTORC2 Caught in a SINful Akt. Dev Cell 11:433-434.
    • (2006) Dev Cell , vol.11 , pp. 433-434
    • Polak, P.1    Hall, M.N.2
  • 61
    • 10044276784 scopus 로고    scopus 로고
    • The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
    • Reiling JH, Hafen E. 2004. The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Gene Dev 18:2879-2892.
    • (2004) Gene Dev , vol.18 , pp. 2879-2892
    • Reiling, J.H.1    Hafen, E.2
  • 62
    • 33747819801 scopus 로고    scopus 로고
    • mTOR and cancer: Insights into a complex relationship
    • Sabatini DM. 2006. mTOR and cancer: Insights into a complex relationship. Nat Rev Cancer 6:729-734.
    • (2006) Nat Rev Cancer , vol.6 , pp. 729-734
    • Sabatini, D.M.1
  • 63
  • 65
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. 2005. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307:1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 66
    • 0036160714 scopus 로고    scopus 로고
    • Mutational analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangileiomyomatosis
    • Sato T, Seyama K, Fujii H, Maruyama H, Setoguchi Y, Iwakami S, Fukuchi Y, Hino O. 2002. Mutational analysis of the TSC1 and TSC2 genes in Japanese patients with pulmonary lymphangileiomyomatosis. J Hum Genet 47:20-28.
    • (2002) J Hum Genet , vol.47 , pp. 20-28
    • Sato, T.1    Seyama, K.2    Fujii, H.3    Maruyama, H.4    Setoguchi, Y.5    Iwakami, S.6    Fukuchi, Y.7    Hino, O.8
  • 67
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw RJ, Cantley LC. 2006. Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441:424-430.
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 68
    • 33748950810 scopus 로고    scopus 로고
    • Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
    • Shiota C, Woo J-T, Lindner J, Shelton KD, Magnuson MA. 2006. Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell 11:583-589.
    • (2006) Dev Cell , vol.11 , pp. 583-589
    • Shiota, C.1    Woo, J.-T.2    Lindner, J.3    Shelton, K.D.4    Magnuson, M.A.5
  • 69
    • 0031923762 scopus 로고    scopus 로고
    • Evidence that lymphangiomyomatosis is caused by TSC2 mutations: Chromosome 16p13 loss of heterozygosity in angiolipomas and lymph nodes from women with lymphangiomyomatosis
    • Smolarek TA, Wessner LL, McCormack FX, Mylet JC, Menon AG, Henske EP. 1998. Evidence that lymphangiomyomatosis is caused by TSC2 mutations: Chromosome 16p13 loss of heterozygosity in angiolipomas and lymph nodes from women with lymphangiomyomatosis. Am J Hum Genet 62:810-815.
    • (1998) Am J Hum Genet , vol.62 , pp. 810-815
    • Smolarek, T.A.1    Wessner, L.L.2    McCormack, F.X.3    Mylet, J.C.4    Menon, A.G.5    Henske, E.P.6
  • 71
    • 33744505375 scopus 로고    scopus 로고
    • Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6 K1
    • Um SH, D'Alessio D, Thomas G. 2006. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6 K1. Cell Metabol 3:393-402.
    • (2006) Cell Metabol , vol.3 , pp. 393-402
    • Um, S.H.1    D'Alessio, D.2    Thomas, G.3
  • 72
    • 33845647336 scopus 로고    scopus 로고
    • Intersection of signal transduction pathways and development
    • Vivekanand P, Rebay I, 2006. Intersection of signal transduction pathways and development. Annu Rev Genet 40:139-157.
    • (2006) Annu Rev Genet , vol.40 , pp. 139-157
    • Vivekanand, P.1    Rebay, I.2
  • 74
    • 15044363028 scopus 로고    scopus 로고
    • Recent advances in the protein kinase B signaling pathway
    • Woodgett JR. 2005. Recent advances in the protein kinase B signaling pathway. Curr Opin Cell Biol 17:150-157.
    • (2005) Curr Opin Cell Biol , vol.17 , pp. 150-157
    • Woodgett, J.R.1
  • 75
    • 33751079895 scopus 로고    scopus 로고
    • Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
    • Yang Q, Inoki K, Ikenoue T, Guan K-L. 2006. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev 20:2820-2832.
    • (2006) Genes Dev , vol.20 , pp. 2820-2832
    • Yang, Q.1    Inoki, K.2    Ikenoue, T.3    Guan, K.-L.4
  • 76
    • 0344155285 scopus 로고    scopus 로고
    • Multiple roles of the tuberous sclerosis complex genes
    • Yeung RS. 2003. Multiple roles of the tuberous sclerosis complex genes. Genes Chromosomes Cancer 38:368-375.
    • (2003) Genes Chromosomes Cancer , vol.38 , pp. 368-375
    • Yeung, R.S.1
  • 77
    • 9744268262 scopus 로고    scopus 로고
    • Lessons from the Eker Rat Model: From cage to bedside
    • Yeung RS. 2004. Lessons from the Eker Rat Model: From cage to bedside. Curr Mol Med 4:799-806.
    • (2004) Curr Mol Med , vol.4 , pp. 799-806
    • Yeung, R.S.1
  • 78
    • 0035888683 scopus 로고    scopus 로고
    • Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis
    • Yu J, Astrinidis A, Henske EP. 2001. Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis. Am J Respir Crit Care Med 164:1537-1540.
    • (2001) Am J Respir Crit Care Med , vol.164 , pp. 1537-1540
    • Yu, J.1    Astrinidis, A.2    Henske, E.P.3
  • 80
    • 10044240459 scopus 로고    scopus 로고
    • Combined smooth muscle and melanocytic differentiation in lymphangioleiomyomatosis
    • Zhe X, Schuger L. 2004. Combined smooth muscle and melanocytic differentiation in lymphangioleiomyomatosis. J Histochem Cytochem 52:1537-1542.
    • (2004) J Histochem Cytochem , vol.52 , pp. 1537-1542
    • Zhe, X.1    Schuger, L.2
  • 81
    • 0037383924 scopus 로고    scopus 로고
    • TIMP-3 downregulation in lymphangioleiomyomatosis: Potential consequence of abnormal SRF expression
    • Zhe X, Yang Y, Jakkaraju S, Schuger L. 2003. TIMP-3 downregulation in lymphangioleiomyomatosis: Potential consequence of abnormal SRF expression. Am J Respir Cell Mol Biol 28:504-511.
    • (2003) Am J Respir Cell Mol Biol , vol.28 , pp. 504-511
    • Zhe, X.1    Yang, Y.2    Jakkaraju, S.3    Schuger, L.4
  • 82
    • 11144244666 scopus 로고    scopus 로고
    • Imbalanced plasminogen system in lymphangioleiomyomatosis: Potential role of serum response factor
    • Zhe X, Yang Y, Schuger L. 2005. Imbalanced plasminogen system in lymphangioleiomyomatosis: Potential role of serum response factor. Am J Respir Cell Mol Biol 32:28-34.
    • (2005) Am J Respir Cell Mol Biol , vol.32 , pp. 28-34
    • Zhe, X.1    Yang, Y.2    Schuger, L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.